UniProtKB - P35579 (MYH9_HUMAN)
Myosin-9
MYH9
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 174 – 181 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin binding Source: MGI
- actin-dependent ATPase activity Source: MGI
- actin filament binding Source: UniProtKB
- ADP binding Source: MGI
- ATPase activity Source: UniProtKB
- ATP binding Source: MGI
- cadherin binding Source: BHF-UCL
- calmodulin binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- integrin binding Source: UniProtKB
- microfilament motor activity Source: UniProtKB
- motor activity Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- protein-membrane adaptor activity Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- actin filament-based movement Source: UniProtKB
- actomyosin structure organization Source: UniProtKB
- angiogenesis Source: UniProtKB
- blood vessel endothelial cell migration Source: UniProtKB
- cytokinetic process Source: UniProtKB
- establishment of meiotic spindle localization Source: Ensembl
- establishment of T cell polarity Source: Ensembl
- integrin-mediated signaling pathway Source: UniProtKB
- in utero embryonic development Source: Ensembl
- leukocyte migration Source: UniProtKB
- lysosome localization Source: UniProtKB
- meiotic spindle organization Source: Ensembl
- membrane protein ectodomain proteolysis Source: UniProtKB
- monocyte differentiation Source: UniProtKB
- myoblast fusion Source: Ensembl
- negative regulation of actin filament severing Source: UniProtKB
- phagocytosis, engulfment Source: UniProtKB
- plasma membrane repair Source: UniProtKB
- platelet aggregation Source: UniProtKB
- platelet formation Source: UniProtKB
- positive regulation of protein processing in phagocytic vesicle Source: UniProtKB
- protein transport Source: UniProtKB
- regulated exocytosis Source: UniProtKB
- regulation of cell shape Source: UniProtKB
- regulation of plasma membrane repair Source: UniProtKB
- uropod organization Source: Ensembl
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Myosin |
Biological process | Cell adhesion, Cell shape |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P35579 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-416572, Sema4D induced cell migration and growth-cone collapse R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5625900, RHO GTPases activate CIT R-HSA-5627117, RHO GTPases Activate ROCKs R-HSA-5627123, RHO GTPases activate PAKs R-HSA-9662834, CD163 mediating an anti-inflammatory response R-HSA-9664422, FCGR3A-mediated phagocytosis |
SIGNORi | P35579 |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-9Alternative name(s): Cellular myosin heavy chain, type A Myosin heavy chain 9 Myosin heavy chain, non-muscle IIa Non-muscle myosin heavy chain A Short name: NMMHC-A Non-muscle myosin heavy chain IIa Short name: NMMHC II-a Short name: NMMHC-IIA |
Gene namesi | Name:MYH9 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100345.20 |
HGNCi | HGNC:7579, MYH9 |
MIMi | 160775, gene |
neXtProti | NX_P35579 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- cell cortex By similarity
Note: Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610).2 Publications
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
- actomyosin Source: UniProtKB
- actomyosin contractile ring Source: UniProtKB
- myosin II complex Source: UniProtKB
- spindle Source: Ensembl
- stress fiber Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- cleavage furrow Source: UniProtKB
- immunological synapse Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- adherens junction Source: Ensembl
- brush border Source: Ensembl
- cell leading edge Source: UniProtKB
- cytoplasm Source: UniProtKB
- focal adhesion Source: Ensembl
- membrane Source: UniProtKB
- myosin II filament Source: UniProtKB
- neuromuscular junction Source: Ensembl
- protein-containing complex Source: UniProtKB
- ruffle Source: UniProtKB
- uropod Source: MGI
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss (MATINS)11 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010791 | 93 | N → K in MATINS. 1 PublicationCorresponds to variant dbSNP:rs121913655EnsemblClinVar. | 1 | |
Natural variantiVAR_018308 | 95 | A → T in MATINS. 1 Publication | 1 | |
Natural variantiVAR_018309 | 96 | S → L in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913657EnsemblClinVar. | 1 | |
Natural variantiVAR_018310 | 373 | K → N in MATINS. 1 Publication | 1 | |
Natural variantiVAR_010792 | 702 | R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338826EnsemblClinVar. | 1 | |
Natural variantiVAR_018311 | 702 | R → H in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338827EnsemblClinVar. | 1 | |
Natural variantiVAR_044226 | 910 | K → Q in MATINS. 1 PublicationCorresponds to variant dbSNP:rs554332083Ensembl. | 1 | |
Natural variantiVAR_044228 | 1066 – 1072 | Missing in MATINS. 1 Publication | 7 | |
Natural variantiVAR_018312 | 1114 | S → P in MATINS. 1 PublicationCorresponds to variant dbSNP:rs200901330EnsemblClinVar. | 1 | |
Natural variantiVAR_010794 | 1155 | T → I in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913656EnsemblClinVar. | 1 | |
Natural variantiVAR_010795 | 1165 | R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338829EnsemblClinVar. | 1 | |
Natural variantiVAR_018313 | 1165 | R → L in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338830EnsemblClinVar. | 1 | |
Natural variantiVAR_018314 | 1205 – 1207 | Missing in MATINS. 2 Publications | 3 | |
Natural variantiVAR_018315 | 1400 | R → W in MATINS; likely benign variant. 1 PublicationCorresponds to variant dbSNP:rs76368635EnsemblClinVar. | 1 | |
Natural variantiVAR_010796 | 1424 | D → H in MATINS. 5 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar. | 1 | |
Natural variantiVAR_018316 | 1424 | D → N in MATINS; results in reduced protein levels. 7 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar. | 1 | |
Natural variantiVAR_018317 | 1424 | D → Y in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar. | 1 | |
Natural variantiVAR_030385 | 1816 | I → V in MATINS. 1 PublicationCorresponds to variant dbSNP:rs762773112Ensembl. | 1 | |
Natural variantiVAR_010797 | 1841 | E → K in MATINS. 6 PublicationsCorresponds to variant dbSNP:rs80338834EnsemblClinVar. | 1 |
Deafness, autosomal dominant, 17 (DFNA17)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010793 | 705 | R → H in DFNA17. 1 PublicationCorresponds to variant dbSNP:rs80338828EnsemblClinVar. | 1 | |
Natural variantiVAR_083825 | 1228 | E → K in DFNA17; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs746956415EnsemblClinVar. | 1 |
Keywords - Diseasei
Alport syndrome, Cataract, Deafness, Disease mutation, Non-syndromic deafnessOrganism-specific databases
DisGeNETi | 4627 |
GeneReviewsi | MYH9 |
MalaCardsi | MYH9 |
MIMi | 155100, phenotype 603622, phenotype |
OpenTargetsi | ENSG00000100345 |
Orphaneti | 90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA 182050, MYH9-related disease 477742, Nodular fasciitis |
PharmGKBi | PA31377 |
Miscellaneous databases
Pharosi | P35579, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2189151 |
DrugBanki | DB11638, Artenimol |
Polymorphism and mutation databases
BioMutai | MYH9 |
DMDMi | 6166599 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000123416 | 2 – 1960 | Myosin-9Add BLAST | 1959 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 8 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 11 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 102 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 299 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 435 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 613 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 628 | PhosphoserineCombined sources | 1 | |
Modified residuei | 754 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 850 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 860 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 975 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1024 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1114 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1234 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1249 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1357 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1392 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1404 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1410 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1459 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1638 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 1669 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 1714 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1793 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1802 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1845 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 1923 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 1943 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P35579 |
jPOSTi | P35579 |
MassIVEi | P35579 |
PaxDbi | P35579 |
PeptideAtlasi | P35579 |
PRIDEi | P35579 |
ProteomicsDBi | 55093 [P35579-1] 55094 [P35579-2] |
TopDownProteomicsi | P35579-1 [P35579-1] |
PTM databases
CarbonylDBi | P35579 |
GlyGeni | P35579, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35579 |
MetOSitei | P35579 |
PhosphoSitePlusi | P35579 |
SwissPalmi | P35579 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000100345, Expressed in metanephric glomerulus and 232 other tissues |
ExpressionAtlasi | P35579, baseline and differential |
Genevisiblei | P35579, HS |
Organism-specific databases
HPAi | ENSG00000100345, Low tissue specificity |
Interactioni
Subunit structurei
Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
Interacts with RASIP1 (By similarity).
Interacts with DDR1 (By similarity).
Interacts with SLC6A4 (By similarity).
Interacts with PDLIM2 (By similarity).
Interacts with SVIL (PubMed:12917436, PubMed:17925381).
Interacts with HTRA3 (PubMed:22229724).
Interacts with Myo7a (By similarity).
Interacts with C9orf135 (PubMed:28345668).
Interacts with LIMCH1; independently of the integration of MYH9 into the myosin complex (PubMed:28228547).
Interacts with RAB3A (PubMed:27325790).
Interacts with ZBED4 (PubMed:22693546).
By similarity7 PublicationsBinary interactionsi
Hide detailsP35579
GO - Molecular functioni
- actin binding Source: MGI
- actin filament binding Source: UniProtKB
- cadherin binding Source: BHF-UCL
- calmodulin binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- integrin binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110712, 396 interactors |
CORUMi | P35579 |
DIPi | DIP-33103N |
IntActi | P35579, 323 interactors |
MINTi | P35579 |
STRINGi | 9606.ENSP00000216181 |
Miscellaneous databases
RNActi | P35579, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P35579 |
SMRi | P35579 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 77 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 81 – 776 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 696 | |
Domaini | 779 – 808 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 838 | Mediates interaction with LIMCH11 PublicationAdd BLAST | 837 | |
Regioni | 654 – 676 | Actin-bindingAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 837 – 1926 | Sequence analysisAdd BLAST | 1090 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0161, Eukaryota |
GeneTreei | ENSGT00940000155632 |
HOGENOMi | CLU_000192_4_0_1 |
InParanoidi | P35579 |
OMAi | EMETFQA |
PhylomeDBi | P35579 |
TreeFami | TF333601 |
Family and domain databases
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR036305, RGS_sf |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQQAADKYL YVDKNFINNP LAQADWAAKK LVWVPSDKSG FEPASLKEEV
60 70 80 90 100
GEEAIVELVE NGKKVKVNKD DIQKMNPPKF SKVEDMAELT CLNEASVLHN
110 120 130 140 150
LKERYYSGLI YTYSGLFCVV INPYKNLPIY SEEIVEMYKG KKRHEMPPHI
160 170 180 190 200
YAITDTAYRS MMQDREDQSI LCTGESGAGK TENTKKVIQY LAYVASSHKS
210 220 230 240 250
KKDQGELERQ LLQANPILEA FGNAKTVKND NSSRFGKFIR INFDVNGYIV
260 270 280 290 300
GANIETYLLE KSRAIRQAKE ERTFHIFYYL LSGAGEHLKT DLLLEPYNKY
310 320 330 340 350
RFLSNGHVTI PGQQDKDMFQ ETMEAMRIMG IPEEEQMGLL RVISGVLQLG
360 370 380 390 400
NIVFKKERNT DQASMPDNTA AQKVSHLLGI NVTDFTRGIL TPRIKVGRDY
410 420 430 440 450
VQKAQTKEQA DFAIEALAKA TYERMFRWLV LRINKALDKT KRQGASFIGI
460 470 480 490 500
LDIAGFEIFD LNSFEQLCIN YTNEKLQQLF NHTMFILEQE EYQREGIEWN
510 520 530 540 550
FIDFGLDLQP CIDLIEKPAG PPGILALLDE ECWFPKATDK SFVEKVMQEQ
560 570 580 590 600
GTHPKFQKPK QLKDKADFCI IHYAGKVDYK ADEWLMKNMD PLNDNIATLL
610 620 630 640 650
HQSSDKFVSE LWKDVDRIIG LDQVAGMSET ALPGAFKTRK GMFRTVGQLY
660 670 680 690 700
KEQLAKLMAT LRNTNPNFVR CIIPNHEKKA GKLDPHLVLD QLRCNGVLEG
710 720 730 740 750
IRICRQGFPN RVVFQEFRQR YEILTPNSIP KGFMDGKQAC VLMIKALELD
760 770 780 790 800
SNLYRIGQSK VFFRAGVLAH LEEERDLKIT DVIIGFQACC RGYLARKAFA
810 820 830 840 850
KRQQQLTAMK VLQRNCAAYL KLRNWQWWRL FTKVKPLLQV SRQEEEMMAK
860 870 880 890 900
EEELVKVREK QLAAENRLTE METLQSQLMA EKLQLQEQLQ AETELCAEAE
910 920 930 940 950
ELRARLTAKK QELEEICHDL EARVEEEEER CQHLQAEKKK MQQNIQELEE
960 970 980 990 1000
QLEEEESARQ KLQLEKVTTE AKLKKLEEEQ IILEDQNCKL AKEKKLLEDR
1010 1020 1030 1040 1050
IAEFTTNLTE EEEKSKSLAK LKNKHEAMIT DLEERLRREE KQRQELEKTR
1060 1070 1080 1090 1100
RKLEGDSTDL SDQIAELQAQ IAELKMQLAK KEEELQAALA RVEEEAAQKN
1110 1120 1130 1140 1150
MALKKIRELE SQISELQEDL ESERASRNKA EKQKRDLGEE LEALKTELED
1160 1170 1180 1190 1200
TLDSTAAQQE LRSKREQEVN ILKKTLEEEA KTHEAQIQEM RQKHSQAVEE
1210 1220 1230 1240 1250
LAEQLEQTKR VKANLEKAKQ TLENERGELA NEVKVLLQGK GDSEHKRKKV
1260 1270 1280 1290 1300
EAQLQELQVK FNEGERVRTE LADKVTKLQV ELDNVTGLLS QSDSKSSKLT
1310 1320 1330 1340 1350
KDFSALESQL QDTQELLQEE NRQKLSLSTK LKQVEDEKNS FREQLEEEEE
1360 1370 1380 1390 1400
AKHNLEKQIA TLHAQVADMK KKMEDSVGCL ETAEEVKRKL QKDLEGLSQR
1410 1420 1430 1440 1450
HEEKVAAYDK LEKTKTRLQQ ELDDLLVDLD HQRQSACNLE KKQKKFDQLL
1460 1470 1480 1490 1500
AEEKTISAKY AEERDRAEAE AREKETKALS LARALEEAME QKAELERLNK
1510 1520 1530 1540 1550
QFRTEMEDLM SSKDDVGKSV HELEKSKRAL EQQVEEMKTQ LEELEDELQA
1560 1570 1580 1590 1600
TEDAKLRLEV NLQAMKAQFE RDLQGRDEQS EEKKKQLVRQ VREMEAELED
1610 1620 1630 1640 1650
ERKQRSMAVA ARKKLEMDLK DLEAHIDSAN KNRDEAIKQL RKLQAQMKDC
1660 1670 1680 1690 1700
MRELDDTRAS REEILAQAKE NEKKLKSMEA EMIQLQEELA AAERAKRQAQ
1710 1720 1730 1740 1750
QERDELADEI ANSSGKGALA LEEKRRLEAR IAQLEEELEE EQGNTELIND
1760 1770 1780 1790 1800
RLKKANLQID QINTDLNLER SHAQKNENAR QQLERQNKEL KVKLQEMEGT
1810 1820 1830 1840 1850
VKSKYKASIT ALEAKIAQLE EQLDNETKER QAACKQVRRT EKKLKDVLLQ
1860 1870 1880 1890 1900
VDDERRNAEQ YKDQADKAST RLKQLKRQLE EAEEEAQRAN ASRRKLQREL
1910 1920 1930 1940 1950
EDATETADAM NREVSSLKNK LRRGDLPFVV PRRMARKGAG DGSDEEVDGK
1960
ADGAEAKPAE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5BKV1 | Q5BKV1_HUMAN | MYH9 protein | MYH9 | 218 | Annotation score: | ||
B1AH99 | B1AH99_HUMAN | Myosin-9 | MYH9 | 103 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 53 – 55 | EAI → RGH (PubMed:1860190).Curated | 3 | |
Sequence conflicti | 660 | T → S (PubMed:1860190).Curated | 1 | |
Sequence conflicti | 869 | T → M in AAA36349 (PubMed:1967836).Curated | 1 | |
Sequence conflicti | 931 | C → Y in AAA36349 (PubMed:1967836).Curated | 1 | |
Sequence conflicti | 1000 | R → I in BAF84298 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1240 – 1241 | KG → GR in AAA36349 (PubMed:1967836).Curated | 2 | |
Sequence conflicti | 1350 | E → EE (PubMed:1967836).Curated | 1 | |
Sequence conflicti | 1462 | E → G in CAD89954 (PubMed:15461802).Curated | 1 | |
Sequence conflicti | 1546 | D → G in CAD89954 (PubMed:15461802).Curated | 1 | |
Sequence conflicti | 1764 | T → A in AAA36349 (PubMed:1967836).Curated | 1 | |
Sequence conflicti | 1771 | S → G in AAA36349 (PubMed:1967836).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010791 | 93 | N → K in MATINS. 1 PublicationCorresponds to variant dbSNP:rs121913655EnsemblClinVar. | 1 | |
Natural variantiVAR_018308 | 95 | A → T in MATINS. 1 Publication | 1 | |
Natural variantiVAR_018309 | 96 | S → L in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913657EnsemblClinVar. | 1 | |
Natural variantiVAR_018310 | 373 | K → N in MATINS. 1 Publication | 1 | |
Natural variantiVAR_010792 | 702 | R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338826EnsemblClinVar. | 1 | |
Natural variantiVAR_018311 | 702 | R → H in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338827EnsemblClinVar. | 1 | |
Natural variantiVAR_010793 | 705 | R → H in DFNA17. 1 PublicationCorresponds to variant dbSNP:rs80338828EnsemblClinVar. | 1 | |
Natural variantiVAR_036006 | 810 | K → N in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_044226 | 910 | K → Q in MATINS. 1 PublicationCorresponds to variant dbSNP:rs554332083Ensembl. | 1 | |
Natural variantiVAR_044227 | 967 | V → E. Corresponds to variant dbSNP:rs16996652EnsemblClinVar. | 1 | |
Natural variantiVAR_044228 | 1066 – 1072 | Missing in MATINS. 1 Publication | 7 | |
Natural variantiVAR_018312 | 1114 | S → P in MATINS. 1 PublicationCorresponds to variant dbSNP:rs200901330EnsemblClinVar. | 1 | |
Natural variantiVAR_010794 | 1155 | T → I in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913656EnsemblClinVar. | 1 | |
Natural variantiVAR_010795 | 1165 | R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338829EnsemblClinVar. | 1 | |
Natural variantiVAR_018313 | 1165 | R → L in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338830EnsemblClinVar. | 1 | |
Natural variantiVAR_018314 | 1205 – 1207 | Missing in MATINS. 2 Publications | 3 | |
Natural variantiVAR_083825 | 1228 | E → K in DFNA17; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs746956415EnsemblClinVar. | 1 | |
Natural variantiVAR_018315 | 1400 | R → W in MATINS; likely benign variant. 1 PublicationCorresponds to variant dbSNP:rs76368635EnsemblClinVar. | 1 | |
Natural variantiVAR_010796 | 1424 | D → H in MATINS. 5 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar. | 1 | |
Natural variantiVAR_018316 | 1424 | D → N in MATINS; results in reduced protein levels. 7 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar. | 1 | |
Natural variantiVAR_018317 | 1424 | D → Y in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar. | 1 | |
Natural variantiVAR_018318 | 1626 | I → V1 PublicationCorresponds to variant dbSNP:rs2269529EnsemblClinVar. | 1 | |
Natural variantiVAR_030385 | 1816 | I → V in MATINS. 1 PublicationCorresponds to variant dbSNP:rs762773112Ensembl. | 1 | |
Natural variantiVAR_010797 | 1841 | E → K in MATINS. 6 PublicationsCorresponds to variant dbSNP:rs80338834EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035409 | 1 – 136 | Missing in isoform 2. 1 PublicationAdd BLAST | 136 | |
Alternative sequenceiVSP_035410 | 980 – 1421 | Missing in isoform 2. 1 PublicationAdd BLAST | 442 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456526 mRNA Translation: CAG30412.1 AB191263 mRNA Translation: BAD52439.1 AL832639 mRNA Translation: CAD89954.1 Frameshift. AB290175 mRNA Translation: BAG06729.1 Z82215 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60096.1 M81105 mRNA Translation: AAA59888.1 AK291609 mRNA Translation: BAF84298.1 M69180 mRNA Translation: AAA61765.1 M31013 mRNA Translation: AAA36349.1 |
CCDSi | CCDS13927.1 [P35579-1] |
PIRi | A61231 |
RefSeqi | NP_002464.1, NM_002473.5 [P35579-1] XP_011528499.1, XM_011530197.2 XP_016884292.1, XM_017028803.1 XP_016884293.1, XM_017028804.1 XP_016884294.1, XM_017028805.1 XP_016884295.1, XM_017028806.1 |
Genome annotation databases
Ensembli | ENST00000216181; ENSP00000216181; ENSG00000100345 [P35579-1] |
GeneIDi | 4627 |
KEGGi | hsa:4627 |
UCSCi | uc003apg.4, human [P35579-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR456526 mRNA Translation: CAG30412.1 AB191263 mRNA Translation: BAD52439.1 AL832639 mRNA Translation: CAD89954.1 Frameshift. AB290175 mRNA Translation: BAG06729.1 Z82215 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60096.1 M81105 mRNA Translation: AAA59888.1 AK291609 mRNA Translation: BAF84298.1 M69180 mRNA Translation: AAA61765.1 M31013 mRNA Translation: AAA36349.1 |
CCDSi | CCDS13927.1 [P35579-1] |
PIRi | A61231 |
RefSeqi | NP_002464.1, NM_002473.5 [P35579-1] XP_011528499.1, XM_011530197.2 XP_016884292.1, XM_017028803.1 XP_016884293.1, XM_017028804.1 XP_016884294.1, XM_017028805.1 XP_016884295.1, XM_017028806.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LNK | NMR | - | C | 1897-1935 | [»] | |
3ZWH | X-ray | 1.94 | Q | 1893-1937 | [»] | |
4CFQ | X-ray | 1.37 | Q/R | 1893-1937 | [»] | |
4CFR | X-ray | 1.40 | Q | 1893-1937 | [»] | |
4ETO | X-ray | 1.54 | P | 1908-1923 | [»] | |
BMRBi | P35579 | |||||
SMRi | P35579 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110712, 396 interactors |
CORUMi | P35579 |
DIPi | DIP-33103N |
IntActi | P35579, 323 interactors |
MINTi | P35579 |
STRINGi | 9606.ENSP00000216181 |
Chemistry databases
ChEMBLi | CHEMBL2189151 |
DrugBanki | DB11638, Artenimol |
PTM databases
CarbonylDBi | P35579 |
GlyGeni | P35579, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35579 |
MetOSitei | P35579 |
PhosphoSitePlusi | P35579 |
SwissPalmi | P35579 |
Polymorphism and mutation databases
BioMutai | MYH9 |
DMDMi | 6166599 |
Proteomic databases
EPDi | P35579 |
jPOSTi | P35579 |
MassIVEi | P35579 |
PaxDbi | P35579 |
PeptideAtlasi | P35579 |
PRIDEi | P35579 |
ProteomicsDBi | 55093 [P35579-1] 55094 [P35579-2] |
TopDownProteomicsi | P35579-1 [P35579-1] |
Protocols and materials databases
ABCDi | P35579, 5 sequenced antibodies |
Antibodypediai | 887, 459 antibodies |
DNASUi | 4627 |
Genome annotation databases
Ensembli | ENST00000216181; ENSP00000216181; ENSG00000100345 [P35579-1] |
GeneIDi | 4627 |
KEGGi | hsa:4627 |
UCSCi | uc003apg.4, human [P35579-1] |
Organism-specific databases
CTDi | 4627 |
DisGeNETi | 4627 |
EuPathDBi | HostDB:ENSG00000100345.20 |
GeneCardsi | MYH9 |
GeneReviewsi | MYH9 |
HGNCi | HGNC:7579, MYH9 |
HPAi | ENSG00000100345, Low tissue specificity |
MalaCardsi | MYH9 |
MIMi | 155100, phenotype 160775, gene 603622, phenotype |
neXtProti | NX_P35579 |
OpenTargetsi | ENSG00000100345 |
Orphaneti | 90635, Autosomal dominant non-syndromic sensorineural deafness type DFNA 182050, MYH9-related disease 477742, Nodular fasciitis |
PharmGKBi | PA31377 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0161, Eukaryota |
GeneTreei | ENSGT00940000155632 |
HOGENOMi | CLU_000192_4_0_1 |
InParanoidi | P35579 |
OMAi | EMETFQA |
PhylomeDBi | P35579 |
TreeFami | TF333601 |
Enzyme and pathway databases
PathwayCommonsi | P35579 |
Reactomei | R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-3928663, EPHA-mediated growth cone collapse R-HSA-416572, Sema4D induced cell migration and growth-cone collapse R-HSA-5625740, RHO GTPases activate PKNs R-HSA-5625900, RHO GTPases activate CIT R-HSA-5627117, RHO GTPases Activate ROCKs R-HSA-5627123, RHO GTPases activate PAKs R-HSA-9662834, CD163 mediating an anti-inflammatory response R-HSA-9664422, FCGR3A-mediated phagocytosis |
SIGNORi | P35579 |
Miscellaneous databases
BioGRID-ORCSi | 4627, 331 hits in 859 CRISPR screens |
ChiTaRSi | MYH9, human |
GeneWikii | MYH9 |
GenomeRNAii | 4627 |
Pharosi | P35579, Tbio |
PROi | PR:P35579 |
RNActi | P35579, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000100345, Expressed in metanephric glomerulus and 232 other tissues |
ExpressionAtlasi | P35579, baseline and differential |
Genevisiblei | P35579, HS |
Family and domain databases
Gene3Di | 2.30.30.360, 1 hit 3.40.850.10, 1 hit 4.10.270.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR027401, Myosin_IQ_contain_sf IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR036305, RGS_sf |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF48097, SSF48097, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYH9_HUMAN | |
Accessioni | P35579Primary (citable) accession number: P35579 Secondary accession number(s): A8K6E4 Q86T83 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 238 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations