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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Acholeplasma laidlawii
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlycolysis
LigandPyruvate, Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
OrganismiAcholeplasma laidlawii
Taxonomic identifieri2148 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesAcholeplasmatalesAcholeplasmataceaeAcholeplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000162197‹1 – 345Pyruvate dehydrogenase E1 component subunit alphaAdd BLAST›345

Proteomic databases

PRIDEiP35485

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Structurei

3D structure databases

ProteinModelPortaliP35485
SMRiP35485
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4107RUY Bacteria
COG1071 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR001017 DH_E1
IPR017596 PdhA/BkdA
IPR029061 THDP-binding
PANTHERiPTHR11516:SF41 PTHR11516:SF41, 1 hit
PfamiView protein in Pfam
PF00676 E1_dh, 1 hit
SUPFAMiSSF52518 SSF52518, 1 hit
TIGRFAMsiTIGR03181 PDH_E1_alph_x, 1 hit

Sequencei

Sequence statusi: Fragment.

P35485-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DQNGKVVNEK MEPKLPKETL LKMYKTAVLG RNADIKALQY QRQGRMLTYA
60 70 80 90 100
PNMGQEAAQI GMAAAMEPQD WNSPMYRELN TLLYRGDKLE NVFLYWYGNE
110 120 130 140 150
RGSIKPEGVK ILPTNIIIGS QSNIAAGLAM ASKIRKTNEV TAFTIGDGGT
160 170 180 190 200
AHGEFYEGLN FAASFKAPVV AVIQNNQWAI STPVRKASNS ETLAQKGVAF
210 220 230 240 250
GIPYIQVDGN DMLAMYVASK EAMDRARKGD GPTLIEAFTY RMGPHTTSDD
260 270 280 290 300
PCSIYRTKEE ENEWAKKDQI ARFKTYLINK GYWSEEEDKK LEEEVLAEIN
310 320 330 340
DTFKKVESYG ANVELIEIFE HTYAEMTPQL KEQYEEHKKY LEGVK
Length:345
Mass (Da):38,962
Last modified:June 1, 1994 - v1
Checksum:i797F9F67DE0C2995
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M81753 Genomic DNA Translation: AAA21907.1
PIRiA42653

Similar proteinsi

Entry informationi

Entry nameiODPA_ACHLA
AccessioniPrimary (citable) accession number: P35485
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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