UniProtKB - P35503 (UD13_HUMAN)
UDP-glucuronosyltransferase 1A3
UGT1A3
Functioni
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23756265, PubMed:23288867, PubMed:24641623).
Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265).
Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867).
Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265).
Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623).
Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515).
6 PublicationsLacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.
2 PublicationsMiscellaneous
Catalytic activityi
- EC:2.4.1.176 PublicationsThis reaction proceeds in the forward5 Publications direction.
- This reaction proceeds in the forward3 Publications direction.
- This reaction proceeds in the forward3 Publications direction.
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the forward1 Publication direction.
- chenodeoxycholate + UDP-α-D-glucuronate = chenodeoxycholoyl-24-O-(β-D-glucuronate) + UDP1 PublicationThis reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
Kineticsi
- KM=47 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3)1 Publication
- KM=35 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17)1 Publication
- KM=77 µM for estrone (when assaying glucuronidation at position 3)1 Publication
- KM=479 µM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3)1 Publication
- KM=32 µM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 2)1 Publication
- KM=587 µM for 2-hydroxy-estrone (when assaying glucuronidation at position 3)1 Publication
- KM=222 µM for 2-hydroxy-estrone (when assaying glucuronidation at position 2)1 Publication
- KM=49 µM for 2-methoxy-17beta-estradiol (when assaying glucuronidation at position 3)1 Publication
- KM=250 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3)1 Publication
- KM=66.7 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17)1 Publication
- KM=34.2 µM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 3)1 Publication
- KM=3.95 µM for calcidiol (when assaying glucuronidation at position 25)1 Publication
- KM=5.9 µM for calcidiol (when assaying glucuronidation at position 3)1 Publication
- KM=9.35 µM for 5,6-trans-calcidiol (when assaying glucuronidation at position 25)1 Publication
- KM=35.9 µM for losartan (when assaying glucuronidation at position N2 of the tetrazole ring)1 Publication
- Vmax=39 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
- Vmax=13 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
- Vmax=50 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate)1 Publication
- Vmax=1342 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
- Vmax=39 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronate)1 Publication
- Vmax=41 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 3-O-(beta-D-glucuronate)1 Publication
- Vmax=28 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 2-O-(beta-D-glucuronate)1 Publication
- Vmax=154 pmol/min/mg enzyme for the formation of 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
- Vmax=653 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
- Vmax=86.1 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
- Vmax=683 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate)1 Publication
- Vmax=26 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication
- Vmax=1.74 pmol/min/mg enzyme for the formation of calcidiol 25-O-(beta-D-glucuronate)1 Publication
- Vmax=0.56 pmol/min/mg enzyme for the formation of calcidiol 3-O-(beta-D-glucuronate)1 Publication
- Vmax=0.22 pmol/min/mg enzyme for the formation of 5,6-trans-calcidiol 25-O-(beta-D-glucuronate)1 Publication
- Vmax=225.7 pmol/min/mg enzyme for the formation of losartan N2-(beta-D-glucuronate)1 Publication
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- glucuronosyltransferase activity Source: UniProtKB
- protein heterodimerization activity Source: BHF-UCL
- protein homodimerization activity Source: UniProtKB
- retinoic acid binding Source: BHF-UCL
GO - Biological processi
- bile acid secretion Source: UniProtKB
- cellular glucuronidation Source: UniProtKB
- estrogen metabolic process Source: UniProtKB
- flavonoid glucuronidation Source: BHF-UCL
- negative regulation of cellular glucuronidation Source: BHF-UCL
- negative regulation of fatty acid metabolic process Source: BHF-UCL
- negative regulation of glucuronosyltransferase activity Source: BHF-UCL
- retinoic acid metabolic process Source: BHF-UCL
- vitamin D3 metabolic process Source: UniProtKB
- xenobiotic glucuronidation Source: BHF-UCL
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 2.4.1.17, 2681 |
PathwayCommonsi | P35503 |
Reactomei | R-HSA-156588, Glucuronidation R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
SABIO-RKi | P35503 |
SignaLinki | P35503 |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
Chemistry databases
SwissLipidsi | SLP:000001698 |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-glucuronosyltransferase 1A32 Publications (EC:2.4.1.176 Publications)Short name: UGT1A3 Alternative name(s): UDP-glucuronosyltransferase 1-3 Short name: UDPGT 1-3 Short name: UGT1*3 Short name: UGT1-03 Short name: UGT1.3 UDP-glucuronosyltransferase 1-C Short name: UGT-1C Short name: UGT1C UDP-glucuronosyltransferase 1A isoform 3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12535, UGT1A3 |
MIMi | 191740, gene 606428, gene |
neXtProti | NX_P35503 |
VEuPathDBi | HostDB:ENSG00000243135 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 492 – 508 | HelicalSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 54659 |
MalaCardsi | UGT1A3 |
PharmGKBi | PA37178 |
Miscellaneous databases
Pharosi | P35503, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3542435 |
DrugBanki | DB06403, Ambrisentan DB01217, Anastrozole DB00714, Apomorphine DB01076, Atorvastatin DB13997, Baloxavir marboxil DB13919, Candesartan DB00796, Candesartan cilexetil DB14635, Curcumin sulfate DB00434, Cyproheptadine DB01609, Deferasirox DB11943, Delafloxacin DB09213, Dexibuprofen DB00586, Diclofenac DB08930, Dolutegravir DB05928, Dovitinib DB06210, Eltrombopag DB09038, Empagliflozin DB13874, Enasidenib DB00783, Estradiol DB00977, Ethinylestradiol DB00749, Etodolac DB00973, Ezetimibe DB04953, Ezogabine DB04854, Febuxostat DB01544, Flunitrazepam DB00712, Flurbiprofen DB01095, Fluvastatin DB11796, Fostemsavir DB06741, Gavestinel DB01241, Gemfibrozil DB00327, Hydromorphone DB12471, Ibrexafungerp DB01050, Ibuprofen DB01029, Irbesartan DB00920, Ketotifen DB00555, Lamotrigine DB12070, Letermovir DB04725, Licofelone DB00455, Loratadine DB12130, Lorlatinib DB00678, Losartan DB00227, Lovastatin DB08893, Mirabegron DB01252, Mitiglinide DB00295, Morphine DB06510, Muraglitazar DB11691, Naldemedine DB06230, Nalmefene DB08804, Nandrolone decanoate DB00788, Naproxen DB00960, Pindolol DB08860, Pitavastatin DB00794, Primidone DB00503, Ritonavir DB11689, Selumetinib DB00641, Simvastatin DB00966, Telmisartan DB00871, Terbutaline DB00197, Troglitazone DB00313, Valproic acid |
Genetic variation databases
BioMutai | UGT1A3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Sequence analysisAdd BLAST | 28 | |
ChainiPRO_0000036002 | 29 – 534 | UDP-glucuronosyltransferase 1A3Add BLAST | 506 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 142 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 296 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 348 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P35503 |
MassIVEi | P35503 |
PaxDbi | P35503 |
PeptideAtlasi | P35503 |
PRIDEi | P35503 |
ProteomicsDBi | 55072 [P35503-1] |
PTM databases
GlyConnecti | 1875, 2 N-Linked glycans (1 site) |
GlyGeni | P35503, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | P35503 |
PhosphoSitePlusi | P35503 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000243135, Expressed in intestine and 34 other tissues |
ExpressionAtlasi | P35503, baseline and differential |
Genevisiblei | P35503, HS |
Organism-specific databases
HPAi | ENSG00000243135, Tissue enriched (liver) |
Interactioni
Subunit structurei
Homodimer (PubMed:17179145). Homooligomer (Probable).
Interacts with UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145).
Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).
1 Publication2 PublicationsGO - Molecular functioni
- enzyme binding Source: BHF-UCL
- protein heterodimerization activity Source: BHF-UCL
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120088, 3 interactors |
IntActi | P35503, 7 interactors |
STRINGi | 9606.ENSP00000418532 |
Chemistry databases
BindingDBi | P35503 |
Miscellaneous databases
RNActi | P35503, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1192, Eukaryota |
GeneTreei | ENSGT00940000162976 |
HOGENOMi | CLU_012949_1_3_1 |
InParanoidi | P35503 |
OMAi | KYFCHIS |
PhylomeDBi | P35503 |
TreeFami | TF315472 |
Family and domain databases
CDDi | cd03784, GT1_Gtf-like, 1 hit |
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATGLQVPLP WLATGLLLLL SVQPWAESGK VLVVPIDGSH WLSMREVLRE
60 70 80 90 100
LHARGHQAVV LTPEVNMHIK EENFFTLTTY AISWTQDEFD RHVLGHTQLY
110 120 130 140 150
FETEHFLKKF FRSMAMLNNM SLVYHRSCVE LLHNEALIRH LNATSFDVVL
160 170 180 190 200
TDPVNLCAAV LAKYLSIPTV FFLRNIPCDL DFKGTQCPNP SSYIPRLLTT
210 220 230 240 250
NSDHMTFMQR VKNMLYPLAL SYICHAFSAP YASLASELFQ REVSVVDILS
260 270 280 290 300
HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANRKPLSQE FEAYINASGE
310 320 330 340 350
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT
360 370 380 390 400
ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD
410 420 430 440 450
NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD
460 470 480 490 500
RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV
510 520 530
LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052445 | 6 | Q → R. Corresponds to variant dbSNP:rs28898617Ensembl. | 1 | |
Natural variantiVAR_052446 | 11 | W → R1 PublicationCorresponds to variant dbSNP:rs3821242Ensembl. | 1 | |
Natural variantiVAR_052447 | 45 | R → W. Corresponds to variant dbSNP:rs45625338Ensembl. | 1 | |
Natural variantiVAR_052448 | 47 | V → A1 PublicationCorresponds to variant dbSNP:rs6431625Ensembl. | 1 | |
Natural variantiVAR_052449 | 49 | R → W. Corresponds to variant dbSNP:rs45595237Ensembl. | 1 | |
Natural variantiVAR_052450 | 78 | T → I. Corresponds to variant dbSNP:rs28898618Ensembl. | 1 | |
Natural variantiVAR_052451 | 114 | M → I. Corresponds to variant dbSNP:rs28898619Ensembl. | 1 | |
Natural variantiVAR_052452 | 144 | T → I. Corresponds to variant dbSNP:rs13406898Ensembl. | 1 | |
Natural variantiVAR_058583 | 158 | A → V1 PublicationCorresponds to variant dbSNP:rs61764030EnsemblClinVar. | 1 | |
Natural variantiVAR_052453 | 270 | M → V1 PublicationCorresponds to variant dbSNP:rs45449995Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053959 | 436 – 534 | SYKEN…KSKTH → RKKQQSGRQM in isoform 2. CuratedAdd BLAST | 99 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84127 Genomic DNA Translation: AAA92020.1 M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems. AF297093 Genomic DNA Translation: AAG30423.1 AC006985 Genomic DNA No translation available. AC114812 Genomic DNA No translation available. DQ364248 mRNA Translation: ABC96772.1 |
CCDSi | CCDS2509.1 [P35503-1] |
PIRi | D42586 |
RefSeqi | NP_061966.1, NM_019093.2 [P35503-1] |
Genome annotation databases
Ensembli | ENST00000482026.6; ENSP00000418532.1; ENSG00000288702.1 |
GeneIDi | 54659 |
KEGGi | hsa:54659 |
MANE-Selecti | ENST00000482026.6; ENSP00000418532.1; NM_019093.4; NP_061966.1 |
UCSCi | uc061tvt.1, human [P35503-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84127 Genomic DNA Translation: AAA92020.1 M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems. AF297093 Genomic DNA Translation: AAG30423.1 AC006985 Genomic DNA No translation available. AC114812 Genomic DNA No translation available. DQ364248 mRNA Translation: ABC96772.1 |
CCDSi | CCDS2509.1 [P35503-1] |
PIRi | D42586 |
RefSeqi | NP_061966.1, NM_019093.2 [P35503-1] |
3D structure databases
AlphaFoldDBi | P35503 |
SMRi | P35503 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120088, 3 interactors |
IntActi | P35503, 7 interactors |
STRINGi | 9606.ENSP00000418532 |
Chemistry databases
BindingDBi | P35503 |
ChEMBLi | CHEMBL3542435 |
DrugBanki | DB06403, Ambrisentan DB01217, Anastrozole DB00714, Apomorphine DB01076, Atorvastatin DB13997, Baloxavir marboxil DB13919, Candesartan DB00796, Candesartan cilexetil DB14635, Curcumin sulfate DB00434, Cyproheptadine DB01609, Deferasirox DB11943, Delafloxacin DB09213, Dexibuprofen DB00586, Diclofenac DB08930, Dolutegravir DB05928, Dovitinib DB06210, Eltrombopag DB09038, Empagliflozin DB13874, Enasidenib DB00783, Estradiol DB00977, Ethinylestradiol DB00749, Etodolac DB00973, Ezetimibe DB04953, Ezogabine DB04854, Febuxostat DB01544, Flunitrazepam DB00712, Flurbiprofen DB01095, Fluvastatin DB11796, Fostemsavir DB06741, Gavestinel DB01241, Gemfibrozil DB00327, Hydromorphone DB12471, Ibrexafungerp DB01050, Ibuprofen DB01029, Irbesartan DB00920, Ketotifen DB00555, Lamotrigine DB12070, Letermovir DB04725, Licofelone DB00455, Loratadine DB12130, Lorlatinib DB00678, Losartan DB00227, Lovastatin DB08893, Mirabegron DB01252, Mitiglinide DB00295, Morphine DB06510, Muraglitazar DB11691, Naldemedine DB06230, Nalmefene DB08804, Nandrolone decanoate DB00788, Naproxen DB00960, Pindolol DB08860, Pitavastatin DB00794, Primidone DB00503, Ritonavir DB11689, Selumetinib DB00641, Simvastatin DB00966, Telmisartan DB00871, Terbutaline DB00197, Troglitazone DB00313, Valproic acid |
SwissLipidsi | SLP:000001698 |
Protein family/group databases
CAZyi | GT1, Glycosyltransferase Family 1 |
PTM databases
GlyConnecti | 1875, 2 N-Linked glycans (1 site) |
GlyGeni | P35503, 4 sites, 2 N-linked glycans (1 site) |
iPTMneti | P35503 |
PhosphoSitePlusi | P35503 |
Genetic variation databases
BioMutai | UGT1A3 |
Proteomic databases
jPOSTi | P35503 |
MassIVEi | P35503 |
PaxDbi | P35503 |
PeptideAtlasi | P35503 |
PRIDEi | P35503 |
ProteomicsDBi | 55072 [P35503-1] |
Protocols and materials databases
Antibodypediai | 35062, 16 antibodies from 9 providers |
DNASUi | 54659 |
Genome annotation databases
Ensembli | ENST00000482026.6; ENSP00000418532.1; ENSG00000288702.1 |
GeneIDi | 54659 |
KEGGi | hsa:54659 |
MANE-Selecti | ENST00000482026.6; ENSP00000418532.1; NM_019093.4; NP_061966.1 |
UCSCi | uc061tvt.1, human [P35503-1] |
Organism-specific databases
CTDi | 54659 |
DisGeNETi | 54659 |
GeneCardsi | UGT1A3 |
HGNCi | HGNC:12535, UGT1A3 |
HPAi | ENSG00000243135, Tissue enriched (liver) |
MalaCardsi | UGT1A3 |
MIMi | 191740, gene 606428, gene |
neXtProti | NX_P35503 |
PharmGKBi | PA37178 |
VEuPathDBi | HostDB:ENSG00000243135 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1192, Eukaryota |
GeneTreei | ENSGT00940000162976 |
HOGENOMi | CLU_012949_1_3_1 |
InParanoidi | P35503 |
OMAi | KYFCHIS |
PhylomeDBi | P35503 |
TreeFami | TF315472 |
Enzyme and pathway databases
BRENDAi | 2.4.1.17, 2681 |
PathwayCommonsi | P35503 |
Reactomei | R-HSA-156588, Glucuronidation R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis |
SABIO-RKi | P35503 |
SignaLinki | P35503 |
Miscellaneous databases
BioGRID-ORCSi | 54659, 5 hits in 921 CRISPR screens |
GeneWikii | UGT1A3 |
GenomeRNAii | 54659 |
Pharosi | P35503, Tbio |
PROi | PR:P35503 |
RNActi | P35503, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000243135, Expressed in intestine and 34 other tissues |
ExpressionAtlasi | P35503, baseline and differential |
Genevisiblei | P35503, HS |
Family and domain databases
CDDi | cd03784, GT1_Gtf-like, 1 hit |
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans IPR035595, UDP_glycos_trans_CS |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
PROSITEi | View protein in PROSITE PS00375, UDPGT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UD13_HUMAN | |
Accessioni | P35503Primary (citable) accession number: P35503 Secondary accession number(s): B8K287 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families