UniProtKB - P35606 (COPB2_HUMAN)
Coatomer subunit beta'
COPB2
Functioni
GO - Molecular functioni
- structural molecule activity Source: InterPro
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- intracellular protein transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: UniProtKB
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
- toxin transport Source: Ensembl
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P35606 |
Reactomei | R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
SignaLinki | P35606 |
Names & Taxonomyi
Protein namesi | Recommended name: Coatomer subunit beta'Alternative name(s): Beta'-coat protein Short name: Beta'-COP p102 |
Gene namesi | Name:COPB2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2232, COPB2 |
MIMi | 606990, gene |
neXtProti | NX_P35606 |
VEuPathDBi | HostDB:ENSG00000184432.9 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol By similarity
Golgi apparatus
- Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- COPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Shows only a slight preference for the cis-Golgi apparatus, compared with the trans-Golgi.By similarity
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Golgi apparatus
- COPI vesicle coat Source: UniProtKB
- Golgi membrane Source: Reactome
Other locations
- transport vesicle Source: Reactome
Keywords - Cellular componenti
Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, MembranePathology & Biotechi
Involvement in diseasei
Microcephaly 19, primary, autosomal recessive (MCPH19)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080601 | 254 | R → C in MCPH19; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1229568621EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Primary microcephalyOrganism-specific databases
DisGeNETi | 9276 |
MalaCardsi | COPB2 |
MIMi | 617800, phenotype |
OpenTargetsi | ENSG00000184432 |
Orphaneti | 2512, Autosomal recessive primary microcephaly |
PharmGKBi | PA26748 |
Miscellaneous databases
Pharosi | P35606, Tbio |
Genetic variation databases
BioMutai | COPB2 |
DMDMi | 544076 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000050912 | 2 – 906 | Coatomer subunit beta'Add BLAST | 905 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 627 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 859 | PhosphoserineCombined sources | 1 | |
Modified residuei | 861 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P35606 |
jPOSTi | P35606 |
MassIVEi | P35606 |
MaxQBi | P35606 |
PaxDbi | P35606 |
PeptideAtlasi | P35606 |
PRIDEi | P35606 |
ProteomicsDBi | 55099 [P35606-1] 5603 |
PTM databases
iPTMneti | P35606 |
MetOSitei | P35606 |
PhosphoSitePlusi | P35606 |
SwissPalmi | P35606 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184432, Expressed in stromal cell of endometrium and 248 other tissues |
ExpressionAtlasi | P35606, baseline and differential |
Genevisiblei | P35606, HS |
Organism-specific databases
HPAi | ENSG00000184432, Low tissue specificity |
Interactioni
Subunit structurei
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Probably interacts with PEX11A.
Interacts with SCYL1 (By similarity).
Interacts with JAGN1 (PubMed:25129144).
By similarity1 PublicationBinary interactionsi
P35606
With | #Exp. | IntAct |
---|---|---|
NFKB1 [P19838] | 3 | EBI-1056534,EBI-300010 |
Protein-protein interaction databases
BioGRIDi | 114693, 130 interactors |
CORUMi | P35606 |
DIPi | DIP-27603N |
IntActi | P35606, 51 interactors |
MINTi | P35606 |
STRINGi | 9606.ENSP00000329419 |
Miscellaneous databases
RNActi | P35606, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 13 – 52 | WD 1Add BLAST | 40 | |
Repeati | 55 – 94 | WD 2Add BLAST | 40 | |
Repeati | 97 – 136 | WD 3Add BLAST | 40 | |
Repeati | 140 – 180 | WD 4Add BLAST | 41 | |
Repeati | 183 – 224 | WD 5Add BLAST | 42 | |
Repeati | 227 – 266 | WD 6Add BLAST | 40 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 866 – 891 | Sequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0276, Eukaryota |
GeneTreei | ENSGT00900000141083 |
HOGENOMi | CLU_005507_1_0_1 |
OMAi | ATDPEHK |
OrthoDBi | 139008at2759 |
PhylomeDBi | P35606 |
TreeFami | TF300688 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR006692, Coatomer_WD-assoc_reg IPR016453, COPB2 IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF04053, Coatomer_WDAD, 1 hit PF00400, WD40, 4 hits |
PIRSFi | PIRSF005567, Coatomer_beta'_subunit, 1 hit |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 2 hits |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLRLDIKRK LTARSDRVKS VDLHPTEPWM LASLYNGSVC VWNHETQTLV
60 70 80 90 100
KTFEVCDLPV RAAKFVARKN WVVTGADDMQ IRVFNYNTLE RVHMFEAHSD
110 120 130 140 150
YIRCIAVHPT QPFILTSSDD MLIKLWDWDK KWSCSQVFEG HTHYVMQIVI
160 170 180 190 200
NPKDNNQFAS ASLDRTIKVW QLGSSSPNFT LEGHEKGVNC IDYYSGGDKP
210 220 230 240 250
YLISGADDRL VKIWDYQNKT CVQTLEGHAQ NVSCASFHPE LPIIITGSED
260 270 280 290 300
GTVRIWHSST YRLESTLNYG MERVWCVASL RGSNNVALGY DEGSIIVKLG
310 320 330 340 350
REEPAMSMDA NGKIIWAKHS EVQQANLKAM GDAEIKDGER LPLAVKDMGS
360 370 380 390 400
CEIYPQTIQH NPNGRFVVVC GDGEYIIYTA MALRNKSFGS AQEFAWAHDS
410 420 430 440 450
SEYAIRESNS IVKIFKNFKE KKSFKPDFGA ESIYGGFLLG VRSVNGLAFY
460 470 480 490 500
DWDNTELIRR IEIQPKHIFW SDSGELVCIA TEESFFILKY LSEKVLAAQE
510 520 530 540 550
THEGVTEDGI EDAFEVLGEI QEIVKTGLWV GDCFIYTSSV NRLNYYVGGE
560 570 580 590 600
IVTIAHLDRT MYLLGYIPKD NRLYLGDKEL NIISYSLLVS VLEYQTAVMR
610 620 630 640 650
RDFSMADKVL PTIPKEQRTR VAHFLEKQGF KQQALTVSTD PEHRFELALQ
660 670 680 690 700
LGELKIAYQL AVEAESEQKW KQLAELAISK CQFGLAQECL HHAQDYGGLL
710 720 730 740 750
LLATASGNAN MVNKLAEGAE RDGKNNVAFM SYFLQGKVDA CLELLIRTGR
760 770 780 790 800
LPEAAFLART YLPSQVSRVV KLWRENLSKV NQKAAESLAD PTEYENLFPG
810 820 830 840 850
LKEAFVVEEW VKETHADLWP AKQYPLVTPN EERNVMEEGK DFQPSRSTAQ
860 870 880 890 900
QELDGKPASP TPVIVASHTA NKEEKSLLEL EVDLDNLELE DIDTTDINLD
EDILDD
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y938 | H0Y938_HUMAN | Coatomer subunit beta' | COPB2 | 898 | Annotation score: | ||
D6R997 | D6R997_HUMAN | Coatomer subunit beta' | COPB2 | 152 | Annotation score: | ||
D6RBT6 | D6RBT6_HUMAN | Coatomer subunit beta' | COPB2 | 111 | Annotation score: | ||
D6RBG7 | D6RBG7_HUMAN | Coatomer subunit beta' | COPB2 | 89 | Annotation score: | ||
D6RCL6 | D6RCL6_HUMAN | Coatomer subunit beta' | COPB2 | 86 | Annotation score: | ||
D6RBZ7 | D6RBZ7_HUMAN | Coatomer subunit beta' | COPB2 | 77 | Annotation score: | ||
H0YAC7 | H0YAC7_HUMAN | Coatomer subunit beta' | COPB2 | 904 | Annotation score: | ||
A0A7I2V258 | A0A7I2V258_HUMAN | Coatomer subunit beta' | COPB2 | 828 | Annotation score: | ||
A0A7I2V3G0 | A0A7I2V3G0_HUMAN | Coatomer subunit beta' | COPB2 | 271 | Annotation score: | ||
A0A7I2V526 | A0A7I2V526_HUMAN | Coatomer subunit beta' | COPB2 | 57 | Annotation score: | ||
There is more potential isoformShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_080601 | 254 | R → C in MCPH19; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1229568621EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056165 | 1 – 29 | Missing in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70476 mRNA Translation: CAA49900.1 AK302943 mRNA Translation: BAG64100.1 AC024933 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79040.1 BC000326 mRNA Translation: AAH00326.1 |
CCDSi | CCDS3108.1 [P35606-1] |
PIRi | S35342 |
RefSeqi | NP_004757.1, NM_004766.2 [P35606-1] XP_016863001.1, XM_017007512.1 |
Genome annotation databases
Ensembli | ENST00000333188; ENSP00000329419; ENSG00000184432 [P35606-1] ENST00000507777; ENSP00000422295; ENSG00000184432 [P35606-2] ENST00000512242; ENSP00000427185; ENSG00000184432 [P35606-2] ENST00000514508; ENSP00000422469; ENSG00000184432 [P35606-2] |
GeneIDi | 9276 |
KEGGi | hsa:9276 |
UCSCi | uc003etf.5, human [P35606-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X70476 mRNA Translation: CAA49900.1 AK302943 mRNA Translation: BAG64100.1 AC024933 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79040.1 BC000326 mRNA Translation: AAH00326.1 |
CCDSi | CCDS3108.1 [P35606-1] |
PIRi | S35342 |
RefSeqi | NP_004757.1, NM_004766.2 [P35606-1] XP_016863001.1, XM_017007512.1 |
3D structure databases
SMRi | P35606 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 114693, 130 interactors |
CORUMi | P35606 |
DIPi | DIP-27603N |
IntActi | P35606, 51 interactors |
MINTi | P35606 |
STRINGi | 9606.ENSP00000329419 |
PTM databases
iPTMneti | P35606 |
MetOSitei | P35606 |
PhosphoSitePlusi | P35606 |
SwissPalmi | P35606 |
Genetic variation databases
BioMutai | COPB2 |
DMDMi | 544076 |
Proteomic databases
EPDi | P35606 |
jPOSTi | P35606 |
MassIVEi | P35606 |
MaxQBi | P35606 |
PaxDbi | P35606 |
PeptideAtlasi | P35606 |
PRIDEi | P35606 |
ProteomicsDBi | 55099 [P35606-1] 5603 |
Protocols and materials databases
Antibodypediai | 33460, 117 antibodies |
DNASUi | 9276 |
Genome annotation databases
Ensembli | ENST00000333188; ENSP00000329419; ENSG00000184432 [P35606-1] ENST00000507777; ENSP00000422295; ENSG00000184432 [P35606-2] ENST00000512242; ENSP00000427185; ENSG00000184432 [P35606-2] ENST00000514508; ENSP00000422469; ENSG00000184432 [P35606-2] |
GeneIDi | 9276 |
KEGGi | hsa:9276 |
UCSCi | uc003etf.5, human [P35606-1] |
Organism-specific databases
CTDi | 9276 |
DisGeNETi | 9276 |
GeneCardsi | COPB2 |
HGNCi | HGNC:2232, COPB2 |
HPAi | ENSG00000184432, Low tissue specificity |
MalaCardsi | COPB2 |
MIMi | 606990, gene 617800, phenotype |
neXtProti | NX_P35606 |
OpenTargetsi | ENSG00000184432 |
Orphaneti | 2512, Autosomal recessive primary microcephaly |
PharmGKBi | PA26748 |
VEuPathDBi | HostDB:ENSG00000184432.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0276, Eukaryota |
GeneTreei | ENSGT00900000141083 |
HOGENOMi | CLU_005507_1_0_1 |
OMAi | ATDPEHK |
OrthoDBi | 139008at2759 |
PhylomeDBi | P35606 |
TreeFami | TF300688 |
Enzyme and pathway databases
PathwayCommonsi | P35606 |
Reactomei | R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
SignaLinki | P35606 |
Miscellaneous databases
BioGRID-ORCSi | 9276, 792 hits in 1001 CRISPR screens |
ChiTaRSi | COPB2, human |
GeneWikii | COPB2 |
GenomeRNAii | 9276 |
Pharosi | P35606, Tbio |
PROi | PR:P35606 |
RNActi | P35606, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184432, Expressed in stromal cell of endometrium and 248 other tissues |
ExpressionAtlasi | P35606, baseline and differential |
Genevisiblei | P35606, HS |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR006692, Coatomer_WD-assoc_reg IPR016453, COPB2 IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF04053, Coatomer_WDAD, 1 hit PF00400, WD40, 4 hits |
PIRSFi | PIRSF005567, Coatomer_beta'_subunit, 1 hit |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 2 hits |
PROSITEi | View protein in PROSITE PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COPB2_HUMAN | |
Accessioni | P35606Primary (citable) accession number: P35606 Secondary accession number(s): B4DZI8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 207 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families