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UniProtKB - P35503 (UD13_HUMAN)

Entry version 178 (07 Apr 2021)
Sequence version 1 (01 Jun 1994)
Previous versions | rss
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Protein

UDP-glucuronosyltransferase 1A3

Gene

UGT1A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:15472229, PubMed:18674515, PubMed:18719240, PubMed:23756265, PubMed:23288867, PubMed:24641623). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229, PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis (PubMed:24641623). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II (PubMed:18674515).6 Publications
Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1.2 Publications

Miscellaneous

UGT1A3 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. From the 27 possible mRNA isoforms, 9 produce functionally active polypeptides (UGT1A1, 1A3, 1A4, 1A5, 1A6, 1A7, 1A8, 1A9 and 1A10) called isoforms 1 (i1). Use of an alternative exon 5 (5b) as terminal exon is leading to 9 additional alternatively spliced products termed isoforms i2 and which lack transferase activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Some kinetic parameters were assessed using commercial enzymes, which may represent a mix of both active and inactive protein forms, and therefore modify the kinetic values.1 Publication
  1. KM=47 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3)1 Publication
  2. KM=35 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17)1 Publication
  3. KM=77 µM for estrone (when assaying glucuronidation at position 3)1 Publication
  4. KM=479 µM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 3)1 Publication
  5. KM=32 µM for 2-hydroxy-17beta-estradiol (when assaying glucuronidation at position 2)1 Publication
  6. KM=587 µM for 2-hydroxy-estrone (when assaying glucuronidation at position 3)1 Publication
  7. KM=222 µM for 2-hydroxy-estrone (when assaying glucuronidation at position 2)1 Publication
  8. KM=49 µM for 2-methoxy-17beta-estradiol (when assaying glucuronidation at position 3)1 Publication
  9. KM=250 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 3)1 Publication
  10. KM=66.7 µM for 17beta-estradiol/estradiol (when assaying glucuronidation at position 17)1 Publication
  11. KM=34.2 µM for 17alpha-estradiol/epiestradiol (when assaying glucuronidation at position 3)1 Publication
  12. KM=3.95 µM for calcidiol (when assaying glucuronidation at position 25)1 Publication
  13. KM=5.9 µM for calcidiol (when assaying glucuronidation at position 3)1 Publication
  14. KM=9.35 µM for 5,6-trans-calcidiol (when assaying glucuronidation at position 25)1 Publication
  15. KM=35.9 µM for losartan (when assaying glucuronidation at position N2 of the tetrazole ring)1 Publication
  1. Vmax=39 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  2. Vmax=13 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  3. Vmax=50 pmol/min/mg enzyme for the formation of estrone 3-O-(beta-D-glucuronate)1 Publication
  4. Vmax=1342 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  5. Vmax=39 pmol/min/mg enzyme for the formation of 2-hydroxy-17beta-estradiol 2-O-(beta-D-glucuronate)1 Publication
  6. Vmax=41 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 3-O-(beta-D-glucuronate)1 Publication
  7. Vmax=28 pmol/min/mg enzyme for the formation of 2-hydroxy-estrone 2-O-(beta-D-glucuronate)1 Publication
  8. Vmax=154 pmol/min/mg enzyme for the formation of 2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  9. Vmax=653 pmol/min/mg enzyme for the formation of 17beta-estradiol 3-O-(beta-D-glucuronate)1 Publication
  10. Vmax=86.1 pmol/min/mg enzyme for the formation of 17beta-estradiol 17-O-(beta-D-glucuronate)1 Publication
  11. Vmax=683 pmol/min/mg enzyme for the formation of 17alpha-estradiol 3-O-(beta-D-glucuronate)1 Publication
  12. Vmax=26 pmol/min/mg enzyme for the formation of 17alpha-estradiol 17-O-(beta-D-glucuronate)1 Publication
  13. Vmax=1.74 pmol/min/mg enzyme for the formation of calcidiol 25-O-(beta-D-glucuronate)1 Publication
  14. Vmax=0.56 pmol/min/mg enzyme for the formation of calcidiol 3-O-(beta-D-glucuronate)1 Publication
  15. Vmax=0.22 pmol/min/mg enzyme for the formation of 5,6-trans-calcidiol 25-O-(beta-D-glucuronate)1 Publication
  16. Vmax=225.7 pmol/min/mg enzyme for the formation of losartan N2-(beta-D-glucuronate)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS09519-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.4.1.17, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P35503

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156588, Glucuronidation
R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P35503

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT1, Glycosyltransferase Family 1

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001698

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1A32 Publications (EC:2.4.1.176 Publications)
Short name:
UGT1A3
Alternative name(s):
UDP-glucuronosyltransferase 1-3
Short name:
UDPGT 1-3
Short name:
UGT1*3
Short name:
UGT1-03
Short name:
UGT1.3
UDP-glucuronosyltransferase 1-C
Short name:
UGT-1C
Short name:
UGT1C
UDP-glucuronosyltransferase 1A isoform 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UGT1A3Imported
Synonyms:GNT1, UGT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:12535, UGT1A3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		191740, gene
606428, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35503

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000243135.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei492 – 508HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54659

Open Targets

More...OpenTargetsi		ENSG00000243135

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA37178

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P35503, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3542435

Drug and drug target database

More...DrugBanki		DB06403, Ambrisentan
DB01217, Anastrozole
DB00714, Apomorphine
DB01076, Atorvastatin
DB13997, Baloxavir marboxil
DB13919, Candesartan
DB00796, Candesartan cilexetil
DB14635, Curcumin sulfate
DB00434, Cyproheptadine
DB01609, Deferasirox
DB11943, Delafloxacin
DB09213, Dexibuprofen
DB00586, Diclofenac
DB08930, Dolutegravir
DB05928, Dovitinib
DB06210, Eltrombopag
DB09038, Empagliflozin
DB13874, Enasidenib
DB00783, Estradiol
DB00977, Ethinylestradiol
DB00749, Etodolac
DB00973, Ezetimibe
DB04953, Ezogabine
DB01544, Flunitrazepam
DB00712, Flurbiprofen
DB01095, Fluvastatin
DB11796, Fostemsavir
DB06741, Gavestinel
DB01241, Gemfibrozil
DB00327, Hydromorphone
DB01050, Ibuprofen
DB01029, Irbesartan
DB00555, Lamotrigine
DB12070, Letermovir
DB04725, Licofelone
DB00455, Loratadine
DB12130, Lorlatinib
DB00678, Losartan
DB00227, Lovastatin
DB01252, Mitiglinide
DB00295, Morphine
DB06510, Muraglitazar
DB11691, Naldemedine
DB06230, Nalmefene
DB00788, Naproxen
DB08860, Pitavastatin
DB00794, Primidone
DB00503, Ritonavir
DB11689, Selumetinib
DB00641, Simvastatin
DB00966, Telmisartan
DB00197, Troglitazone
DB00313, Valproic acid

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UGT1A3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003600229 – 534UDP-glucuronosyltransferase 1A3Add BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P35503

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P35503

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35503

PeptideAtlas

More...PeptideAtlasi		P35503

PRoteomics IDEntifications database

More...PRIDEi		P35503

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55072 [P35503-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1875, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P35503, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35503

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35503

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, kidney, colon, esophagus and small intestine.1 Publication
Expressed in liver, kidney and colon. Not expressed in esophagus and small intestine.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000243135, Expressed in intestine and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35503, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35503, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000243135, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:17179145). Homooligomer (Probable).

Interacts with UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 to form heterodimers (PubMed:17179145).

Isoform 1 interacts with isoform 2/i2 suggesting that oligomerization is involved in negative regulation of transferase activity by isoform 2. Isoform 1 also interacts with respective i2 isoforms of UGT1A1, UGT1A4, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 (PubMed:20610558).

1 Publication2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P35503, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000418532

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P35503

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35503, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35503

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1192, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_012949_1_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35503

Identification of Orthologs from Complete Genome Data

More...OMAi		KYFCHIS

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35503

TreeFam database of animal gene trees

More...TreeFami		TF315472

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00201, UDPGT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00375, UDPGT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P35503-1) [UniParc]FASTAAdd to basket
Also known as: i11 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATGLQVPLP WLATGLLLLL SVQPWAESGK VLVVPIDGSH WLSMREVLRE 
        60         70         80         90        100
LHARGHQAVV LTPEVNMHIK EENFFTLTTY AISWTQDEFD RHVLGHTQLY 
       110        120        130        140        150
FETEHFLKKF FRSMAMLNNM SLVYHRSCVE LLHNEALIRH LNATSFDVVL 
       160        170        180        190        200
TDPVNLCAAV LAKYLSIPTV FFLRNIPCDL DFKGTQCPNP SSYIPRLLTT 
       210        220        230        240        250
NSDHMTFMQR VKNMLYPLAL SYICHAFSAP YASLASELFQ REVSVVDILS 
       260        270        280        290        300
HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANRKPLSQE FEAYINASGE 
       310        320        330        340        350
HGIVVFSLGS MVSEIPEKKA MAIADALGKI PQTVLWRYTG TRPSNLANNT 
       360        370        380        390        400
ILVKWLPQND LLGHPMTRAF ITHAGSHGVY ESICNGVPMV MMPLFGDQMD 
       410        420        430        440        450
NAKRMETKGA GVTLNVLEMT SEDLENALKA VINDKSYKEN IMRLSSLHKD 
       460        470        480        490        500
RPVEPLDLAV FWVEFVMRHK GAPHLRPAAH DLTWYQYHSL DVIGFLLAVV 
       510        520        530 
LTVAFITFKC CAYGYRKCLG KKGRVKKAHK SKTH
Length:534
Mass (Da):60,338
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C5833652A4D9B3D
GO
Isoform 2 (identifier: P35503-3) [UniParc]FASTAAdd to basket
Also known as: i21 Publication, UGT1A3s

The sequence of this isoform differs from the canonical sequence as follows:
     436-534: SYKENIMRLS...VKKAHKSKTH → RKKQQSGRQM

Show »
Length:445
Mass (Da):50,115
Checksum:iC30BB9928D337B4F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0524456Q → R. Corresponds to variant dbSNP:rs28898617Ensembl.1
Natural variantiVAR_05244611W → R1 PublicationCorresponds to variant dbSNP:rs3821242Ensembl.1
Natural variantiVAR_05244745R → W. Corresponds to variant dbSNP:rs45625338Ensembl.1
Natural variantiVAR_05244847V → A1 PublicationCorresponds to variant dbSNP:rs6431625Ensembl.1
Natural variantiVAR_05244949R → W. Corresponds to variant dbSNP:rs45595237Ensembl.1
Natural variantiVAR_05245078T → I. Corresponds to variant dbSNP:rs28898618Ensembl.1
Natural variantiVAR_052451114M → I. Corresponds to variant dbSNP:rs28898619Ensembl.1
Natural variantiVAR_052452144T → I. Corresponds to variant dbSNP:rs13406898Ensembl.1
Natural variantiVAR_058583158A → V1 PublicationCorresponds to variant dbSNP:rs61764030Ensembl.1
Natural variantiVAR_052453270M → V1 PublicationCorresponds to variant dbSNP:rs45449995Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053959436 – 534SYKEN…KSKTH → RKKQQSGRQM in isoform 2. CuratedAdd BLAST99

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M84127 Genomic DNA Translation: AAA92020.1
M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems.
AF297093 Genomic DNA Translation: AAG30423.1
AC006985 Genomic DNA No translation available.
AC114812 Genomic DNA No translation available.
DQ364248 mRNA Translation: ABC96772.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2509.1 [P35503-1]

Protein sequence database of the Protein Information Resource

More...PIRi		D42586

NCBI Reference Sequences

More...RefSeqi		NP_061966.1, NM_019093.2 [P35503-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000482026; ENSP00000418532; ENSG00000243135 [P35503-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54659

UCSC genome browser

More...UCSCi		uc061tvt.1, human [P35503-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84127 Genomic DNA Translation: AAA92020.1
M84124, M84122, M84123 Genomic DNA Translation: AAA61247.1 Sequence problems.
AF297093 Genomic DNA Translation: AAG30423.1
AC006985 Genomic DNA No translation available.
AC114812 Genomic DNA No translation available.
DQ364248 mRNA Translation: ABC96772.1
CCDSiCCDS2509.1 [P35503-1]
PIRiD42586
RefSeqiNP_061966.1, NM_019093.2 [P35503-1]

3D structure databases

SMRiP35503
ModBaseiSearch...

Protein-protein interaction databases

IntActiP35503, 7 interactors
STRINGi9606.ENSP00000418532

Chemistry databases

BindingDBiP35503
ChEMBLiCHEMBL3542435
DrugBankiDB06403, Ambrisentan
DB01217, Anastrozole
DB00714, Apomorphine
DB01076, Atorvastatin
DB13997, Baloxavir marboxil
DB13919, Candesartan
DB00796, Candesartan cilexetil
DB14635, Curcumin sulfate
DB00434, Cyproheptadine
DB01609, Deferasirox
DB11943, Delafloxacin
DB09213, Dexibuprofen
DB00586, Diclofenac
DB08930, Dolutegravir
DB05928, Dovitinib
DB06210, Eltrombopag
DB09038, Empagliflozin
DB13874, Enasidenib
DB00783, Estradiol
DB00977, Ethinylestradiol
DB00749, Etodolac
DB00973, Ezetimibe
DB04953, Ezogabine
DB01544, Flunitrazepam
DB00712, Flurbiprofen
DB01095, Fluvastatin
DB11796, Fostemsavir
DB06741, Gavestinel
DB01241, Gemfibrozil
DB00327, Hydromorphone
DB01050, Ibuprofen
DB01029, Irbesartan
DB00555, Lamotrigine
DB12070, Letermovir
DB04725, Licofelone
DB00455, Loratadine
DB12130, Lorlatinib
DB00678, Losartan
DB00227, Lovastatin
DB01252, Mitiglinide
DB00295, Morphine
DB06510, Muraglitazar
DB11691, Naldemedine
DB06230, Nalmefene
DB00788, Naproxen
DB08860, Pitavastatin
DB00794, Primidone
DB00503, Ritonavir
DB11689, Selumetinib
DB00641, Simvastatin
DB00966, Telmisartan
DB00197, Troglitazone
DB00313, Valproic acid
SwissLipidsiSLP:000001698

Protein family/group databases

CAZyiGT1, Glycosyltransferase Family 1

PTM databases

GlyConnecti1875, 2 N-Linked glycans (1 site)
GlyGeniP35503, 4 sites
iPTMnetiP35503
PhosphoSitePlusiP35503

Genetic variation databases

BioMutaiUGT1A3

Proteomic databases

jPOSTiP35503
MassIVEiP35503
PaxDbiP35503
PeptideAtlasiP35503
PRIDEiP35503
ProteomicsDBi55072 [P35503-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		35062, 16 antibodies

The DNASU plasmid repository

More...DNASUi		54659

Genome annotation databases

EnsembliENST00000482026; ENSP00000418532; ENSG00000243135 [P35503-1]
GeneIDi54659
KEGGihsa:54659
UCSCiuc061tvt.1, human [P35503-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54659
DisGeNETi54659

GeneCards: human genes, protein and diseases

More...GeneCardsi		UGT1A3
HGNCiHGNC:12535, UGT1A3
HPAiENSG00000243135, Tissue enriched (liver)
MIMi191740, gene
606428, gene
neXtProtiNX_P35503
OpenTargetsiENSG00000243135
PharmGKBiPA37178
VEuPathDBiHostDB:ENSG00000243135.6

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1192, Eukaryota
GeneTreeiENSGT00940000162976
HOGENOMiCLU_012949_1_3_1
InParanoidiP35503
OMAiKYFCHIS
PhylomeDBiP35503
TreeFamiTF315472

Enzyme and pathway databases

BioCyciMetaCyc:HS09519-MONOMER
BRENDAi2.4.1.17, 2681
PathwayCommonsiP35503
ReactomeiR-HSA-156588, Glucuronidation
R-HSA-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
SABIO-RKiP35503

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54659, 3 hits in 858 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UGT1A3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54659
PharosiP35503, Tbio

Protein Ontology

More...PROi		PR:P35503
RNActiP35503, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000243135, Expressed in intestine and 33 other tissues
ExpressionAtlasiP35503, baseline and differential
GenevisibleiP35503, HS

Family and domain databases

InterProiView protein in InterPro
IPR002213, UDP_glucos_trans
IPR035595, UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201, UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375, UDPGT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUD13_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35503
Secondary accession number(s): B8K287
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: April 7, 2021
This is version 178 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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