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Protein

Ubiquitin-like protein FUBI

Gene

FAU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This protein is synthesized with ribosomal S30 as its C-terminal extension.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like protein FUBI
Gene namesi
Name:FAU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149806.10
HGNCiHGNC:3597 FAU
MIMi134690 gene
neXtProtiNX_P35544

Pathology & Biotechi

Organism-specific databases

DisGeNETi2197
PharmGKBiPA28010

Polymorphism and mutation databases

BioMutaiZNHIT2
DMDMi549147

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001148821 – 74Ubiquitin-like protein FUBIAdd BLAST74

Proteomic databases

EPDiP35544
MaxQBiP35544
PaxDbiP35544
PeptideAtlasiP35544
PRIDEiP35544
ProteomicsDBi55079

Expressioni

Gene expression databases

BgeeiENSG00000149806 Expressed in 89 organ(s), highest expression level in ectocervix
CleanExiHS_FAU
ExpressionAtlasiP35544 baseline and differential
GenevisibleiP35544 HS

Interactioni

Protein-protein interaction databases

BioGridi108491, 75 interactors
IntActiP35544, 2 interactors
MINTiP35544
STRINGi9606.ENSP00000431822

Structurei

Secondary structure

174
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35544
SMRiP35544
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35544

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin family.Curated

Phylogenomic databases

eggNOGiKOG0001 Eukaryota
KOG0009 Eukaryota
ENOG41123KC LUCA
HOVERGENiHBG000057
InParanoidiP35544
KOiK02983
OrthoDBiEOG091G0X8P
PhylomeDBiP35544
TreeFamiTF313779

Family and domain databases

CDDicd01793 Fubi, 1 hit
InterProiView protein in InterPro
IPR039415 FUBI
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 1 hit
PS50053 UBIQUITIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

P35544-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLFVRAQEL HTFEVTGQET VAQIKAHVAS LEGIAPEDQV VLLAGAPLED
60 70
EATLGQCGVE ALTTLEVAGR MLGG
Length:74
Mass (Da):7,760
Last modified:June 1, 1994 - v1
Checksum:i396E67918520D387
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P62861RS30_HUMAN
40S ribosomal protein S30
FAU
59Annotation score:
E9PR30E9PR30_HUMAN
40S ribosomal protein S30
FAU
98Annotation score:
E9PM49E9PM49_HUMAN
40S ribosomal protein S30
FAU
108Annotation score:
J3KN89J3KN89_HUMAN
40S ribosomal protein S30
FAU
87Annotation score:
E9PMS9E9PMS9_HUMAN
40S ribosomal protein S30
FAU
75Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01964453T → I1 PublicationCorresponds to variant dbSNP:rs13807Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA Translation: CAA46714.1 Different termination.
X65923 mRNA Translation: CAA46716.1 Different termination.
AK026639 mRNA Translation: BAB15515.1 Different termination.
CR541974 mRNA Translation: CAG46772.1 Different termination.
AY398663 Genomic DNA Translation: AAQ87877.1 Different termination.
AP003068 Genomic DNA No translation available.
BC033877 mRNA Translation: AAH33877.1 Different termination.
PIRiJC1278
RefSeqiNP_001988.1, NM_001997.4
UniGeneiHs.387208

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806
ENST00000529639; ENSP00000435370; ENSG00000149806
ENST00000531743; ENSP00000431822; ENSG00000149806
GeneIDi2197
KEGGihsa:2197

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65921 Genomic DNA Translation: CAA46714.1 Different termination.
X65923 mRNA Translation: CAA46716.1 Different termination.
AK026639 mRNA Translation: BAB15515.1 Different termination.
CR541974 mRNA Translation: CAG46772.1 Different termination.
AY398663 Genomic DNA Translation: AAQ87877.1 Different termination.
AP003068 Genomic DNA No translation available.
BC033877 mRNA Translation: AAH33877.1 Different termination.
PIRiJC1278
RefSeqiNP_001988.1, NM_001997.4
UniGeneiHs.387208

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L7RNMR-A1-74[»]
ProteinModelPortaliP35544
SMRiP35544
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108491, 75 interactors
IntActiP35544, 2 interactors
MINTiP35544
STRINGi9606.ENSP00000431822

Polymorphism and mutation databases

BioMutaiZNHIT2
DMDMi549147

Proteomic databases

EPDiP35544
MaxQBiP35544
PaxDbiP35544
PeptideAtlasiP35544
PRIDEiP35544
ProteomicsDBi55079

Protocols and materials databases

DNASUi2197
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000527548; ENSP00000434440; ENSG00000149806
ENST00000529639; ENSP00000435370; ENSG00000149806
ENST00000531743; ENSP00000431822; ENSG00000149806
GeneIDi2197
KEGGihsa:2197

Organism-specific databases

CTDi2197
DisGeNETi2197
EuPathDBiHostDB:ENSG00000149806.10
GeneCardsiFAU
HGNCiHGNC:3597 FAU
MIMi134690 gene
neXtProtiNX_P35544
PharmGKBiPA28010
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0001 Eukaryota
KOG0009 Eukaryota
ENOG41123KC LUCA
HOVERGENiHBG000057
InParanoidiP35544
KOiK02983
OrthoDBiEOG091G0X8P
PhylomeDBiP35544
TreeFamiTF313779

Miscellaneous databases

ChiTaRSiFAU human
EvolutionaryTraceiP35544
GeneWikiiFAU_(gene)
GenomeRNAii2197
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000149806 Expressed in 89 organ(s), highest expression level in ectocervix
CleanExiHS_FAU
ExpressionAtlasiP35544 baseline and differential
GenevisibleiP35544 HS

Family and domain databases

CDDicd01793 Fubi, 1 hit
InterProiView protein in InterPro
IPR039415 FUBI
IPR019956 Ubiquitin
IPR029071 Ubiquitin-like_domsf
IPR019954 Ubiquitin_CS
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
PRINTSiPR00348 UBIQUITIN
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00299 UBIQUITIN_1, 1 hit
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBIM_HUMAN
AccessioniPrimary (citable) accession number: P35544
Secondary accession number(s): Q9H5V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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