ADD1

Functionⁱ

Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

GO - Molecular functionⁱ

actin binding
Source: ProtInc
Traceable author statementⁱ
- 1840603
actin filament binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7642559
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
calmodulin binding Source: UniProtKB-KW
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7642559
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7642559
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
spectrin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7642559
structural molecule activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16289097

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cytoskeleton organization
Source: BHF-UCL
Inferred by curatorⁱ
- 3693401
actin filament bundle assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 3693401
barbed-end actin filament capping
Source: BHF-UCL
Inferred from direct assayⁱ
- 8626479
cell morphogenesis Source: Ensembl
cellular response to calcium ion
Source: CAFA
Inferred from direct assayⁱ
- 25978380
cell volume homeostasis Source: Ensembl
erythrocyte differentiation Source: Ensembl
hemoglobin metabolic process Source: Ensembl
homeostasis of number of cells within a tissue Source: Ensembl
in utero embryonic development Source: Ensembl
IRE1-mediated unfolded protein response Source: Reactome
multicellular organism growth Source: Ensembl
positive regulation of adherens junction organization
Source: CAFA
Inferred from direct assayⁱ
- 25978380
positive regulation of establishment of endothelial barrier
Source: CAFA
Inferred from direct assayⁱ
- 25978380
positive regulation of protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 3693401
- 7642559
transmembrane transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Calmodulin-binding

Molecular function

Actin-binding, Calmodulin-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-5223345 Miscellaneous transport and binding events
SIGNORⁱ	P35611

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-adducin Alternative name(s): Erythrocyte adducin subunit alpha
Gene namesⁱ	Name:ADD1 Synonyms:ADDA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000087274.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:243 ADD1
MIMⁱ	102680 gene
neXtProtⁱ	NX_P35611

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	445	T → D: Abolishes phosphorylation by ROCK2; when associated with D-480. 1 Publication		1
Mutagenesisⁱ	480	T → D: Abolishes phosphorylation by ROCK2; when associated with D-445. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	118
MalaCards human disease database More...MalaCardsⁱ	ADD1
Open Targets More...OpenTargetsⁱ	ENSG00000087274
PharmGKBⁱ	PA31

Polymorphism and mutation databases

BioMutaⁱ	ADD1
DMDMⁱ	12644231

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218530	1 – 737	Alpha-adducinAdd BLAST		737

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	12	PhosphoserineCombined sources	1
Modified residueⁱ	59	Phosphoserine; by PKACombined sources1 Publication	1
Modified residueⁱ	64	PhosphoserineCombined sources	1
Modified residueⁱ	331	PhosphothreonineCombined sources	1
Modified residueⁱ	334	PhosphoserineCombined sources	1
Modified residueⁱ	353	PhosphoserineCombined sources	1
Modified residueⁱ	355	PhosphoserineCombined sources	1
Modified residueⁱ	358	PhosphoserineCombined sources	1
Modified residueⁱ	366	PhosphoserineCombined sources	1
Modified residueⁱ	408	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	427	PhosphoserineBy similarity	1
Modified residueⁱ	429	PhosphothreonineBy similarity	1
Modified residueⁱ	431	PhosphoserineCombined sources	1
Modified residueⁱ	436	Phosphoserine; by PKACombined sources1 Publication	1
Modified residueⁱ	445	Phosphothreonine; by ROCK21 Publication	1
Modified residueⁱ	464	PhosphoserineBy similarity	1
Modified residueⁱ	465	PhosphoserineCombined sources	1
Modified residueⁱ	480	Phosphothreonine; by ROCK21 Publication	1
Modified residueⁱ	481	Phosphoserine; by PKA1 Publication	1
Modified residueⁱ	586	PhosphoserineBy similarity	1
Modified residueⁱ	600	PhosphoserineBy similarity	1
Modified residueⁱ	613	PhosphoserineBy similarity	1
Modified residueⁱ	614	PhosphothreonineBy similarity	1
Modified residueⁱ	678	PhosphoserineCombined sources	1
Modified residueⁱ	707	PhosphoserineCombined sources	1
Modified residueⁱ	710	PhosphoserineCombined sources	1
Modified residueⁱ	714	PhosphoserineCombined sources	1
Modified residueⁱ	716	Phosphoserine; by PKCCombined sources1 Publication	1
Modified residueⁱ	726	Phosphoserine; by PKA and PKC1 Publication	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P35611
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35611
PaxDbⁱ	P35611
PeptideAtlas More...PeptideAtlasⁱ	P35611
PRIDEⁱ	P35611
ProteomicsDBⁱ	55102 55103 [P35611-2] 55104 [P35611-3]

PTM databases

iPTMnetⁱ	P35611
PhosphoSitePlusⁱ	P35611

Miscellaneous databases

PMAP-CutDBⁱ	P35611

PMAP-CutDBⁱ

P35611

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.

Gene expression databases

Bgeeⁱ	ENSG00000087274 Expressed in 239 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_ADD1
ExpressionAtlasⁱ	P35611 baseline and differential
Genevisibleⁱ	P35611 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009794 HPA035873 HPA035874

HPAⁱ

CAB009794
HPA035873
HPA035874

Interactionⁱ

Subunit structureⁱ

Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
HMG20A	Q9NP66	3	EBI-10206868,EBI-740641

With

Entry

#Exp.

IntAct

Notes

HMG20A

Q9NP66

3

EBI-10206868,EBI-740641

GO - Molecular functionⁱ

actin binding
Source: ProtInc
Traceable author statementⁱ
- 1840603
actin filament binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7642559
cadherin binding
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 25468996
calmodulin binding Source: UniProtKB-KW
protein heterodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7642559
protein homodimerization activity
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7642559
spectrin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7642559
transcription factor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 16289097

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106631, 61 interactors
IntActⁱ	P35611, 46 interactors
Molecular INTeraction database More...MINTⁱ	P35611
STRINGⁱ	9606.ENSP00000264758

Structureⁱ

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00240
ProteinModelPortalⁱ	P35611
SMRⁱ	P35611
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	717 – 734	Interaction with calmodulinSequence analysisAdd BLAST		18

Domainⁱ

Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.

Sequence similaritiesⁱ

Belongs to the aldolase class II family. Adducin subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG3699 Eukaryota COG0235 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016462
HOGENOMⁱ	HOG000116349
HOVERGENⁱ	HBG004180
InParanoidⁱ	P35611
KEGG Orthology (KO) More...KOⁱ	K18622
OMAⁱ	QKGPEEN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0324
PhylomeDBⁱ	P35611
TreeFamⁱ	TF313003

Family and domain databases

Gene3Dⁱ	3.40.225.10, 1 hit
InterProⁱ	View protein in InterPro IPR027766 ADD1 IPR001303 Aldolase_II/adducin_N IPR036409 Aldolase_II/adducin_N_sf
PANTHERⁱ	PTHR10672:SF4 PTHR10672:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00596 Aldolase_II, 1 hit
SMARTⁱ	View protein in SMART SM01007 Aldolase_II, 1 hit
SUPFAMⁱ	SSF53639 SSF53639, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 6 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P35611-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN 
        60         70         80         90        100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT 
       110        120        130        140        150
NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA 
       160        170        180        190        200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI 
       210        220        230        240        250
NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA 
       260        270        280        290        300
MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 
       310        320        330        340        350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK 
       360        370        380        390        400
AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL 
       410        420        430        440        450
REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS 
       460        470        480        490        500
GRGDEASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ 
       510        520        530        540        550
EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT ASKAIIEKEY 
       560        570        580        590        600
QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS 
       610        620        630        640        650
PPDQPAVPHP PPSTPIKLEE DLVPEPTTGD DSDAATFKPT LPDLSPDEPS 
       660        670        680        690        700
EALGFPMLEK EEEAHRPPSP TEAPTEASPE PAPDPAPVAE EAAPSAVEEG 
       710        720        730 
AAADPGSDGS PGKSPSKKKK KFRTPSFLKK SKKKSDS

Length:737

Mass (Da):80,955

Last modified:December 1, 2000 - v2

Checksum:ⁱDF13AB30B12F20B6

GO

Isoform 2 (identifier: P35611-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
621-631: DLVPEPTTGDD → GDGCAREYLLP
632-737: Missing.

« Hide

        10         20         30         40         50
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN 
        60         70         80         90        100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT 
       110        120        130        140        150
NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA 
       160        170        180        190        200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI 
       210        220        230        240        250
NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA 
       260        270        280        290        300
MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 
       310        320        330        340        350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK 
       360        370        380        390        400
AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL 
       410        420        430        440        450
REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS 
       460        470        480        490        500
GRGDEASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ 
       510        520        530        540        550
EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQGELVT ASKAIIEKEY 
       560        570        580        590        600
QPHVIVSTTG PNPFTTLTDR ELEEYRREVE RKQKGSEENL DEAREQKEKS 
       610        620        630 
PPDQPAVPHP PPSTPIKLEE GDGCAREYLL P

Show »

Length:631

Mass (Da):69,985

Checksum:ⁱ350DDCF58AB61357

GO

Isoform 3 (identifier: P35611-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
471-471: K → KVWTNITHDHVKPLLQSLSSGVCVPSCITNCL

« Hide

        10         20         30         40         50
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN 
        60         70         80         90        100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT 
       110        120        130        140        150
NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA 
       160        170        180        190        200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI 
       210        220        230        240        250
NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA 
       260        270        280        290        300
MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 
       310        320        330        340        350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK 
       360        370        380        390        400
AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL 
       410        420        430        440        450
REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS 
       460        470        480        490        500
GRGDEASEEG QNGSSPKSKT KVWTNITHDH VKPLLQSLSS GVCVPSCITN 
       510        520        530        540        550
CLWTKEDGHR TSTSAVPNLF VPLNTNPKEV QEMRNKIREQ NLQDIKTAGP 
       560        570        580        590        600
QSQVLCGVVM DRSLVQGELV TASKAIIEKE YQPHVIVSTT GPNPFTTLTD 
       610        620        630        640        650
RELEEYRREV ERKQKGSEEN LDEAREQKEK SPPDQPAVPH PPPSTPIKLE 
       660        670        680        690        700
EDLVPEPTTG DDSDAATFKP TLPDLSPDEP SEALGFPMLE KEEEAHRPPS 
       710        720        730        740        750
PTEAPTEASP EPAPDPAPVA EEAAPSAVEE GAAADPGSDG SPGKSPSKKK 
       760 
KKFRTPSFLK KSKKKSDS

Show »

Length:768

Mass (Da):84,303

Checksum:ⁱD97BFFA790F661CA

GO

Isoform 4 (identifier: P35611-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-535: Q → QDAPLSDCTETIEGLELTEQTFSPAKSLSFRK
     621-631: DLVPEPTTGDD → GDGCAREYLLP
     632-737: Missing.

« Hide

        10         20         30         40         50
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN 
        60         70         80         90        100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT 
       110        120        130        140        150
NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA 
       160        170        180        190        200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI 
       210        220        230        240        250
NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA 
       260        270        280        290        300
MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 
       310        320        330        340        350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK 
       360        370        380        390        400
AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL 
       410        420        430        440        450
REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS 
       460        470        480        490        500
GRGDEASEEG QNGSSPKSKT KWTKEDGHRT STSAVPNLFV PLNTNPKEVQ 
       510        520        530        540        550
EMRNKIREQN LQDIKTAGPQ SQVLCGVVMD RSLVQDAPLS DCTETIEGLE 
       560        570        580        590        600
LTEQTFSPAK SLSFRKGELV TASKAIIEKE YQPHVIVSTT GPNPFTTLTD 
       610        620        630        640        650
RELEEYRREV ERKQKGSEEN LDEAREQKEK SPPDQPAVPH PPPSTPIKLE 
       660 
EGDGCAREYL LP

Note: No experimental confirmation available.

Show »

Length:662

Mass (Da):73,382

Checksum:ⁱ28B30DE00E7C3624

GO

Isoform 5 (identifier: P35611-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
472-511: WTKEDGHRTS...MRNKIREQNL → VWTNITHDHV...LVCAYLTVHS
512-737: Missing.

« Hide

        10         20         30         40         50
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN 
        60         70         80         90        100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT 
       110        120        130        140        150
NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA 
       160        170        180        190        200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI 
       210        220        230        240        250
NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA 
       260        270        280        290        300
MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 
       310        320        330        340        350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK 
       360        370        380        390        400
AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL 
       410        420        430        440        450
REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS 
       460        470        480        490        500
GRGDEASEEG QNGSSPKSKT KVWTNITHDH VKPLLQSLSS GVCVPSCITN 
       510 
CLVCAYLTVH S

Note: No experimental confirmation available.

Show »

Length:511

Mass (Da):56,286

Checksum:ⁱ4CD8F88129465C07

GO

Isoform 6 (identifier: P35611-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     471-471: K → KVWTNITHDHVKPLLQSLSSGVCVPSCITNCL
     621-631: DLVPEPTTGDD → GDGCAREYLLP
     632-737: Missing.

« Hide

        10         20         30         40         50
MNGDSRAAVV TSPPPTTAPH KERYFDRVDE NNPEYLRERN MAPDLRQDFN 
        60         70         80         90        100
MMEQKKRVSM ILQSPAFCEE LESMIQEQFK KGKNPTGLLA LQQIADFMTT 
       110        120        130        140        150
NVPNVYPAAP QGGMAALNMS LGMVTPVNDL RGSDSIAYDK GEKLLRCKLA 
       160        170        180        190        200
AFYRLADLFG WSQLIYNHIT TRVNSEQEHF LIVPFGLLYS EVTASSLVKI 
       210        220        230        240        250
NLQGDIVDRG STNLGVNQAG FTLHSAIYAA RPDVKCVVHI HTPAGAAVSA 
       260        270        280        290        300
MKCGLLPISP EALSLGEVAY HDYHGILVDE EEKVLIQKNL GPKSKVLILR 
       310        320        330        340        350
NHGLVSVGES VEEAFYYIHN LVVACEIQVR TLASAGGPDN LVLLNPEKYK 
       360        370        380        390        400
AKSRSPGSPV GEGTGSPPKW QIGEQEFEAL MRMLDNLGYR TGYPYRYPAL 
       410        420        430        440        450
REKSKKYSDV EVPASVTGYS FASDGDSGTC SPLRHSFQKQ QREKTRWLNS 
       460        470        480        490        500
GRGDEASEEG QNGSSPKSKT KVWTNITHDH VKPLLQSLSS GVCVPSCITN 
       510        520        530        540        550
CLWTKEDGHR TSTSAVPNLF VPLNTNPKEV QEMRNKIREQ NLQDIKTAGP 
       560        570        580        590        600
QSQVLCGVVM DRSLVQGELV TASKAIIEKE YQPHVIVSTT GPNPFTTLTD 
       610        620        630        640        650
RELEEYRREV ERKQKGSEEN LDEAREQKEK SPPDQPAVPH PPPSTPIKLE 
       660 
EGDGCAREYL LP

Show »

Length:662

Mass (Da):73,333

Checksum:ⁱ2F406B91F481F774

GO

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0Y9H2	H0Y9H2_HUMAN	Alpha-adducin Alpha-adducin	ADD1	444	Annotation score:
E7EV99	E7EV99_HUMAN	Alpha-adducin Alpha-adducin	ADD1	632	Annotation score:
E7ENY0	E7ENY0_HUMAN	Alpha-adducin Alpha-adducin	ADD1	663	Annotation score:
H0YG19	H0YG19_HUMAN	Alpha-adducin Alpha-adducin	ADD1	114	Annotation score:
A0A0A0MSR2	A0A0A0MSR2_HUMAN	Alpha-adducin Alpha-adducin	ADD1	400	Annotation score:
D6RF25	D6RF25_HUMAN	Alpha-adducin Alpha-adducin	ADD1	142	Annotation score:
D6RJE2	D6RJE2_HUMAN	Alpha-adducin Alpha-adducin	ADD1	69	Annotation score:
H0YFD8	H0YFD8_HUMAN	Alpha-adducin Alpha-adducin	ADD1	105	Annotation score:
D6RAH3	D6RAH3_HUMAN	Alpha-adducin Alpha-adducin	ADD1	137	Annotation score:

Sequence cautionⁱ

The sequence CAA98970 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	606	A → E in AAB05645 (PubMed:7774961).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_022108	6	R → C. Corresponds to variant dbSNP:rs2295497Ensembl.	1
Natural variantⁱVAR_014863	270	Y → N. Corresponds to variant dbSNP:rs4971Ensembl.	1
Natural variantⁱVAR_014864	376	E → D. Corresponds to variant dbSNP:rs4972Ensembl.	1
Natural variantⁱVAR_014184	460	G → W2 PublicationsCorresponds to variant dbSNP:rs4961EnsemblClinVar.	1
Natural variantⁱVAR_014865	510	N → I. Corresponds to variant dbSNP:rs4962Ensembl.	1
Natural variantⁱVAR_014185	586	S → C2 PublicationsCorresponds to variant dbSNP:rs4963Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_000174	471	K → KVWTNITHDHVKPLLQSLSS GVCVPSCITNCL in isoform 3 and isoform 6. 1 Publication	1
Alternative sequenceⁱVSP_055402	472 – 511	WTKED…REQNL → VWTNITHDHVKPLLQSLSSG VCVPSCITNCLVCAYLTVHS in isoform 5. 1 PublicationAdd BLAST	40
Alternative sequenceⁱVSP_055403	512 – 737	Missing in isoform 5. 1 PublicationAdd BLAST	226
Alternative sequenceⁱVSP_054420	535	Q → QDAPLSDCTETIEGLELTEQ TFSPAKSLSFRK in isoform 4. 1 Publication	1
Alternative sequenceⁱVSP_000175	621 – 631	DLVPEPTTGDD → GDGCAREYLLP in isoform 2, isoform 4 and isoform 6. 2 PublicationsAdd BLAST	11
Alternative sequenceⁱVSP_000176	632 – 737	Missing in isoform 2, isoform 4 and isoform 6. 2 PublicationsAdd BLAST	106

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X58141 mRNA Translation: CAA41149.1 L07261 mRNA No translation available. L29296 L29298 Genomic DNA Translation: AAB05645.1 AK295457 mRNA Translation: BAG58391.1 Z74617 Genomic DNA Translation: CAA98970.1 Sequence problems. Z68280 Genomic DNA No translation available. AL390065, AL121750, BX465861 Genomic DNA Translation: CAM21299.1 BX465861, AL121750, AL390065 Genomic DNA Translation: CAM25274.1 AL121750, AL390065, BX465861 Genomic DNA Translation: CAM28230.1 AL121750, AL390065, BX465861 Genomic DNA Translation: CAM28231.1 AL121750, AL390065, BX465861 Genomic DNA Translation: CAM28232.1 CH471131 Genomic DNA Translation: EAW82498.1 CH471131 Genomic DNA Translation: EAW82499.1 CH471131 Genomic DNA Translation: EAW82501.1 CH471131 Genomic DNA Translation: EAW82502.1 CH471131 Genomic DNA Translation: EAW82503.1 CH471131 Genomic DNA Translation: EAW82504.1 CH471131 Genomic DNA Translation: EAW82505.1 BC042998 mRNA Translation: AAH42998.1 AH004561 mRNA Translation: AAB30914.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3363.1 [P35611-3] CCDS3364.1 [P35611-6] CCDS43205.1 [P35611-1] CCDS75094.1 [P35611-4]
PIRⁱ	S18207
NCBI Reference Sequences More...RefSeqⁱ	NP_001110.2, NM_001119.4 [P35611-1] NP_001273574.1, NM_001286645.1 [P35611-4] NP_054908.2, NM_014189.3 [P35611-3] NP_054909.2, NM_014190.3 [P35611-2] NP_789771.1, NM_176801.2 [P35611-6] XP_005247994.1, XM_005247937.2 XP_016863193.1, XM_017007704.1 [P35611-3] XP_016863195.1, XM_017007706.1 [P35611-1] XP_016863196.1, XM_017007707.1 XP_016863197.1, XM_017007708.1 XP_016863198.1, XM_017007709.1 [P35611-2] XP_016863199.1, XM_017007710.1
UniGeneⁱ	Hs.183706

Genome annotation databases

Ensemblⁱ	ENST00000264758; ENSP00000264758; ENSG00000087274 [P35611-3] ENST00000355842; ENSP00000348100; ENSG00000087274 [P35611-4] ENST00000398123; ENSP00000381191; ENSG00000087274 [P35611-6] ENST00000398125; ENSP00000381193; ENSG00000087274 [P35611-6] ENST00000398129; ENSP00000381197; ENSG00000087274 [P35611-1]
GeneIDⁱ	118
KEGGⁱ	hsa:118
UCSC genome browser More...UCSCⁱ	uc003gfo.4 human [P35611-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35611	Alpha-adducin		PONAB		737	UniRef90_P35611
Alpha-adducin		RAT		735
Alpha-adducin		MOUSE		735
Adducin 1		MUSPF		775
alpha-adducin isoform X3		DELLE		754
+112
P35611-2	Isoform 2 of Alpha-adducin		RAT		631	UniRef90_Q63028-2
Adducin 1		CANLF		786
ADD1 isoform 9		PONAB		632
Alpha-adducin		HUMAN		632
ADD1 isoform 9		PANTR		632
+59
P35611-3	alpha-adducin isoform X1		DELLE		785	UniRef90_P35611-3
alpha-adducin isoform X1		ODORO		778
alpha-adducin isoform X2		PHYCD		778
alpha-adducin isoform X1		NEOSC		773
Alpha-adducin isoform b		CALJA		772
+134
P35611-4	Uncharacterized protein		MONDO		787	UniRef90_F6YW76
alpha-adducin		Florida manatee		772
alpha-adducin isoform X3		ALLSI		769
Adducin 1		SAIBB		766
Uncharacterized protein		AOTNA		766
+166
P35611-5	Alpha-adducin (Fragment)		ESCRO		417	UniRef90_P35611-5
Uncharacterized protein		AOTNA		415
Alpha-adducin		CAMFR		413
P35611-6	ADD1 isoform 12		PANTR		662	UniRef90_A0A2J8K6C9
Uncharacterized protein		PANPA		662
Adducin 1		MACMU		662
Uncharacterized protein		CERAT		662
Uncharacterized protein		MANLE		662
+68

Protein	Similar proteins		Species	Score	Length	Source
P35611	Alpha-adducin		PONAB		737	UniRef50_P35611
Alpha-adducin		RAT		735
Alpha-adducin		MOUSE		735
Adducin 1		MUSPF		775
alpha-adducin isoform X3		DELLE		754
+1451
P35611-5	Alpha-adducin (Fragment)		ESCRO		417	UniRef50_P35611-5
Uncharacterized protein		AOTNA		415
Alpha-adducin		CAMFR		413
Alpha-adducin		FUNHE		489
UPI000E7806F8		mainland tiger snake		585
+1
P35611-6	Adducin 1		FICAL		790	UniRef50_U3K5E0
Uncharacterized protein		BAMTH		785
Alpha-adducin (Fragment)		ANAPL		55
Alpha-adducin		FUKDA		854
Alpha-adducin		CHEMY		986
+223

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X58141 mRNA Translation: CAA41149.1 L07261 mRNA No translation available. L29296 L29298 Genomic DNA Translation: AAB05645.1 AK295457 mRNA Translation: BAG58391.1 Z74617 Genomic DNA Translation: CAA98970.1 Sequence problems. Z68280 Genomic DNA No translation available. AL390065, AL121750, BX465861 Genomic DNA Translation: CAM21299.1 BX465861, AL121750, AL390065 Genomic DNA Translation: CAM25274.1 AL121750, AL390065, BX465861 Genomic DNA Translation: CAM28230.1 AL121750, AL390065, BX465861 Genomic DNA Translation: CAM28231.1 AL121750, AL390065, BX465861 Genomic DNA Translation: CAM28232.1 CH471131 Genomic DNA Translation: EAW82498.1 CH471131 Genomic DNA Translation: EAW82499.1 CH471131 Genomic DNA Translation: EAW82501.1 CH471131 Genomic DNA Translation: EAW82502.1 CH471131 Genomic DNA Translation: EAW82503.1 CH471131 Genomic DNA Translation: EAW82504.1 CH471131 Genomic DNA Translation: EAW82505.1 BC042998 mRNA Translation: AAH42998.1 AH004561 mRNA Translation: AAB30914.2
CCDSⁱ	CCDS3363.1 [P35611-3] CCDS3364.1 [P35611-6] CCDS43205.1 [P35611-1] CCDS75094.1 [P35611-4]
PIRⁱ	S18207
RefSeqⁱ	NP_001110.2, NM_001119.4 [P35611-1] NP_001273574.1, NM_001286645.1 [P35611-4] NP_054908.2, NM_014189.3 [P35611-3] NP_054909.2, NM_014190.3 [P35611-2] NP_789771.1, NM_176801.2 [P35611-6] XP_005247994.1, XM_005247937.2 XP_016863193.1, XM_017007704.1 [P35611-3] XP_016863195.1, XM_017007706.1 [P35611-1] XP_016863196.1, XM_017007707.1 XP_016863197.1, XM_017007708.1 XP_016863198.1, XM_017007709.1 [P35611-2] XP_016863199.1, XM_017007710.1
UniGeneⁱ	Hs.183706

3D structure databases

DisProtⁱ	DP00240
ProteinModelPortalⁱ	P35611
SMRⁱ	P35611
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106631, 61 interactors
IntActⁱ	P35611, 46 interactors
MINTⁱ	P35611
STRINGⁱ	9606.ENSP00000264758

PTM databases

iPTMnetⁱ	P35611
PhosphoSitePlusⁱ	P35611

Polymorphism and mutation databases

BioMutaⁱ	ADD1
DMDMⁱ	12644231

Proteomic databases

EPDⁱ	P35611
MaxQBⁱ	P35611
PaxDbⁱ	P35611
PeptideAtlasⁱ	P35611
PRIDEⁱ	P35611
ProteomicsDBⁱ	55102 55103 [P35611-2] 55104 [P35611-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	118
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000264758; ENSP00000264758; ENSG00000087274 [P35611-3] ENST00000355842; ENSP00000348100; ENSG00000087274 [P35611-4] ENST00000398123; ENSP00000381191; ENSG00000087274 [P35611-6] ENST00000398125; ENSP00000381193; ENSG00000087274 [P35611-6] ENST00000398129; ENSP00000381197; ENSG00000087274 [P35611-1]
GeneIDⁱ	118
KEGGⁱ	hsa:118
UCSCⁱ	uc003gfo.4 human [P35611-1]

Organism-specific databases

CTDⁱ	118
DisGeNETⁱ	118
EuPathDBⁱ	HostDB:ENSG00000087274.16
GeneCardsⁱ	ADD1
HGNCⁱ	HGNC:243 ADD1
HPAⁱ	CAB009794 HPA035873 HPA035874
MalaCardsⁱ	ADD1
MIMⁱ	102680 gene
neXtProtⁱ	NX_P35611
OpenTargetsⁱ	ENSG00000087274
PharmGKBⁱ	PA31
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3699 Eukaryota COG0235 LUCA
GeneTreeⁱ	ENSGT00390000016462
HOGENOMⁱ	HOG000116349
HOVERGENⁱ	HBG004180
InParanoidⁱ	P35611
KOⁱ	K18622
OMAⁱ	QKGPEEN
OrthoDBⁱ	EOG091G0324
PhylomeDBⁱ	P35611
TreeFamⁱ	TF313003

Enzyme and pathway databases

Reactomeⁱ	R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-5223345 Miscellaneous transport and binding events
SIGNORⁱ	P35611

Miscellaneous databases

ChiTaRSⁱ	ADD1 human
GeneWikiⁱ	ADD1
GenomeRNAiⁱ	118
PMAP-CutDBⁱ	P35611
Protein Ontology More...PROⁱ	PR:P35611
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000087274 Expressed in 239 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_ADD1
ExpressionAtlasⁱ	P35611 baseline and differential
Genevisibleⁱ	P35611 HS

Family and domain databases

Gene3Dⁱ	3.40.225.10, 1 hit
InterProⁱ	View protein in InterPro IPR027766 ADD1 IPR001303 Aldolase_II/adducin_N IPR036409 Aldolase_II/adducin_N_sf
PANTHERⁱ	PTHR10672:SF4 PTHR10672:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00596 Aldolase_II, 1 hit
SMARTⁱ	View protein in SMART SM01007 Aldolase_II, 1 hit
SUPFAMⁱ	SSF53639 SSF53639, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADDA_HUMAN
Accessionⁱ	P35611Primary (citable) accession number: P35611 Secondary accession number(s): A2A3N8 Q9UJB6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P35611 (ADDA_HUMAN)

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Alpha-adducin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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Keywords - Coding sequence diversityi

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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GO - Molecular functionⁱ

Structureⁱ

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Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ