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Protein

Serum amyloid A-4 protein

Gene

SAA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAcute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-4 protein
Alternative name(s):
Constitutively expressed serum amyloid A protein
Short name:
C-SAA
Gene namesi
Name:SAA4
Synonyms:CSAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000148965.9
HGNCiHGNC:10516 SAA4
MIMi104752 gene
neXtProtiNX_P35542

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6291
OpenTargetsiENSG00000148965
PharmGKBiPA34924

Polymorphism and mutation databases

BioMutaiSAA4
DMDMi296452894

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000003158319 – 130Serum amyloid A-4 proteinAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...) asparagine; partial3 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP35542
PeptideAtlasiP35542
PRIDEiP35542
ProteomicsDBi55078
TopDownProteomicsiP35542

PTM databases

iPTMnetiP35542
PhosphoSitePlusiP35542

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Constitutively expressed.

Gene expression databases

BgeeiENSG00000148965
CleanExiHS_SAA4
GenevisibleiP35542 HS

Organism-specific databases

HPAiCAB026061
HPA060139

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112199, 1 interactor
IntActiP35542, 2 interactors
STRINGi9606.ENSP00000278222

Structurei

3D structure databases

ProteinModelPortaliP35542
SMRiP35542
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JDSY Eukaryota
ENOG4111APX LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
HOVERGENiHBG016327
InParanoidiP35542
KOiK17310
OrthoDBiEOG091G17YH
PhylomeDBiP35542
TreeFamiTF332544

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35542-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS
60 70 80 90 100
NRYLYARGNY DAAQRGPGGV WAAKLISRSR VYLQGLIDCY LFGNSSTVLE
110 120 130
DSKSNEKAEE WGRSGKDPDR FRPDGLPKKY
Length:130
Mass (Da):14,747
Last modified:May 18, 2010 - v2
Checksum:i0F9BD50ACCF00B1C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05189389C → Y Polymorphism; confirmed at protein level. 7 PublicationsCorresponds to variant dbSNP:rs2460827Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05920 Genomic DNA No translation available.
M81349 mRNA Translation: AAA60298.1
S48983, S48980, S48981 Genomic DNA Translation: AAB24060.1
CR541758 mRNA Translation: CAG46558.1
AC090099 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68415.1
BC007026 mRNA Translation: AAH07026.1
CCDSiCCDS7832.1
PIRiA38974
RefSeqiNP_006503.2, NM_006512.3
UniGeneiHs.1955

Genome annotation databases

EnsembliENST00000278222; ENSP00000278222; ENSG00000148965
GeneIDi6291
KEGGihsa:6291
UCSCiuc001mny.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSAA4_HUMAN
AccessioniPrimary (citable) accession number: P35542
Secondary accession number(s): Q6FHJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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