Igfbp6

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functionⁱ

insulin-like growth factor I binding
Source: RGD
Inferred from physical interactionⁱ
- 7689963
insulin-like growth factor II binding
Source: RGD
Inferred from physical interactionⁱ
- 7689963

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of cell growth Source: InterPro
regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

Reactomeⁱ	R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Reactomeⁱ

R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 6 Short name: IBP-6 Short name: IGF-binding protein 6 Short name: IGFBP-6
Gene namesⁱ	Name:Igfbp6 Synonyms:Igfbp-6
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	2877 Igfbp6

RGDⁱ

2877 Igfbp6

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	1 PublicationAdd BLAST		25
ChainⁱPRO_0000014391	26 – 226	Insulin-like growth factor-binding protein 6Add BLAST		201

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	30 ↔ 33	PROSITE-ProRule annotation
Disulfide bondⁱ	49 ↔ 55	PROSITE-ProRule annotation
Disulfide bondⁱ	63 ↔ 76	PROSITE-ProRule annotation
Disulfide bondⁱ	70 ↔ 96	PROSITE-ProRule annotation
Disulfide bondⁱ	148 ↔ 176	PROSITE-ProRule annotation
Disulfide bondⁱ	187 ↔ 198	PROSITE-ProRule annotation
Disulfide bondⁱ	200 ↔ 220	PROSITE-ProRule annotation

Post-translational modificationⁱ

O-glycosylated.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P35572
PRIDEⁱ	P35572

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000010977
Genevisibleⁱ	P35572 RN

Interactionⁱ

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000014807

STRINGⁱ

10116.ENSRNOP00000014807

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35572
SMRⁱ	P35572
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 99	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		74
Domainⁱ	145 – 220	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		76

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVZ3 Eukaryota ENOG410YQXU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P35572
OMAⁱ	RDQQRNP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L46
PhylomeDBⁱ	P35572
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022326 IGFBP-6 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF14 PTHR11551:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01982 IGFBPFAMILY6
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P35572-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTWDGLPTQP LLMLLMLLFA AGSESALAGC PGCGPGVQEE DAGSPADGCA 
        60         70         80         90        100
ETGGCFRREG QPCGVYIPKC APGLQCQPRE NEETPLRALL IGQGRCQRAR 
       110        120        130        140        150
GPSEETTKES KPHGGASRPR DRDRQKNPRT SAAPIRPSPV QDGEMGPCRR 
       160        170        180        190        200
HLDSVLQQLQ TEVFRGGANG LYVPNCDLRG FYRKQQCRSS QGNRRGPCWC 
       210        220 
VDPMGQPLPV SPDGQGSSQC SARSSG

Length:226

Mass (Da):24,193

Last modified:June 1, 1994 - v1

Checksum:ⁱ212D419303AE3137

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69055 mRNA Translation: AAA42019.1 L11006 Genomic DNA No translation available. BC099742 mRNA Translation: AAH99742.1
PIRⁱ	JN0464
NCBI Reference Sequences More...RefSeqⁱ	NP_037236.1, NM_013104.3
UniGeneⁱ	Rn.6431

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977
GeneIDⁱ	25641
KEGGⁱ	rno:25641

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P35572	Insulin-like growth factor-binding protein 6		MOUSE		238
UPI000A31B390		MUSCR		238

Protein	Similar proteins		Species	Score	Length
P35572	UPI000A31B390		MUSCR		238
Insulin-like growth factor-binding protein 6		MOUSE		238
insulin-like growth factor-binding protein 6		ERIEU		229
UPI00038C5238		MICOH		229
Insulin like growth factor binding protein 6		FELCA		222
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69055 mRNA Translation: AAA42019.1 L11006 Genomic DNA No translation available. BC099742 mRNA Translation: AAH99742.1
PIRⁱ	JN0464
NCBI Reference Sequences More...RefSeqⁱ	NP_037236.1, NM_013104.3
UniGeneⁱ	Rn.6431

3D structure databases

ProteinModelPortalⁱ	P35572
SMRⁱ	P35572
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000014807

STRINGⁱ

10116.ENSRNOP00000014807

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Proteomic databases

PaxDbⁱ	P35572
PRIDEⁱ	P35572

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977
GeneIDⁱ	25641
KEGGⁱ	rno:25641

Organism-specific databases

CTDⁱ	3489
Rat genome database More...RGDⁱ	2877 Igfbp6

Phylogenomic databases

eggNOGⁱ	ENOG410IVZ3 Eukaryota ENOG410YQXU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P35572
OMAⁱ	RDQQRNP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L46
PhylomeDBⁱ	P35572
TreeFamⁱ	TF331211

Enzyme and pathway databases

Reactomeⁱ	R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Reactomeⁱ

R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P35572

PROⁱ

PR:P35572

Gene expression databases

Bgeeⁱ	ENSRNOG00000010977
Genevisibleⁱ	P35572 RN

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022326 IGFBP-6 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF14 PTHR11551:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01982 IGFBPFAMILY6
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP6_RAT
Accessionⁱ	P35572Primary (citable) accession number: P35572 Secondary accession number(s): Q499W1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	June 20, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35572 (IBP6_RAT)

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Insulin-like growth factor-binding protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ