UniProtKB - P35475 (IDUA_HUMAN)

BLAST

>sp|P35475|IDUA_HUMAN Alpha-L-iduronidase OS=Homo sapiens OX=9606 GN=IDUA PE=1 SV=2
MRPLRPRAALLALLASLLAAPPVAPAEAPHLVHVDAARALWPLRRFWRSTGFCPPLPHSQ
ADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTRGSTGRGLSYNFTHLDGYLDL
LRENQLLPGFELMGSASGHFTDFEDKQQVFEWKDLVSSLARRYIGRYGLAHVSKWNFETW
NEPDHHDFDNVSMTMQGFLNYYDACSEGLRAASPALRLGGPGDSFHTPPRSPLSWGLLRH
CHDGTNFFTGEAGVRLDYISLHRKGARSSISILEQEKVVAQQIRQLFPKFADTPIYNDEA
DPLVGWSLPQPWRADVTYAAMVVKVIAQHQNLLLANTTSAFPYALLSNDNAFLSYHPHPF
AQRTLTARFQVNNTRPPHVQLLRKPVLTAMGLLALLDEEQLWAEVSQAGTVLDSNHTVGV
LASAHRPQGPADAWRAAVLIYASDDTRAHPNRSVAVTLRLRGVPPGPGLVYVTRYLDNGL
CSPDGEWRRLGRPVFPTAEQFRRMRAAEDPVAAAPRPLPAGGRLTLRPALRLPSLLLVHV
CARPEKPPGQVTRLRALPLTQGQLVLVWSDEHVGSKCLWTYEIQFSQDGKAYTPVSRKPS
TFNLFVFSPDTGAVSGSYRVRALDYWARPGPFSDPVPYLEVPVPRGPPSPGNP

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History
Entry version 178 (05 Dec 2018)
Sequence version 2 (04 Apr 2006)
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Protein

Alpha-L-iduronidase

Gene

IDUA

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Catalytic activityⁱ

Hydrolysis of unsulfated alpha-L-iduronosidic linkages in dermatan sulfate.
2 Publications
Manual assertion based on experiment inⁱ
- Ref.7
  "Insights into mucopolysaccharidosis I from the structure and action of alpha-L-iduronidase."
  Bie H., Yin J., He X., Kermode A.R., Goddard-Borger E.D., Withers S.G., James M.N.
  Nat. Chem. Biol. 9:739-745(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 27-653 IN COMPLEX WITH IDURONATE ANALOGS, CATALYTIC ACTIVITY, ACTIVE SITE, CHARACTERIZATION OF VARIANT MPS1H ARG-533, DISULFIDE BOND, GLYCOSYLATION AT ASN-110; ASN-372 AND ASN-415.
- Ref.8
  "Human alpha-L-iduronidase uses its own N-glycan as a substrate-binding and catalytic module."
  Maita N., Tsukimura T., Taniguchi T., Saito S., Ohno K., Taniguchi H., Sakuraba H.
  Proc. Natl. Acad. Sci. U.S.A. 110:14628-14633(2013) [PubMed] [Europe PMC] [Abstract]
  Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 27-653 IN COMPLEX WITH IDURONATE, CATALYTIC ACTIVITY, DISULFIDE BOND, SUBUNIT, GLYCOSYLATION AT ASN-110; ASN-372; ASN-415 AND ASN-451, IDENTIFICATION BY MASS SPECTROMETRY.
EC:3.2.1.76

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	91	Substrate	1
Binding siteⁱ	181	Substrate	1
Active siteⁱ	182	Proton donorPROSITE-ProRule annotation1 Publication	1
Binding siteⁱ	264	Substrate	1
Active siteⁱ	299	Nucleophile1 Publication	1
Binding siteⁱ	349	Substrate	1
Binding siteⁱ	363	Substrate	1

GO - Molecular functionⁱ

L-iduronidase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24036510
signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chondroitin sulfate catabolic process Source: Reactome
dermatan sulfate catabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 24036510
disaccharide metabolic process
Source: ProtInc
Traceable author statementⁱ
- 2470345
glycosaminoglycan catabolic process Source: Reactome
heparin catabolic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 21873421

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase

Molecular function

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05096-MONOMER
BRENDAⁱ	3.2.1.76 2681
Reactomeⁱ	R-HSA-2024096 HS-GAG degradation R-HSA-2024101 CS/DS degradation R-HSA-2206302 MPS I - Hurler syndrome
SABIO-RKⁱ	P35475

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH39 Glycoside Hydrolase Family 39

CAZyⁱ

GH39 Glycoside Hydrolase Family 39

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-L-iduronidase (EC:3.2.1.76)
Gene namesⁱ	Name:IDUA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000127415.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5391 IDUA
MIMⁱ	252800 gene
neXtProtⁱ	NX_P35475

Keywords - Cellular componentⁱ

Lysosome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mucopolysaccharidosis 1H (MPS1H)15 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA severe form of mucopolysaccharidosis type 1, a rare lysosomal storage disease characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate. Patients with MPS1H usually present, within the first year of life, a combination of hepatosplenomegaly, skeletal deformities, corneal clouding and severe mental retardation. Obstructive airways disease, respiratory infection and cardiac complications usually result in death before 10 years of age.

Mucopolysaccharidosis 1H/S (MPS1H/S)8 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of mucopolysaccharidosis type 1, a rare lysosomal storage disease characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate. MPS1H/S represents an intermediate phenotype of the MPS1 clinical spectrum. It is characterized by relatively little neurological involvement, but most of the somatic symptoms described for severe MPS1 develop in the early to mid-teens, causing considerable loss of mobility.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_020975	79	A → V in MPS1H/S; reduction of activity and protein levels. 1 PublicationCorresponds to variant dbSNP:rs747981483EnsemblClinVar.	1
Natural variantⁱVAR_003353	82	H → P in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs794727239EnsemblClinVar.	1
Natural variantⁱVAR_066216	84	G → R in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_066218	178	E → K in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_066219	188	F → L in MPS1H/S; associated with R-423. 1 Publication	1
Natural variantⁱVAR_020980	238	L → Q in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs148789453EnsemblClinVar.	1
Natural variantⁱVAR_020981	260	S → F in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_066221	265	G → R in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs369090960Ensembl.	1
Natural variantⁱVAR_017436	346	L → R in MPS1H/S; 0.4% of normal activity. 1 PublicationCorresponds to variant dbSNP:rs121965033EnsemblClinVar.	1
Natural variantⁱVAR_020984	363	R → C in MPS1H/S; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs750496798EnsemblClinVar.	1
Natural variantⁱVAR_066226	396	L → P in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_066227	436	A → P in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_003376	496	P → L in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs772416503EnsemblClinVar.	1
Natural variantⁱVAR_066229	496	P → R in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs772416503EnsemblClinVar.	1
Natural variantⁱVAR_003377	504	M → T in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_066230	535	L → F in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_020986	602	F → I in MPS1H/S; reduction of activity and protein levels. 1 Publication	1
Natural variantⁱVAR_017437	619	R → G in MPS1H/S; 1.5% of normal activity. 1 PublicationCorresponds to variant dbSNP:rs121965031EnsemblClinVar.	1
Natural variantⁱVAR_003379	626	W → R in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs1281475543Ensembl.	1
Natural variantⁱVAR_020987	628	R → P in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs200448421Ensembl.	1

Mucopolysaccharidosis 1S (MPS1S)8 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA mild form of mucopolysaccharidosis type 1, a rare lysosomal storage disease characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate. Patients with MPS1S may have little or no neurological involvement, normal stature and life span, but present development of joints stiffness, mild hepatosplenomegaly, aortic valve disease and corneal clouding.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_072367	18	L → P in MPS1S. 1 PublicationCorresponds to variant dbSNP:rs794726878EnsemblClinVar.	1
Natural variantⁱVAR_066215	76	Y → C in MPS1S. 1 PublicationCorresponds to variant dbSNP:rs780165694EnsemblClinVar.	1
Natural variantⁱVAR_003354	89	R → Q in MPS1S. 2 PublicationsCorresponds to variant dbSNP:rs121965029EnsemblClinVar.	1
Natural variantⁱVAR_003355	89	R → W in MPS1S. 2 PublicationsCorresponds to variant dbSNP:rs754966840EnsemblClinVar.	1
Natural variantⁱVAR_066220	219	G → E in MPS1S. 1 PublicationCorresponds to variant dbSNP:rs1230234600Ensembl.	1
Natural variantⁱVAR_066223	306	W → L in MPS1S. 1 Publication	1
Natural variantⁱVAR_066224	348	N → K in MPS1S. 1 PublicationCorresponds to variant dbSNP:rs746766617EnsemblClinVar.	1
Natural variantⁱVAR_020983	350	N → I in MPS1S. 1 Publication	1
Natural variantⁱVAR_003367	383	R → H in MPS1S; 2-3% of normal activity. 2 PublicationsCorresponds to variant dbSNP:rs754949360EnsemblClinVar.	1
Natural variantⁱVAR_003371	445	Missing in MPS1S. 1 Publication	1
Natural variantⁱVAR_003375	492	R → P in MPS1S. 2 PublicationsCorresponds to variant dbSNP:rs121965026EnsemblClinVar.	1

Keywords - Diseaseⁱ

Disease mutation, Mucopolysaccharidosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3425
GeneReviewsⁱ	IDUA
MalaCards human disease database More...MalaCardsⁱ	IDUA
MIMⁱ	607014 phenotype 607015 phenotype 607016 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000127415
Orphanetⁱ	93473 Hurler syndrome 93476 Hurler-Scheie syndrome 93474 Scheie syndrome
PharmGKBⁱ	PA29638

Polymorphism and mutation databases

BioMutaⁱ	IDUA
DMDMⁱ	92090608

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	Sequence analysisAdd BLAST		27
ChainⁱPRO_0000012200	28 – 653	Alpha-L-iduronidaseAdd BLAST		626

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	110	N-linked (GlcNAc...) asparagine3 Publications	1
Glycosylationⁱ	190	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	336	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	372	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	415	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	451	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	541 ↔ 577	2 Publications

Post-translational modificationⁱ

N-glycosylation at Asn-372 contributes to substrate binding and is required for full enzymatic activity.3 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P35475
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35475
PaxDbⁱ	P35475
PeptideAtlas More...PeptideAtlasⁱ	P35475
PRIDEⁱ	P35475
ProteomicsDBⁱ	55068

PTM databases

GlyConnectⁱ	1006
iPTMnetⁱ	P35475
PhosphoSitePlusⁱ	P35475

Expressionⁱ

Tissue specificityⁱ

Ubiquitous.

Gene expression databases

Bgeeⁱ	ENSG00000127415 Expressed in 143 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_IDUA
ExpressionAtlasⁱ	P35475 baseline and differential
Genevisibleⁱ	P35475 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025901 HPA046979 HPA054254

HPAⁱ

CAB025901
HPA046979
HPA054254

Interactionⁱ

Subunit structureⁱ

Monomer.2 Publications

GO - Molecular functionⁱ

signaling receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109651, 2 interactors
IntActⁱ	P35475, 1 interactor
STRINGⁱ	9606.ENSP00000247933

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	30 – 42	Combined sources	13
Beta strandⁱ	49 – 52	Combined sources	4
Helixⁱ	58 – 60	Combined sources	3
Helixⁱ	64 – 66	Combined sources	3
Helixⁱ	68 – 78	Combined sources	11
Helixⁱ	81 – 83	Combined sources	3
Beta strandⁱ	87 – 90	Combined sources	4
Helixⁱ	93 – 95	Combined sources	3
Beta strandⁱ	98 – 100	Combined sources	3
Turnⁱ	103 – 105	Combined sources	3
Beta strandⁱ	108 – 110	Combined sources	3
Helixⁱ	112 – 123	Combined sources	12
Beta strandⁱ	127 – 131	Combined sources	5
Turnⁱ	136 – 139	Combined sources	4
Beta strandⁱ	142 – 144	Combined sources	3
Helixⁱ	146 – 167	Combined sources	22
Helixⁱ	169 – 172	Combined sources	4
Beta strandⁱ	176 – 178	Combined sources	3
Helixⁱ	183 – 185	Combined sources	3
Helixⁱ	195 – 212	Combined sources	18
Beta strandⁱ	217 – 223	Combined sources	7
Helixⁱ	232 – 243	Combined sources	12
Turnⁱ	247 – 249	Combined sources	3
Beta strandⁱ	257 – 261	Combined sources	5
Helixⁱ	269 – 286	Combined sources	18
Helixⁱ	288 – 290	Combined sources	3
Beta strandⁱ	295 – 298	Combined sources	4
Beta strandⁱ	302 – 304	Combined sources	3
Beta strandⁱ	306 – 308	Combined sources	3
Helixⁱ	311 – 314	Combined sources	4
Helixⁱ	316 – 332	Combined sources	17
Beta strandⁱ	334 – 336	Combined sources	3
Beta strandⁱ	343 – 346	Combined sources	4
Turnⁱ	359 – 361	Combined sources	3
Beta strandⁱ	362 – 371	Combined sources	10
Beta strandⁱ	374 – 376	Combined sources	3
Beta strandⁱ	378 – 383	Combined sources	6
Helixⁱ	385 – 393	Combined sources	9
Beta strandⁱ	398 – 407	Combined sources	10
Beta strandⁱ	410 – 412	Combined sources	3
Beta strandⁱ	414 – 425	Combined sources	12
Beta strandⁱ	429 – 431	Combined sources	3
Beta strandⁱ	435 – 442	Combined sources	8
Beta strandⁱ	449 – 461	Combined sources	13
Beta strandⁱ	470 – 477	Combined sources	8
Turnⁱ	478 – 480	Combined sources	3
Helixⁱ	483 – 489	Combined sources	7
Helixⁱ	498 – 505	Combined sources	8
Beta strandⁱ	511 – 517	Combined sources	7
Turnⁱ	520 – 522	Combined sources	3
Beta strandⁱ	524 – 526	Combined sources	3
Beta strandⁱ	529 – 541	Combined sources	13
Beta strandⁱ	552 – 560	Combined sources	9
Beta strandⁱ	563 – 569	Combined sources	7
Turnⁱ	571 – 573	Combined sources	3
Beta strandⁱ	578 – 586	Combined sources	9
Beta strandⁱ	602 – 607	Combined sources	6
Beta strandⁱ	616 – 624	Combined sources	9
Beta strandⁱ	636 – 638	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P35475
SMRⁱ	P35475
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	305 – 306	Substrate binding		2

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 39 family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IEET Eukaryota ENOG410XWW3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015494
HOGENOMⁱ	HOG000007042
HOVERGENⁱ	HBG006121
InParanoidⁱ	P35475
KEGG Orthology (KO) More...KOⁱ	K01217
OMAⁱ	IANESAF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N7H
PhylomeDBⁱ	P35475
TreeFamⁱ	TF323228

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR000514 Glyco_hydro_39 IPR017853 Glycoside_hydrolase_SF IPR013783 Ig-like_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01229 Glyco_hydro_39, 1 hit
PRINTSⁱ	PR00745 GLHYDRLASE39
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS01027 GLYCOSYL_HYDROL_F39, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P35475-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPLRPRAAL LALLASLLAA PPVAPAEAPH LVHVDAARAL WPLRRFWRST 
        60         70         80         90        100
GFCPPLPHSQ ADQYVLSWDQ QLNLAYVGAV PHRGIKQVRT HWLLELVTTR 
       110        120        130        140        150
GSTGRGLSYN FTHLDGYLDL LRENQLLPGF ELMGSASGHF TDFEDKQQVF 
       160        170        180        190        200
EWKDLVSSLA RRYIGRYGLA HVSKWNFETW NEPDHHDFDN VSMTMQGFLN 
       210        220        230        240        250
YYDACSEGLR AASPALRLGG PGDSFHTPPR SPLSWGLLRH CHDGTNFFTG 
       260        270        280        290        300
EAGVRLDYIS LHRKGARSSI SILEQEKVVA QQIRQLFPKF ADTPIYNDEA 
       310        320        330        340        350
DPLVGWSLPQ PWRADVTYAA MVVKVIAQHQ NLLLANTTSA FPYALLSNDN 
       360        370        380        390        400
AFLSYHPHPF AQRTLTARFQ VNNTRPPHVQ LLRKPVLTAM GLLALLDEEQ 
       410        420        430        440        450
LWAEVSQAGT VLDSNHTVGV LASAHRPQGP ADAWRAAVLI YASDDTRAHP 
       460        470        480        490        500
NRSVAVTLRL RGVPPGPGLV YVTRYLDNGL CSPDGEWRRL GRPVFPTAEQ 
       510        520        530        540        550
FRRMRAAEDP VAAAPRPLPA GGRLTLRPAL RLPSLLLVHV CARPEKPPGQ 
       560        570        580        590        600
VTRLRALPLT QGQLVLVWSD EHVGSKCLWT YEIQFSQDGK AYTPVSRKPS 
       610        620        630        640        650
TFNLFVFSPD TGAVSGSYRV RALDYWARPG PFSDPVPYLE VPVPRGPPSP 

GNP

Length:653

Mass (Da):72,670

Last modified:April 4, 2006 - v2

Checksum:ⁱ9D2399B22FD172BD

Isoform 2 (identifier: P35475-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
53-100: CPPLPHSQADQYVLSWDQQLNLAYVGAVPHRGIKQVRTHWLLELVTTR → W
265-324: GARSSISILE...DVTYAAMVVK → VRPAPPSAPV...PGPSCPGHPQ

« Hide

        10         20         30         40         50
MRPLRPRAAL LALLASLLAA PPVAPAEAPH LVHVDAARAL WPLRRFWRST 
        60         70         80         90        100
GFWGSTGRGL SYNFTHLDGY LDLLRENQLL PGFELMGSAS GHFTDFEDKQ 
       110        120        130        140        150
QVFEWKDLVS SLARRYIGRY GLAHVSKWNF ETWNEPDHHD FDNVSMTMQG 
       160        170        180        190        200
FLNYYDACSE GLRAASPALR LGGPGDSFHT PPRSPLSWGL LRHCHDGTNF 
       210        220        230        240        250
FTGEAGVRLD YISLHRKVRP APPSAPVFCA LSRCAPGRAD PGGAEAAPPA 
       260        270        280        290        300
GCAQLHLHPG AGEGRRAADP AALPQVRGHP HLQRRGGPAG GLVPATAVEG 
       310        320        330        340        350
GRDLRGHGGE GGPAQRPARP PATFLPRRDR RAVAAPPGPS CPGHPQVIAQ 
       360        370        380        390        400
HQNLLLANTT SAFPYALLSN DNAFLSYHPH PFAQRTLTAR FQVNNTRPPH 
       410        420        430        440        450
VQLLRKPVLT AMGLLALLDE EQLWAEVSQA GTVLDSNHTV GVLASAHRPQ 
       460        470        480        490        500
GPADAWRAAV LIYASDDTRA HPNRSVAVTL RLRGVPPGPG LVYVTRYLDN 
       510        520        530        540        550
GLCSPDGEWR RLGRPVFPTA EQFRRMRAAE DPVAAAPRPL PAGGRLTLRP 
       560        570        580        590        600
ALRLPSLLLV HVCARPEKPP GQVTRLRALP LTQGQLVLVW SDEHVGSKCL 
       610        620        630        640        650
WTYEIQFSQD GKAYTPVSRK PSTFNLFVFS PDTGAVSGSY RVRALDYWAR 
       660        670 
PGPFSDPVPY LEVPVPRGPP SPGNP

Note: No experimental confirmation available.

Show »

Length:675

Mass (Da):73,455

Checksum:ⁱ6599D5F961F1E06C

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6R9D5	D6R9D5_HUMAN	Alpha-L-iduronidase Alpha-L-iduronidase	IDUA	224	Annotation score:
D6REB5	D6REB5_HUMAN	Alpha-L-iduronidase Alpha-L-iduronidase	IDUA	521	Annotation score:
H0Y9B3	H0Y9B3_HUMAN	Alpha-L-iduronidase Alpha-L-iduronidase	IDUA	232	Annotation score:
D6RBD5	D6RBD5_HUMAN	Alpha-L-iduronidase Alpha-L-iduronidase	IDUA	176	Annotation score:
H0Y9R9	H0Y9R9_HUMAN	Alpha-L-iduronidase Alpha-L-iduronidase	IDUA	195	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	622	A → T in AAA51698 (PubMed:1505961).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_003349	16 – 19	Missing in MPS1H. 1 Publication	4
Natural variantⁱVAR_072367	18	L → P in MPS1S. 1 PublicationCorresponds to variant dbSNP:rs794726878EnsemblClinVar.	1
Natural variantⁱVAR_003350	33	H → Q5 PublicationsCorresponds to variant dbSNP:rs10794537EnsemblClinVar.	1
Natural variantⁱVAR_003351	51	G → D in MPS1H. 2 PublicationsCorresponds to variant dbSNP:rs794726877EnsemblClinVar.	1
Natural variantⁱVAR_003352	75	A → T in MPS1H. 2 PublicationsCorresponds to variant dbSNP:rs758452450EnsemblClinVar.	1
Natural variantⁱVAR_066215	76	Y → C in MPS1S. 1 PublicationCorresponds to variant dbSNP:rs780165694EnsemblClinVar.	1
Natural variantⁱVAR_020975	79	A → V in MPS1H/S; reduction of activity and protein levels. 1 PublicationCorresponds to variant dbSNP:rs747981483EnsemblClinVar.	1
Natural variantⁱVAR_003353	82	H → P in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs794727239EnsemblClinVar.	1
Natural variantⁱVAR_020976	82	H → Q Reduction of protein levels. 1 PublicationCorresponds to variant dbSNP:rs148775298EnsemblClinVar.	1
Natural variantⁱVAR_066216	84	G → R in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_003354	89	R → Q in MPS1S. 2 PublicationsCorresponds to variant dbSNP:rs121965029EnsemblClinVar.	1
Natural variantⁱVAR_003355	89	R → W in MPS1S. 2 PublicationsCorresponds to variant dbSNP:rs754966840EnsemblClinVar.	1
Natural variantⁱVAR_066217	103	T → P in MPS1H; uncertain pathological role. 1 Publication	1
Natural variantⁱVAR_003356	105	R → Q3 PublicationsCorresponds to variant dbSNP:rs3755955EnsemblClinVar.	1
Natural variantⁱVAR_003357	116	G → R. Corresponds to variant dbSNP:rs148946496Ensembl.	1
Natural variantⁱVAR_020977	133	M → I in MPS1H. 1 PublicationCorresponds to variant dbSNP:rs558683362EnsemblClinVar.	1
Natural variantⁱVAR_066218	178	E → K in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_020978	182	E → K in MPS1H. 1 PublicationCorresponds to variant dbSNP:rs754154200Ensembl.	1
Natural variantⁱVAR_066219	188	F → L in MPS1H/S; associated with R-423. 1 Publication	1
Natural variantⁱVAR_020979	208	G → D in MPS1H. 1 Publication	1
Natural variantⁱVAR_003358	218	L → P in MPS1H. 1 PublicationCorresponds to variant dbSNP:rs869025584EnsemblClinVar.	1
Natural variantⁱVAR_066220	219	G → E in MPS1S. 1 PublicationCorresponds to variant dbSNP:rs1230234600Ensembl.	1
Natural variantⁱVAR_020980	238	L → Q in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs148789453EnsemblClinVar.	1
Natural variantⁱVAR_020981	260	S → F in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_066221	265	G → R in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs369090960Ensembl.	1
Natural variantⁱVAR_066222	276	E → K in MPS1H/S and MPS1S. 1 Publication	1
Natural variantⁱVAR_003359	279	V → A.	1
Natural variantⁱVAR_017435	300	A → T in IDUA pseudodeficiency. 1 PublicationCorresponds to variant dbSNP:rs121965030EnsemblClinVar.	1
Natural variantⁱVAR_066223	306	W → L in MPS1S. 1 Publication	1
Natural variantⁱVAR_003360	315	D → Y in MPS1H; loss of function; undetectable enzyme activity. 1 Publication	1
Natural variantⁱVAR_003361	327	A → P in MPS1H; MPS1H/S. 5 PublicationsCorresponds to variant dbSNP:rs199801029EnsemblClinVar.	1
Natural variantⁱVAR_017436	346	L → R in MPS1H/S; 0.4% of normal activity. 1 PublicationCorresponds to variant dbSNP:rs121965033EnsemblClinVar.	1
Natural variantⁱVAR_066224	348	N → K in MPS1S. 1 PublicationCorresponds to variant dbSNP:rs746766617EnsemblClinVar.	1
Natural variantⁱVAR_003363	349 – 350	Missing in MPS1H. 1 Publication	2
Natural variantⁱVAR_003362	349	D → N in MPS1H. Corresponds to variant dbSNP:rs368454909EnsemblClinVar.	1
Natural variantⁱVAR_020982	349	D → Y in MPS1H. 1 Publication	1
Natural variantⁱVAR_020983	350	N → I in MPS1S. 1 Publication	1
Natural variantⁱVAR_003364	361	A → T4 PublicationsCorresponds to variant dbSNP:rs6831280EnsemblClinVar.	1
Natural variantⁱVAR_020984	363	R → C in MPS1H/S; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs750496798EnsemblClinVar.	1
Natural variantⁱVAR_003365	366	T → P in MPS1H. 1 PublicationCorresponds to variant dbSNP:rs121965024EnsemblClinVar.	1
Natural variantⁱVAR_003366	380	Q → R in MPS1H/S and MPS1S. 3 PublicationsCorresponds to variant dbSNP:rs762903007EnsemblClinVar.	1
Natural variantⁱVAR_003367	383	R → H in MPS1S; 2-3% of normal activity. 2 PublicationsCorresponds to variant dbSNP:rs754949360EnsemblClinVar.	1
Natural variantⁱVAR_066225	385	P → R in MPS1H. 1 Publication	1
Natural variantⁱVAR_003368	388	T → R in MPS1H. 1 PublicationCorresponds to variant dbSNP:rs794727896EnsemblClinVar.	1
Natural variantⁱVAR_003369	396	L → LALL in MPS1H.	1
Natural variantⁱVAR_066226	396	L → P in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_003370	409	G → R in MPS1H. 1 PublicationCorresponds to variant dbSNP:rs11934801EnsemblClinVar.	1
Natural variantⁱVAR_020985	423	S → R in MPS1S and MPS1H/S; associated with L-188 in a patient with MPS1H/S; significant reduction of activity and protein levels. 2 PublicationsCorresponds to variant dbSNP:rs931627770Ensembl.	1
Natural variantⁱVAR_066227	436	A → P in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_003371	445	Missing in MPS1S. 1 Publication	1
Natural variantⁱVAR_066228	449	H → N1 PublicationCorresponds to variant dbSNP:rs532731688EnsemblClinVar.	1
Natural variantⁱVAR_003372	454	V → I3 PublicationsCorresponds to variant dbSNP:rs73066479EnsemblClinVar.	1
Natural variantⁱVAR_003373	489	R → P in MPS1H. 1 Publication	1
Natural variantⁱVAR_003374	490	L → P in MPS1H/S and MPS1S. 2 PublicationsCorresponds to variant dbSNP:rs121965027EnsemblClinVar.	1
Natural variantⁱVAR_003375	492	R → P in MPS1S. 2 PublicationsCorresponds to variant dbSNP:rs121965026EnsemblClinVar.	1
Natural variantⁱVAR_003376	496	P → L in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs772416503EnsemblClinVar.	1
Natural variantⁱVAR_066229	496	P → R in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs772416503EnsemblClinVar.	1
Natural variantⁱVAR_003377	504	M → T in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_003378	533	P → R in MPS1H and MPS1H/S; in 3% of the MPS1H patients; reduces catalytic activity and protein stability. 5 PublicationsCorresponds to variant dbSNP:rs121965021EnsemblClinVar.	1
Natural variantⁱVAR_066230	535	L → F in MPS1H/S. 1 Publication	1
Natural variantⁱVAR_066231	591	A → T1 PublicationCorresponds to variant dbSNP:rs398123257EnsemblClinVar.	1
Natural variantⁱVAR_020986	602	F → I in MPS1H/S; reduction of activity and protein levels. 1 Publication	1
Natural variantⁱVAR_017437	619	R → G in MPS1H/S; 1.5% of normal activity. 1 PublicationCorresponds to variant dbSNP:rs121965031EnsemblClinVar.	1
Natural variantⁱVAR_072368	620	V → F in MPS1H; loss of function; undetectable enzyme activity. 1 Publication	1
Natural variantⁱVAR_003379	626	W → R in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs1281475543Ensembl.	1
Natural variantⁱVAR_020987	628	R → P in MPS1H/S. 1 PublicationCorresponds to variant dbSNP:rs200448421Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_057029	53 – 100	CPPLP…LVTTR → W in isoform 2. 1 PublicationAdd BLAST		48
Alternative sequenceⁱVSP_057030	265 – 324	GARSS…AMVVK → VRPAPPSAPVFCALSRCAPG RADPGGAEAAPPAGCAQLHL HPGAGEGRRAADPAALPQVR GHPHLQRRGGPAGGLVPATA VEGGRDLRGHGGEGGPAQRP ARPPATFLPRRDRRAVAAPP GPSCPGHPQ in isoform 2. 1 PublicationAdd BLAST		60

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74715 mRNA Translation: AAA81589.1 M95740, M95739 Genomic DNA Translation: AAA51698.1 AK125223 mRNA Translation: BAG54168.1 AC019103 Genomic DNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3343.1 [P35475-1]
PIRⁱ	S53645
NCBI Reference Sequences More...RefSeqⁱ	NP_000194.2, NM_000203.4 [P35475-1]
UniGeneⁱ	Hs.89560

Genome annotation databases

Ensemblⁱ	ENST00000247933; ENSP00000247933; ENSG00000127415 [P35475-1]
GeneIDⁱ	3425
KEGGⁱ	hsa:3425
UCSC genome browser More...UCSCⁱ	uc003gby.5 human [P35475-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35475	Alpha-L-iduronidase		HUMAN		521	UniRef100_P35475
UPI0002C8656A		HUMAN		627
UPI0007DC5DB8		HUMAN		333

Protein	Similar proteins		Species	Score	Length	Source
P35475	Alpha-L-iduronidase		HUMAN		521	UniRef90_P35475
IDUA isoform 1		PANTR		660
Iduronidase, alpha-L-		PAPAN		654
Alpha-L-iduronidase		CALJA		653
Iduronidase, alpha-L-		Cebus capucinus imitator		653
+30

Protein	Similar proteins		Species	Score	Length	Source
P35475	Alpha-L-iduronidase		CANLF		655	UniRef50_P35475
Alpha-L-iduronidase		HUMAN		521
IDUA isoform 1		PANTR		660
Iduronidase, alpha-L-		PAPAN		654
Iduronidase, alpha-L-		MACFA		653
+62

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74715 mRNA Translation: AAA81589.1 M95740, M95739 Genomic DNA Translation: AAA51698.1 AK125223 mRNA Translation: BAG54168.1 AC019103 Genomic DNA No translation available.
CCDSⁱ	CCDS3343.1 [P35475-1]
PIRⁱ	S53645
RefSeqⁱ	NP_000194.2, NM_000203.4 [P35475-1]
UniGeneⁱ	Hs.89560

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1Y24	model	-	A	36-522	[»]
	3W81	X-ray	2.30	A/B	27-653	[»]
	3W82	X-ray	2.76	A/B	27-653	[»]
	4KGJ	X-ray	2.99	A/B	27-653	[»]
	4KGL	X-ray	2.70	A/B	27-653	[»]
	4KH2	X-ray	2.36	A/B	27-653	[»]
	4MJ2	X-ray	2.10	A/B	1-653	[»]
	4MJ4	X-ray	2.17	A	1-653	[»]
	4OBR	X-ray	2.46	A/B	27-653	[»]
	4OBS	X-ray	2.26	A	27-653	[»]
ProteinModelPortalⁱ	P35475
SMRⁱ	P35475
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109651, 2 interactors
IntActⁱ	P35475, 1 interactor
STRINGⁱ	9606.ENSP00000247933

Protein family/group databases

CAZyⁱ	GH39 Glycoside Hydrolase Family 39

CAZyⁱ

GH39 Glycoside Hydrolase Family 39

PTM databases

GlyConnectⁱ	1006
iPTMnetⁱ	P35475
PhosphoSitePlusⁱ	P35475

Polymorphism and mutation databases

BioMutaⁱ	IDUA
DMDMⁱ	92090608

Proteomic databases

EPDⁱ	P35475
MaxQBⁱ	P35475
PaxDbⁱ	P35475
PeptideAtlasⁱ	P35475
PRIDEⁱ	P35475
ProteomicsDBⁱ	55068

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000247933; ENSP00000247933; ENSG00000127415 [P35475-1]
GeneIDⁱ	3425
KEGGⁱ	hsa:3425
UCSCⁱ	uc003gby.5 human [P35475-1]

Organism-specific databases

CTDⁱ	3425
DisGeNETⁱ	3425
EuPathDBⁱ	HostDB:ENSG00000127415.12
GeneCardsⁱ	IDUA
GeneReviewsⁱ	IDUA
H-InvDBⁱ	HIX0200643
HGNCⁱ	HGNC:5391 IDUA
HPAⁱ	CAB025901 HPA046979 HPA054254
MalaCardsⁱ	IDUA
MIMⁱ	252800 gene 607014 phenotype 607015 phenotype 607016 phenotype
neXtProtⁱ	NX_P35475
OpenTargetsⁱ	ENSG00000127415
Orphanetⁱ	93473 Hurler syndrome 93476 Hurler-Scheie syndrome 93474 Scheie syndrome
PharmGKBⁱ	PA29638
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEET Eukaryota ENOG410XWW3 LUCA
GeneTreeⁱ	ENSGT00390000015494
HOGENOMⁱ	HOG000007042
HOVERGENⁱ	HBG006121
InParanoidⁱ	P35475
KOⁱ	K01217
OMAⁱ	IANESAF
OrthoDBⁱ	EOG091G0N7H
PhylomeDBⁱ	P35475
TreeFamⁱ	TF323228

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05096-MONOMER
BRENDAⁱ	3.2.1.76 2681
Reactomeⁱ	R-HSA-2024096 HS-GAG degradation R-HSA-2024101 CS/DS degradation R-HSA-2206302 MPS I - Hurler syndrome
SABIO-RKⁱ	P35475

Miscellaneous databases

ChiTaRSⁱ	IDUA human
GenomeRNAiⁱ	3425
Protein Ontology More...PROⁱ	PR:P35475
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000127415 Expressed in 143 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_IDUA
ExpressionAtlasⁱ	P35475 baseline and differential
Genevisibleⁱ	P35475 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR000514 Glyco_hydro_39 IPR017853 Glycoside_hydrolase_SF IPR013783 Ig-like_fold
Pfamⁱ	View protein in Pfam PF01229 Glyco_hydro_39, 1 hit
PRINTSⁱ	PR00745 GLHYDRLASE39
SUPFAMⁱ	SSF51445 SSF51445, 1 hit
PROSITEⁱ	View protein in PROSITE PS01027 GLYCOSYL_HYDROL_F39, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IDUA_HUMAN
Accessionⁱ	P35475Primary (citable) accession number: P35475 Secondary accession number(s): B3KWK6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	April 4, 2006
	Last modified:	December 5, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P35475 (IDUA_HUMAN)

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Alpha-L-iduronidase

IDUA

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Extracellular region or secreted

Lysosome

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ