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UniProtKB - P35462 (DRD3_HUMAN)

Entry version 197 (12 Aug 2020)
Sequence version 2 (01 Nov 1995)
Previous versions | rss
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Protein

D(3) dopamine receptor

Gene

DRD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei110Agonist1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P35462

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390651, Dopamine receptors
R-HSA-418594, G alpha (i) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P35462

SIGNOR Signaling Network Open Resource

More...SIGNORi		P35462

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.3.9, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DRD3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000151577.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:3024, DRD3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		126451, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35462

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32Extracellular1 PublicationAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 55Helical; Name=11 PublicationAdd BLAST23
Topological domaini56 – 65Cytoplasmic1 Publication10
Transmembranei66 – 88Helical; Name=21 PublicationAdd BLAST23
Topological domaini89 – 104Extracellular1 PublicationAdd BLAST16
Transmembranei105 – 126Helical; Name=31 PublicationAdd BLAST22
Topological domaini127 – 149Cytoplasmic1 PublicationAdd BLAST23
Transmembranei150 – 170Helical; Name=41 PublicationAdd BLAST21
Topological domaini171 – 187Extracellular1 PublicationAdd BLAST17
Transmembranei188 – 209Helical; Name=51 PublicationAdd BLAST22
Topological domaini210 – 329Cytoplasmic1 PublicationAdd BLAST120
Transmembranei330 – 351Helical; Name=61 PublicationAdd BLAST22
Topological domaini352 – 366Extracellular1 PublicationAdd BLAST15
Transmembranei367 – 386Helical; Name=71 PublicationAdd BLAST20
Topological domaini387 – 400Cytoplasmic1 PublicationAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Tremor, hereditary essential 1 (ETM1)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
Related information in OMIM
Schizophrenia (SCZD)2 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Related information in OMIM

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNET

More...DisGeNETi		1814

MalaCards human disease database

More...MalaCardsi		DRD3
MIMi181500, phenotype
190300, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		862, NON RARE IN EUROPE: Hereditary essential tremor

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27479

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P35462, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL234

Drug and drug target database

More...DrugBanki		DB05766, ACP-104
DB06288, Amisulpride
DB00543, Amoxapine
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB09207, AS-8112
DB06216, Asenapine
DB09223, Blonanserin
DB01200, Bromocriptine
DB00490, Buspirone
DB00248, Cabergoline
DB09014, Captodiame
DB06016, Cariprazine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB00363, Clozapine
DB11274, Dihydro-alpha-ergocryptine
DB13345, Dihydroergocristine
DB01184, Domperidone
DB00988, Dopamine
DB11275, Epicriptine
DB01049, Ergoloid mesylate
DB00502, Haloperidol
DB04946, Iloperidone
DB01235, Levodopa
DB00589, Lisuride
DB00408, Loxapine
DB01403, Methotrimeprazine
DB06148, Mianserin
DB00334, Olanzapine
DB01267, Paliperidone
DB12061, Pardoprunox
DB01186, Pergolide
DB01100, Pimozide
DB09286, Pipamperone
DB12478, Piribedil
DB00413, Pramipexole
DB01224, Quetiapine
DB00409, Remoxipride
DB00268, Ropinirole
DB05271, Rotigotine
DB06454, Sarizotan
DB00391, Sulpiride
DB06477, Sumanirole
DB09289, Tianeptine
DB13025, Tiapride
DB01392, Yohimbine
DB00246, Ziprasidone

DrugCentral

More...DrugCentrali		P35462

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		216

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DRD3

Domain mapping of disease mutations (DMDM)

More...DMDMi		1169206

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693971 – 400D(3) dopamine receptorAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi103 ↔ 181PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi355 ↔ 358PROSITE-ProRule annotationCombined sources1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).1 Publication
Palmitoylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35462

PeptideAtlas

More...PeptideAtlasi		P35462

PRoteomics IDEntifications database

More...PRIDEi		P35462

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55066 [P35462-1]
55067 [P35462-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P35462, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35462

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35462

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P35462

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151577, Expressed in nucleus accumbens and 20 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35462, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35462, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000151577, Tissue enhanced (blood, brain, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CLIC6 (By similarity).

Interacts with GRK4 (PubMed:19520868).

Interacts with PALM (PubMed:16386234).

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).

By similarity3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108148, 13 interactors

Database of interacting proteins

More...DIPi		DIP-5976N

Protein interaction database and analysis system

More...IntActi		P35462, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000373169

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P35462

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35462, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35462

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni189 – 196Agonist binding8
Regioni342 – 350Agonist binding9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35462

KEGG Orthology (KO)

More...KOi		K04146

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35462

TreeFam database of animal gene trees

More...TreeFami		TF334382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001620, Dopamine_D3_rcpt
IPR000929, Dopamine_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00568, DOPAMINED3R
PR00242, DOPAMINER
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P35462-1) [UniParc]FASTAAdd to basket
Also known as: D3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV 
        60         70         80         90        100
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR 
       110        120        130        140        150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV 
       160        170        180        190        200
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP 
       210        220        230        240        250
FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL 
       260        270        280        290        300
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK 
       310        320        330        340        350
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV 
       360        370        380        390        400
LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC
Length:400
Mass (Da):44,225
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CDA789D78378DDA
GO
Isoform 3 (identifier: P35462-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-320: SPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGV → M

Show »
Length:367
Mass (Da):40,760
Checksum:i40F7FFA4519042FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PCM4E9PCM4_HUMAN
D(3) dopamine receptor
DRD3
367Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA03543 differs from that shown. Reason: Frameshift.Curated
The sequence AAA64369 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti396K → L in AAH95510 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0034639S → G Polymorphism; associated with susceptibility to essential tremor; risk factor for schizophrenia; gain of function. 9 PublicationsCorresponds to variant dbSNP:rs6280Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040570287 – 320SPTIA…QPRGV → M in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L20469 mRNA Translation: AAA03543.1 Frameshift.
AH003061 Genomic DNA Translation: AAA64369.1 Sequence problems.
U32499 mRNA Translation: AAA73929.1
AC092896 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79610.1
BC095510 mRNA Translation: AAH95510.1
BC128123 mRNA Translation: AAI28124.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2978.1 [P35462-1]
CCDS33829.1 [P35462-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A48258
A55419
G01977

NCBI Reference Sequences

More...RefSeqi		NP_000787.2, NM_000796.5
NP_001269492.1, NM_001282563.2
NP_001277738.1, NM_001290809.1
NP_387512.3, NM_033663.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000383673; ENSP00000373169; ENSG00000151577
ENST00000460779; ENSP00000419402; ENSG00000151577
ENST00000467632; ENSP00000420662; ENSG00000151577

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1814

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1814

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20469 mRNA Translation: AAA03543.1 Frameshift.
AH003061 Genomic DNA Translation: AAA64369.1 Sequence problems.
U32499 mRNA Translation: AAA73929.1
AC092896 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79610.1
BC095510 mRNA Translation: AAH95510.1
BC128123 mRNA Translation: AAI28124.1
CCDSiCCDS2978.1 [P35462-1]
CCDS33829.1 [P35462-3]
PIRiA48258
A55419
G01977
RefSeqiNP_000787.2, NM_000796.5
NP_001269492.1, NM_001282563.2
NP_001277738.1, NM_001290809.1
NP_387512.3, NM_033663.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PBLX-ray2.89A/B2-221[»]
A/B319-400[»]
SMRiP35462
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108148, 13 interactors
DIPiDIP-5976N
IntActiP35462, 6 interactors
STRINGi9606.ENSP00000373169

Chemistry databases

BindingDBiP35462
ChEMBLiCHEMBL234
DrugBankiDB05766, ACP-104
DB06288, Amisulpride
DB00543, Amoxapine
DB00714, Apomorphine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB09207, AS-8112
DB06216, Asenapine
DB09223, Blonanserin
DB01200, Bromocriptine
DB00490, Buspirone
DB00248, Cabergoline
DB09014, Captodiame
DB06016, Cariprazine
DB00477, Chlorpromazine
DB01239, Chlorprothixene
DB00363, Clozapine
DB11274, Dihydro-alpha-ergocryptine
DB13345, Dihydroergocristine
DB01184, Domperidone
DB00988, Dopamine
DB11275, Epicriptine
DB01049, Ergoloid mesylate
DB00502, Haloperidol
DB04946, Iloperidone
DB01235, Levodopa
DB00589, Lisuride
DB00408, Loxapine
DB01403, Methotrimeprazine
DB06148, Mianserin
DB00334, Olanzapine
DB01267, Paliperidone
DB12061, Pardoprunox
DB01186, Pergolide
DB01100, Pimozide
DB09286, Pipamperone
DB12478, Piribedil
DB00413, Pramipexole
DB01224, Quetiapine
DB00409, Remoxipride
DB00268, Ropinirole
DB05271, Rotigotine
DB06454, Sarizotan
DB00391, Sulpiride
DB06477, Sumanirole
DB09289, Tianeptine
DB13025, Tiapride
DB01392, Yohimbine
DB00246, Ziprasidone
DrugCentraliP35462
GuidetoPHARMACOLOGYi216

Protein family/group databases

TCDBi9.A.14.3.9, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP35462, 4 sites
iPTMnetiP35462
PhosphoSitePlusiP35462
SwissPalmiP35462

Polymorphism and mutation databases

BioMutaiDRD3
DMDMi1169206

Proteomic databases

PaxDbiP35462
PeptideAtlasiP35462
PRIDEiP35462
ProteomicsDBi55066 [P35462-1]
55067 [P35462-3]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P35462, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16482, 260 antibodies

The DNASU plasmid repository

More...DNASUi		1814

Genome annotation databases

EnsembliENST00000383673; ENSP00000373169; ENSG00000151577
ENST00000460779; ENSP00000419402; ENSG00000151577
ENST00000467632; ENSP00000420662; ENSG00000151577
GeneIDi1814
KEGGihsa:1814

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1814
DisGeNETi1814
EuPathDBiHostDB:ENSG00000151577.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		DRD3
HGNCiHGNC:3024, DRD3
HPAiENSG00000151577, Tissue enhanced (blood, brain, testis)
MalaCardsiDRD3
MIMi126451, gene
181500, phenotype
190300, phenotype
neXtProtiNX_P35462
Orphaneti862, NON RARE IN EUROPE: Hereditary essential tremor
PharmGKBiPA27479

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
InParanoidiP35462
KOiK04146
PhylomeDBiP35462
TreeFamiTF334382

Enzyme and pathway databases

PathwayCommonsiP35462
ReactomeiR-HSA-390651, Dopamine receptors
R-HSA-418594, G alpha (i) signalling events
SignaLinkiP35462
SIGNORiP35462

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1814, 2 hits in 868 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1814
PharosiP35462, Tclin

Protein Ontology

More...PROi		PR:P35462
RNActiP35462, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000151577, Expressed in nucleus accumbens and 20 other tissues
ExpressionAtlasiP35462, baseline and differential
GenevisibleiP35462, HS

Family and domain databases

InterProiView protein in InterPro
IPR001620, Dopamine_D3_rcpt
IPR000929, Dopamine_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00568, DOPAMINED3R
PR00242, DOPAMINER
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRD3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35462
Secondary accession number(s): A1A4V5, Q4VBM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: August 12, 2020
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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