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UniProtKB - P35600 (RFC1_DROME)

Entry version 160 (02 Dec 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Replication factor C subunit 1

Gene

Gnf1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds to the primer-template junction (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi487 – 494ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: FlyBase
  • DNA clamp loader activity Source: InterPro
Complete GO annotation on QuickGO ...

GO - Biological processi

  • dendrite morphogenesis Source: FlyBase
  • DNA repair Source: InterPro
  • DNA replication Source: FlyBase
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processDNA replication, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-110312, Translesion synthesis by REV1
R-DME-110314, Recognition of DNA damage by PCNA-containing replication complex
R-DME-110320, Translesion Synthesis by POLH
R-DME-5651801, PCNA-Dependent Long Patch Base Excision Repair
R-DME-5655862, Translesion synthesis by POLK
R-DME-5656121, Translesion synthesis by POLI
R-DME-5656169, Termination of translesion DNA synthesis
R-DME-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER
R-DME-5696400, Dual Incision in GG-NER
R-DME-6782135, Dual incision in TC-NER
R-DME-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-69091, Polymerase switching

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replication factor C subunit 1
Alternative name(s):
Activator 1 140 kDa subunit
Activator 1 subunit 1
Germline transcription factor 1
Replication factor C large subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gnf1
ORF Names:CG1119
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0004913, Gnf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001217741 – 986Replication factor C subunit 1Add BLAST986

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei18Phosphoserine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei40Phosphoserine1 Publication1
Modified residuei41Phosphoserine1 Publication1
Modified residuei48Phosphoserine1 Publication1
Modified residuei58Phosphoserine1 Publication1
Modified residuei60Phosphothreonine1 Publication1
Modified residuei62Phosphoserine1 Publication1
Modified residuei63Phosphoserine1 Publication1
Modified residuei71Phosphothreonine1 Publication1
Modified residuei128Phosphoserine1 Publication1
Modified residuei137Phosphoserine1 Publication1
Modified residuei149Phosphoserine1 Publication1
Modified residuei154Phosphoserine1 Publication1
Modified residuei156Phosphoserine1 Publication1
Modified residuei164Phosphoserine1 Publication1
Modified residuei194Phosphoserine1 Publication1
Modified residuei197Phosphothreonine1 Publication1
Modified residuei938Phosphoserine1 Publication1
Modified residuei939Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35600

PRoteomics IDEntifications database

More...PRIDEi		P35600

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35600

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0004913, Expressed in embryo and 49 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35600, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with C-terminus of PCNA.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		65822, 28 interactors

Database of interacting proteins

More...DIPi		DIP-18735N

Protein interaction database and analysis system

More...IntActi		P35600, 9 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0099511

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35600

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini232 – 322BRCTPROSITE-ProRule annotationAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi955 – 959Nuclear localization signalSequence analysis5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the activator 1 large subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1968, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111066

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003574_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35600

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35600

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10190, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR008921, DNA_pol3_clamp-load_cplx_C
IPR013725, DNA_replication_fac_RFC1_C
IPR027417, P-loop_NTPase
IPR012178, RFC1

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00004, AAA, 1 hit
PF00533, BRCT, 1 hit
PF08519, RFC1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036578, RFC1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 1 hit
SM00292, BRCT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48019, SSF48019, 1 hit
SSF52113, SSF52113, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50172, BRCT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P35600-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRGIDSFFK RLPAKAKSAE AENGETPSKA PKRRKAVIIS SDEDEVVSPP 
        60         70         80         90        100
ETKKRKASKT ASSEDDVVAA TPEPIAKKAR NGQKPALSKL KRHVDPTELF 
       110        120        130        140        150
GGETKRVIVP KPKTKAVLEF ENEDIDRSLM EVDLDESIKE AAPEKKVHSI 
       160        170        180        190        200
TRSSPSPKRA KNSSPEPPKP KSTKSKATTP RVKKEKPAAD LESSVLTDEE 
       210        220        230        240        250
RHERKRASAV LYQKYKNRSS CLNPGSKEIP KGSPDCLSGL TFVVTGVLES 
       260        270        280        290        300
MEREEAESVI KEYGGKVMTV VGKKLKYLVV GEEAGPKKLA VAEELNIPIL 
       310        320        330        340        350
SEDGLFDLIR EKSGIAKQVK EEKKSPKKEH SSEEKGKKEV KTSRRSSDKK 
       360        370        380        390        400
EKEATKLKYG EKHDIAKHKV KEEHTSPKET KDKLNDVPAV TLKVKKEPSS 
       410        420        430        440        450
QKEHPPSPRT ADLKTLDVVG MAWVDKHKPT SIKEIVGQAG AASNVTKLMN 
       460        470        480        490        500
WLSKWYVNHD GNKKPQRPNP WAKNDDGSFY KAALLSGPPG IGKTTTATLV 
       510        520        530        540        550
VKELGFDAVE FNASDTRSKR LLKDEVSTLL SNKSLSGYFT GQGQAVSRKH 
       560        570        580        590        600
VLIMDEVDGM AGNEDRGGMQ ELIALIKDSS IPIICMCNDR NHPKIRSLVN 
       610        620        630        640        650
YCYDLRFQRP RLEQIKGKIM SICFKEKVKI SPAKVEEIIA ATNNDIRQSI 
       660        670        680        690        700
NHIALLSAKE DASQKSGQQV ATKDLKLGPW EVVRKVFTAD EHKHMSFADK 
       710        720        730        740        750
SDLFFHDYSL APLFVQQNYL QVLPQGNKKD VLAKVAATAD ALSLGDLVEK 
       760        770        780        790        800
RIRANSAWSL LPTQAFFSSV LPGEHMCGHF TGQINFPGWL GKNSKSGKRA 
       810        820        830        840        850
RLAQELHDHT RVCTSGSRLS VRLDYAPFLL DNIVRPLAKD GQEGVPAALD 
       860        870        880        890        900
VMKDYHLLRE DLDSLVELTS WPGKKSPLDA VDGRVKAALT RSYNKEVMAY 
       910        920        930        940        950
SYSAQAGIKK KKSEAAGADD DYLDEGPGEE DGAGGHLSSE EDEDKDNLEL 
       960        970        980 
DSLIKAKKRT TTSKASGGSK KATSSTASKS KAKAKK
Length:986
Mass (Da):108,615
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1E9C8EE0879545F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti447K → NHNLKLKAKQERVKVLHYFN FPR in AAM52589 (Ref. 5) Curated1
Sequence conflicti559G → A in AAA28573 (PubMed:9705493).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L17340 Genomic DNA Translation: AAA28573.1
U97685 mRNA Translation: AAB58311.1
AE014297 Genomic DNA Translation: AAF52082.1
AE014297 Genomic DNA Translation: AAX52937.1
AY122077 mRNA Translation: AAM52589.1
BT003618 mRNA Translation: AAO39621.1

NCBI Reference Sequences

More...RefSeqi		NP_001014605.1, NM_001014605.3
NP_524229.1, NM_079505.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0078837; FBpp0078478; FBgn0004913

Database of genes from NCBI RefSeq genomes

More...GeneIDi		40607

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1119

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L17340 Genomic DNA Translation: AAA28573.1
U97685 mRNA Translation: AAB58311.1
AE014297 Genomic DNA Translation: AAF52082.1
AE014297 Genomic DNA Translation: AAX52937.1
AY122077 mRNA Translation: AAM52589.1
BT003618 mRNA Translation: AAO39621.1
RefSeqiNP_001014605.1, NM_001014605.3
NP_524229.1, NM_079505.3

3D structure databases

SMRiP35600
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65822, 28 interactors
DIPiDIP-18735N
IntActiP35600, 9 interactors
STRINGi7227.FBpp0099511

PTM databases

iPTMnetiP35600

Proteomic databases

PaxDbiP35600
PRIDEiP35600

Genome annotation databases

EnsemblMetazoaiFBtr0078837; FBpp0078478; FBgn0004913
GeneIDi40607
KEGGidme:Dmel_CG1119

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100035172
FlyBaseiFBgn0004913, Gnf1

Phylogenomic databases

eggNOGiKOG1968, Eukaryota
GeneTreeiENSGT00730000111066
HOGENOMiCLU_003574_0_1_1
InParanoidiP35600
PhylomeDBiP35600

Enzyme and pathway databases

ReactomeiR-DME-110312, Translesion synthesis by REV1
R-DME-110314, Recognition of DNA damage by PCNA-containing replication complex
R-DME-110320, Translesion Synthesis by POLH
R-DME-5651801, PCNA-Dependent Long Patch Base Excision Repair
R-DME-5655862, Translesion synthesis by POLK
R-DME-5656121, Translesion synthesis by POLI
R-DME-5656169, Termination of translesion DNA synthesis
R-DME-5696397, Gap-filling DNA repair synthesis and ligation in GG-NER
R-DME-5696400, Dual Incision in GG-NER
R-DME-6782135, Dual incision in TC-NER
R-DME-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-DME-69091, Polymerase switching

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		40607, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		40607

Protein Ontology

More...PROi		PR:P35600

Gene expression databases

BgeeiFBgn0004913, Expressed in embryo and 49 other tissues
GenevisibleiP35600, DM

Family and domain databases

Gene3Di3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR003959, ATPase_AAA_core
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
IPR008921, DNA_pol3_clamp-load_cplx_C
IPR013725, DNA_replication_fac_RFC1_C
IPR027417, P-loop_NTPase
IPR012178, RFC1
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF00533, BRCT, 1 hit
PF08519, RFC1, 1 hit
PIRSFiPIRSF036578, RFC1, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00292, BRCT, 1 hit
SUPFAMiSSF48019, SSF48019, 1 hit
SSF52113, SSF52113, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50172, BRCT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFC1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35600
Secondary accession number(s): O02031, Q8MR76
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 1, 2000
Last modified: December 2, 2020
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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