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UniProtKB - P35579 (MYH9_HUMAN)

Protein

Myosin-9

Gene

MYH9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi174 – 181ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: MGI
  • actin-dependent ATPase activity Source: MGI
  • actin filament binding Source: UniProtKB
  • ADP binding Source: MGI
  • ATPase activity Source: UniProtKB
  • ATP binding Source: MGI
  • cadherin binding Source: BHF-UCL
  • calmodulin binding Source: UniProtKB-KW
  • integrin binding Source: UniProtKB
  • microfilament motor activity Source: UniProtKB
  • motor activity Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein membrane anchor Source: UniProtKB
  • RNA binding Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processCell adhesion, Cell shape
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

SIGNOR Signaling Network Open Resource

More...SIGNORi		P35579

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-9
Alternative name(s):
Cellular myosin heavy chain, type A
Myosin heavy chain 9
Myosin heavy chain, non-muscle IIa
Non-muscle myosin heavy chain A
Short name:
NMMHC-A
Non-muscle myosin heavy chain IIa
Short name:
NMMHC II-a
Short name:
NMMHC-IIA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000100345.20

Human Gene Nomenclature Database

More...HGNCi		HGNC:7579 MYH9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		160775 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35579

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss (MATINS)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by thrombocytopenia, giant platelets and Dohle body-like inclusions in peripheral blood leukocytes with variable ultrastructural appearance. Some affected individuals lack leukocyte inclusion bodies on classic staining of peripheral blood smears. Alport syndrome-like features of nephritis, hearing loss, and eye abnormalities are present in some patients.
See also OMIM:155100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01079193N → K in MATINS. 1 PublicationCorresponds to variant dbSNP:rs121913655EnsemblClinVar.1
Natural variantiVAR_01830895A → T in MATINS. 1 Publication1
Natural variantiVAR_01830996S → L in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913657EnsemblClinVar.1
Natural variantiVAR_018310373K → N in MATINS. 1 Publication1
Natural variantiVAR_010792702R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338826EnsemblClinVar.1
Natural variantiVAR_018311702R → H in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338827EnsemblClinVar.1
Natural variantiVAR_044226910K → Q in MATINS. 1 PublicationCorresponds to variant dbSNP:rs554332083Ensembl.1
Natural variantiVAR_0442281066 – 1072Missing in MATINS. 1 Publication7
Natural variantiVAR_0183121114S → P in MATINS. 1 PublicationCorresponds to variant dbSNP:rs200901330EnsemblClinVar.1
Natural variantiVAR_0107941155T → I in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913656EnsemblClinVar.1
Natural variantiVAR_0107951165R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338829EnsemblClinVar.1
Natural variantiVAR_0183131165R → L in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338830EnsemblClinVar.1
Natural variantiVAR_0183141205 – 1207Missing in MATINS. 2 Publications3
Natural variantiVAR_0183151400R → W in MATINS; unknown pathological significance; might contribute to pathogenicity when associated with L-96. 1 PublicationCorresponds to variant dbSNP:rs76368635EnsemblClinVar.1
Natural variantiVAR_0107961424D → H in MATINS. 5 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183161424D → N in MATINS; results in reduced protein levels. 7 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183171424D → Y in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0303851816I → V in MATINS. 1 PublicationCorresponds to variant dbSNP:rs762773112Ensembl.1
Natural variantiVAR_0107971841E → K in MATINS. 6 PublicationsCorresponds to variant dbSNP:rs80338834EnsemblClinVar.1
Deafness, autosomal dominant, 17 (DFNA17)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of deafness characterized by progressive high frequency hearing impairment and cochleosaccular degeneration.
See also OMIM:603622
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010793705R → H in DFNA17. 1 PublicationCorresponds to variant dbSNP:rs80338828EnsemblClinVar.1
Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures.
Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD).

Keywords - Diseasei

Alport syndrome, Cataract, Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		4627

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		MYH9

MalaCards human disease database

More...MalaCardsi		MYH9
MIMi155100 phenotype
603622 phenotype

Open Targets

More...OpenTargetsi		ENSG00000100345

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
182050 MYH9-related disease
477742 Nodular fasciitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31377

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2189151

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MYH9

Domain mapping of disease mutations (DMDM)

More...DMDMi		6166599

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234162 – 1960Myosin-9Add BLAST1959

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei8N6-acetyllysineCombined sources1
Modified residuei11PhosphotyrosineCombined sources1
Modified residuei102N6-acetyllysineCombined sources1
Modified residuei299N6-acetyllysineCombined sources1
Modified residuei435N6-acetyllysineBy similarity1
Modified residuei613N6-acetyllysineBy similarity1
Modified residuei628PhosphoserineCombined sources1
Modified residuei754PhosphotyrosineCombined sources1
Modified residuei850N6-succinyllysineBy similarity1
Modified residuei860N6-acetyllysineBy similarity1
Modified residuei975N6-acetyllysineBy similarity1
Modified residuei1024N6-acetyllysineCombined sources1
Modified residuei1114PhosphoserineBy similarity1
Modified residuei1234N6-acetyllysineBy similarity1
Modified residuei1249N6-acetyllysineBy similarity1
Modified residuei1357N6-acetyllysineCombined sources1
Modified residuei1392N6-acetyllysineCombined sources1
Modified residuei1404N6-acetyllysineCombined sources1
Modified residuei1410N6-acetyllysineCombined sources1
Modified residuei1459N6-acetyllysineCombined sources1
Modified residuei1638N6-acetyllysineCombined sources1
Modified residuei1669N6-succinyllysineBy similarity1
Modified residuei1714PhosphoserineCombined sources1
Modified residuei1793N6-acetyllysineBy similarity1
Modified residuei1802N6-acetyllysineBy similarity1
Modified residuei1845N6-acetyllysineBy similarity1
Modified residuei1923Omega-N-methylarginineBy similarity1
Modified residuei1943PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ISGylated.1 Publication
Ubiquitination.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P35579

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35579

PeptideAtlas

More...PeptideAtlasi		P35579

PRoteomics IDEntifications database

More...PRIDEi		P35579

ProteomicsDB human proteome resource

More...ProteomicsDBi		55093
55094 [P35579-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P35579-1 [P35579-1]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P35579

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35579

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35579

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P35579

Miscellaneous databases

CutDB - Proteolytic event database

More...PMAP-CutDBi		P35579

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the kidney, expressed in the glomeruli. Also expressed in leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100345 Expressed in 219 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

More...CleanExi		HS_MYH9

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35579 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35579 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB015386
HPA001644
HPA064783

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1 (By similarity). Interacts with DDR1 (By similarity). Interacts with SLC6A4 (By similarity). Interacts with PDLIM2 (By similarity). Interacts with SVIL (PubMed:12917436, PubMed:17925381). Interacts with HTRA3 (PubMed:22229724). Interacts with Myo7a (By similarity). Interacts with C9orf135 (PubMed:28345668). Interacts with LIMCH1; independently of the integration of MYH9 into the myosin complex (PubMed:28228547).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110712, 325 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P35579

Database of interacting proteins

More...DIPi		DIP-33103N

Protein interaction database and analysis system

More...IntActi		P35579, 276 interactors

Molecular INTeraction database

More...MINTi		P35579

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216181

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P35579

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35579

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 77Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini81 – 776Myosin motorPROSITE-ProRule annotationAdd BLAST696
Domaini779 – 808IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 838Mediates interaction with LIMCH11 PublicationAdd BLAST837
Regioni654 – 676Actin-bindingAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili837 – 1926Sequence analysisAdd BLAST1090

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155632

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000173958

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG004704

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35579

KEGG Orthology (KO)

More...KOi		K10352

Identification of Orthologs from Complete Genome Data

More...OMAi		CKQVRRA

Database of Orthologous Groups

More...OrthoDBi		EOG091G009J

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35579

TreeFam database of animal gene trees

More...TreeFami		TF333601

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
IPR036305 RGS_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48097 SSF48097, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35579-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQQAADKYL YVDKNFINNP LAQADWAAKK LVWVPSDKSG FEPASLKEEV 
        60         70         80         90        100
GEEAIVELVE NGKKVKVNKD DIQKMNPPKF SKVEDMAELT CLNEASVLHN 
       110        120        130        140        150
LKERYYSGLI YTYSGLFCVV INPYKNLPIY SEEIVEMYKG KKRHEMPPHI 
       160        170        180        190        200
YAITDTAYRS MMQDREDQSI LCTGESGAGK TENTKKVIQY LAYVASSHKS 
       210        220        230        240        250
KKDQGELERQ LLQANPILEA FGNAKTVKND NSSRFGKFIR INFDVNGYIV 
       260        270        280        290        300
GANIETYLLE KSRAIRQAKE ERTFHIFYYL LSGAGEHLKT DLLLEPYNKY 
       310        320        330        340        350
RFLSNGHVTI PGQQDKDMFQ ETMEAMRIMG IPEEEQMGLL RVISGVLQLG 
       360        370        380        390        400
NIVFKKERNT DQASMPDNTA AQKVSHLLGI NVTDFTRGIL TPRIKVGRDY 
       410        420        430        440        450
VQKAQTKEQA DFAIEALAKA TYERMFRWLV LRINKALDKT KRQGASFIGI 
       460        470        480        490        500
LDIAGFEIFD LNSFEQLCIN YTNEKLQQLF NHTMFILEQE EYQREGIEWN 
       510        520        530        540        550
FIDFGLDLQP CIDLIEKPAG PPGILALLDE ECWFPKATDK SFVEKVMQEQ 
       560        570        580        590        600
GTHPKFQKPK QLKDKADFCI IHYAGKVDYK ADEWLMKNMD PLNDNIATLL 
       610        620        630        640        650
HQSSDKFVSE LWKDVDRIIG LDQVAGMSET ALPGAFKTRK GMFRTVGQLY 
       660        670        680        690        700
KEQLAKLMAT LRNTNPNFVR CIIPNHEKKA GKLDPHLVLD QLRCNGVLEG 
       710        720        730        740        750
IRICRQGFPN RVVFQEFRQR YEILTPNSIP KGFMDGKQAC VLMIKALELD 
       760        770        780        790        800
SNLYRIGQSK VFFRAGVLAH LEEERDLKIT DVIIGFQACC RGYLARKAFA 
       810        820        830        840        850
KRQQQLTAMK VLQRNCAAYL KLRNWQWWRL FTKVKPLLQV SRQEEEMMAK 
       860        870        880        890        900
EEELVKVREK QLAAENRLTE METLQSQLMA EKLQLQEQLQ AETELCAEAE 
       910        920        930        940        950
ELRARLTAKK QELEEICHDL EARVEEEEER CQHLQAEKKK MQQNIQELEE 
       960        970        980        990       1000
QLEEEESARQ KLQLEKVTTE AKLKKLEEEQ IILEDQNCKL AKEKKLLEDR 
      1010       1020       1030       1040       1050
IAEFTTNLTE EEEKSKSLAK LKNKHEAMIT DLEERLRREE KQRQELEKTR 
      1060       1070       1080       1090       1100
RKLEGDSTDL SDQIAELQAQ IAELKMQLAK KEEELQAALA RVEEEAAQKN 
      1110       1120       1130       1140       1150
MALKKIRELE SQISELQEDL ESERASRNKA EKQKRDLGEE LEALKTELED 
      1160       1170       1180       1190       1200
TLDSTAAQQE LRSKREQEVN ILKKTLEEEA KTHEAQIQEM RQKHSQAVEE 
      1210       1220       1230       1240       1250
LAEQLEQTKR VKANLEKAKQ TLENERGELA NEVKVLLQGK GDSEHKRKKV 
      1260       1270       1280       1290       1300
EAQLQELQVK FNEGERVRTE LADKVTKLQV ELDNVTGLLS QSDSKSSKLT 
      1310       1320       1330       1340       1350
KDFSALESQL QDTQELLQEE NRQKLSLSTK LKQVEDEKNS FREQLEEEEE 
      1360       1370       1380       1390       1400
AKHNLEKQIA TLHAQVADMK KKMEDSVGCL ETAEEVKRKL QKDLEGLSQR 
      1410       1420       1430       1440       1450
HEEKVAAYDK LEKTKTRLQQ ELDDLLVDLD HQRQSACNLE KKQKKFDQLL 
      1460       1470       1480       1490       1500
AEEKTISAKY AEERDRAEAE AREKETKALS LARALEEAME QKAELERLNK 
      1510       1520       1530       1540       1550
QFRTEMEDLM SSKDDVGKSV HELEKSKRAL EQQVEEMKTQ LEELEDELQA 
      1560       1570       1580       1590       1600
TEDAKLRLEV NLQAMKAQFE RDLQGRDEQS EEKKKQLVRQ VREMEAELED 
      1610       1620       1630       1640       1650
ERKQRSMAVA ARKKLEMDLK DLEAHIDSAN KNRDEAIKQL RKLQAQMKDC 
      1660       1670       1680       1690       1700
MRELDDTRAS REEILAQAKE NEKKLKSMEA EMIQLQEELA AAERAKRQAQ 
      1710       1720       1730       1740       1750
QERDELADEI ANSSGKGALA LEEKRRLEAR IAQLEEELEE EQGNTELIND 
      1760       1770       1780       1790       1800
RLKKANLQID QINTDLNLER SHAQKNENAR QQLERQNKEL KVKLQEMEGT 
      1810       1820       1830       1840       1850
VKSKYKASIT ALEAKIAQLE EQLDNETKER QAACKQVRRT EKKLKDVLLQ 
      1860       1870       1880       1890       1900
VDDERRNAEQ YKDQADKAST RLKQLKRQLE EAEEEAQRAN ASRRKLQREL 
      1910       1920       1930       1940       1950
EDATETADAM NREVSSLKNK LRRGDLPFVV PRRMARKGAG DGSDEEVDGK 
      1960
ADGAEAKPAE
Length:1,960
Mass (Da):226,532
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i588F84BB8C106E6F
GO
Isoform 2 (identifier: P35579-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     980-1421: Missing.

Show »
Length:1,382
Mass (Da):159,864
Checksum:i02727B4F964F5839
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5BKV1Q5BKV1_HUMAN
MYH9 protein
MYH9
218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AH99B1AH99_HUMAN
Myosin-9
MYH9
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD89954 differs from that shown. Reason: Frameshift at position 1890.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53 – 55EAI → RGH (PubMed:1860190).Curated3
Sequence conflicti660T → S (PubMed:1860190).Curated1
Sequence conflicti869T → M in AAA36349 (PubMed:1967836).Curated1
Sequence conflicti931C → Y in AAA36349 (PubMed:1967836).Curated1
Sequence conflicti1000R → I in BAF84298 (PubMed:14702039).Curated1
Sequence conflicti1240 – 1241KG → GR in AAA36349 (PubMed:1967836).Curated2
Sequence conflicti1350E → EE (PubMed:1967836).Curated1
Sequence conflicti1462E → G in CAD89954 (PubMed:15461802).Curated1
Sequence conflicti1546D → G in CAD89954 (PubMed:15461802).Curated1
Sequence conflicti1764T → A in AAA36349 (PubMed:1967836).Curated1
Sequence conflicti1771S → G in AAA36349 (PubMed:1967836).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01079193N → K in MATINS. 1 PublicationCorresponds to variant dbSNP:rs121913655EnsemblClinVar.1
Natural variantiVAR_01830895A → T in MATINS. 1 Publication1
Natural variantiVAR_01830996S → L in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913657EnsemblClinVar.1
Natural variantiVAR_018310373K → N in MATINS. 1 Publication1
Natural variantiVAR_010792702R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338826EnsemblClinVar.1
Natural variantiVAR_018311702R → H in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338827EnsemblClinVar.1
Natural variantiVAR_010793705R → H in DFNA17. 1 PublicationCorresponds to variant dbSNP:rs80338828EnsemblClinVar.1
Natural variantiVAR_036006810K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_044226910K → Q in MATINS. 1 PublicationCorresponds to variant dbSNP:rs554332083Ensembl.1
Natural variantiVAR_044227967V → E. Corresponds to variant dbSNP:rs16996652EnsemblClinVar.1
Natural variantiVAR_0442281066 – 1072Missing in MATINS. 1 Publication7
Natural variantiVAR_0183121114S → P in MATINS. 1 PublicationCorresponds to variant dbSNP:rs200901330EnsemblClinVar.1
Natural variantiVAR_0107941155T → I in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913656EnsemblClinVar.1
Natural variantiVAR_0107951165R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338829EnsemblClinVar.1
Natural variantiVAR_0183131165R → L in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338830EnsemblClinVar.1
Natural variantiVAR_0183141205 – 1207Missing in MATINS. 2 Publications3
Natural variantiVAR_0183151400R → W in MATINS; unknown pathological significance; might contribute to pathogenicity when associated with L-96. 1 PublicationCorresponds to variant dbSNP:rs76368635EnsemblClinVar.1
Natural variantiVAR_0107961424D → H in MATINS. 5 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183161424D → N in MATINS; results in reduced protein levels. 7 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183171424D → Y in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183181626I → V1 PublicationCorresponds to variant dbSNP:rs2269529EnsemblClinVar.1
Natural variantiVAR_0303851816I → V in MATINS. 1 PublicationCorresponds to variant dbSNP:rs762773112Ensembl.1
Natural variantiVAR_0107971841E → K in MATINS. 6 PublicationsCorresponds to variant dbSNP:rs80338834EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0354091 – 136Missing in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_035410980 – 1421Missing in isoform 2. 1 PublicationAdd BLAST442

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CR456526 mRNA Translation: CAG30412.1
AB191263 mRNA Translation: BAD52439.1
AL832639 mRNA Translation: CAD89954.1 Frameshift.
AB290175 mRNA Translation: BAG06729.1
Z82215 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60096.1
M81105 mRNA Translation: AAA59888.1
AK291609 mRNA Translation: BAF84298.1
M69180 mRNA Translation: AAA61765.1
M31013 mRNA Translation: AAA36349.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13927.1 [P35579-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A61231

NCBI Reference Sequences

More...RefSeqi		NP_002464.1, NM_002473.5 [P35579-1]
XP_011528499.1, XM_011530197.2 [P35579-1]
XP_016884292.1, XM_017028803.1 [P35579-1]
XP_016884293.1, XM_017028804.1 [P35579-1]
XP_016884294.1, XM_017028805.1 [P35579-1]
XP_016884295.1, XM_017028806.1 [P35579-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.474751

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216181; ENSP00000216181; ENSG00000100345 [P35579-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4627

UCSC genome browser

More...UCSCi		uc003apg.4 human [P35579-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456526 mRNA Translation: CAG30412.1
AB191263 mRNA Translation: BAD52439.1
AL832639 mRNA Translation: CAD89954.1 Frameshift.
AB290175 mRNA Translation: BAG06729.1
Z82215 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60096.1
M81105 mRNA Translation: AAA59888.1
AK291609 mRNA Translation: BAF84298.1
M69180 mRNA Translation: AAA61765.1
M31013 mRNA Translation: AAA36349.1
CCDSiCCDS13927.1 [P35579-1]
PIRiA61231
RefSeqiNP_002464.1, NM_002473.5 [P35579-1]
XP_011528499.1, XM_011530197.2 [P35579-1]
XP_016884292.1, XM_017028803.1 [P35579-1]
XP_016884293.1, XM_017028804.1 [P35579-1]
XP_016884294.1, XM_017028805.1 [P35579-1]
XP_016884295.1, XM_017028806.1 [P35579-1]
UniGeneiHs.474751

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNKNMR-C1897-1935[»]
3ZWHX-ray1.94Q1893-1937[»]
4CFQX-ray1.37Q/R1893-1937[»]
4CFRX-ray1.40Q1893-1937[»]
4ETOX-ray1.54P1908-1923[»]
ProteinModelPortaliP35579
SMRiP35579
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110712, 325 interactors
CORUMiP35579
DIPiDIP-33103N
IntActiP35579, 276 interactors
MINTiP35579
STRINGi9606.ENSP00000216181

Chemistry databases

ChEMBLiCHEMBL2189151

PTM databases

CarbonylDBiP35579
iPTMnetiP35579
PhosphoSitePlusiP35579
SwissPalmiP35579

Polymorphism and mutation databases

BioMutaiMYH9
DMDMi6166599

Proteomic databases

EPDiP35579
PaxDbiP35579
PeptideAtlasiP35579
PRIDEiP35579
ProteomicsDBi55093
55094 [P35579-2]
TopDownProteomicsiP35579-1 [P35579-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		4627
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216181; ENSP00000216181; ENSG00000100345 [P35579-1]
GeneIDi4627
KEGGihsa:4627
UCSCiuc003apg.4 human [P35579-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4627
DisGeNETi4627
EuPathDBiHostDB:ENSG00000100345.20

GeneCards: human genes, protein and diseases

More...GeneCardsi		MYH9
GeneReviewsiMYH9
HGNCiHGNC:7579 MYH9
HPAiCAB015386
HPA001644
HPA064783
MalaCardsiMYH9
MIMi155100 phenotype
160775 gene
603622 phenotype
neXtProtiNX_P35579
OpenTargetsiENSG00000100345
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
182050 MYH9-related disease
477742 Nodular fasciitis
PharmGKBiPA31377

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000155632
HOGENOMiHOG000173958
HOVERGENiHBG004704
InParanoidiP35579
KOiK10352
OMAiCKQVRRA
OrthoDBiEOG091G009J
PhylomeDBiP35579
TreeFamiTF333601

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs
SIGNORiP35579

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MYH9 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MYH9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4627
PMAP-CutDBiP35579

Protein Ontology

More...PROi		PR:P35579

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100345 Expressed in 219 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_MYH9
ExpressionAtlasiP35579 baseline and differential
GenevisibleiP35579 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35579
Secondary accession number(s): A8K6E4
, O60805, Q60FE2, Q86T83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 221 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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