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Protein

AP-1 complex subunit mu-1

Gene

Ap1m1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit mu-1
Alternative name(s):
AP-mu chain family member mu1A
Adaptor protein complex AP-1 subunit mu-1
Adaptor-related protein complex 1 subunit mu-1
Clathrin assembly protein complex 1 mu-1 medium chain 1
Clathrin coat assembly protein AP47
Clathrin coat-associated protein AP47
Golgi adaptor HA1/AP1 adaptin mu-1 subunit
Mu-adaptin 1
Mu1A-adaptin
Gene namesi
Name:Ap1m1
Synonyms:Cltnm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:102776 Ap1m1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001937712 – 423AP-1 complex subunit mu-1Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei152PhosphothreonineCombined sources1
Modified residuei154PhosphothreonineCombined sources1
Modified residuei223PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP35585
PaxDbiP35585
PeptideAtlasiP35585
PRIDEiP35585

PTM databases

iPTMnetiP35585
PhosphoSitePlusiP35585

Expressioni

Gene expression databases

BgeeiENSMUSG00000003033 Expressed in 281 organ(s), highest expression level in striatum
ExpressionAtlasiP35585 baseline and differential
GenevisibleiP35585 MM

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Interacts with MARCH11 (By similarity).By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi198125, 1 interactor
CORUMiP35585
DIPiDIP-35323N
IntActiP35585, 10 interactors
MINTiP35585
STRINGi10090.ENSMUSP00000003117

Structurei

Secondary structure

1423
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35585
SMRiP35585
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35585

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini168 – 421MHDPROSITE-ProRule annotationAdd BLAST254

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0937 Eukaryota
ENOG410XPFS LUCA
GeneTreeiENSGT00530000062779
HOGENOMiHOG000173247
HOVERGENiHBG050516
InParanoidiP35585
KOiK12393
OMAiQQVTPCF
OrthoDBiEOG091G06XI
PhylomeDBiP35585
TreeFamiTF300393

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P35585-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASAVYVLD LKGKVLICRN YRGDVDMSEV EHFMPILMEK EEEGMLSPIL
60 70 80 90 100
AHGGVRFMWI KHNNLYLVAT SKKNACVSLV FSFLYKVVQV FSEYFKELEE
110 120 130 140 150
ESIRDNFVII YELLDELMDF GYPQTTDSKI LQEYITQEGH KLETGAPRPP
160 170 180 190 200
ATVTNAVSWR SEGIKYRKNE VFLDVIEAVN LLVSANGNVL RSEIVGSIKM
210 220 230 240 250
RVFLSGMPEL RLGLNDKVLF DNTGRGKSKS VELEDVKFHQ CVRLSRFEND
260 270 280 290 300
RTISFIPPDG EFELMSYRLN THVKPLIWIE SVIEKHSHSR IEYMVKAKSQ
310 320 330 340 350
FKRRSTANNV EIHIPVPNDA DSPKFKTTVG SVKWVPENSE IVWSVKSFPG
360 370 380 390 400
GKEYLMRAHF GLPSVEAEDK EGKPPISVKF EIPYFTTSGI QVRYLKIIEK
410 420
SGYQALPWVR YITQNGDYQL RTQ
Length:423
Mass (Da):48,543
Last modified:January 23, 2007 - v3
Checksum:i1213566B3A681B4C
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YZ71D3YZ71_MOUSE
AP-1 complex subunit mu-1
Ap1m1
181Annotation score:
A0A1D5RLW6A0A1D5RLW6_MOUSE
AP-1 complex subunit mu-1
Ap1m1
132Annotation score:
S4R1Q4S4R1Q4_MOUSE
AP-1 complex subunit mu-1
Ap1m1
107Annotation score:
A0A1D5RMJ1A0A1D5RMJ1_MOUSE
AP-1 complex subunit mu-1
Ap1m1
63Annotation score:
A0A1D5RLL9A0A1D5RLL9_MOUSE
AP-1 complex subunit mu-1
Ap1m1
55Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62419 mRNA Translation: AAA37244.1
AF139405
, AF139394, AF139395, AF139396, AF139397, AF139398, AF139399, AF139400, AF139401, AF139402, AF139403, AF139404 Genomic DNA Translation: AAF61814.1
BC003823 mRNA Translation: AAH03823.1
CCDSiCCDS22411.1
PIRiS19693
RefSeqiNP_031482.1, NM_007456.5
UniGeneiMm.290086

Genome annotation databases

EnsembliENSMUST00000003117; ENSMUSP00000003117; ENSMUSG00000003033
GeneIDi11767
KEGGimmu:11767
UCSCiuc009mfp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62419 mRNA Translation: AAA37244.1
AF139405
, AF139394, AF139395, AF139396, AF139397, AF139398, AF139399, AF139400, AF139401, AF139402, AF139403, AF139404 Genomic DNA Translation: AAF61814.1
BC003823 mRNA Translation: AAH03823.1
CCDSiCCDS22411.1
PIRiS19693
RefSeqiNP_031482.1, NM_007456.5
UniGeneiMm.290086

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W63X-ray4.00M/N/O/P/R/V1-423[»]
4EMZX-ray2.90A/M158-423[»]
4EN2X-ray2.58A/M158-423[»]
4HMYX-ray7.00M1-423[»]
4P6ZX-ray3.00M1-423[»]
6CM9electron microscopy3.73M1-423[»]
6CRIelectron microscopy6.80M/W/X2-423[»]
6D83electron microscopy4.27M1-423[»]
6D84electron microscopy6.72M/P1-423[»]
6DFFelectron microscopy3.90M1-423[»]
ProteinModelPortaliP35585
SMRiP35585
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198125, 1 interactor
CORUMiP35585
DIPiDIP-35323N
IntActiP35585, 10 interactors
MINTiP35585
STRINGi10090.ENSMUSP00000003117

PTM databases

iPTMnetiP35585
PhosphoSitePlusiP35585

Proteomic databases

EPDiP35585
PaxDbiP35585
PeptideAtlasiP35585
PRIDEiP35585

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003117; ENSMUSP00000003117; ENSMUSG00000003033
GeneIDi11767
KEGGimmu:11767
UCSCiuc009mfp.1 mouse

Organism-specific databases

CTDi8907
MGIiMGI:102776 Ap1m1

Phylogenomic databases

eggNOGiKOG0937 Eukaryota
ENOG410XPFS LUCA
GeneTreeiENSGT00530000062779
HOGENOMiHOG000173247
HOVERGENiHBG050516
InParanoidiP35585
KOiK12393
OMAiQQVTPCF
OrthoDBiEOG091G06XI
PhylomeDBiP35585
TreeFamiTF300393

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

EvolutionaryTraceiP35585
PROiPR:P35585
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003033 Expressed in 281 organ(s), highest expression level in striatum
ExpressionAtlasiP35585 baseline and differential
GenevisibleiP35585 MM

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP1M1_MOUSE
AccessioniPrimary (citable) accession number: P35585
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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