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UniProtKB - P35573 (GDE_HUMAN)

Protein

Glycogen debranching enzyme

Gene

AGL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei526By similarity1
Active sitei529By similarity1
Active sitei627By similarity1

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionGlycosidase, Glycosyltransferase, Hydrolase, Multifunctional enzyme, Transferase
Biological processGlycogen biosynthesis

Enzyme and pathway databases

BioCyciMetaCyc:HS08717-MONOMER
BRENDAi3.2.1.33 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-70221 Glycogen breakdown (glycogenolysis)

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13
GH133 Glycoside Hydrolase Family 133

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen debranching enzyme
Alternative name(s):
Glycogen debrancher
Including the following 2 domains:
4-alpha-glucanotransferase (EC:2.4.1.25)
Alternative name(s):
Oligo-1,4-1,4-glucantransferase
Amylo-alpha-1,6-glucosidase (EC:3.2.1.33)
Short name:
Amylo-1,6-glucosidase
Alternative name(s):
Dextrin 6-alpha-D-glucosidase
Gene namesi
Name:AGL
Synonyms:GDE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162688.15
HGNCiHGNC:321 AGL
MIMi610860 gene
neXtProtiNX_P35573

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Glycogen storage disease 3 (GSD3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder associated with an accumulation of abnormal glycogen with short outer chains. It is clinically characterized by hepatomegaly, hypoglycemia, short stature, and variable myopathy. Glycogen storage disease type 3 includes different forms: GSD type 3A patients lack glycogen debrancher enzyme activity in both liver and muscle, while GSD type 3B patients are enzyme-deficient in liver only. In rare cases, selective loss of only 1 of the 2 debranching activities, glucosidase or transferase, results in GSD type 3C or type 3D, respectively.
See also OMIM:232400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0092311448G → R in GSD3; deficient in ability to bind glycogen; unstable due to enhanced ubiquitination; forms aggresomes upon proteasome impairment. 2 PublicationsCorresponds to variant dbSNP:rs118203964EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNETi178
GeneReviewsiAGL
MalaCardsiAGL
MIMi232400 phenotype
OpenTargetsiENSG00000162688
Orphaneti366 Glycogen storage disease due to glycogen debranching enzyme deficiency
PharmGKBiPA24618

Chemistry databases

ChEMBLiCHEMBL5272

Polymorphism and mutation databases

BioMutaiAGL
DMDMi116242491

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000874501 – 1532Glycogen debranching enzymeAdd BLAST1532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1

Post-translational modificationi

The N-terminus is blocked.
Ubiquitinated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP35573
MaxQBiP35573
PaxDbiP35573
PeptideAtlasiP35573
PRIDEiP35573
ProteomicsDBi55089
55090 [P35573-2]
55091 [P35573-3]

PTM databases

iPTMnetiP35573
PhosphoSitePlusiP35573

Expressioni

Tissue specificityi

Liver, kidney and lymphoblastoid cells express predominantly isoform 1; whereas muscle and heart express not only isoform 1, but also muscle-specific isoform mRNAs (isoforms 2, 3 and 4). Isoforms 5 and 6 are present in both liver and muscle.

Gene expression databases

BgeeiENSG00000162688 Expressed in 238 organ(s), highest expression level in biceps brachii
CleanExiHS_AGL
ExpressionAtlasiP35573 baseline and differential
GenevisibleiP35573 HS

Organism-specific databases

HPAiHPA028498
HPA054340

Interactioni

Subunit structurei

Monomer. Interacts with NHLRC1/malin.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi106686, 53 interactors
IntActiP35573, 11 interactors
MINTiP35573
STRINGi9606.ENSP00000294724

Chemistry databases

BindingDBiP35573

Structurei

3D structure databases

ProteinModelPortaliP35573
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni? – 1532Amylo-1,6-glucosidase
Regioni1 – ?4-alpha-glucanotransferase

Sequence similaritiesi

Belongs to the glycogen debranching enzyme family.Curated

Phylogenomic databases

eggNOGiKOG3625 Eukaryota
COG3408 LUCA
GeneTreeiENSGT00390000012596
HOVERGENiHBG005824
InParanoidiP35573
KOiK01196
OMAiMSSFVQN
OrthoDBiEOG091G00L5
PhylomeDBiP35573
TreeFamiTF300697

Family and domain databases

CDDicd11327 AmyAc_Glg_debranch_2, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR010401 AGL/Gdb1
IPR032788 AGL_central
IPR029436 AGL_euk_N
IPR032792 AGL_glucanoTrfase
IPR032790 GDE_C
IPR006421 Glycogen_debranch_met
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10569 PTHR10569, 1 hit
PfamiView protein in Pfam
PF06202 GDE_C, 1 hit
PF14701 hDGE_amylase, 1 hit
PF14702 hGDE_central, 1 hit
PF14699 hGDE_N, 1 hit
SUPFAMiSSF48208 SSF48208, 2 hits
SSF51445 SSF51445, 2 hits
TIGRFAMsiTIGR01531 glyc_debranch, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P35573-1) [UniParc]FASTAAdd to basket
Also known as: 2, 3, 4

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGHSKQIRIL LLNEMEKLEK TLFRLEQGYE LQFRLGPTLQ GKAVTVYTNY 
        60         70         80         90        100
PFPGETFNRE KFRSLDWENP TEREDDSDKY CKLNLQQSGS FQYYFLQGNE 
       110        120        130        140        150
KSGGGYIVVD PILRVGADNH VLPLDCVTLQ TFLAKCLGPF DEWESRLRVA 
       160        170        180        190        200
KESGYNMIHF TPLQTLGLSR SCYSLANQLE LNPDFSRPNR KYTWNDVGQL 
       210        220        230        240        250
VEKLKKEWNV ICITDVVYNH TAANSKWIQE HPECAYNLVN SPHLKPAWVL 
       260        270        280        290        300
DRALWRFSCD VAEGKYKEKG IPALIENDHH MNSIRKIIWE DIFPKLKLWE 
       310        320        330        340        350
FFQVDVNKAV EQFRRLLTQE NRRVTKSDPN QHLTIIQDPE YRRFGCTVDM 
       360        370        380        390        400
NIALTTFIPH DKGPAAIEEC CNWFHKRMEE LNSEKHRLIN YHQEQAVNCL 
       410        420        430        440        450
LGNVFYERLA GHGPKLGPVT RKHPLVTRYF TFPFEEIDFS MEESMIHLPN 
       460        470        480        490        500
KACFLMAHNG WVMGDDPLRN FAEPGSEVYL RRELICWGDS VKLRYGNKPE 
       510        520        530        540        550
DCPYLWAHMK KYTEITATYF QGVRLDNCHS TPLHVAEYML DAARNLQPNL 
       560        570        580        590        600
YVVAELFTGS EDLDNVFVTR LGISSLIREA MSAYNSHEEG RLVYRYGGEP 
       610        620        630        640        650
VGSFVQPCLR PLMPAIAHAL FMDITHDNEC PIVHRSAYDA LPSTTIVSMA 
       660        670        680        690        700
CCASGSTRGY DELVPHQISV VSEERFYTKW NPEALPSNTG EVNFQSGIIA 
       710        720        730        740        750
ARCAISKLHQ ELGAKGFIQV YVDQVDEDIV AVTRHSPSIH QSVVAVSRTA 
       760        770        780        790        800
FRNPKTSFYS KEVPQMCIPG KIEEVVLEAR TIERNTKPYR KDENSINGTP 
       810        820        830        840        850
DITVEIREHI QLNESKIVKQ AGVATKGPNE YIQEIEFENL SPGSVIIFRV 
       860        870        880        890        900
SLDPHAQVAV GILRNHLTQF SPHFKSGSLA VDNADPILKI PFASLASRLT 
       910        920        930        940        950
LAELNQILYR CESEEKEDGG GCYDIPNWSA LKYAGLQGLM SVLAEIRPKN 
       960        970        980        990       1000
DLGHPFCNNL RSGDWMIDYV SNRLISRSGT IAEVGKWLQA MFFYLKQIPR 
      1010       1020       1030       1040       1050
YLIPCYFDAI LIGAYTTLLD TAWKQMSSFV QNGSTFVKHL SLGSVQLCGV 
      1060       1070       1080       1090       1100
GKFPSLPILS PALMDVPYRL NEITKEKEQC CVSLAAGLPH FSSGIFRCWG 
      1110       1120       1130       1140       1150
RDTFIALRGI LLITGRYVEA RNIILAFAGT LRHGLIPNLL GEGIYARYNC 
      1160       1170       1180       1190       1200
RDAVWWWLQC IQDYCKMVPN GLDILKCPVS RMYPTDDSAP LPAGTLDQPL 
      1210       1220       1230       1240       1250
FEVIQEAMQK HMQGIQFRER NAGPQIDRNM KDEGFNITAG VDEETGFVYG 
      1260       1270       1280       1290       1300
GNRFNCGTWM DKMGESDRAR NRGIPATPRD GSAVEIVGLS KSAVRWLLEL 
      1310       1320       1330       1340       1350
SKKNIFPYHE VTVKRHGKAI KVSYDEWNRK IQDNFEKLFH VSEDPSDLNE 
      1360       1370       1380       1390       1400
KHPNLVHKRG IYKDSYGASS PWCDYQLRPN FTIAMVVAPE LFTTEKAWKA 
      1410       1420       1430       1440       1450
LEIAEKKLLG PLGMKTLDPD DMVYCGIYDN ALDNDNYNLA KGFNYHQGPE 
      1460       1470       1480       1490       1500
WLWPIGYFLR AKLYFSRLMG PETTAKTIVL VKNVLSRHYV HLERSPWKGL 
      1510       1520       1530 
PELTNENAQY CPFSCETQAW SIATILETLY DL
Note: The products of the mRNAs termed isoforms 1 to 4 are identical.
Length:1,532
Mass (Da):174,764
Last modified:October 17, 2006 - v3
Checksum:i9BF1BCC43B7904D3
GO
Isoform 5 (identifier: P35573-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGHSKQIRILLLNEMEKLEKTLFRLEQ → MSLLTCAFYL

Show »
Length:1,515
Mass (Da):172,626
Checksum:iABAC29497A4B08C6
GO
Isoform 6 (identifier: P35573-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: MGHSKQIRILLLNEMEKLEKTLFRLEQ → MAPILSINLFI

Show »
Length:1,516
Mass (Da):172,696
Checksum:iC26E3817344DB637
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1C7CYW1A0A1C7CYW1_HUMAN
Glycogen debranching enzyme
AGL
68Annotation score:

Sequence cautioni

The sequence BAD92104 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1398W → G in AAB41040 (PubMed:1374391).Curated1
Sequence conflicti1398W → G in AAB48466 (PubMed:8954797).Curated1
Sequence conflicti1398W → G in AAB48467 (PubMed:8954797).Curated1
Sequence conflicti1398W → G in AAB48468 (PubMed:8954797).Curated1
Sequence conflicti1398W → G in AAB48469 (PubMed:8954797).Curated1
Sequence conflicti1398W → G in AAB48470 (PubMed:8954797).Curated1
Sequence conflicti1398W → G (PubMed:9332391).Curated1
Isoform 6 (identifier: P35573-3)
Sequence conflicti4I → L in AAB48470 (PubMed:8954797).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03208438T → A. Corresponds to variant dbSNP:rs35278779EnsemblClinVar.1
Natural variantiVAR_028051229Q → R. Corresponds to variant dbSNP:rs17121403EnsemblClinVar.1
Natural variantiVAR_009621387R → Q. Corresponds to variant dbSNP:rs17121464EnsemblClinVar.1
Natural variantiVAR_028052701A → S. Corresponds to variant dbSNP:rs3736297Ensembl.1
Natural variantiVAR_032085962S → C. Corresponds to variant dbSNP:rs34714252EnsemblClinVar.1
Natural variantiVAR_0203891067P → S. Corresponds to variant dbSNP:rs3753494EnsemblClinVar.1
Natural variantiVAR_0092301115G → R1 PublicationCorresponds to variant dbSNP:rs2230307EnsemblClinVar.1
Natural variantiVAR_0280531144I → N. Corresponds to variant dbSNP:rs2230308EnsemblClinVar.1
Natural variantiVAR_0510101207A → T. Corresponds to variant dbSNP:rs11807956EnsemblClinVar.1
Natural variantiVAR_0280541253R → H. Corresponds to variant dbSNP:rs12043139EnsemblClinVar.1
Natural variantiVAR_0096221343E → K. Corresponds to variant dbSNP:rs112795811EnsemblClinVar.1
Natural variantiVAR_0092311448G → R in GSD3; deficient in ability to bind glycogen; unstable due to enhanced ubiquitination; forms aggresomes upon proteasome impairment. 2 PublicationsCorresponds to variant dbSNP:rs118203964EnsemblClinVar.1
Natural variantiVAR_0280551487R → G. Corresponds to variant dbSNP:rs12118058Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0042701 – 27MGHSK…FRLEQ → MSLLTCAFYL in isoform 5. CuratedAdd BLAST27
Alternative sequenceiVSP_0042711 – 27MGHSK…FRLEQ → MAPILSINLFI in isoform 6. CuratedAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85168 mRNA Translation: AAB41040.1
U84007 mRNA Translation: AAB48466.1
U84008 mRNA Translation: AAB48467.1
U84009 mRNA Translation: AAB48468.1
U84010 mRNA Translation: AAB48469.1
U84011 mRNA Translation: AAB48470.1
AB035443 Genomic DNA Translation: BAA88405.1
AB208867 mRNA Translation: BAD92104.1 Different initiation.
AC096949 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72985.1
CH471097 Genomic DNA Translation: EAW72982.1
CH471097 Genomic DNA Translation: EAW72983.1
CH471097 Genomic DNA Translation: EAW72987.1
BC078663 mRNA Translation: AAH78663.1
CCDSiCCDS759.1 [P35573-1]
CCDS760.1 [P35573-3]
RefSeqiNP_000019.2, NM_000028.2 [P35573-1]
NP_000633.2, NM_000642.2 [P35573-1]
NP_000634.2, NM_000643.2 [P35573-1]
NP_000635.2, NM_000644.2 [P35573-1]
NP_000637.2, NM_000646.2 [P35573-3]
XP_005270614.1, XM_005270557.2 [P35573-1]
UniGeneiHs.904

Genome annotation databases

EnsembliENST00000294724; ENSP00000294724; ENSG00000162688 [P35573-1]
ENST00000361915; ENSP00000355106; ENSG00000162688 [P35573-1]
ENST00000370161; ENSP00000359180; ENSG00000162688 [P35573-3]
ENST00000370163; ENSP00000359182; ENSG00000162688 [P35573-1]
ENST00000370165; ENSP00000359184; ENSG00000162688 [P35573-1]
GeneIDi178
KEGGihsa:178
UCSCiuc001dsi.2 human [P35573-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85168 mRNA Translation: AAB41040.1
U84007 mRNA Translation: AAB48466.1
U84008 mRNA Translation: AAB48467.1
U84009 mRNA Translation: AAB48468.1
U84010 mRNA Translation: AAB48469.1
U84011 mRNA Translation: AAB48470.1
AB035443 Genomic DNA Translation: BAA88405.1
AB208867 mRNA Translation: BAD92104.1 Different initiation.
AC096949 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW72985.1
CH471097 Genomic DNA Translation: EAW72982.1
CH471097 Genomic DNA Translation: EAW72983.1
CH471097 Genomic DNA Translation: EAW72987.1
BC078663 mRNA Translation: AAH78663.1
CCDSiCCDS759.1 [P35573-1]
CCDS760.1 [P35573-3]
RefSeqiNP_000019.2, NM_000028.2 [P35573-1]
NP_000633.2, NM_000642.2 [P35573-1]
NP_000634.2, NM_000643.2 [P35573-1]
NP_000635.2, NM_000644.2 [P35573-1]
NP_000637.2, NM_000646.2 [P35573-3]
XP_005270614.1, XM_005270557.2 [P35573-1]
UniGeneiHs.904

3D structure databases

ProteinModelPortaliP35573
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106686, 53 interactors
IntActiP35573, 11 interactors
MINTiP35573
STRINGi9606.ENSP00000294724

Chemistry databases

BindingDBiP35573
ChEMBLiCHEMBL5272

Protein family/group databases

CAZyiGH13 Glycoside Hydrolase Family 13
GH133 Glycoside Hydrolase Family 133

PTM databases

iPTMnetiP35573
PhosphoSitePlusiP35573

Polymorphism and mutation databases

BioMutaiAGL
DMDMi116242491

Proteomic databases

EPDiP35573
MaxQBiP35573
PaxDbiP35573
PeptideAtlasiP35573
PRIDEiP35573
ProteomicsDBi55089
55090 [P35573-2]
55091 [P35573-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294724; ENSP00000294724; ENSG00000162688 [P35573-1]
ENST00000361915; ENSP00000355106; ENSG00000162688 [P35573-1]
ENST00000370161; ENSP00000359180; ENSG00000162688 [P35573-3]
ENST00000370163; ENSP00000359182; ENSG00000162688 [P35573-1]
ENST00000370165; ENSP00000359184; ENSG00000162688 [P35573-1]
GeneIDi178
KEGGihsa:178
UCSCiuc001dsi.2 human [P35573-1]

Organism-specific databases

CTDi178
DisGeNETi178
EuPathDBiHostDB:ENSG00000162688.15
GeneCardsiAGL
GeneReviewsiAGL
HGNCiHGNC:321 AGL
HPAiHPA028498
HPA054340
MalaCardsiAGL
MIMi232400 phenotype
610860 gene
neXtProtiNX_P35573
OpenTargetsiENSG00000162688
Orphaneti366 Glycogen storage disease due to glycogen debranching enzyme deficiency
PharmGKBiPA24618
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3625 Eukaryota
COG3408 LUCA
GeneTreeiENSGT00390000012596
HOVERGENiHBG005824
InParanoidiP35573
KOiK01196
OMAiMSSFVQN
OrthoDBiEOG091G00L5
PhylomeDBiP35573
TreeFamiTF300697

Enzyme and pathway databases

BioCyciMetaCyc:HS08717-MONOMER
BRENDAi3.2.1.33 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-70221 Glycogen breakdown (glycogenolysis)

Miscellaneous databases

ChiTaRSiAGL human
GeneWikiiGlycogen_debranching_enzyme
GenomeRNAii178
PROiPR:P35573
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162688 Expressed in 238 organ(s), highest expression level in biceps brachii
CleanExiHS_AGL
ExpressionAtlasiP35573 baseline and differential
GenevisibleiP35573 HS

Family and domain databases

CDDicd11327 AmyAc_Glg_debranch_2, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR010401 AGL/Gdb1
IPR032788 AGL_central
IPR029436 AGL_euk_N
IPR032792 AGL_glucanoTrfase
IPR032790 GDE_C
IPR006421 Glycogen_debranch_met
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10569 PTHR10569, 1 hit
PfamiView protein in Pfam
PF06202 GDE_C, 1 hit
PF14701 hDGE_amylase, 1 hit
PF14702 hGDE_central, 1 hit
PF14699 hGDE_N, 1 hit
SUPFAMiSSF48208 SSF48208, 2 hits
SSF51445 SSF51445, 2 hits
TIGRFAMsiTIGR01531 glyc_debranch, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDE_HUMAN
AccessioniPrimary (citable) accession number: P35573
Secondary accession number(s): A6NCX7
, A6NEK2, D3DT51, P78354, P78544, Q59H92, Q6AZ90, Q9UF08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 17, 2006
Last modified: October 10, 2018
This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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