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Entry version 185 (12 Aug 2020)
Sequence version 3 (23 Jan 2007)
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Protein

Beta-adducin

Gene

ADD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P35612

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5223345, Miscellaneous transport and binding events

SIGNOR Signaling Network Open Resource

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SIGNORi
P35612

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-adducin
Alternative name(s):
Erythrocyte adducin subunit beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADD2
Synonyms:ADDB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000075340.22

Human Gene Nomenclature Database

More...
HGNCi
HGNC:244, ADD2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
102681, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35612

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
119

Open Targets

More...
OpenTargetsi
ENSG00000075340

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24566

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P35612, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADD2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
543774

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002185331 – 726Beta-adducinAdd BLAST726

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1
Modified residuei25PhosphoserineBy similarity1
Modified residuei55Phosphothreonine; by PKA1 Publication1
Modified residuei60PhosphoserineBy similarity1
Modified residuei344PhosphoserineBy similarity1
Modified residuei530PhosphoserineCombined sources1
Modified residuei532PhosphoserineCombined sources1
Modified residuei533PhosphothreonineBy similarity1
Modified residuei535PhosphoserineBy similarity1
Modified residuei592PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei600PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei611PhosphothreonineCombined sources1
Modified residuei613PhosphoserineCombined sources1
Modified residuei617PhosphoserineCombined sources1
Modified residuei619PhosphoserineBy similarity1
Modified residuei621PhosphoserineCombined sources1
Modified residuei675PhosphothreonineCombined sources1
Modified residuei686PhosphoserineBy similarity1
Modified residuei689PhosphoserineBy similarity1
Modified residuei693PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei699PhosphoserineBy similarity1
Modified residuei701PhosphoserineBy similarity1
Modified residuei703Phosphoserine; by PKC1 Publication1
Modified residuei713Phosphoserine; by PKA and PKC1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P35612

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P35612

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P35612

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P35612

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35612

PeptideAtlas

More...
PeptideAtlasi
P35612

PRoteomics IDEntifications database

More...
PRIDEi
P35612

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55105 [P35612-1]
55106 [P35612-2]
55107 [P35612-3]
55108 [P35612-4]
55109 [P35612-5]
55110 [P35612-6]
55111 [P35612-7]
55112 [P35612-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35612

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35612

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Fetal kidney expresses isoforms 3, 4, 5, 6 and 7, and fetal liver expresses isoforms 3 and 4.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000075340, Expressed in cortical plate and 197 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35612, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35612, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000075340, Group enriched (bone marrow, brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit.

Found in a complex with ADD2, DMTN and SLC2A1.

Interacts with SLC2A1.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
106632, 25 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P35612

Protein interaction database and analysis system

More...
IntActi
P35612, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264436

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P35612, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35612

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni425 – 444Interaction with calmodulinSequence analysisAdd BLAST20
Regioni704 – 721Interaction with calmodulinSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3699, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159299

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006033_9_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35612

KEGG Orthology (KO)

More...
KOi
K18622

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFNGGME

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35612

TreeFam database of animal gene trees

More...
TreeFami
TF313003

Family and domain databases

Database of protein disorder

More...
DisProti
DP00241

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.225.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027773, ADD2
IPR001303, Aldolase_II/adducin_N
IPR036409, Aldolase_II/adducin_N_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10672:SF6, PTHR10672:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00596, Aldolase_II, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01007, Aldolase_II, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53639, SSF53639, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 9 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35612-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEETVPEAA SPPPPQGQPY FDRFSEDDPE YMRLRNRAAD LRQDFNLMEQ
60 70 80 90 100
KKRVTMILQS PSFREELEGL IQEQMKKGNN SSNIWALRQI ADFMASTSHA
110 120 130 140 150
VFPTSSMNVS MMTPINDLHT ADSLNLAKGE RLMRCKISSV YRLLDLYGWA
160 170 180 190 200
QLSDTYVTLR VSKEQDHFLI SPKGVSCSEV TASSLIKVNI LGEVVEKGSS
210 220 230 240 250
CFPVDTTGFC LHSAIYAARP DVRCIIHLHT PATAAVSAMK WGLLPVSHNA
260 270 280 290 300
LLVGDMAYYD FNGEMEQEAD RINLQKCLGP TCKILVLRNH GVVALGDTVE
310 320 330 340 350
EAFYKIFHLQ AACEIQVSAL SSAGGVENLI LLEQEKHRPH EVGSVQWAGS
360 370 380 390 400
TFGPMQKSRL GEHEFEALMR MLDNLGYRTG YTYRHPFVQE KTKHKSEVEI
410 420 430 440 450
PATVTAFVFE EDGAPVPALR QHAQKQQKEK TRWLNTPNTY LRVNVADEVQ
460 470 480 490 500
RSMGSPRPKT TWMKADEVEK SSSGMPIRIE NPNQFVPLYT DPQEVLEMRN
510 520 530 540 550
KIREQNRQDV KSAGPQSQLL ASVIAEKSRS PSTESQLMSK GDEDTKDDSE
560 570 580 590 600
ETVPNPFSQL TDQELEEYKK EVERKKLELD GEKETAPEEP GSPAKSAPAS
610 620 630 640 650
PVQSPAKEAE TKSPLVSPSK SLEEGTKKTE TSKAATTEPE TTQPEGVVVN
660 670 680 690 700
GREEEQTAEE ILSKGLSQMT TSADTDVDTS KDKTESVTSG PMSPEGSPSK
710 720
SPSKKKKKFR TPSFLKKSKK KEKVES
Length:726
Mass (Da):80,854
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB07F7303D929DBA4
GO
Isoform 2 (identifier: P35612-2) [UniParc]FASTAAdd to basket
Also known as: Adducin 63

The sequence of this isoform differs from the canonical sequence as follows:
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.

Show »
Length:559
Mass (Da):62,467
Checksum:iB62B278AE8F48FD4
GO
Isoform 3 (identifier: P35612-3) [UniParc]FASTAAdd to basket
Also known as: Beta-4, E

The sequence of this isoform differs from the canonical sequence as follows:
     581-726: GEKETAPEEP...KSKKKEKVES → ETGQEREPGS...QRRRQRQRAL

Show »
Length:643
Mass (Da):72,721
Checksum:i46A10F1D1278E955
GO
Isoform 4 (identifier: P35612-4) [UniParc]FASTAAdd to basket
Also known as: Beta-4a

The sequence of this isoform differs from the canonical sequence as follows:
     581-587: GEKETAP → APGWFSS
     588-726: Missing.

Show »
Length:587
Mass (Da):66,154
Checksum:iB7ACFE32B2731FB5
GO
Isoform 5 (identifier: P35612-5) [UniParc]FASTAAdd to basket
Also known as: Beta-4b

The sequence of this isoform differs from the canonical sequence as follows:
     188-493: Missing.
     581-586: GEKETA → ETGQER
     587-726: Missing.

Show »
Length:280
Mass (Da):31,935
Checksum:i851E20275B19D246
GO
Isoform 6 (identifier: P35612-6) [UniParc]FASTAAdd to basket
Also known as: Beta-4c

The sequence of this isoform differs from the canonical sequence as follows:
     188-493: Missing.
     581-587: GEKETAP → APGWFSS
     588-726: Missing.

Show »
Length:281
Mass (Da):31,967
Checksum:i1CF4ACF5875DDF12
GO
Isoform 7 (identifier: P35612-7) [UniParc]FASTAAdd to basket
Also known as: Beta-4d

The sequence of this isoform differs from the canonical sequence as follows:
     78-566: Missing.
     581-587: GEKETAP → APGWFSS
     588-726: Missing.

Show »
Length:98
Mass (Da):11,625
Checksum:i2FABB44289701D9B
GO
Isoform 8 (identifier: P35612-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPRRRVPGANCKPTGK
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.

Show »
Length:574
Mass (Da):64,086
Checksum:i4169DB571ED52F85
GO
Isoform 9 (identifier: P35612-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPRRRVPGANCKPTGKM
     532-559: STESQLMSKGDEDTKDDSEETVPNPFSQ → VEQRLPLTGGETCLPSGSSVPGAGLQDP
     560-726: Missing.

Show »
Length:575
Mass (Da):64,217
Checksum:i99629BA28D32AE6E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JTM0C9JTM0_HUMAN
Beta-adducin
ADD2
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J080C9J080_HUMAN
Beta-adducin
ADD2
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1C7CYY0A0A1C7CYY0_HUMAN
Beta-adducin
ADD2
279Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J299C9J299_HUMAN
Beta-adducin
ADD2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJK3C9JJK3_HUMAN
Beta-adducin
ADD2
17Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92464 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01486628D → N. Corresponds to variant dbSNP:rs4986Ensembl.1
Natural variantiVAR_04819598S → C. Corresponds to variant dbSNP:rs4987Ensembl.1
Natural variantiVAR_014867335E → D. Corresponds to variant dbSNP:rs4982Ensembl.1
Natural variantiVAR_025318439T → A1 PublicationCorresponds to variant dbSNP:rs17855969Ensembl.1
Natural variantiVAR_014868663S → R. Corresponds to variant dbSNP:rs4985Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0436251M → MPRRRVPGANCKPTGK in isoform 8. 1 Publication1
Alternative sequenceiVSP_0553091M → MPRRRVPGANCKPTGKM in isoform 9. 1 Publication1
Alternative sequenceiVSP_01724178 – 566Missing in isoform 7. 1 PublicationAdd BLAST489
Alternative sequenceiVSP_017242188 – 493Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_000181532 – 559STESQ…NPFSQ → VEQRLPLTGGETCLPSGSSV PGAGLQDP in isoform 2, isoform 8 and isoform 9. 2 PublicationsAdd BLAST28
Alternative sequenceiVSP_000182560 – 726Missing in isoform 2, isoform 8 and isoform 9. 2 PublicationsAdd BLAST167
Alternative sequenceiVSP_000183581 – 726GEKET…EKVES → ETGQEREPGSGPAVCEFFSV ALHIWSNILERKKLPQKSLA HLQSLHLLLQCRAQRRRQRQ RAL in isoform 3. 2 PublicationsAdd BLAST146
Alternative sequenceiVSP_017244581 – 587GEKETAP → APGWFSS in isoform 4, isoform 6 and isoform 7. 1 Publication7
Alternative sequenceiVSP_017243581 – 586GEKETA → ETGQER in isoform 5. 1 Publication6
Alternative sequenceiVSP_017245587 – 726Missing in isoform 5. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_017246588 – 726Missing in isoform 4, isoform 6 and isoform 7. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X58199 mRNA Translation: CAA41176.1
AF486420 mRNA Translation: AAP71863.1
AF486421 mRNA Translation: AAP71864.1
AF486422 mRNA Translation: AAP71865.1
AF486423 mRNA Translation: AAP71866.1
AK291007 mRNA Translation: BAF83696.1
AK297250 mRNA Translation: BAG59729.1
AK309773 mRNA No translation available.
AB209227 mRNA Translation: BAD92464.1 Different initiation.
AB593080 mRNA Translation: BAJ84020.1
AC005234 Genomic DNA Translation: AAD12715.1
AC007395 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99801.1
CH471053 Genomic DNA Translation: EAW99806.1
CH471053 Genomic DNA Translation: EAW99807.1
CH471053 Genomic DNA Translation: EAW99808.1
BC041666 mRNA Translation: AAH41666.1
BC051882 mRNA Translation: AAH51882.1
BC056881 mRNA Translation: AAH56881.1
BC065525 mRNA Translation: AAH65525.1
U43959 mRNA Translation: AAA86421.1
S81079, S81077 Genomic DNA Translation: AAD14349.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1906.1 [P35612-1]
CCDS1909.1 [P35612-3]
CCDS46318.1 [P35612-2]
CCDS54365.1 [P35612-9]

Protein sequence database of the Protein Information Resource

More...
PIRi
S18208

NCBI Reference Sequences

More...
RefSeqi
NP_001171983.1, NM_001185054.1 [P35612-1]
NP_001171984.1, NM_001185055.1 [P35612-9]
NP_001608.1, NM_001617.3 [P35612-1]
NP_059516.2, NM_017482.3 [P35612-2]
NP_059522.1, NM_017488.3 [P35612-3]
XP_011530804.1, XM_011532502.2 [P35612-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000264436; ENSP00000264436; ENSG00000075340 [P35612-1]
ENST00000355733; ENSP00000347972; ENSG00000075340 [P35612-3]
ENST00000403045; ENSP00000384303; ENSG00000075340 [P35612-1]
ENST00000407644; ENSP00000384677; ENSG00000075340 [P35612-1]
ENST00000413157; ENSP00000388072; ENSG00000075340 [P35612-2]
ENST00000430656; ENSP00000398112; ENSG00000075340 [P35612-9]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
119

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:119

UCSC genome browser

More...
UCSCi
uc002sgy.4, human [P35612-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58199 mRNA Translation: CAA41176.1
AF486420 mRNA Translation: AAP71863.1
AF486421 mRNA Translation: AAP71864.1
AF486422 mRNA Translation: AAP71865.1
AF486423 mRNA Translation: AAP71866.1
AK291007 mRNA Translation: BAF83696.1
AK297250 mRNA Translation: BAG59729.1
AK309773 mRNA No translation available.
AB209227 mRNA Translation: BAD92464.1 Different initiation.
AB593080 mRNA Translation: BAJ84020.1
AC005234 Genomic DNA Translation: AAD12715.1
AC007395 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAW99801.1
CH471053 Genomic DNA Translation: EAW99806.1
CH471053 Genomic DNA Translation: EAW99807.1
CH471053 Genomic DNA Translation: EAW99808.1
BC041666 mRNA Translation: AAH41666.1
BC051882 mRNA Translation: AAH51882.1
BC056881 mRNA Translation: AAH56881.1
BC065525 mRNA Translation: AAH65525.1
U43959 mRNA Translation: AAA86421.1
S81079, S81077 Genomic DNA Translation: AAD14349.1
CCDSiCCDS1906.1 [P35612-1]
CCDS1909.1 [P35612-3]
CCDS46318.1 [P35612-2]
CCDS54365.1 [P35612-9]
PIRiS18208
RefSeqiNP_001171983.1, NM_001185054.1 [P35612-1]
NP_001171984.1, NM_001185055.1 [P35612-9]
NP_001608.1, NM_001617.3 [P35612-1]
NP_059516.2, NM_017482.3 [P35612-2]
NP_059522.1, NM_017488.3 [P35612-3]
XP_011530804.1, XM_011532502.2 [P35612-1]

3D structure databases

SMRiP35612
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106632, 25 interactors
CORUMiP35612
IntActiP35612, 13 interactors
STRINGi9606.ENSP00000264436

PTM databases

iPTMnetiP35612
PhosphoSitePlusiP35612

Polymorphism and mutation databases

BioMutaiADD2
DMDMi543774

Proteomic databases

EPDiP35612
jPOSTiP35612
MassIVEiP35612
MaxQBiP35612
PaxDbiP35612
PeptideAtlasiP35612
PRIDEiP35612
ProteomicsDBi55105 [P35612-1]
55106 [P35612-2]
55107 [P35612-3]
55108 [P35612-4]
55109 [P35612-5]
55110 [P35612-6]
55111 [P35612-7]
55112 [P35612-8]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4066, 224 antibodies

Genome annotation databases

EnsembliENST00000264436; ENSP00000264436; ENSG00000075340 [P35612-1]
ENST00000355733; ENSP00000347972; ENSG00000075340 [P35612-3]
ENST00000403045; ENSP00000384303; ENSG00000075340 [P35612-1]
ENST00000407644; ENSP00000384677; ENSG00000075340 [P35612-1]
ENST00000413157; ENSP00000388072; ENSG00000075340 [P35612-2]
ENST00000430656; ENSP00000398112; ENSG00000075340 [P35612-9]
GeneIDi119
KEGGihsa:119
UCSCiuc002sgy.4, human [P35612-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
119
DisGeNETi119
EuPathDBiHostDB:ENSG00000075340.22

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADD2
HGNCiHGNC:244, ADD2
HPAiENSG00000075340, Group enriched (bone marrow, brain)
MIMi102681, gene
neXtProtiNX_P35612
OpenTargetsiENSG00000075340
PharmGKBiPA24566

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3699, Eukaryota
GeneTreeiENSGT00940000159299
HOGENOMiCLU_006033_9_2_1
InParanoidiP35612
KOiK18622
OMAiDFNGGME
PhylomeDBiP35612
TreeFamiTF313003

Enzyme and pathway databases

PathwayCommonsiP35612
ReactomeiR-HSA-5223345, Miscellaneous transport and binding events
SIGNORiP35612

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
119, 7 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADD2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ADD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
119
PharosiP35612, Tbio

Protein Ontology

More...
PROi
PR:P35612
RNActiP35612, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000075340, Expressed in cortical plate and 197 other tissues
ExpressionAtlasiP35612, baseline and differential
GenevisibleiP35612, HS

Family and domain databases

DisProtiDP00241
Gene3Di3.40.225.10, 1 hit
InterProiView protein in InterPro
IPR027773, ADD2
IPR001303, Aldolase_II/adducin_N
IPR036409, Aldolase_II/adducin_N_sf
PANTHERiPTHR10672:SF6, PTHR10672:SF6, 1 hit
PfamiView protein in Pfam
PF00596, Aldolase_II, 1 hit
SMARTiView protein in SMART
SM01007, Aldolase_II, 1 hit
SUPFAMiSSF53639, SSF53639, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADDB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35612
Secondary accession number(s): A8K4P2
, B4DM17, D6W5G7, D6W5G8, Q13482, Q16412, Q59G82, Q5U5P4, Q6P0P2, Q6PGQ4, Q7Z688, Q7Z689, Q7Z690, Q7Z691
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: August 12, 2020
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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