UniProtKB - P35572 (IBP6_RAT)
Protein
Insulin-like growth factor-binding protein 6
Gene
Igfbp6
Organism
Rattus norvegicus (Rat)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration.By similarity
GO - Molecular functioni
- fibronectin binding Source: GO_Central
- identical protein binding Source: RGD
- insulin-like growth factor I binding Source: RGD
- insulin-like growth factor II binding Source: RGD
GO - Biological processi
- activation of MAPK activity Source: UniProtKB
- cell migration Source: UniProtKB
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 6Short name: IBP-6 Short name: IGF-binding protein 6 Short name: IGFBP-6 |
Gene namesi | Name:Igfbp6 Synonyms:Igfbp-6 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2877, Igfbp6 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: RGD
- insulin-like growth factor binary complex Source: RGD
Golgi apparatus
- Golgi apparatus Source: RGD
Other locations
- cytoplasm Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | 1 PublicationAdd BLAST | 25 | |
ChainiPRO_0000014391 | 26 – 226 | Insulin-like growth factor-binding protein 6Add BLAST | 201 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 33 | PROSITE-ProRule annotation | ||
Disulfide bondi | 49 ↔ 55 | PROSITE-ProRule annotation | ||
Disulfide bondi | 63 ↔ 76 | PROSITE-ProRule annotation | ||
Disulfide bondi | 70 ↔ 96 | PROSITE-ProRule annotation | ||
Disulfide bondi | 148 ↔ 176 | PROSITE-ProRule annotation | ||
Disulfide bondi | 187 ↔ 198 | PROSITE-ProRule annotation | ||
Disulfide bondi | 200 ↔ 220 | PROSITE-ProRule annotation |
Post-translational modificationi
O-glycosylated.
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P35572 |
PRIDEi | P35572 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000010977, Expressed in esophagus and 22 other tissues |
Genevisiblei | P35572, RN |
Interactioni
Subunit structurei
Interacts (via C-terminal domain) with PHB2.
By similarityGO - Molecular functioni
- fibronectin binding Source: GO_Central
- identical protein binding Source: RGD
- insulin-like growth factor I binding Source: RGD
- insulin-like growth factor II binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014807 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 99 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 74 | |
Domaini | 145 – 220 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 76 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QV3Q, Eukaryota |
GeneTreei | ENSGT00940000160528 |
HOGENOMi | CLU_070833_1_0_1 |
InParanoidi | P35572 |
OMAi | IAHCGSW |
OrthoDBi | 979270at2759 |
PhylomeDBi | P35572 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022326, IGFBP-6 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF14, PTHR11551:SF14, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01982, IGFBPFAMILY6 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35572-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTWDGLPTQP LLMLLMLLFA AGSESALAGC PGCGPGVQEE DAGSPADGCA
60 70 80 90 100
ETGGCFRREG QPCGVYIPKC APGLQCQPRE NEETPLRALL IGQGRCQRAR
110 120 130 140 150
GPSEETTKES KPHGGASRPR DRDRQKNPRT SAAPIRPSPV QDGEMGPCRR
160 170 180 190 200
HLDSVLQQLQ TEVFRGGANG LYVPNCDLRG FYRKQQCRSS QGNRRGPCWC
210 220
VDPMGQPLPV SPDGQGSSQC SARSSG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M69055 mRNA Translation: AAA42019.1 L11006 Genomic DNA No translation available. BC099742 mRNA Translation: AAH99742.1 |
PIRi | JN0464 |
RefSeqi | NP_037236.1, NM_013104.3 |
Genome annotation databases
Ensembli | ENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977 |
GeneIDi | 25641 |
KEGGi | rno:25641 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M69055 mRNA Translation: AAA42019.1 L11006 Genomic DNA No translation available. BC099742 mRNA Translation: AAH99742.1 |
PIRi | JN0464 |
RefSeqi | NP_037236.1, NM_013104.3 |
3D structure databases
SMRi | P35572 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000014807 |
Protein family/group databases
MEROPSi | I31.952 |
Proteomic databases
PaxDbi | P35572 |
PRIDEi | P35572 |
Genome annotation databases
Ensembli | ENSRNOT00000014807; ENSRNOP00000014807; ENSRNOG00000010977 |
GeneIDi | 25641 |
KEGGi | rno:25641 |
Organism-specific databases
CTDi | 3489 |
RGDi | 2877, Igfbp6 |
Phylogenomic databases
eggNOGi | ENOG502QV3Q, Eukaryota |
GeneTreei | ENSGT00940000160528 |
HOGENOMi | CLU_070833_1_0_1 |
InParanoidi | P35572 |
OMAi | IAHCGSW |
OrthoDBi | 979270at2759 |
PhylomeDBi | P35572 |
TreeFami | TF331211 |
Enzyme and pathway databases
Reactomei | R-RNO-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Miscellaneous databases
PROi | PR:P35572 |
Gene expression databases
Bgeei | ENSRNOG00000010977, Expressed in esophagus and 22 other tissues |
Genevisiblei | P35572, RN |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022326, IGFBP-6 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF14, PTHR11551:SF14, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01982, IGFBPFAMILY6 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP6_RAT | |
Accessioni | P35572Primary (citable) accession number: P35572 Secondary accession number(s): Q499W1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |