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Entry version 147 (18 Sep 2019)
Sequence version 2 (18 May 2010)
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Protein

Serum amyloid A-4 protein

Gene

SAA4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAcute phase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serum amyloid A-4 protein
Alternative name(s):
Constitutively expressed serum amyloid A protein
Short name:
C-SAA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SAA4
Synonyms:CSAA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10516 SAA4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
104752 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35542

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

HDL, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6291

Open Targets

More...
OpenTargetsi
ENSG00000148965

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34924

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SAA4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452894

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Add BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003158319 – 130Serum amyloid A-4 proteinAdd BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagine; partial3 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P35542

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P35542

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35542

PeptideAtlas

More...
PeptideAtlasi
P35542

PRoteomics IDEntifications database

More...
PRIDEi
P35542

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55078

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P35542

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1739

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35542

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35542

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the liver; secreted in plasma.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Constitutively expressed.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000148965 Expressed in 67 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35542 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB026061
HPA060139

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112199, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P35542, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000278222

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35542

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JDSY Eukaryota
ENOG4111APX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004737

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000126881

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35542

KEGG Orthology (KO)

More...
KOi
K17310

Database of Orthologous Groups

More...
OrthoDBi
1417043at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35542

TreeFam database of animal gene trees

More...
TreeFami
TF332544

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000096 Serum_amyloid_A

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00277 SAA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002472 Serum_amyloid_A, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00306 SERUMAMYLOID

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00197 SAA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00992 SAA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P35542-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLFTGIVFC SLVMGVTSES WRSFFKEALQ GVGDMGRAYW DIMISNHQNS
60 70 80 90 100
NRYLYARGNY DAAQRGPGGV WAAKLISRSR VYLQGLIDCY LFGNSSTVLE
110 120 130
DSKSNEKAEE WGRSGKDPDR FRPDGLPKKY
Length:130
Mass (Da):14,747
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F9BD50ACCF00B1C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05189389C → Y Polymorphism; confirmed at protein level. 7 PublicationsCorresponds to variant dbSNP:rs2460827Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L05920 Genomic DNA No translation available.
M81349 mRNA Translation: AAA60298.1
S48983, S48980, S48981 Genomic DNA Translation: AAB24060.1
CR541758 mRNA Translation: CAG46558.1
AC090099 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68415.1
BC007026 mRNA Translation: AAH07026.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7832.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A38974

NCBI Reference Sequences

More...
RefSeqi
NP_006503.2, NM_006512.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000278222; ENSP00000278222; ENSG00000148965

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6291

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6291

UCSC genome browser

More...
UCSCi
uc001mny.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05920 Genomic DNA No translation available.
M81349 mRNA Translation: AAA60298.1
S48983, S48980, S48981 Genomic DNA Translation: AAB24060.1
CR541758 mRNA Translation: CAG46558.1
AC090099 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68415.1
BC007026 mRNA Translation: AAH07026.1
CCDSiCCDS7832.1
PIRiA38974
RefSeqiNP_006503.2, NM_006512.3

3D structure databases

SMRiP35542
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112199, 1 interactor
IntActiP35542, 2 interactors
STRINGi9606.ENSP00000278222

PTM databases

GlyConnecti1739
iPTMnetiP35542
PhosphoSitePlusiP35542

Polymorphism and mutation databases

BioMutaiSAA4
DMDMi296452894

Proteomic databases

jPOSTiP35542
MassIVEiP35542
PaxDbiP35542
PeptideAtlasiP35542
PRIDEiP35542
ProteomicsDBi55078
TopDownProteomicsiP35542

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000278222; ENSP00000278222; ENSG00000148965
GeneIDi6291
KEGGihsa:6291
UCSCiuc001mny.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6291
DisGeNETi6291

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SAA4
HGNCiHGNC:10516 SAA4
HPAiCAB026061
HPA060139
MIMi104752 gene
neXtProtiNX_P35542
OpenTargetsiENSG00000148965
PharmGKBiPA34924

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JDSY Eukaryota
ENOG4111APX LUCA
GeneTreeiENSGT00390000004737
HOGENOMiHOG000126881
InParanoidiP35542
KOiK17310
OrthoDBi1417043at2759
PhylomeDBiP35542
TreeFamiTF332544

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6291

Pharos

More...
Pharosi
P35542

Protein Ontology

More...
PROi
PR:P35542

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000148965 Expressed in 67 organ(s), highest expression level in liver
GenevisibleiP35542 HS

Family and domain databases

InterProiView protein in InterPro
IPR000096 Serum_amyloid_A
PfamiView protein in Pfam
PF00277 SAA, 1 hit
PIRSFiPIRSF002472 Serum_amyloid_A, 1 hit
PRINTSiPR00306 SERUMAMYLOID
SMARTiView protein in SMART
SM00197 SAA, 1 hit
PROSITEiView protein in PROSITE
PS00992 SAA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAA4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35542
Secondary accession number(s): Q6FHJ4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: May 18, 2010
Last modified: September 18, 2019
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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