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UniProtKB - P35527 (K1C9_HUMAN)

Entry version 203 (02 Dec 2020)
Sequence version 3 (16 Jun 2009)
Previous versions | rss
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Protein

Keratin, type I cytoskeletal 9

Gene

KRT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly.2 Publications

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Caution

Was originally thought to be a 60 kDa chain of placental scatter protein.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P35527

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 9
Alternative name(s):
Cytokeratin-9
Short name:
CK-9
Keratin-9
Short name:
K9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000171403.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:6447, KRT9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607606, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35527

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Keratoderma, palmoplantar, epidermolytic (EPPK)23 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA dermatological disorder characterized by diffuse thickening of the epidermis on the entire surface of palms and soles sharply bordered with erythematous margins. Some patients may present knuckle pads, thick pads of skin appearing over the proximal phalangeal joints.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071977157M → K in EPPK. 1 PublicationCorresponds to variant dbSNP:rs59510579EnsemblClinVar.1
Natural variantiVAR_036805157M → R in EPPK. 1 PublicationCorresponds to variant dbSNP:rs59510579EnsemblClinVar.1
Natural variantiVAR_010499157M → T in EPPK. 2 PublicationsCorresponds to variant dbSNP:rs59510579EnsemblClinVar.1
Natural variantiVAR_010500157M → V in EPPK. 3 PublicationsCorresponds to variant dbSNP:rs58597584EnsemblClinVar.1
Natural variantiVAR_035438160L → F in EPPK; with knuckle pads. 1 PublicationCorresponds to variant dbSNP:rs28940896EnsemblClinVar.1
Natural variantiVAR_010501160L → V in EPPK. 1 PublicationCorresponds to variant dbSNP:rs28940896EnsemblClinVar.1
Natural variantiVAR_036806161N → H in EPPK. 2 PublicationsCorresponds to variant dbSNP:rs59296273EnsemblClinVar.1
Natural variantiVAR_036807161N → I in EPPK. 2 PublicationsCorresponds to variant dbSNP:rs56707768EnsemblClinVar.1
Natural variantiVAR_003822161N → K in EPPK. 1 PublicationCorresponds to variant dbSNP:rs57536312EnsemblClinVar.1
Natural variantiVAR_010502161N → S in EPPK. 2 PublicationsCorresponds to variant dbSNP:rs56707768EnsemblClinVar.1
Natural variantiVAR_010503161N → Y in EPPK. 1 PublicationCorresponds to variant dbSNP:rs59296273EnsemblClinVar.1
Natural variantiVAR_036808163R → P in EPPK. 1 PublicationCorresponds to variant dbSNP:rs57758262EnsemblClinVar.1
Natural variantiVAR_003823163R → Q in EPPK. 6 PublicationsCorresponds to variant dbSNP:rs57758262EnsemblClinVar.1
Natural variantiVAR_003824163R → W in EPPK. 5 PublicationsCorresponds to variant dbSNP:rs59616921EnsemblClinVar.1
Natural variantiVAR_036809167Y → WL in EPPK. 1
Natural variantiVAR_003825168L → S in EPPK. 1 PublicationCorresponds to variant dbSNP:rs61157095EnsemblClinVar.1
Natural variantiVAR_035439171V → M in EPPK. 1 PublicationCorresponds to variant dbSNP:rs57019720EnsemblClinVar.1
Natural variantiVAR_010504172Q → P in EPPK. 1 PublicationCorresponds to variant dbSNP:rs59878153EnsemblClinVar.1
Natural variantiVAR_071978406C → R in EPPK. 1 PublicationCorresponds to variant dbSNP:rs77688767EnsemblClinVar.1
Natural variantiVAR_071979454Y → H in EPPK. 1 PublicationCorresponds to variant dbSNP:rs267607420EnsemblClinVar.1
Natural variantiVAR_036810458L → F in EPPK. 1 PublicationCorresponds to variant dbSNP:rs58120120EnsemblClinVar.1
Natural variantiVAR_071980458L → P in EPPK. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi163R → QHA: Leads to aggregate formation. 1 Publication1

Keywords - Diseasei

Disease mutation, Palmoplantar keratoderma

Organism-specific databases

DisGeNET

More...DisGeNETi		3857

MalaCards human disease database

More...MalaCardsi		KRT9
MIMi144200, phenotype
149100, phenotype

Open Targets

More...OpenTargetsi		ENSG00000171403

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		2199, Epidermolytic palmoplantar keratoderma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30235

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P35527, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB09130, Copper
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRT9

Domain mapping of disease mutations (DMDM)

More...DMDMi		239938886

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636401 – 623Keratin, type I cytoskeletal 9Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P35527

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P35527

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P35527

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35527

PeptideAtlas

More...PeptideAtlasi		P35527

PRoteomics IDEntifications database

More...PRIDEi		P35527

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		12645
55077

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P35527

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P35527

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1951, 12 N-Linked glycans (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P35527, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35527

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35527

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P35527

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the terminally differentiated epidermis of palms and soles.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by intrinsic regulatory mechanisms and by extrinsic signals from a subset of dermal palmoplantar fibroblasts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000171403, Expressed in mammalian vulva and 41 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35527, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35527, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000171403, Group enriched (lymphoid tissue, skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110055, 87 interactors

Protein interaction database and analysis system

More...IntActi		P35527, 38 interactors

Molecular INTeraction database

More...MINTi		P35527

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000246662

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35527, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35527

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini153 – 465IF rodPROSITE-ProRule annotationAdd BLAST313

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 152HeadAdd BLAST152
Regioni153 – 188Coil 1AAdd BLAST36
Regioni189 – 207Linker 1Add BLAST19
Regioni208 – 299Coil 1BAdd BLAST92
Regioni300 – 322Linker 12Add BLAST23
Regioni323 – 461Coil 2Add BLAST139
Regioni462 – 623TailAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 26Poly-GlyAdd BLAST12

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTM6, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162894

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012560_8_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35527

Identification of Orthologs from Complete Genome Data

More...OMAi		TNEKSAM

Database of Orthologous Groups

More...OrthoDBi		798081at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35527

TreeFam database of animal gene trees

More...TreeFami		TF332742

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.1160, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I

The PANTHER Classification System

More...PANTHERi		PTHR23239, PTHR23239, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00038, Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01248, TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01391, Filament, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35527-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCRQFSSSY LSRSGGGGGG GLGSGGSIRS SYSRFSSSGG GGGGGRFSSS 
        60         70         80         90        100
SGYGGGSSRV CGRGGGGSFG YSYGGGSGGG FSASSLGGGF GGGSRGFGGA 
       110        120        130        140        150
SGGGYSSSGG FGGGFGGGSG GGFGGGYGSG FGGFGGFGGG AGGGDGGILT 
       160        170        180        190        200
ANEKSTMQEL NSRLASYLDK VQALEEANND LENKIQDWYD KKGPAAIQKN 
       210        220        230        240        250
YSPYYNTIDD LKDQIVDLTV GNNKTLLDID NTRMTLDDFR IKFEMEQNLR 
       260        270        280        290        300
QGVDADINGL RQVLDNLTME KSDLEMQYET LQEELMALKK NHKEEMSQLT 
       310        320        330        340        350
GQNSGDVNVE INVAPGKDLT KTLNDMRQEY EQLIAKNRKD IENQYETQIT 
       360        370        380        390        400
QIEHEVSSSG QEVQSSAKEV TQLRHGVQEL EIELQSQLSK KAALEKSLED 
       410        420        430        440        450
TKNRYCGQLQ MIQEQISNLE AQITDVRQEI ECQNQEYSLL LSIKMRLEKE 
       460        470        480        490        500
IETYHNLLEG GQEDFESSGA GKIGLGGRGG SGGSYGRGSR GGSGGSYGGG 
       510        520        530        540        550
GSGGGYGGGS GSRGGSGGSY GGGSGSGGGS GGGYGGGSGG GHSGGSGGGH 
       560        570        580        590        600
SGGSGGNYGG GSGSGGGSGG GYGGGSGSRG GSGGSHGGGS GFGGESGGSY 
       610        620 
GGGEEASGSG GGYGGGSGKS SHS
Length:623
Mass (Da):62,064
Last modified:June 16, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45C833749B63873D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQQ3K7EQQ3_HUMAN
Keratin, type I cytoskeletal 9
KRT9
390Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12 – 13SR → T in AAC60619 (PubMed:7507869).Curated2
Sequence conflicti12 – 13SR → T in CAA52924 (PubMed:7512862).Curated2
Sequence conflicti41G → R in AAC60619 (PubMed:7507869).Curated1
Sequence conflicti41G → R in CAA82315 (PubMed:7507869).Curated1
Sequence conflicti41G → R in CAA52924 (PubMed:7512862).Curated1
Sequence conflicti134F → L in AAC60619 (PubMed:7507869).Curated1
Sequence conflicti134F → L in CAA82315 (PubMed:7507869).Curated1
Sequence conflicti134F → L in CAA52924 (PubMed:7512862).Curated1
Sequence conflicti157 – 170MQELN…SYLDK → HLGAGSTPITASQP in AAI21171 (PubMed:15489334).CuratedAdd BLAST14

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071977157M → K in EPPK. 1 PublicationCorresponds to variant dbSNP:rs59510579EnsemblClinVar.1
Natural variantiVAR_036805157M → R in EPPK. 1 PublicationCorresponds to variant dbSNP:rs59510579EnsemblClinVar.1
Natural variantiVAR_010499157M → T in EPPK. 2 PublicationsCorresponds to variant dbSNP:rs59510579EnsemblClinVar.1
Natural variantiVAR_010500157M → V in EPPK. 3 PublicationsCorresponds to variant dbSNP:rs58597584EnsemblClinVar.1
Natural variantiVAR_035438160L → F in EPPK; with knuckle pads. 1 PublicationCorresponds to variant dbSNP:rs28940896EnsemblClinVar.1
Natural variantiVAR_010501160L → V in EPPK. 1 PublicationCorresponds to variant dbSNP:rs28940896EnsemblClinVar.1
Natural variantiVAR_036806161N → H in EPPK. 2 PublicationsCorresponds to variant dbSNP:rs59296273EnsemblClinVar.1
Natural variantiVAR_036807161N → I in EPPK. 2 PublicationsCorresponds to variant dbSNP:rs56707768EnsemblClinVar.1
Natural variantiVAR_003822161N → K in EPPK. 1 PublicationCorresponds to variant dbSNP:rs57536312EnsemblClinVar.1
Natural variantiVAR_010502161N → S in EPPK. 2 PublicationsCorresponds to variant dbSNP:rs56707768EnsemblClinVar.1
Natural variantiVAR_010503161N → Y in EPPK. 1 PublicationCorresponds to variant dbSNP:rs59296273EnsemblClinVar.1
Natural variantiVAR_036808163R → P in EPPK. 1 PublicationCorresponds to variant dbSNP:rs57758262EnsemblClinVar.1
Natural variantiVAR_003823163R → Q in EPPK. 6 PublicationsCorresponds to variant dbSNP:rs57758262EnsemblClinVar.1
Natural variantiVAR_003824163R → W in EPPK. 5 PublicationsCorresponds to variant dbSNP:rs59616921EnsemblClinVar.1
Natural variantiVAR_036809167Y → WL in EPPK. 1
Natural variantiVAR_003825168L → S in EPPK. 1 PublicationCorresponds to variant dbSNP:rs61157095EnsemblClinVar.1
Natural variantiVAR_035439171V → M in EPPK. 1 PublicationCorresponds to variant dbSNP:rs57019720EnsemblClinVar.1
Natural variantiVAR_010504172Q → P in EPPK. 1 PublicationCorresponds to variant dbSNP:rs59878153EnsemblClinVar.1
Natural variantiVAR_071978406C → R in EPPK. 1 PublicationCorresponds to variant dbSNP:rs77688767EnsemblClinVar.1
Natural variantiVAR_071979454Y → H in EPPK. 1 PublicationCorresponds to variant dbSNP:rs267607420EnsemblClinVar.1
Natural variantiVAR_036810458L → F in EPPK. 1 PublicationCorresponds to variant dbSNP:rs58120120EnsemblClinVar.1
Natural variantiVAR_071980458L → P in EPPK. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z29074 mRNA Translation: CAA82315.1
S69510 mRNA Translation: AAC60619.1
X75015 Genomic DNA Translation: CAA52924.1
AC019349 Genomic DNA No translation available.
AB001594 mRNA Translation: BAA19418.1
BC121170 mRNA Translation: AAI21171.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32654.1

Protein sequence database of the Protein Information Resource

More...PIRi		I37984

NCBI Reference Sequences

More...RefSeqi		NP_000217.2, NM_000226.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000246662; ENSP00000246662; ENSG00000171403

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3857

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3857

UCSC genome browser

More...UCSCi		uc002hxe.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29074 mRNA Translation: CAA82315.1
S69510 mRNA Translation: AAC60619.1
X75015 Genomic DNA Translation: CAA52924.1
AC019349 Genomic DNA No translation available.
AB001594 mRNA Translation: BAA19418.1
BC121170 mRNA Translation: AAI21171.1
CCDSiCCDS32654.1
PIRiI37984
RefSeqiNP_000217.2, NM_000226.3

3D structure databases

SMRiP35527
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110055, 87 interactors
IntActiP35527, 38 interactors
MINTiP35527
STRINGi9606.ENSP00000246662

Chemistry databases

DrugBankiDB09130, Copper
DB01593, Zinc
DB14487, Zinc acetate
DB14533, Zinc chloride
DB14548, Zinc sulfate, unspecified form

PTM databases

GlyConnecti1951, 12 N-Linked glycans (2 sites)
GlyGeniP35527, 2 sites
iPTMnetiP35527
PhosphoSitePlusiP35527
SwissPalmiP35527

Polymorphism and mutation databases

BioMutaiKRT9
DMDMi239938886

2D gel databases

DOSAC-COBS-2DPAGEiP35527

Proteomic databases

EPDiP35527
jPOSTiP35527
MassIVEiP35527
PaxDbiP35527
PeptideAtlasiP35527
PRIDEiP35527
ProteomicsDBi12645
55077
TopDownProteomicsiP35527

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1544, 197 antibodies

The DNASU plasmid repository

More...DNASUi		3857

Genome annotation databases

EnsembliENST00000246662; ENSP00000246662; ENSG00000171403
GeneIDi3857
KEGGihsa:3857
UCSCiuc002hxe.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3857
DisGeNETi3857
EuPathDBiHostDB:ENSG00000171403.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRT9
HGNCiHGNC:6447, KRT9
HPAiENSG00000171403, Group enriched (lymphoid tissue, skin)
MalaCardsiKRT9
MIMi144200, phenotype
149100, phenotype
607606, gene
neXtProtiNX_P35527
OpenTargetsiENSG00000171403
Orphaneti2199, Epidermolytic palmoplantar keratoderma
PharmGKBiPA30235

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QTM6, Eukaryota
GeneTreeiENSGT00940000162894
HOGENOMiCLU_012560_8_3_1
InParanoidiP35527
OMAiTNEKSAM
OrthoDBi798081at2759
PhylomeDBiP35527
TreeFamiTF332742

Enzyme and pathway databases

PathwayCommonsiP35527
ReactomeiR-HSA-6805567, Keratinization
R-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3857, 4 hits in 841 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Keratin_9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3857
PharosiP35527, Tbio

Protein Ontology

More...PROi		PR:P35527
RNActiP35527, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000171403, Expressed in mammalian vulva and 41 other tissues
ExpressionAtlasiP35527, baseline and differential
GenevisibleiP35527, HS

Family and domain databases

Gene3Di1.20.5.1160, 1 hit
InterProiView protein in InterPro
IPR018039, IF_conserved
IPR039008, IF_rod_dom
IPR042180, IF_rod_dom_coil1B
IPR002957, Keratin_I
PANTHERiPTHR23239, PTHR23239, 2 hits
PfamiView protein in Pfam
PF00038, Filament, 1 hit
PRINTSiPR01248, TYPE1KERATIN
SMARTiView protein in SMART
SM01391, Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226, IF_ROD_1, 1 hit
PS51842, IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35527
Secondary accession number(s): O00109, Q0IJ47, Q14665
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 16, 2009
Last modified: December 2, 2020
This is version 203 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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