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Protein

Hepatocyte nuclear factor 3-gamma

Gene

Foxa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility.By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi118 – 209Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 3-gamma
Short name:
HNF-3-gamma
Short name:
HNF-3G
Alternative name(s):
Forkhead box protein A3
Gene namesi
Name:Foxa3
Synonyms:Hnf3g, Tcf-3g, Tcf3g
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1347477 Foxa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduced expression levels of several HNF3 target genes (phosphoenolpyruvate carboxykinase, transferrin, tyrosine aminotransferase) by 50 to 70%,. The germinal epithelium of testes is characterized by a loss of germ cells secondary to an increase in germ cell apoptosis that ultimately leads to a Sertoli cell-only syndrome. Significantly lower blood glucose in fasted mice.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918011 – 353Hepatocyte nuclear factor 3-gammaAdd BLAST353

Proteomic databases

MaxQBiP35584
PaxDbiP35584
PeptideAtlasiP35584
PRIDEiP35584

PTM databases

iPTMnetiP35584
PhosphoSitePlusiP35584

Expressioni

Tissue specificityi

Restricted mainly to endoderm-derived tissues (lung, liver, stomach, and small intestine), also present additionally in ovary, testis, heart, and adipose tissue, but missing from lung.1 Publication

Developmental stagei

Expression peaks around day 15.5 of gestation. Expressed from day 6 to day 70 during postnatal testicular development.1 Publication

Gene expression databases

BgeeiENSMUSG00000040891 Expressed in 114 organ(s), highest expression level in mucous cell of stomach
CleanExiMM_FOXA3
GenevisibleiP35584 MM

Interactioni

Subunit structurei

Interacts with FOXA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043173

Structurei

3D structure databases

ProteinModelPortaliP35584
SMRiP35584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3563 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231817
HOVERGENiHBG006621
InParanoidiP35584
KOiK08038
OMAiDPHYNFN
OrthoDBiEOG091G0HW9
PhylomeDBiP35584
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR013638 Fork-head_N
IPR001766 Fork_head_dom
IPR018533 Forkhead_box_C
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF08430 Forkhead_N, 1 hit
PF09354 HNF_C, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

P35584-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGSVKMEAH DLAEWSYYPE AGEVYSPVNP VPTMAPLNSY MTLNPLSSPY
60 70 80 90 100
PPGGLQASPL PTGPLAPPAP TAPLGPTFPS LGTGGSTGGS ASGYVAPGPG
110 120 130 140 150
LVHGKEMAKG YRRPLAHAKP PYSYISLITM AIQQAPGKML TLSEIYQWIM
160 170 180 190 200
DLFPYYRENQ QRWQNSIRHS LSFNDCFVKV ARSPDKPGKG SYWALHPSSG
210 220 230 240 250
NMFENGCYLR RQKRFKLEEK AKKGNSATSA SRNGTAGSAT SATTTAATAV
260 270 280 290 300
TSPAQPQPTP SEPEAQSGDD VGGLDCASPP SSTPYFSGLE LPGELKLDAP
310 320 330 340 350
YNFNHPFSIN NLMSEQTSTP SKLDVGFGGY GAESGEPGVY YQSLYSRSLL

NAS
Length:353
Mass (Da):37,601
Last modified:June 1, 1994 - v1
Checksum:i28F060A8E944D5B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74938 mRNA Translation: CAA52892.1
CCDSiCCDS20886.1
PIRiC54258
RefSeqiNP_032286.1, NM_008260.2
UniGeneiMm.42260

Genome annotation databases

EnsembliENSMUST00000036018; ENSMUSP00000043173; ENSMUSG00000040891
GeneIDi15377
KEGGimmu:15377
UCSCiuc009fkd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74938 mRNA Translation: CAA52892.1
CCDSiCCDS20886.1
PIRiC54258
RefSeqiNP_032286.1, NM_008260.2
UniGeneiMm.42260

3D structure databases

ProteinModelPortaliP35584
SMRiP35584
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043173

PTM databases

iPTMnetiP35584
PhosphoSitePlusiP35584

Proteomic databases

MaxQBiP35584
PaxDbiP35584
PeptideAtlasiP35584
PRIDEiP35584

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036018; ENSMUSP00000043173; ENSMUSG00000040891
GeneIDi15377
KEGGimmu:15377
UCSCiuc009fkd.1 mouse

Organism-specific databases

CTDi3171
MGIiMGI:1347477 Foxa3

Phylogenomic databases

eggNOGiKOG3563 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231817
HOVERGENiHBG006621
InParanoidiP35584
KOiK08038
OMAiDPHYNFN
OrthoDBiEOG091G0HW9
PhylomeDBiP35584
TreeFamiTF316127

Miscellaneous databases

PROiPR:P35584
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040891 Expressed in 114 organ(s), highest expression level in mucous cell of stomach
CleanExiMM_FOXA3
GenevisibleiP35584 MM

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR013638 Fork-head_N
IPR001766 Fork_head_dom
IPR018533 Forkhead_box_C
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF08430 Forkhead_N, 1 hit
PF09354 HNF_C, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXA3_MOUSE
AccessioniPrimary (citable) accession number: P35584
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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