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UniProtKB - P35462 (DRD3_HUMAN)
Protein
D(3) dopamine receptor
Gene
DRD3
Organism
Homo sapiens (Human)
Status
Functioni
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 110 | Eticlopride; antagonistCombined sources1 Publication | 1 | |
Binding sitei | 345 | Eticlopride; antagonistCombined sources1 Publication | 1 | |
Binding sitei | 349 | Eticlopride; antagonistCombined sources1 Publication | 1 |
GO - Molecular functioni
- D1 dopamine receptor binding Source: Ensembl
- dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
- G protein-coupled receptor activity Source: GO_Central
- protein domain specific binding Source: Ensembl
GO - Biological processi
- acid secretion Source: BHF-UCL
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adenylate cyclase-activating dopamine receptor signaling pathway Source: BHF-UCL
- adenylate cyclase-inhibiting dopamine receptor signaling pathway Source: BHF-UCL
- arachidonic acid secretion Source: BHF-UCL
- autophagy Source: Ensembl
- behavioral response to cocaine Source: BHF-UCL
- cellular calcium ion homeostasis Source: BHF-UCL
- circadian regulation of gene expression Source: BHF-UCL
- dopamine metabolic process Source: BHF-UCL
- gastric emptying Source: Ensembl
- G protein-coupled receptor internalization Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- learning Source: BHF-UCL
- learning or memory Source: BHF-UCL
- locomotory behavior Source: BHF-UCL
- musculoskeletal movement, spinal reflex action Source: BHF-UCL
- negative regulation of adenylate cyclase activity Source: GO_Central
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of blood pressure Source: BHF-UCL
- negative regulation of cytosolic calcium ion concentration Source: GO_Central
- negative regulation of oligodendrocyte differentiation Source: BHF-UCL
- negative regulation of protein kinase B signaling Source: BHF-UCL
- negative regulation of protein secretion Source: BHF-UCL
- negative regulation of sodium:proton antiporter activity Source: Ensembl
- negative regulation of synaptic transmission, glutamatergic Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- negative regulation of voltage-gated calcium channel activity Source: GO_Central
- phospholipase C-activating dopamine receptor signaling pathway Source: GO_Central
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of cytokinesis Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: GO_Central
- positive regulation of dopamine receptor signaling pathway Source: BHF-UCL
- positive regulation of mitotic nuclear division Source: BHF-UCL
- positive regulation of renal sodium excretion Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- prepulse inhibition Source: BHF-UCL
- regulation of circadian sleep/wake cycle, sleep Source: Ensembl
- regulation of dopamine secretion Source: BHF-UCL
- regulation of dopamine uptake involved in synaptic transmission Source: BHF-UCL
- regulation of locomotion involved in locomotory behavior Source: Ensembl
- regulation of postsynaptic neurotransmitter receptor internalization Source: Ensembl
- regulation of potassium ion transport Source: GO_Central
- response to cocaine Source: BHF-UCL
- response to histamine Source: BHF-UCL
- response to morphine Source: BHF-UCL
- response to xenobiotic stimulus Source: BHF-UCL
- social behavior Source: BHF-UCL
- visual learning Source: BHF-UCL
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P35462 |
Reactomei | R-HSA-390651, Dopamine receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P35462 |
SIGNORi | P35462 |
Protein family/group databases
TCDBi | 9.A.14.3.9, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: D(3) dopamine receptorCuratedAlternative name(s): Dopamine D3 receptor |
Gene namesi | Name:DRD3Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3024, DRD3 |
MIMi | 126451, gene |
neXtProti | NX_P35462 |
VEuPathDBi | HostDB:ENSG00000151577 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
Plasma Membrane
- integral component of plasma membrane Source: BHF-UCL
- integral component of postsynaptic density membrane Source: Ensembl
- plasma membrane Source: UniProtKB
Other locations
- apical part of cell Source: Ensembl
- cell projection Source: Ensembl
- endocytic vesicle Source: Ensembl
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | Extracellular1 PublicationAdd BLAST | 32 | |
Transmembranei | 33 – 55 | Helical; Name=11 PublicationAdd BLAST | 23 | |
Topological domaini | 56 – 65 | Cytoplasmic1 Publication | 10 | |
Transmembranei | 66 – 88 | Helical; Name=21 PublicationAdd BLAST | 23 | |
Topological domaini | 89 – 104 | Extracellular1 PublicationAdd BLAST | 16 | |
Transmembranei | 105 – 126 | Helical; Name=31 PublicationAdd BLAST | 22 | |
Topological domaini | 127 – 149 | Cytoplasmic1 PublicationAdd BLAST | 23 | |
Transmembranei | 150 – 170 | Helical; Name=41 PublicationAdd BLAST | 21 | |
Topological domaini | 171 – 187 | Extracellular1 PublicationAdd BLAST | 17 | |
Transmembranei | 188 – 209 | Helical; Name=51 PublicationAdd BLAST | 22 | |
Topological domaini | 210 – 329 | Cytoplasmic1 PublicationAdd BLAST | 120 | |
Transmembranei | 330 – 351 | Helical; Name=61 PublicationAdd BLAST | 22 | |
Topological domaini | 352 – 366 | Extracellular1 PublicationAdd BLAST | 15 | |
Transmembranei | 367 – 386 | Helical; Name=71 PublicationAdd BLAST | 20 | |
Topological domaini | 387 – 400 | Cytoplasmic1 PublicationAdd BLAST | 14 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Tremor, hereditary essential 1 (ETM1)2 Publications
Disease susceptibility is associated with variants affecting the gene represented in this entry. Glycine at position 9 results in gain of function and is associated with susceptibility to essential tremor.2 Publications
Disease descriptionA common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
Related information in OMIMSchizophrenia (SCZD)2 Publications
Disease susceptibility may be associated with variants affecting the gene represented in this entry. Glycine at position 9 results in gain of function and may be a risk factor for schizophrenia.2 Publications
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Related information in OMIMKeywords - Diseasei
SchizophreniaOrganism-specific databases
DisGeNETi | 1814 |
MalaCardsi | DRD3 |
MIMi | 181500, phenotype 190300, phenotype |
Orphaneti | 862, NON RARE IN EUROPE: Hereditary essential tremor |
PharmGKBi | PA27479 |
Miscellaneous databases
Pharosi | P35462, Tclin |
Chemistry databases
ChEMBLi | CHEMBL234 |
DrugBanki | DB05766, ACP-104 DB06288, Amisulpride DB00543, Amoxapine DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB09207, AS-8112 DB06216, Asenapine DB09223, Blonanserin DB01200, Bromocriptine DB00490, Buspirone DB00248, Cabergoline DB09014, Captodiame DB06016, Cariprazine DB00477, Chlorpromazine DB01239, Chlorprothixene DB00363, Clozapine DB11274, Dihydro-alpha-ergocryptine DB13345, Dihydroergocristine DB01184, Domperidone DB00988, Dopamine DB11275, Epicriptine DB01049, Ergoloid mesylate DB00502, Haloperidol DB04946, Iloperidone DB01235, Levodopa DB00589, Lisuride DB00408, Loxapine DB01403, Methotrimeprazine DB06148, Mianserin DB00334, Olanzapine DB01267, Paliperidone DB12061, Pardoprunox DB01186, Pergolide DB01100, Pimozide DB09286, Pipamperone DB12478, Piribedil DB00413, Pramipexole DB01224, Quetiapine DB00409, Remoxipride DB00268, Ropinirole DB05271, Rotigotine DB06454, Sarizotan DB00391, Sulpiride DB06477, Sumanirole DB09289, Tianeptine DB13025, Tiapride DB01392, Yohimbine DB00246, Ziprasidone |
DrugCentrali | P35462 |
GuidetoPHARMACOLOGYi | 216 |
Genetic variation databases
BioMutai | DRD3 |
DMDMi | 1169206 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069397 | 1 – 400 | D(3) dopamine receptorAdd BLAST | 400 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 12 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 19 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 97 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 103 ↔ 181 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 173 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 355 ↔ 358 | PROSITE-ProRule annotationCombined sources1 Publication |
Post-translational modificationi
Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).1 Publication
Palmitoylated.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P35462 |
PeptideAtlasi | P35462 |
PRIDEi | P35462 |
PTM databases
GlyGeni | P35462, 4 sites |
iPTMneti | P35462 |
PhosphoSitePlusi | P35462 |
SwissPalmi | P35462 |
Expressioni
Tissue specificityi
Brain.
Gene expression databases
Bgeei | ENSG00000151577, Expressed in nucleus accumbens and 20 other tissues |
ExpressionAtlasi | P35462, baseline and differential |
Genevisiblei | P35462, HS |
Organism-specific databases
HPAi | ENSG00000151577, Tissue enriched (brain) |
Interactioni
Subunit structurei
GO - Molecular functioni
- D1 dopamine receptor binding Source: Ensembl
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108148, 28 interactors |
DIPi | DIP-5976N |
IntActi | P35462, 6 interactors |
STRINGi | 9606.ENSP00000373169 |
Chemistry databases
BindingDBi | P35462 |
Miscellaneous databases
RNActi | P35462, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P35462 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P35462 |
PhylomeDBi | P35462 |
TreeFami | TF334382 |
Family and domain databases
InterProi | View protein in InterPro IPR001620, Dopamine_D3_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00568, DOPAMINED3R PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P35462-1) [UniParc]FASTAAdd to basket
Also known as: D3
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASLSQLSGH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV
60 70 80 90 100
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR
110 120 130 140 150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV
160 170 180 190 200
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP
210 220 230 240 250
FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL
260 270 280 290 300
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK
310 320 330 340 350
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV
360 370 380 390 400
LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PCM4 | E9PCM4_HUMAN | D(3) dopamine receptor | DRD3 | 367 | Annotation score: |
Sequence cautioni
The sequence AAA03543 differs from that shown. Reason: Frameshift.Curated
The sequence AAA64369 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 396 | K → L in AAH95510 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_003463 | 9 | G → S8 PublicationsCorresponds to variant dbSNP:rs6280EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040570 | 287 – 320 | SPTIA…QPRGV → M in isoform 3. 1 PublicationAdd BLAST | 34 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20469 mRNA Translation: AAA03543.1 Frameshift. AH003061 Genomic DNA Translation: AAA64369.1 Sequence problems. U32499 mRNA Translation: AAA73929.1 AC092896 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79610.1 BC095510 mRNA Translation: AAH95510.1 BC128123 mRNA Translation: AAI28124.1 |
CCDSi | CCDS2978.1 [P35462-1] CCDS33829.1 [P35462-3] |
PIRi | A48258 A55419 G01977 |
RefSeqi | NP_000787.2, NM_000796.5 NP_001269492.1, NM_001282563.2 NP_001277738.1, NM_001290809.1 NP_387512.3, NM_033663.5 |
Genome annotation databases
Ensembli | ENST00000383673; ENSP00000373169; ENSG00000151577 ENST00000460779; ENSP00000419402; ENSG00000151577 ENST00000467632; ENSP00000420662; ENSG00000151577 |
GeneIDi | 1814 |
KEGGi | hsa:1814 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L20469 mRNA Translation: AAA03543.1 Frameshift. AH003061 Genomic DNA Translation: AAA64369.1 Sequence problems. U32499 mRNA Translation: AAA73929.1 AC092896 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79610.1 BC095510 mRNA Translation: AAH95510.1 BC128123 mRNA Translation: AAI28124.1 |
CCDSi | CCDS2978.1 [P35462-1] CCDS33829.1 [P35462-3] |
PIRi | A48258 A55419 G01977 |
RefSeqi | NP_000787.2, NM_000796.5 NP_001269492.1, NM_001282563.2 NP_001277738.1, NM_001290809.1 NP_387512.3, NM_033663.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3PBL | X-ray | 2.89 | A/B | 2-221 | [»] | |
A/B | 319-400 | [»] | ||||
7CMU | electron microscopy | 3.00 | R | 1-400 | [»] | |
7CMV | electron microscopy | 2.70 | R | 1-400 | [»] | |
SMRi | P35462 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108148, 28 interactors |
DIPi | DIP-5976N |
IntActi | P35462, 6 interactors |
STRINGi | 9606.ENSP00000373169 |
Chemistry databases
BindingDBi | P35462 |
ChEMBLi | CHEMBL234 |
DrugBanki | DB05766, ACP-104 DB06288, Amisulpride DB00543, Amoxapine DB00714, Apomorphine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB09207, AS-8112 DB06216, Asenapine DB09223, Blonanserin DB01200, Bromocriptine DB00490, Buspirone DB00248, Cabergoline DB09014, Captodiame DB06016, Cariprazine DB00477, Chlorpromazine DB01239, Chlorprothixene DB00363, Clozapine DB11274, Dihydro-alpha-ergocryptine DB13345, Dihydroergocristine DB01184, Domperidone DB00988, Dopamine DB11275, Epicriptine DB01049, Ergoloid mesylate DB00502, Haloperidol DB04946, Iloperidone DB01235, Levodopa DB00589, Lisuride DB00408, Loxapine DB01403, Methotrimeprazine DB06148, Mianserin DB00334, Olanzapine DB01267, Paliperidone DB12061, Pardoprunox DB01186, Pergolide DB01100, Pimozide DB09286, Pipamperone DB12478, Piribedil DB00413, Pramipexole DB01224, Quetiapine DB00409, Remoxipride DB00268, Ropinirole DB05271, Rotigotine DB06454, Sarizotan DB00391, Sulpiride DB06477, Sumanirole DB09289, Tianeptine DB13025, Tiapride DB01392, Yohimbine DB00246, Ziprasidone |
DrugCentrali | P35462 |
GuidetoPHARMACOLOGYi | 216 |
Protein family/group databases
TCDBi | 9.A.14.3.9, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P35462, 4 sites |
iPTMneti | P35462 |
PhosphoSitePlusi | P35462 |
SwissPalmi | P35462 |
Genetic variation databases
BioMutai | DRD3 |
DMDMi | 1169206 |
Proteomic databases
PaxDbi | P35462 |
PeptideAtlasi | P35462 |
PRIDEi | P35462 |
Protocols and materials databases
ABCDi | P35462, 1 sequenced antibody |
Antibodypediai | 16482, 277 antibodies from 38 providers |
DNASUi | 1814 |
Genome annotation databases
Ensembli | ENST00000383673; ENSP00000373169; ENSG00000151577 ENST00000460779; ENSP00000419402; ENSG00000151577 ENST00000467632; ENSP00000420662; ENSG00000151577 |
GeneIDi | 1814 |
KEGGi | hsa:1814 |
Organism-specific databases
CTDi | 1814 |
DisGeNETi | 1814 |
GeneCardsi | DRD3 |
HGNCi | HGNC:3024, DRD3 |
HPAi | ENSG00000151577, Tissue enriched (brain) |
MalaCardsi | DRD3 |
MIMi | 126451, gene 181500, phenotype 190300, phenotype |
neXtProti | NX_P35462 |
Orphaneti | 862, NON RARE IN EUROPE: Hereditary essential tremor |
PharmGKBi | PA27479 |
VEuPathDBi | HostDB:ENSG00000151577 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P35462 |
PhylomeDBi | P35462 |
TreeFami | TF334382 |
Enzyme and pathway databases
PathwayCommonsi | P35462 |
Reactomei | R-HSA-390651, Dopamine receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P35462 |
SIGNORi | P35462 |
Miscellaneous databases
BioGRID-ORCSi | 1814, 2 hits in 1032 CRISPR screens |
GenomeRNAii | 1814 |
Pharosi | P35462, Tclin |
PROi | PR:P35462 |
RNActi | P35462, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151577, Expressed in nucleus accumbens and 20 other tissues |
ExpressionAtlasi | P35462, baseline and differential |
Genevisiblei | P35462, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001620, Dopamine_D3_rcpt IPR000929, Dopamine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00568, DOPAMINED3R PR00242, DOPAMINER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DRD3_HUMAN | |
Accessioni | P35462Primary (citable) accession number: P35462 Secondary accession number(s): A1A4V5, Q4VBM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | February 23, 2022 | |
Last modified: | February 23, 2022 | |
This is version 204 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families