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Protein

Protein S100-A1

Gene

S100a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as a Ca2+ signal transducer (By similarity). In response to an increase in intracellular Ca2+ levels, binds calcium which triggers a conformational change (PubMed:16169012, PubMed:18650434). This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity (By similarity).By similarity2 Publications

Miscellaneous

Able to bind zinc in vitro; the binding sites are different from the calcium binding sites. The physiological relevance of zinc binding is unclear. Physiological concentrations of potassium antagonize the binding of both divalent cations, especially affecting the high-affinity calcium-binding sites.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinity3 PublicationsAdd BLAST14
Calcium bindingi63 – 742; high affinity3 PublicationsAdd BLAST12

GO - Molecular functioni

  • ATPase binding Source: Ensembl
  • calcium-dependent protein binding Source: RGD
  • calcium ion binding Source: RGD
  • protein homodimerization activity Source: RGD
  • S100 protein binding Source: Ensembl

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene namesi
Name:S100a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3614 S100a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439631 – 94Protein S100-A1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86S-nitrosocysteineBy similarity1

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiP35467
PRIDEiP35467

Expressioni

Tissue specificityi

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000012410
GenevisibleiP35467 RN

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain (By similarity). Also forms heterodimers with S100P (By similarity). Interacts with AGER (PubMed:19910580). Interacts with CAPZA1 (PubMed:19452629). Interacts with FKBP4. Interacts with RYR1 and RYR2 (PubMed:18650434). Interacts with CACYBP in a calcium-dependent manner (By similarity). Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity (By similarity).By similarity3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ATPase binding Source: Ensembl
  • calcium-dependent protein binding Source: RGD
  • protein homodimerization activity Source: RGD
  • S100 protein binding Source: Ensembl

Protein-protein interaction databases

BioGridi254914, 1 interactor
IntActiP35467, 4 interactors
MINTiP35467
STRINGi10116.ENSRNOP00000017000

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Beta strandi22 – 25Combined sources4
Beta strandi27 – 30Combined sources4
Helixi31 – 41Combined sources11
Helixi43 – 47Combined sources5
Helixi49 – 51Combined sources3
Helixi52 – 64Combined sources13
Beta strandi68 – 70Combined sources3
Helixi72 – 85Combined sources14
Helixi91 – 93Combined sources3

3D structure databases

ProteinModelPortaliP35467
SMRiP35467
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35467

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXZ2 Eukaryota
ENOG4111987 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP35467
OMAiTAAMGSE
OrthoDBiEOG091G10JX
PhylomeDBiP35467
TreeFamiTF332727

Family and domain databases

CDDicd05025 S-100A1, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR028486 S100-A1
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF66 PTHR11639:SF66, 1 hit
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P35467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSELETAME TLINVFHAHS GKEGDKYKLS KKELKDLLQT ELSSFLDVQK
60 70 80 90
DADAVDKIMK ELDENGDGEV DFQEFVVLVA ALTVACNNFF WENS
Length:94
Mass (Da):10,560
Last modified:January 23, 2007 - v3
Checksum:i7B9C0A6C1C4FCCE0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14N → H in AAB20539 (PubMed:1742602).Curated1
Sequence conflicti57K → R in AAB20539 (PubMed:1742602).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26358, U26357 Genomic DNA Translation: AAB53657.1
S68809 mRNA Translation: AAB20539.2
RefSeqiNP_001007637.1, NM_001007636.3

Genome annotation databases

EnsembliENSRNOT00000017000; ENSRNOP00000017000; ENSRNOG00000012410
GeneIDi295214
KEGGirno:295214
UCSCiRGD:3614 rat

Similar proteinsi

Entry informationi

Entry nameiS10A1_RAT
AccessioniPrimary (citable) accession number: P35467
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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