The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P35573 (GDE_HUMAN)
Protein
Glycogen debranching enzyme
Gene
AGL
Organism
Homo sapiens (Human)
Status
Functioni
Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.
Catalytic activityi
- Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan. EC:2.4.1.25
- Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. EC:3.2.1.33
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 526 | By similarity | 1 | |
Active sitei | 529 | By similarity | 1 | |
Active sitei | 627 | By similarity | 1 |
GO - Molecular functioni
- 4-alpha-glucanotransferase activity Source: Reactome
- amylo-alpha-1,6-glucosidase activity Source: Reactome
- beta-maltose 4-alpha-glucanotransferase activity Source: UniProtKB-EC
- glycogen debranching enzyme activity Source: ProtInc
- polysaccharide binding Source: Ensembl
- polyubiquitin modification-dependent protein binding Source: Ensembl
GO - Biological processi
- glycogen biosynthetic process Source: UniProtKB-KW
- glycogen catabolic process Source: GO_Central
- response to glucocorticoid Source: Ensembl
- response to nutrient Source: Ensembl
Keywordsi
Molecular function | Glycosidase, Glycosyltransferase, Hydrolase, Multifunctional enzyme, Transferase |
Biological process | Glycogen biosynthesis |
Enzyme and pathway databases
BRENDAi | 3.2.1.33, 2681 |
PathwayCommonsi | P35573 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-70221, Glycogen breakdown (glycogenolysis) |
SignaLinki | P35573 |
Protein family/group databases
CAZyi | GH13, Glycoside Hydrolase Family 13 GH133, Glycoside Hydrolase Family 133 |
Names & Taxonomyi
Protein namesi | Recommended name: Glycogen debranching enzymeAlternative name(s): Glycogen debrancher Including the following 2 domains: |
Gene namesi | Name:AGL Synonyms:GDE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:321, AGL |
MIMi | 610860, gene |
neXtProti | NX_P35573 |
VEuPathDBi | HostDB:ENSG00000162688 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Note: Under glycogenolytic conditions localizes to the nucleus.
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- sarcoplasmic reticulum Source: Ensembl
Extracellular region or secreted
- extracellular region Source: Reactome
Nucleus
- nucleus Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB
- ficolin-1-rich granule lumen Source: Reactome
- inclusion body Source: Ensembl
- isoamylase complex Source: ProtInc
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Glycogen storage disease 3 (GSD3)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA metabolic disorder associated with an accumulation of abnormal glycogen with short outer chains. It is clinically characterized by hepatomegaly, hypoglycemia, short stature, and variable myopathy. Glycogen storage disease type 3 includes different forms: GSD type 3A patients lack glycogen debrancher enzyme activity in both liver and muscle, while GSD type 3B patients are enzyme-deficient in liver only. In rare cases, selective loss of only 1 of the 2 debranching activities, glucosidase or transferase, results in GSD type 3C or type 3D, respectively.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_009231 | 1448 | G → R in GSD3; deficient in ability to bind glycogen; unstable due to enhanced ubiquitination; forms aggresomes upon proteasome impairment. 2 PublicationsCorresponds to variant dbSNP:rs118203964EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Glycogen storage diseaseOrganism-specific databases
DisGeNETi | 178 |
GeneReviewsi | AGL |
MalaCardsi | AGL |
MIMi | 232400, phenotype |
OpenTargetsi | ENSG00000162688 |
Orphaneti | 366, Glycogen storage disease due to glycogen debranching enzyme deficiency |
PharmGKBi | PA24618 |
Miscellaneous databases
Pharosi | P35573, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5272 |
DrugCentrali | P35573 |
Genetic variation databases
BioMutai | AGL |
DMDMi | 116242491 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087450 | 1 – 1532 | Glycogen debranching enzymeAdd BLAST | 1532 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 64 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
The N-terminus is blocked.
Ubiquitinated.1 Publication
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P35573 |
jPOSTi | P35573 |
MassIVEi | P35573 |
MaxQBi | P35573 |
PaxDbi | P35573 |
PeptideAtlasi | P35573 |
PRIDEi | P35573 |
ProteomicsDBi | 55089 [P35573-1] 55090 [P35573-2] 55091 [P35573-3] |
PTM databases
GlyGeni | P35573, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35573 |
PhosphoSitePlusi | P35573 |
Expressioni
Tissue specificityi
Liver, kidney and lymphoblastoid cells express predominantly isoform 1; whereas muscle and heart express not only isoform 1, but also muscle-specific isoform mRNAs (isoforms 2, 3 and 4). Isoforms 5 and 6 are present in both liver and muscle.
Gene expression databases
Bgeei | ENSG00000162688, Expressed in biceps brachii and 252 other tissues |
ExpressionAtlasi | P35573, baseline and differential |
Genevisiblei | P35573, HS |
Organism-specific databases
HPAi | ENSG00000162688, Group enriched (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Monomer.
Interacts with NHLRC1/malin.
1 PublicationGO - Molecular functioni
- polyubiquitin modification-dependent protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 106686, 74 interactors |
IntActi | P35573, 28 interactors |
MINTi | P35573 |
STRINGi | 9606.ENSP00000294724 |
Chemistry databases
BindingDBi | P35573 |
Miscellaneous databases
RNActi | P35573, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | ? – 1532 | Amylo-1,6-glucosidase | ||
Regioni | 1 – ? | 4-alpha-glucanotransferase |
Sequence similaritiesi
Belongs to the glycogen debranching enzyme family.Curated
Phylogenomic databases
eggNOGi | KOG3625, Eukaryota |
GeneTreei | ENSGT00390000012596 |
HOGENOMi | CLU_001517_2_0_1 |
InParanoidi | P35573 |
OMAi | DKMGEST |
PhylomeDBi | P35573 |
TreeFami | TF300697 |
Family and domain databases
CDDi | cd11327, AmyAc_Glg_debranch_2, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR010401, AGL/Gdb1 IPR032788, AGL_central IPR029436, AGL_euk_N IPR032792, AGL_glucanoTrfase IPR032790, GDE_C IPR006421, Glycogen_debranch_met IPR017853, Glycoside_hydrolase_SF |
PANTHERi | PTHR10569, PTHR10569, 1 hit |
Pfami | View protein in Pfam PF06202, GDE_C, 1 hit PF14701, hDGE_amylase, 1 hit PF14702, hGDE_central, 1 hit PF14699, hGDE_N, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit SSF51445, SSF51445, 1 hit |
TIGRFAMsi | TIGR01531, glyc_debranch, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P35573-1) [UniParc]FASTAAdd to basket
Also known as: 2, 3, 4
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGHSKQIRIL LLNEMEKLEK TLFRLEQGYE LQFRLGPTLQ GKAVTVYTNY
60 70 80 90 100
PFPGETFNRE KFRSLDWENP TEREDDSDKY CKLNLQQSGS FQYYFLQGNE
110 120 130 140 150
KSGGGYIVVD PILRVGADNH VLPLDCVTLQ TFLAKCLGPF DEWESRLRVA
160 170 180 190 200
KESGYNMIHF TPLQTLGLSR SCYSLANQLE LNPDFSRPNR KYTWNDVGQL
210 220 230 240 250
VEKLKKEWNV ICITDVVYNH TAANSKWIQE HPECAYNLVN SPHLKPAWVL
260 270 280 290 300
DRALWRFSCD VAEGKYKEKG IPALIENDHH MNSIRKIIWE DIFPKLKLWE
310 320 330 340 350
FFQVDVNKAV EQFRRLLTQE NRRVTKSDPN QHLTIIQDPE YRRFGCTVDM
360 370 380 390 400
NIALTTFIPH DKGPAAIEEC CNWFHKRMEE LNSEKHRLIN YHQEQAVNCL
410 420 430 440 450
LGNVFYERLA GHGPKLGPVT RKHPLVTRYF TFPFEEIDFS MEESMIHLPN
460 470 480 490 500
KACFLMAHNG WVMGDDPLRN FAEPGSEVYL RRELICWGDS VKLRYGNKPE
510 520 530 540 550
DCPYLWAHMK KYTEITATYF QGVRLDNCHS TPLHVAEYML DAARNLQPNL
560 570 580 590 600
YVVAELFTGS EDLDNVFVTR LGISSLIREA MSAYNSHEEG RLVYRYGGEP
610 620 630 640 650
VGSFVQPCLR PLMPAIAHAL FMDITHDNEC PIVHRSAYDA LPSTTIVSMA
660 670 680 690 700
CCASGSTRGY DELVPHQISV VSEERFYTKW NPEALPSNTG EVNFQSGIIA
710 720 730 740 750
ARCAISKLHQ ELGAKGFIQV YVDQVDEDIV AVTRHSPSIH QSVVAVSRTA
760 770 780 790 800
FRNPKTSFYS KEVPQMCIPG KIEEVVLEAR TIERNTKPYR KDENSINGTP
810 820 830 840 850
DITVEIREHI QLNESKIVKQ AGVATKGPNE YIQEIEFENL SPGSVIIFRV
860 870 880 890 900
SLDPHAQVAV GILRNHLTQF SPHFKSGSLA VDNADPILKI PFASLASRLT
910 920 930 940 950
LAELNQILYR CESEEKEDGG GCYDIPNWSA LKYAGLQGLM SVLAEIRPKN
960 970 980 990 1000
DLGHPFCNNL RSGDWMIDYV SNRLISRSGT IAEVGKWLQA MFFYLKQIPR
1010 1020 1030 1040 1050
YLIPCYFDAI LIGAYTTLLD TAWKQMSSFV QNGSTFVKHL SLGSVQLCGV
1060 1070 1080 1090 1100
GKFPSLPILS PALMDVPYRL NEITKEKEQC CVSLAAGLPH FSSGIFRCWG
1110 1120 1130 1140 1150
RDTFIALRGI LLITGRYVEA RNIILAFAGT LRHGLIPNLL GEGIYARYNC
1160 1170 1180 1190 1200
RDAVWWWLQC IQDYCKMVPN GLDILKCPVS RMYPTDDSAP LPAGTLDQPL
1210 1220 1230 1240 1250
FEVIQEAMQK HMQGIQFRER NAGPQIDRNM KDEGFNITAG VDEETGFVYG
1260 1270 1280 1290 1300
GNRFNCGTWM DKMGESDRAR NRGIPATPRD GSAVEIVGLS KSAVRWLLEL
1310 1320 1330 1340 1350
SKKNIFPYHE VTVKRHGKAI KVSYDEWNRK IQDNFEKLFH VSEDPSDLNE
1360 1370 1380 1390 1400
KHPNLVHKRG IYKDSYGASS PWCDYQLRPN FTIAMVVAPE LFTTEKAWKA
1410 1420 1430 1440 1450
LEIAEKKLLG PLGMKTLDPD DMVYCGIYDN ALDNDNYNLA KGFNYHQGPE
1460 1470 1480 1490 1500
WLWPIGYFLR AKLYFSRLMG PETTAKTIVL VKNVLSRHYV HLERSPWKGL
1510 1520 1530
PELTNENAQY CPFSCETQAW SIATILETLY DL
Note: The products of the mRNAs termed isoforms 1 to 4 are identical.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1C7CYW1 | A0A1C7CYW1_HUMAN | Glycogen debranching enzyme | AGL | 68 | Annotation score: |
Sequence cautioni
The sequence BAD92104 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 1398 | W → G in AAB41040 (PubMed:1374391).Curated | 1 | ||
Sequence conflicti | 1398 | W → G in AAB48466 (PubMed:8954797).Curated | 1 | ||
Sequence conflicti | 1398 | W → G in AAB48467 (PubMed:8954797).Curated | 1 | ||
Sequence conflicti | 1398 | W → G in AAB48468 (PubMed:8954797).Curated | 1 | ||
Sequence conflicti | 1398 | W → G in AAB48469 (PubMed:8954797).Curated | 1 | ||
Sequence conflicti | 1398 | W → G in AAB48470 (PubMed:8954797).Curated | 1 | ||
Sequence conflicti | 1398 | W → G (PubMed:9332391).Curated | 1 | ||
Isoform 6 (identifier: P35573-3) | |||||
Sequence conflicti | 4 | I → L in AAB48470 (PubMed:8954797).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032084 | 38 | T → A. Corresponds to variant dbSNP:rs35278779EnsemblClinVar. | 1 | |
Natural variantiVAR_028051 | 229 | Q → R. Corresponds to variant dbSNP:rs17121403EnsemblClinVar. | 1 | |
Natural variantiVAR_009621 | 387 | R → Q. Corresponds to variant dbSNP:rs17121464EnsemblClinVar. | 1 | |
Natural variantiVAR_028052 | 701 | A → S. Corresponds to variant dbSNP:rs3736297Ensembl. | 1 | |
Natural variantiVAR_032085 | 962 | S → C. Corresponds to variant dbSNP:rs34714252EnsemblClinVar. | 1 | |
Natural variantiVAR_020389 | 1067 | P → S. Corresponds to variant dbSNP:rs3753494EnsemblClinVar. | 1 | |
Natural variantiVAR_009230 | 1115 | G → R1 PublicationCorresponds to variant dbSNP:rs2230307EnsemblClinVar. | 1 | |
Natural variantiVAR_028053 | 1144 | I → N. Corresponds to variant dbSNP:rs2230308EnsemblClinVar. | 1 | |
Natural variantiVAR_051010 | 1207 | A → T. Corresponds to variant dbSNP:rs11807956EnsemblClinVar. | 1 | |
Natural variantiVAR_028054 | 1253 | R → H. Corresponds to variant dbSNP:rs12043139EnsemblClinVar. | 1 | |
Natural variantiVAR_009622 | 1343 | E → K. Corresponds to variant dbSNP:rs112795811EnsemblClinVar. | 1 | |
Natural variantiVAR_009231 | 1448 | G → R in GSD3; deficient in ability to bind glycogen; unstable due to enhanced ubiquitination; forms aggresomes upon proteasome impairment. 2 PublicationsCorresponds to variant dbSNP:rs118203964EnsemblClinVar. | 1 | |
Natural variantiVAR_028055 | 1487 | R → G. Corresponds to variant dbSNP:rs12118058Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004270 | 1 – 27 | MGHSK…FRLEQ → MSLLTCAFYL in isoform 5. CuratedAdd BLAST | 27 | |
Alternative sequenceiVSP_004271 | 1 – 27 | MGHSK…FRLEQ → MAPILSINLFI in isoform 6. CuratedAdd BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85168 mRNA Translation: AAB41040.1 U84007 mRNA Translation: AAB48466.1 U84008 mRNA Translation: AAB48467.1 U84009 mRNA Translation: AAB48468.1 U84010 mRNA Translation: AAB48469.1 U84011 mRNA Translation: AAB48470.1 AB035443 Genomic DNA Translation: BAA88405.1 AB208867 mRNA Translation: BAD92104.1 Different initiation. AC096949 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW72985.1 CH471097 Genomic DNA Translation: EAW72982.1 CH471097 Genomic DNA Translation: EAW72983.1 CH471097 Genomic DNA Translation: EAW72987.1 BC078663 mRNA Translation: AAH78663.1 |
CCDSi | CCDS759.1 [P35573-1] CCDS760.1 [P35573-3] |
RefSeqi | NP_000019.2, NM_000028.2 [P35573-1] NP_000633.2, NM_000642.2 [P35573-1] NP_000634.2, NM_000643.2 [P35573-1] NP_000635.2, NM_000644.2 [P35573-1] NP_000637.2, NM_000646.2 [P35573-3] XP_005270614.1, XM_005270557.2 [P35573-1] |
Genome annotation databases
Ensembli | ENST00000294724.8; ENSP00000294724.4; ENSG00000162688.17 ENST00000361915.8; ENSP00000355106.3; ENSG00000162688.17 ENST00000370161.6; ENSP00000359180.2; ENSG00000162688.17 [P35573-3] ENST00000370163.7; ENSP00000359182.3; ENSG00000162688.17 ENST00000370165.7; ENSP00000359184.3; ENSG00000162688.17 |
GeneIDi | 178 |
KEGGi | hsa:178 |
MANE-Selecti | ENST00000361915.8; ENSP00000355106.3; NM_000642.3; NP_000633.2 |
UCSCi | uc001dsi.2, human [P35573-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85168 mRNA Translation: AAB41040.1 U84007 mRNA Translation: AAB48466.1 U84008 mRNA Translation: AAB48467.1 U84009 mRNA Translation: AAB48468.1 U84010 mRNA Translation: AAB48469.1 U84011 mRNA Translation: AAB48470.1 AB035443 Genomic DNA Translation: BAA88405.1 AB208867 mRNA Translation: BAD92104.1 Different initiation. AC096949 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW72985.1 CH471097 Genomic DNA Translation: EAW72982.1 CH471097 Genomic DNA Translation: EAW72983.1 CH471097 Genomic DNA Translation: EAW72987.1 BC078663 mRNA Translation: AAH78663.1 |
CCDSi | CCDS759.1 [P35573-1] CCDS760.1 [P35573-3] |
RefSeqi | NP_000019.2, NM_000028.2 [P35573-1] NP_000633.2, NM_000642.2 [P35573-1] NP_000634.2, NM_000643.2 [P35573-1] NP_000635.2, NM_000644.2 [P35573-1] NP_000637.2, NM_000646.2 [P35573-3] XP_005270614.1, XM_005270557.2 [P35573-1] |
3D structure databases
AlphaFoldDBi | P35573 |
SMRi | P35573 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106686, 74 interactors |
IntActi | P35573, 28 interactors |
MINTi | P35573 |
STRINGi | 9606.ENSP00000294724 |
Chemistry databases
BindingDBi | P35573 |
ChEMBLi | CHEMBL5272 |
DrugCentrali | P35573 |
Protein family/group databases
CAZyi | GH13, Glycoside Hydrolase Family 13 GH133, Glycoside Hydrolase Family 133 |
PTM databases
GlyGeni | P35573, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P35573 |
PhosphoSitePlusi | P35573 |
Genetic variation databases
BioMutai | AGL |
DMDMi | 116242491 |
Proteomic databases
EPDi | P35573 |
jPOSTi | P35573 |
MassIVEi | P35573 |
MaxQBi | P35573 |
PaxDbi | P35573 |
PeptideAtlasi | P35573 |
PRIDEi | P35573 |
ProteomicsDBi | 55089 [P35573-1] 55090 [P35573-2] 55091 [P35573-3] |
Protocols and materials databases
Antibodypediai | 33684, 172 antibodies from 26 providers |
DNASUi | 178 |
Genome annotation databases
Ensembli | ENST00000294724.8; ENSP00000294724.4; ENSG00000162688.17 ENST00000361915.8; ENSP00000355106.3; ENSG00000162688.17 ENST00000370161.6; ENSP00000359180.2; ENSG00000162688.17 [P35573-3] ENST00000370163.7; ENSP00000359182.3; ENSG00000162688.17 ENST00000370165.7; ENSP00000359184.3; ENSG00000162688.17 |
GeneIDi | 178 |
KEGGi | hsa:178 |
MANE-Selecti | ENST00000361915.8; ENSP00000355106.3; NM_000642.3; NP_000633.2 |
UCSCi | uc001dsi.2, human [P35573-1] |
Organism-specific databases
CTDi | 178 |
DisGeNETi | 178 |
GeneCardsi | AGL |
GeneReviewsi | AGL |
HGNCi | HGNC:321, AGL |
HPAi | ENSG00000162688, Group enriched (skeletal muscle, tongue) |
MalaCardsi | AGL |
MIMi | 232400, phenotype 610860, gene |
neXtProti | NX_P35573 |
OpenTargetsi | ENSG00000162688 |
Orphaneti | 366, Glycogen storage disease due to glycogen debranching enzyme deficiency |
PharmGKBi | PA24618 |
VEuPathDBi | HostDB:ENSG00000162688 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3625, Eukaryota |
GeneTreei | ENSGT00390000012596 |
HOGENOMi | CLU_001517_2_0_1 |
InParanoidi | P35573 |
OMAi | DKMGEST |
PhylomeDBi | P35573 |
TreeFami | TF300697 |
Enzyme and pathway databases
BRENDAi | 3.2.1.33, 2681 |
PathwayCommonsi | P35573 |
Reactomei | R-HSA-6798695, Neutrophil degranulation R-HSA-70221, Glycogen breakdown (glycogenolysis) |
SignaLinki | P35573 |
Miscellaneous databases
BioGRID-ORCSi | 178, 28 hits in 1083 CRISPR screens |
GeneWikii | Glycogen_debranching_enzyme |
GenomeRNAii | 178 |
Pharosi | P35573, Tbio |
PROi | PR:P35573 |
RNActi | P35573, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162688, Expressed in biceps brachii and 252 other tissues |
ExpressionAtlasi | P35573, baseline and differential |
Genevisiblei | P35573, HS |
Family and domain databases
CDDi | cd11327, AmyAc_Glg_debranch_2, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR010401, AGL/Gdb1 IPR032788, AGL_central IPR029436, AGL_euk_N IPR032792, AGL_glucanoTrfase IPR032790, GDE_C IPR006421, Glycogen_debranch_met IPR017853, Glycoside_hydrolase_SF |
PANTHERi | PTHR10569, PTHR10569, 1 hit |
Pfami | View protein in Pfam PF06202, GDE_C, 1 hit PF14701, hDGE_amylase, 1 hit PF14702, hGDE_central, 1 hit PF14699, hGDE_N, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit SSF51445, SSF51445, 1 hit |
TIGRFAMsi | TIGR01531, glyc_debranch, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GDE_HUMAN | |
Accessioni | P35573Primary (citable) accession number: P35573 Secondary accession number(s): A6NCX7 Q9UF08 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | October 17, 2006 | |
Last modified: | May 25, 2022 | |
This is version 204 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families