Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Modification methylase LlaI

Gene

llaIM

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methylation of specific adenine residues; required for both restriction and modification activities. May recognize a non-palindromic sequence.

Catalytic activityi

S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N-6-methyladenine in DNA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3437 M.LlaI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase LlaI (EC:2.1.1.72)
Short name:
M.LlaI
Alternative name(s):
Adenine-specific methyltransferase LlaI
Gene namesi
Name:llaIM
Encoded oniPlasmid pTR20300 Publication
OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
Taxonomic identifieri1360 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000879611 – 622Modification methylase LlaIAdd BLAST622

Structurei

3D structure databases

ProteinModelPortaliP35516
SMRiP35516
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the N(4)/N(6)-methyltransferase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.1020.10, 1 hit
InterProiView protein in InterPro
IPR012186 Ade-mod_methylase_MStsI
IPR023095 Ade_MeTrfase_dom_2
IPR002052 DNA_methylase_N6_adenine_CS
IPR012327 MeTrfase_D12
IPR029063 SAM-dependent_MTases
PANTHERiPTHR30481 PTHR30481, 1 hit
PfamiView protein in Pfam
PF02086 MethyltransfD12, 2 hits
PIRSFiPIRSF036638 M_m6A_StsI, 1 hit
PRINTSiPR00505 D12N6MTFRASE
SUPFAMiSSF53335 SSF53335, 3 hits
TIGRFAMsiTIGR00571 dam, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

P35516-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRYLGNKTNL LNFIQQVIKK HDIQGQTFAD LFAGTGSVGD YFKGEYTVLS
60 70 80 90 100
NDYMYFSKVI SEAKLLNSEK PKFDSFVKRY GKTPFQWLNE REYTPNDGYF
110 120 130 140 150
VYNNYTPRAE RMYLTEENAL KIDGMRLDIE ELFQEGVISK AEYSYLLASL
160 170 180 190 200
LESVTKVSNT SGTYQAFFKF WESRALKKFT IMPLEMKDSL SVSKDNRCFN
210 220 230 240 250
KNTNRLVREI SGDIAYIDPP YTITQYTNSY HVLETIARYD NPELFGKTGR
260 270 280 290 300
RVKREFSGYS NKSKAYYEFE DLFRQINFTH VLVSYSNQSI VPLDELVDLA
310 320 330 340 350
RRFAVDGIVE VETNEYREYS TNNSSMKGEG KKLQEVIIYF KKNLETNKSP
360 370 380 390 400
LNYAGSKDDV IPRIFKLLPK HVTTFVDAMG GAFNVGANRT ALNKVVYNEY
410 420 430 440 450
HPFVFEMMQM IVNTPADELI RNVEQIVTRY SLEKKGKEAF NRLRDHYNNE
460 470 480 490 500
EQTPINLYTL NIYSFQNILR FNQAKKYNTP IGNNEFNEGY KDRITRFVTR
510 520 530 540 550
APEVEMRLGS YSAINFNEYD DDTVFYFDPP YLVTTAGYND GKRGFDGWDA
560 570 580 590 600
EQEASLLKYL TELDSAGKKF MLSNVLEHKG KTNHLLMEWI QHHGFNVNTI
610 620
GETGIKYPRR EILVTNYNTF ER
Length:622
Mass (Da):72,513
Last modified:June 1, 1994 - v1
Checksum:i69A817F46BE9C772
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17233 Genomic DNA Translation: AAA65073.1
PIRiS35122

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17233 Genomic DNA Translation: AAA65073.1
PIRiS35122

3D structure databases

ProteinModelPortaliP35516
SMRiP35516
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

REBASEi3437 M.LlaI

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.1020.10, 1 hit
InterProiView protein in InterPro
IPR012186 Ade-mod_methylase_MStsI
IPR023095 Ade_MeTrfase_dom_2
IPR002052 DNA_methylase_N6_adenine_CS
IPR012327 MeTrfase_D12
IPR029063 SAM-dependent_MTases
PANTHERiPTHR30481 PTHR30481, 1 hit
PfamiView protein in Pfam
PF02086 MethyltransfD12, 2 hits
PIRSFiPIRSF036638 M_m6A_StsI, 1 hit
PRINTSiPR00505 D12N6MTFRASE
SUPFAMiSSF53335 SSF53335, 3 hits
TIGRFAMsiTIGR00571 dam, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTL1_LACLL
AccessioniPrimary (citable) accession number: P35516
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 18, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again