UniProtKB - P35504 (UD15_HUMAN)
UDP-glucuronosyltransferase 1A5
UGT1A5
Functioni
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18674515).
Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18674515).
Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515).
1 PublicationLacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
1 PublicationMiscellaneous
Catalytic activityi
- EC:2.4.1.171 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
GO - Molecular functioni
- glucuronosyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- flavonoid glucuronidation Source: GO_Central
- xenobiotic glucuronidation Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BRENDAi | 2.4.1.17, 2681 |
PathwayCommonsi | P35504 |
Reactomei | R-HSA-156588, Glucuronidation |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-glucuronosyltransferase 1A51 Publication (EC:2.4.1.171 Publication)Short name: UGT1A5 Alternative name(s): UDP-glucuronosyltransferase 1-5 Short name: UDPGT 1-5 Short name: UGT1*5 Short name: UGT1-05 Short name: UGT1.5 UDP-glucuronosyltransferase 1-E Short name: UGT-1E Short name: UGT1E |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12537, UGT1A5 |
MIMi | 191740, gene 606430, gene |
neXtProti | NX_P35504 |
VEuPathDBi | HostDB:ENSG00000240224 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 492 – 508 | HelicalSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54579 |
MalaCardsi | UGT1A5 |
PharmGKBi | PA37180 |
Miscellaneous databases
Pharosi | P35504, Tdark |
Chemistry databases
ChEMBLi | CHEMBL4523985 |
DrugCentrali | P35504 |
Genetic variation databases
BioMutai | UGT1A5 |
DMDMi | 549153 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000036004 | 29 – 534 | UDP-glucuronosyltransferase 1A5Add BLAST | 506 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 296 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 348 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P35504 |
MassIVEi | P35504 |
PaxDbi | P35504 |
PeptideAtlasi | P35504 |
PRIDEi | P35504 |
ProteomicsDBi | 55073 [P35504-1] |
PTM databases
GlyConnecti | 1877, 2 N-Linked glycans (1 site) |
GlyGeni | P35504, 3 sites, 2 N-linked glycans (1 site) |
iPTMneti | P35504 |
PhosphoSitePlusi | P35504 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000240224, Expressed in intestine and 26 other tissues |
ExpressionAtlasi | P35504, baseline and differential |
Genevisiblei | P35504, HS |
Organism-specific databases
HPAi | ENSG00000240224, Tissue enhanced (gallbladder, intestine, liver) |
Interactioni
Subunit structurei
Homodimer (By similarity). Homooligomer (By similarity).
Interacts with UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (By similarity).
Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 120057, 19 interactors |
STRINGi | 9606.ENSP00000362513 |
Miscellaneous databases
RNActi | P35504, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1192, Eukaryota |
GeneTreei | ENSGT00940000162976 |
HOGENOMi | CLU_012949_1_3_1 |
InParanoidi | P35504 |
OMAi | YMADACP |
PhylomeDBi | P35504 |
TreeFami | TF315472 |
Family and domain databases
CDDi | cd03784, GT1_Gtf-like, 1 hit |
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATGLQVPLP QLATGLLLLL SVQPWAESGK VLVVPTDGSH WLSMREALRD
60 70 80 90 100
LHARGHQVVV LTLEVNMYIK EENFFTLTTY AISWTQDEFD RLLLGHTQSF
110 120 130 140 150
FETEHLLMKF SRRMAIMNNM SLIIHRSCVE LLHNEALIRH LHATSFDVVL
160 170 180 190 200
TDPFHLCAAV LAKYLSIPAV FFLRNIPCDL DFKGTQCPNP SSYIPRLLTT
210 220 230 240 250
NSDHMTFLQR VKNMLYPLAL SYLCHAVSAP YASLASELFQ REVSVVDLVS
260 270 280 290 300
HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANGKPLSQE FEAYINASGE
310 320 330 340 350
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT
360 370 380 390 400
ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD
410 420 430 440 450
NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD
460 470 480 490 500
RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV
510 520 530
LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052455 | 48 | L → S. Corresponds to variant dbSNP:rs3755323Ensembl. | 1 | |
Natural variantiVAR_059845 | 50 | D → E. Corresponds to variant dbSNP:rs3755322Ensembl. | 1 | |
Natural variantiVAR_052456 | 63 | L → P. Corresponds to variant dbSNP:rs3755321Ensembl. | 1 | |
Natural variantiVAR_059846 | 142 | H → N. Corresponds to variant dbSNP:rs3755320Ensembl. | 1 | |
Natural variantiVAR_052457 | 144 | T → S. Corresponds to variant dbSNP:rs28946885Ensembl. | 1 | |
Natural variantiVAR_052458 | 158 | A → G. Corresponds to variant dbSNP:rs12475068Ensembl. | 1 | |
Natural variantiVAR_052459 | 225 | H → Y. Corresponds to variant dbSNP:rs17862867Ensembl. | 1 | |
Natural variantiVAR_052460 | 249 | V → L. Corresponds to variant dbSNP:rs17862868EnsemblClinVar. | 1 | |
Natural variantiVAR_052461 | 259 | G → R. Corresponds to variant dbSNP:rs3892170Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053961 | 436 – 534 | SYKEN…KSKTH → RKKQQSGRQM in isoform 2. 1 PublicationAdd BLAST | 99 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84129 Genomic DNA Translation: AAA61250.1 M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems. AF297093 Genomic DNA Translation: AAG30421.1 AC006985 Genomic DNA No translation available. AC114812 Genomic DNA No translation available. DQ383514 mRNA Translation: ABD42927.1 |
CCDSi | CCDS33404.1 [P35504-1] |
PIRi | B42586 |
RefSeqi | NP_061951.1, NM_019078.1 [P35504-1] |
Genome annotation databases
Ensembli | ENST00000373414.4; ENSP00000362513.3; ENSG00000288705.1 |
GeneIDi | 54579 |
KEGGi | hsa:54579 |
MANE-Selecti | ENST00000373414.4; ENSP00000362513.3; NM_019078.2; NP_061951.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84129 Genomic DNA Translation: AAA61250.1 M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems. AF297093 Genomic DNA Translation: AAG30421.1 AC006985 Genomic DNA No translation available. AC114812 Genomic DNA No translation available. DQ383514 mRNA Translation: ABD42927.1 |
CCDSi | CCDS33404.1 [P35504-1] |
PIRi | B42586 |
RefSeqi | NP_061951.1, NM_019078.1 [P35504-1] |
3D structure databases
AlphaFoldDBi | P35504 |
SMRi | P35504 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120057, 19 interactors |
STRINGi | 9606.ENSP00000362513 |
Chemistry databases
ChEMBLi | CHEMBL4523985 |
DrugCentrali | P35504 |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
PTM databases
GlyConnecti | 1877, 2 N-Linked glycans (1 site) |
GlyGeni | P35504, 3 sites, 2 N-linked glycans (1 site) |
iPTMneti | P35504 |
PhosphoSitePlusi | P35504 |
Genetic variation databases
BioMutai | UGT1A5 |
DMDMi | 549153 |
Proteomic databases
jPOSTi | P35504 |
MassIVEi | P35504 |
PaxDbi | P35504 |
PeptideAtlasi | P35504 |
PRIDEi | P35504 |
ProteomicsDBi | 55073 [P35504-1] |
Protocols and materials databases
Antibodypediai | 47694, 27 antibodies from 13 providers |
DNASUi | 54579 |
Genome annotation databases
Ensembli | ENST00000373414.4; ENSP00000362513.3; ENSG00000288705.1 |
GeneIDi | 54579 |
KEGGi | hsa:54579 |
MANE-Selecti | ENST00000373414.4; ENSP00000362513.3; NM_019078.2; NP_061951.1 |
Organism-specific databases
CTDi | 54579 |
DisGeNETi | 54579 |
GeneCardsi | UGT1A5 |
HGNCi | HGNC:12537, UGT1A5 |
HPAi | ENSG00000240224, Tissue enhanced (gallbladder, intestine, liver) |
MalaCardsi | UGT1A5 |
MIMi | 191740, gene 606430, gene |
neXtProti | NX_P35504 |
PharmGKBi | PA37180 |
VEuPathDBi | HostDB:ENSG00000240224 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1192, Eukaryota |
GeneTreei | ENSGT00940000162976 |
HOGENOMi | CLU_012949_1_3_1 |
InParanoidi | P35504 |
OMAi | YMADACP |
PhylomeDBi | P35504 |
TreeFami | TF315472 |
Enzyme and pathway databases
BRENDAi | 2.4.1.17, 2681 |
PathwayCommonsi | P35504 |
Reactomei | R-HSA-156588, Glucuronidation |
Miscellaneous databases
BioGRID-ORCSi | 54579, 57 hits in 908 CRISPR screens |
GeneWikii | UGT1A5 |
GenomeRNAii | 54579 |
Pharosi | P35504, Tdark |
PROi | PR:P35504 |
RNActi | P35504, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000240224, Expressed in intestine and 26 other tissues |
ExpressionAtlasi | P35504, baseline and differential |
Genevisiblei | P35504, HS |
Family and domain databases
CDDi | cd03784, GT1_Gtf-like, 1 hit |
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UD15_HUMAN | |
Accessioni | P35504Primary (citable) accession number: P35504 Secondary accession number(s): B8K294 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 179 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families