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Protein

Myosin-9

Gene

MYH9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi174 – 181ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: MGI
  • actin-dependent ATPase activity Source: MGI
  • actin filament binding Source: UniProtKB
  • ADP binding Source: MGI
  • ATPase activity Source: UniProtKB
  • ATP binding Source: MGI
  • cadherin binding Source: BHF-UCL
  • calmodulin binding Source: UniProtKB-KW
  • integrin binding Source: UniProtKB
  • microfilament motor activity Source: UniProtKB
  • motor activity Source: UniProtKB
  • protein domain specific binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • protein membrane anchor Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processCell adhesion, Cell shape
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs

SIGNOR Signaling Network Open Resource

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SIGNORi
P35579

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-9
Alternative name(s):
Cellular myosin heavy chain, type A
Myosin heavy chain 9
Myosin heavy chain, non-muscle IIa
Non-muscle myosin heavy chain A
Short name:
NMMHC-A
Non-muscle myosin heavy chain IIa
Short name:
NMMHC II-a
Short name:
NMMHC-IIA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000100345.20

Human Gene Nomenclature Database

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HGNCi
HGNC:7579 MYH9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
160775 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P35579

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss (MATINS)11 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant disorder characterized by thrombocytopenia, giant platelets and Dohle body-like inclusions in peripheral blood leukocytes with variable ultrastructural appearance. Some affected individuals lack leukocyte inclusion bodies on classic staining of peripheral blood smears. Alport syndrome-like features of nephritis, hearing loss, and eye abnormalities are present in some patients.
See also OMIM:155100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01079193N → K in MATINS. 1 PublicationCorresponds to variant dbSNP:rs121913655EnsemblClinVar.1
Natural variantiVAR_01830895A → T in MATINS. 1 Publication1
Natural variantiVAR_01830996S → L in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913657EnsemblClinVar.1
Natural variantiVAR_018310373K → N in MATINS. 1 Publication1
Natural variantiVAR_010792702R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338826EnsemblClinVar.1
Natural variantiVAR_018311702R → H in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338827EnsemblClinVar.1
Natural variantiVAR_044226910K → Q in MATINS. 1 PublicationCorresponds to variant dbSNP:rs554332083Ensembl.1
Natural variantiVAR_0442281066 – 1072Missing in MATINS. 1 Publication7
Natural variantiVAR_0183121114S → P in MATINS. 1 PublicationCorresponds to variant dbSNP:rs200901330EnsemblClinVar.1
Natural variantiVAR_0107941155T → I in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913656EnsemblClinVar.1
Natural variantiVAR_0107951165R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338829EnsemblClinVar.1
Natural variantiVAR_0183131165R → L in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338830EnsemblClinVar.1
Natural variantiVAR_0183141205 – 1207Missing in MATINS. 2 Publications3
Natural variantiVAR_0183151400R → W in MATINS; unknown pathological significance; might contribute to pathogenicity when associated with L-96. 1 PublicationCorresponds to variant dbSNP:rs76368635EnsemblClinVar.1
Natural variantiVAR_0107961424D → H in MATINS. 5 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183161424D → N in MATINS; results in reduced protein levels. 7 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183171424D → Y in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0303851816I → V in MATINS. 1 PublicationCorresponds to variant dbSNP:rs762773112Ensembl.1
Natural variantiVAR_0107971841E → K in MATINS. 6 PublicationsCorresponds to variant dbSNP:rs80338834EnsemblClinVar.1
Deafness, autosomal dominant, 17 (DFNA17)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of deafness characterized by progressive high frequency hearing impairment and cochleosaccular degeneration.
See also OMIM:603622
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010793705R → H in DFNA17. 1 PublicationCorresponds to variant dbSNP:rs80338828EnsemblClinVar.1
Subjects with mutations in the motor domain of MYH9 present with severe thrombocytopenia and develop nephritis and deafness before the age of 40 years, while those with mutations in the tail domain have a much lower risk of noncongenital complications and significantly higher platelet counts. The clinical course of patients with mutations in the four most frequently affected residues of MYH9 (responsible for 70% of MYH9-related cases) were evaluated. Mutations at residue 1933 do not induce kidney damage or cataracts and cause deafness only in the elderly, those in position 702 result in severe thrombocytopenia and produce nephritis and deafness at a juvenile age, while alterations at residue 1424 or 1841 result in intermediate clinical pictures.
Genetic variations in MYH9 are associated with non-diabetic end stage renal disease (ESRD).

Keywords - Diseasei

Alport syndrome, Cataract, Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNET

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DisGeNETi
4627

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
MYH9

MalaCards human disease database

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MalaCardsi
MYH9
MIMi155100 phenotype
603622 phenotype

Open Targets

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OpenTargetsi
ENSG00000100345

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
182050 MYH9-related disease
477742 Nodular fasciitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31377

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2189151

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MYH9

Domain mapping of disease mutations (DMDM)

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DMDMi
6166599

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234162 – 1960Myosin-9Add BLAST1959

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei8N6-acetyllysineCombined sources1
Modified residuei11PhosphotyrosineCombined sources1
Modified residuei102N6-acetyllysineCombined sources1
Modified residuei299N6-acetyllysineCombined sources1
Modified residuei435N6-acetyllysineBy similarity1
Modified residuei613N6-acetyllysineBy similarity1
Modified residuei628PhosphoserineCombined sources1
Modified residuei754PhosphotyrosineCombined sources1
Modified residuei850N6-succinyllysineBy similarity1
Modified residuei860N6-acetyllysineBy similarity1
Modified residuei975N6-acetyllysineBy similarity1
Modified residuei1024N6-acetyllysineCombined sources1
Modified residuei1114PhosphoserineBy similarity1
Modified residuei1234N6-acetyllysineBy similarity1
Modified residuei1249N6-acetyllysineBy similarity1
Modified residuei1357N6-acetyllysineCombined sources1
Modified residuei1392N6-acetyllysineCombined sources1
Modified residuei1404N6-acetyllysineCombined sources1
Modified residuei1410N6-acetyllysineCombined sources1
Modified residuei1459N6-acetyllysineCombined sources1
Modified residuei1638N6-acetyllysineCombined sources1
Modified residuei1669N6-succinyllysineBy similarity1
Modified residuei1714PhosphoserineCombined sources1
Modified residuei1793N6-acetyllysineBy similarity1
Modified residuei1802N6-acetyllysineBy similarity1
Modified residuei1845N6-acetyllysineBy similarity1
Modified residuei1923Omega-N-methylarginineBy similarity1
Modified residuei1943PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

ISGylated.1 Publication
Ubiquitination.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P35579

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P35579

PeptideAtlas

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PeptideAtlasi
P35579

PRoteomics IDEntifications database

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PRIDEi
P35579

ProteomicsDB human proteome resource

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ProteomicsDBi
55093
55094 [P35579-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P35579-1 [P35579-1]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
P35579

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P35579

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P35579

SwissPalm database of S-palmitoylation events

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SwissPalmi
P35579

Miscellaneous databases

CutDB - Proteolytic event database

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PMAP-CutDBi
P35579

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In the kidney, expressed in the glomeruli. Also expressed in leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000100345 Expressed in 219 organ(s), highest expression level in metanephric glomerulus

CleanEx database of gene expression profiles

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CleanExi
HS_MYH9

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P35579 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P35579 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB015386
HPA001644
HPA064783

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1 (By similarity). Interacts with DDR1 (By similarity). Interacts with SLC6A4 (By similarity). Interacts with PDLIM2 (By similarity). Interacts with SVIL (PubMed:12917436, PubMed:17925381). Interacts with HTRA3 (PubMed:22229724). Interacts with Myo7a (By similarity). Interacts with C9orf135 (PubMed:28345668). Interacts with LIMCH1; independently of the integration of MYH9 into the myosin complex (PubMed:28228547).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110712, 325 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P35579

Database of interacting proteins

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DIPi
DIP-33103N

Protein interaction database and analysis system

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IntActi
P35579, 276 interactors

Molecular INTeraction database

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MINTi
P35579

STRING: functional protein association networks

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STRINGi
9606.ENSP00000216181

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P35579

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35579

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 77Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini81 – 776Myosin motorPROSITE-ProRule annotationAdd BLAST696
Domaini779 – 808IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 838Mediates interaction with LIMCH11 PublicationAdd BLAST837
Regioni654 – 676Actin-bindingAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili837 – 1926Sequence analysisAdd BLAST1090

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155632

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000173958

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004704

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P35579

KEGG Orthology (KO)

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KOi
K10352

Identification of Orthologs from Complete Genome Data

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OMAi
CKQVRRA

Database of Orthologous Groups

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OrthoDBi
EOG091G009J

Database for complete collections of gene phylogenies

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PhylomeDBi
P35579

TreeFam database of animal gene trees

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TreeFami
TF333601

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
IPR036305 RGS_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48097 SSF48097, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P35579-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQQAADKYL YVDKNFINNP LAQADWAAKK LVWVPSDKSG FEPASLKEEV
60 70 80 90 100
GEEAIVELVE NGKKVKVNKD DIQKMNPPKF SKVEDMAELT CLNEASVLHN
110 120 130 140 150
LKERYYSGLI YTYSGLFCVV INPYKNLPIY SEEIVEMYKG KKRHEMPPHI
160 170 180 190 200
YAITDTAYRS MMQDREDQSI LCTGESGAGK TENTKKVIQY LAYVASSHKS
210 220 230 240 250
KKDQGELERQ LLQANPILEA FGNAKTVKND NSSRFGKFIR INFDVNGYIV
260 270 280 290 300
GANIETYLLE KSRAIRQAKE ERTFHIFYYL LSGAGEHLKT DLLLEPYNKY
310 320 330 340 350
RFLSNGHVTI PGQQDKDMFQ ETMEAMRIMG IPEEEQMGLL RVISGVLQLG
360 370 380 390 400
NIVFKKERNT DQASMPDNTA AQKVSHLLGI NVTDFTRGIL TPRIKVGRDY
410 420 430 440 450
VQKAQTKEQA DFAIEALAKA TYERMFRWLV LRINKALDKT KRQGASFIGI
460 470 480 490 500
LDIAGFEIFD LNSFEQLCIN YTNEKLQQLF NHTMFILEQE EYQREGIEWN
510 520 530 540 550
FIDFGLDLQP CIDLIEKPAG PPGILALLDE ECWFPKATDK SFVEKVMQEQ
560 570 580 590 600
GTHPKFQKPK QLKDKADFCI IHYAGKVDYK ADEWLMKNMD PLNDNIATLL
610 620 630 640 650
HQSSDKFVSE LWKDVDRIIG LDQVAGMSET ALPGAFKTRK GMFRTVGQLY
660 670 680 690 700
KEQLAKLMAT LRNTNPNFVR CIIPNHEKKA GKLDPHLVLD QLRCNGVLEG
710 720 730 740 750
IRICRQGFPN RVVFQEFRQR YEILTPNSIP KGFMDGKQAC VLMIKALELD
760 770 780 790 800
SNLYRIGQSK VFFRAGVLAH LEEERDLKIT DVIIGFQACC RGYLARKAFA
810 820 830 840 850
KRQQQLTAMK VLQRNCAAYL KLRNWQWWRL FTKVKPLLQV SRQEEEMMAK
860 870 880 890 900
EEELVKVREK QLAAENRLTE METLQSQLMA EKLQLQEQLQ AETELCAEAE
910 920 930 940 950
ELRARLTAKK QELEEICHDL EARVEEEEER CQHLQAEKKK MQQNIQELEE
960 970 980 990 1000
QLEEEESARQ KLQLEKVTTE AKLKKLEEEQ IILEDQNCKL AKEKKLLEDR
1010 1020 1030 1040 1050
IAEFTTNLTE EEEKSKSLAK LKNKHEAMIT DLEERLRREE KQRQELEKTR
1060 1070 1080 1090 1100
RKLEGDSTDL SDQIAELQAQ IAELKMQLAK KEEELQAALA RVEEEAAQKN
1110 1120 1130 1140 1150
MALKKIRELE SQISELQEDL ESERASRNKA EKQKRDLGEE LEALKTELED
1160 1170 1180 1190 1200
TLDSTAAQQE LRSKREQEVN ILKKTLEEEA KTHEAQIQEM RQKHSQAVEE
1210 1220 1230 1240 1250
LAEQLEQTKR VKANLEKAKQ TLENERGELA NEVKVLLQGK GDSEHKRKKV
1260 1270 1280 1290 1300
EAQLQELQVK FNEGERVRTE LADKVTKLQV ELDNVTGLLS QSDSKSSKLT
1310 1320 1330 1340 1350
KDFSALESQL QDTQELLQEE NRQKLSLSTK LKQVEDEKNS FREQLEEEEE
1360 1370 1380 1390 1400
AKHNLEKQIA TLHAQVADMK KKMEDSVGCL ETAEEVKRKL QKDLEGLSQR
1410 1420 1430 1440 1450
HEEKVAAYDK LEKTKTRLQQ ELDDLLVDLD HQRQSACNLE KKQKKFDQLL
1460 1470 1480 1490 1500
AEEKTISAKY AEERDRAEAE AREKETKALS LARALEEAME QKAELERLNK
1510 1520 1530 1540 1550
QFRTEMEDLM SSKDDVGKSV HELEKSKRAL EQQVEEMKTQ LEELEDELQA
1560 1570 1580 1590 1600
TEDAKLRLEV NLQAMKAQFE RDLQGRDEQS EEKKKQLVRQ VREMEAELED
1610 1620 1630 1640 1650
ERKQRSMAVA ARKKLEMDLK DLEAHIDSAN KNRDEAIKQL RKLQAQMKDC
1660 1670 1680 1690 1700
MRELDDTRAS REEILAQAKE NEKKLKSMEA EMIQLQEELA AAERAKRQAQ
1710 1720 1730 1740 1750
QERDELADEI ANSSGKGALA LEEKRRLEAR IAQLEEELEE EQGNTELIND
1760 1770 1780 1790 1800
RLKKANLQID QINTDLNLER SHAQKNENAR QQLERQNKEL KVKLQEMEGT
1810 1820 1830 1840 1850
VKSKYKASIT ALEAKIAQLE EQLDNETKER QAACKQVRRT EKKLKDVLLQ
1860 1870 1880 1890 1900
VDDERRNAEQ YKDQADKAST RLKQLKRQLE EAEEEAQRAN ASRRKLQREL
1910 1920 1930 1940 1950
EDATETADAM NREVSSLKNK LRRGDLPFVV PRRMARKGAG DGSDEEVDGK
1960
ADGAEAKPAE
Length:1,960
Mass (Da):226,532
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i588F84BB8C106E6F
GO
Isoform 2 (identifier: P35579-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-136: Missing.
     980-1421: Missing.

Show »
Length:1,382
Mass (Da):159,864
Checksum:i02727B4F964F5839
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5BKV1Q5BKV1_HUMAN
MYH9 protein
MYH9
218Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AH99B1AH99_HUMAN
Myosin-9
MYH9
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD89954 differs from that shown. Reason: Frameshift at position 1890.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53 – 55EAI → RGH (PubMed:1860190).Curated3
Sequence conflicti660T → S (PubMed:1860190).Curated1
Sequence conflicti869T → M in AAA36349 (PubMed:1967836).Curated1
Sequence conflicti931C → Y in AAA36349 (PubMed:1967836).Curated1
Sequence conflicti1000R → I in BAF84298 (PubMed:14702039).Curated1
Sequence conflicti1240 – 1241KG → GR in AAA36349 (PubMed:1967836).Curated2
Sequence conflicti1350E → EE (PubMed:1967836).Curated1
Sequence conflicti1462E → G in CAD89954 (PubMed:15461802).Curated1
Sequence conflicti1546D → G in CAD89954 (PubMed:15461802).Curated1
Sequence conflicti1764T → A in AAA36349 (PubMed:1967836).Curated1
Sequence conflicti1771S → G in AAA36349 (PubMed:1967836).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01079193N → K in MATINS. 1 PublicationCorresponds to variant dbSNP:rs121913655EnsemblClinVar.1
Natural variantiVAR_01830895A → T in MATINS. 1 Publication1
Natural variantiVAR_01830996S → L in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913657EnsemblClinVar.1
Natural variantiVAR_018310373K → N in MATINS. 1 Publication1
Natural variantiVAR_010792702R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338826EnsemblClinVar.1
Natural variantiVAR_018311702R → H in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338827EnsemblClinVar.1
Natural variantiVAR_010793705R → H in DFNA17. 1 PublicationCorresponds to variant dbSNP:rs80338828EnsemblClinVar.1
Natural variantiVAR_036006810K → N in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_044226910K → Q in MATINS. 1 PublicationCorresponds to variant dbSNP:rs554332083Ensembl.1
Natural variantiVAR_044227967V → E. Corresponds to variant dbSNP:rs16996652EnsemblClinVar.1
Natural variantiVAR_0442281066 – 1072Missing in MATINS. 1 Publication7
Natural variantiVAR_0183121114S → P in MATINS. 1 PublicationCorresponds to variant dbSNP:rs200901330EnsemblClinVar.1
Natural variantiVAR_0107941155T → I in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs121913656EnsemblClinVar.1
Natural variantiVAR_0107951165R → C in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338829EnsemblClinVar.1
Natural variantiVAR_0183131165R → L in MATINS. 3 PublicationsCorresponds to variant dbSNP:rs80338830EnsemblClinVar.1
Natural variantiVAR_0183141205 – 1207Missing in MATINS. 2 Publications3
Natural variantiVAR_0183151400R → W in MATINS; unknown pathological significance; might contribute to pathogenicity when associated with L-96. 1 PublicationCorresponds to variant dbSNP:rs76368635EnsemblClinVar.1
Natural variantiVAR_0107961424D → H in MATINS. 5 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183161424D → N in MATINS; results in reduced protein levels. 7 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183171424D → Y in MATINS. 2 PublicationsCorresponds to variant dbSNP:rs80338831EnsemblClinVar.1
Natural variantiVAR_0183181626I → V1 PublicationCorresponds to variant dbSNP:rs2269529EnsemblClinVar.1
Natural variantiVAR_0303851816I → V in MATINS. 1 PublicationCorresponds to variant dbSNP:rs762773112Ensembl.1
Natural variantiVAR_0107971841E → K in MATINS. 6 PublicationsCorresponds to variant dbSNP:rs80338834EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0354091 – 136Missing in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_035410980 – 1421Missing in isoform 2. 1 PublicationAdd BLAST442

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR456526 mRNA Translation: CAG30412.1
AB191263 mRNA Translation: BAD52439.1
AL832639 mRNA Translation: CAD89954.1 Frameshift.
AB290175 mRNA Translation: BAG06729.1
Z82215 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60096.1
M81105 mRNA Translation: AAA59888.1
AK291609 mRNA Translation: BAF84298.1
M69180 mRNA Translation: AAA61765.1
M31013 mRNA Translation: AAA36349.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13927.1 [P35579-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A61231

NCBI Reference Sequences

More...
RefSeqi
NP_002464.1, NM_002473.5 [P35579-1]
XP_011528499.1, XM_011530197.2 [P35579-1]
XP_016884292.1, XM_017028803.1 [P35579-1]
XP_016884293.1, XM_017028804.1 [P35579-1]
XP_016884294.1, XM_017028805.1 [P35579-1]
XP_016884295.1, XM_017028806.1 [P35579-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.474751

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000216181; ENSP00000216181; ENSG00000100345 [P35579-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4627

UCSC genome browser

More...
UCSCi
uc003apg.4 human [P35579-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR456526 mRNA Translation: CAG30412.1
AB191263 mRNA Translation: BAD52439.1
AL832639 mRNA Translation: CAD89954.1 Frameshift.
AB290175 mRNA Translation: BAG06729.1
Z82215 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60096.1
M81105 mRNA Translation: AAA59888.1
AK291609 mRNA Translation: BAF84298.1
M69180 mRNA Translation: AAA61765.1
M31013 mRNA Translation: AAA36349.1
CCDSiCCDS13927.1 [P35579-1]
PIRiA61231
RefSeqiNP_002464.1, NM_002473.5 [P35579-1]
XP_011528499.1, XM_011530197.2 [P35579-1]
XP_016884292.1, XM_017028803.1 [P35579-1]
XP_016884293.1, XM_017028804.1 [P35579-1]
XP_016884294.1, XM_017028805.1 [P35579-1]
XP_016884295.1, XM_017028806.1 [P35579-1]
UniGeneiHs.474751

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LNKNMR-C1897-1935[»]
3ZWHX-ray1.94Q1893-1937[»]
4CFQX-ray1.37Q/R1893-1937[»]
4CFRX-ray1.40Q1893-1937[»]
4ETOX-ray1.54P1908-1923[»]
ProteinModelPortaliP35579
SMRiP35579
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110712, 325 interactors
CORUMiP35579
DIPiDIP-33103N
IntActiP35579, 276 interactors
MINTiP35579
STRINGi9606.ENSP00000216181

Chemistry databases

ChEMBLiCHEMBL2189151

PTM databases

CarbonylDBiP35579
iPTMnetiP35579
PhosphoSitePlusiP35579
SwissPalmiP35579

Polymorphism and mutation databases

BioMutaiMYH9
DMDMi6166599

Proteomic databases

EPDiP35579
PaxDbiP35579
PeptideAtlasiP35579
PRIDEiP35579
ProteomicsDBi55093
55094 [P35579-2]
TopDownProteomicsiP35579-1 [P35579-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4627
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216181; ENSP00000216181; ENSG00000100345 [P35579-1]
GeneIDi4627
KEGGihsa:4627
UCSCiuc003apg.4 human [P35579-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4627
DisGeNETi4627
EuPathDBiHostDB:ENSG00000100345.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYH9
GeneReviewsiMYH9
HGNCiHGNC:7579 MYH9
HPAiCAB015386
HPA001644
HPA064783
MalaCardsiMYH9
MIMi155100 phenotype
160775 gene
603622 phenotype
neXtProtiNX_P35579
OpenTargetsiENSG00000100345
Orphaneti90635 Autosomal dominant non-syndromic sensorineural deafness type DFNA
182050 MYH9-related disease
477742 Nodular fasciitis
PharmGKBiPA31377

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000155632
HOGENOMiHOG000173958
HOVERGENiHBG004704
InParanoidiP35579
KOiK10352
OMAiCKQVRRA
OrthoDBiEOG091G009J
PhylomeDBiP35579
TreeFamiTF333601

Enzyme and pathway databases

ReactomeiR-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5627123 RHO GTPases activate PAKs
SIGNORiP35579

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYH9 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYH9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4627
PMAP-CutDBiP35579

Protein Ontology

More...
PROi
PR:P35579

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100345 Expressed in 219 organ(s), highest expression level in metanephric glomerulus
CleanExiHS_MYH9
ExpressionAtlasiP35579 baseline and differential
GenevisibleiP35579 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
IPR036305 RGS_sf
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF48097 SSF48097, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35579
Secondary accession number(s): A8K6E4
, O60805, Q60FE2, Q86T83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 221 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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