DRD3

Functionⁱ

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	110	Agonist		1

GO - Molecular functionⁱ

adrenergic receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
D1 dopamine receptor binding Source: Ensembl
dopamine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
dopamine neurotransmitter receptor activity, coupled via Gi/Go
Source: BHF-UCL
Inferred from direct assayⁱ
- 8301582
drug binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 8413587
protein domain specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acid secretion Source: BHF-UCL
adenylate cyclase-activating adrenergic receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
adenylate cyclase-activating dopamine receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 18424554
adenylate cyclase-inhibiting dopamine receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
arachidonic acid secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 8301582
autophagy Source: Ensembl
behavioral response to cocaine
Source: BHF-UCL
Inferred from expression patternⁱ
- 8815892
cellular calcium ion homeostasis
Source: BHF-UCL
Inferred from direct assayⁱ
- 7911712
circadian regulation of gene expression Source: BHF-UCL
dopamine metabolic process
Source: BHF-UCL
Inferred by curatorⁱ
- 8301582
gastric emptying Source: Ensembl
G protein-coupled receptor internalization
Source: BHF-UCL
Inferred from direct assayⁱ
- 18424554
G protein-coupled receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 7911712
learning
Source: BHF-UCL
Non-traceable author statementⁱ
- 15998189
learning or memory
Source: BHF-UCL
Non-traceable author statementⁱ
- 14681904
locomotory behavior Source: BHF-UCL
musculoskeletal movement, spinal reflex action Source: BHF-UCL
negative regulation of apoptotic process Source: Ensembl
negative regulation of blood pressure Source: BHF-UCL
negative regulation of dopamine receptor signaling pathway Source: Ensembl
negative regulation of oligodendrocyte differentiation Source: BHF-UCL
negative regulation of protein kinase B signaling Source: BHF-UCL
negative regulation of protein secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 16839358
negative regulation of sodium:proton antiporter activity Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of cytokinesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22888021
positive regulation of dopamine receptor signaling pathway Source: BHF-UCL
positive regulation of mitotic nuclear division Source: BHF-UCL
positive regulation of renal sodium excretion Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
prepulse inhibition
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18325483
regulation of blood volume by renin-angiotensin Source: Ensembl
regulation of circadian sleep/wake cycle, sleep Source: Ensembl
regulation of dopamine secretion Source: BHF-UCL
regulation of dopamine uptake involved in synaptic transmission
Source: BHF-UCL
Inferred by curatorⁱ
- 8301582
regulation of lipid metabolic process Source: Ensembl
regulation of locomotion involved in locomotory behavior Source: Ensembl
regulation of multicellular organism growth Source: Ensembl
regulation of postsynaptic neurotransmitter receptor internalization Source: Ensembl
response to amphetamine Source: Ensembl
response to cocaine
Source: BHF-UCL
Inferred from expression patternⁱ
- 10415668
response to drug Source: BHF-UCL
response to histamine
Source: BHF-UCL
Inferred from direct assayⁱ
- 16839358
response to morphine Source: BHF-UCL
social behavior
Source: BHF-UCL
Non-traceable author statementⁱ
- 12860355
synaptic transmission, dopaminergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
visual learning Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390651 Dopamine receptors R-HSA-418594 G alpha (i) signalling events
SignaLinkⁱ	P35462

Protein family/group databases

TCDBⁱ

9.A.14.3.9 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: D(3) dopamine receptor Alternative name(s): Dopamine D3 receptor
Gene namesⁱ	Name:DRD3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151577.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3024 DRD3
MIMⁱ	126451 gene
neXtProtⁱ	NX_P35462

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 32	Extracellular1 PublicationAdd BLAST	32
Transmembraneⁱ	33 – 55	Helical; Name=11 PublicationAdd BLAST	23
Topological domainⁱ	56 – 65	Cytoplasmic1 Publication	10
Transmembraneⁱ	66 – 88	Helical; Name=21 PublicationAdd BLAST	23
Topological domainⁱ	89 – 104	Extracellular1 PublicationAdd BLAST	16
Transmembraneⁱ	105 – 126	Helical; Name=31 PublicationAdd BLAST	22
Topological domainⁱ	127 – 149	Cytoplasmic1 PublicationAdd BLAST	23
Transmembraneⁱ	150 – 170	Helical; Name=41 PublicationAdd BLAST	21
Topological domainⁱ	171 – 187	Extracellular1 PublicationAdd BLAST	17
Transmembraneⁱ	188 – 209	Helical; Name=51 PublicationAdd BLAST	22
Topological domainⁱ	210 – 329	Cytoplasmic1 PublicationAdd BLAST	120
Transmembraneⁱ	330 – 351	Helical; Name=61 PublicationAdd BLAST	22
Topological domainⁱ	352 – 366	Extracellular1 PublicationAdd BLAST	15
Transmembraneⁱ	367 – 386	Helical; Name=71 PublicationAdd BLAST	20
Topological domainⁱ	387 – 400	Cytoplasmic1 PublicationAdd BLAST	14

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Tremor, hereditary essential 1 (ETM1)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.

Schizophrenia (SCZD)2 Publications

Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

Keywords - Diseaseⁱ

Schizophrenia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1814
MalaCards human disease database More...MalaCardsⁱ	DRD3
MIMⁱ	181500 phenotype 190300 phenotype
Orphanetⁱ	862 NON RARE IN EUROPE: Hereditary essential tremor
PharmGKBⁱ	PA27479

Chemistry databases

ChEMBLⁱ	CHEMBL234
Drug and drug target database More...DrugBankⁱ	DB05766 ACP-104 DB06288 Amisulpride DB00543 Amoxapine DB00714 Apomorphine DB01238 Aripiprazole DB09207 AS-8112 DB06216 Asenapine DB01200 Bromocriptine DB00248 Cabergoline DB09014 Captodiame DB06016 Cariprazine DB00477 Chlorpromazine DB01239 Chlorprothixene DB00363 Clozapine DB01184 Domperidone DB00988 Dopamine DB00502 Haloperidol DB04946 Iloperidone DB01235 Levodopa DB00589 Lisuride DB00408 Loxapine DB01403 Methotrimeprazine DB06148 Mianserin DB00370 Mirtazapine DB00334 Olanzapine DB01267 Paliperidone DB01186 Pergolide DB01100 Pimozide DB00413 Pramipexole DB01224 Quetiapine DB00409 Remoxipride DB00734 Risperidone DB00268 Ropinirole DB05271 Rotigotine DB05280 SLV 308 DB00391 Sulpiride DB13025 Tiapride DB01392 Yohimbine DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	216

Polymorphism and mutation databases

DMDMⁱ	1169206

DMDMⁱ

1169206

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069397	1 – 400	D(3) dopamine receptorAdd BLAST		400

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	12	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	19	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	97	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	103 ↔ 181	PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationⁱ	173	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	355 ↔ 358	PROSITE-ProRule annotationCombined sources1 Publication

Post-translational modificationⁱ

Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).1 Publication

Palmitoylated.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbⁱ	P35462
PeptideAtlas More...PeptideAtlasⁱ	P35462
PRIDEⁱ	P35462
ProteomicsDBⁱ	55066 55067 [P35462-3]

PTM databases

iPTMnetⁱ	P35462
PhosphoSitePlusⁱ	P35462
SwissPalmⁱ	P35462

Expressionⁱ

Tissue specificityⁱ

Brain.

Gene expression databases

Bgeeⁱ	ENSG00000151577 Expressed in 11 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_DRD3
ExpressionAtlasⁱ	P35462 baseline and differential
Genevisibleⁱ	P35462 HS

Interactionⁱ

Subunit structureⁱ

Interacts with CLIC6 (By similarity). Interacts with GRK4 (PubMed:19520868). Interacts with PALM (PubMed:16386234). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).By similarity3 Publications

GO - Molecular functionⁱ

D1 dopamine receptor binding Source: Ensembl
protein domain specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108148, 10 interactors
Database of interacting proteins More...DIPⁱ	DIP-5976N
IntActⁱ	P35462, 6 interactors
STRINGⁱ	9606.ENSP00000373169

Chemistry databases

BindingDBⁱ

P35462

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	35 – 56	Combined sources	22
Helixⁱ	63 – 81	Combined sources	19
Helixⁱ	83 – 91	Combined sources	9
Helixⁱ	100 – 133	Combined sources	34
Helixⁱ	135 – 140	Combined sources	6
Beta strandⁱ	143 – 145	Combined sources	3
Helixⁱ	147 – 169	Combined sources	23
Turnⁱ	170 – 172	Combined sources	3
Helixⁱ	186 – 196	Combined sources	11
Helixⁱ	198 – 216	Combined sources	19
Helixⁱ	322 – 353	Combined sources	32
Helixⁱ	362 – 386	Combined sources	25
Helixⁱ	388 – 398	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P35462
SMRⁱ	P35462
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	189 – 196	Agonist binding		8
Regionⁱ	342 – 350	Agonist binding		9

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P35462
KEGG Orthology (KO) More...KOⁱ	K04146
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P35462
TreeFamⁱ	TF334382

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15310 7tmA_D3_dopamine_R, 1 hit
InterProⁱ	View protein in InterPro IPR001620 Dopamine_D3_rcpt IPR000929 Dopamine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00568 DOPAMINED3R PR00242 DOPAMINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P35462-1) [UniParc]FASTA Add to basket

Also known as: D3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV 
        60         70         80         90        100
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR 
       110        120        130        140        150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV 
       160        170        180        190        200
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP 
       210        220        230        240        250
FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL 
       260        270        280        290        300
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK 
       310        320        330        340        350
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV 
       360        370        380        390        400
LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC

Length:400

Mass (Da):44,225

Last modified:November 1, 1995 - v2

Checksum:ⁱ2CDA789D78378DDA

GO

Isoform 3 (identifier: P35462-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
287-320: SPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGV → M

« Hide

        10         20         30         40         50
MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV 
        60         70         80         90        100
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR 
       110        120        130        140        150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV 
       160        170        180        190        200
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP 
       210        220        230        240        250
FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL 
       260        270        280        290        300
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLMPLR EKKATQMVAI 
       310        320        330        340        350
VLGAFIVCWL PFFLTHVLNT HCQTCHVSPE LYSATTWLGY VNSALNPVIY 
       360 
TTFNIEFRKA FLKILSC

Show »

Length:367

Mass (Da):40,760

Checksum:ⁱ40F7FFA4519042FD

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PCM4	E9PCM4_HUMAN		D(3) dopamine receptor D(3) dopamine receptor	DRD3	367	Annotation score:

Sequence cautionⁱ

The sequence AAA03543 differs from that shown. Reason: Frameshift at position 288.Curated

The sequence AAA64369 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	396	K → L in AAH95510 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_003463	9	S → G Polymorphism; associated with susceptibility to essential tremor; risk factor for schizophrenia; gain of function. 9 PublicationsCorresponds to variant dbSNP:rs6280Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040570	287 – 320	SPTIA…QPRGV → M in isoform 3. 1 PublicationAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L20469 mRNA Translation: AAA03543.1 Frameshift. AH003061 Genomic DNA Translation: AAA64369.1 Sequence problems. U32499 mRNA Translation: AAA73929.1 AC092896 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79610.1 BC095510 mRNA Translation: AAH95510.1 BC128123 mRNA Translation: AAI28124.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2978.1 [P35462-1] CCDS33829.1 [P35462-3]
PIRⁱ	A48258 A55419 G01977
NCBI Reference Sequences More...RefSeqⁱ	NP_000787.2, NM_000796.5 NP_001269492.1, NM_001282563.2 NP_001277738.1, NM_001290809.1 NP_387512.3, NM_033663.5
UniGeneⁱ	Hs.121478

Genome annotation databases

Ensemblⁱ	ENST00000383673; ENSP00000373169; ENSG00000151577 ENST00000460779; ENSP00000419402; ENSG00000151577 ENST00000467632; ENSP00000420662; ENSG00000151577
GeneIDⁱ	1814
KEGGⁱ	hsa:1814

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35462	Dopamine D3 receptor (Fragment)		HUMAN		90	UniRef100_P35462
Dopamine D3 receptor (Fragment)		HUMAN		56

Protein	Similar proteins		Species	Score	Length	Source
P35462	Dopamine D3 receptor (Fragment)		HUMAN		90	UniRef90_P35462
Dopamine receptor D3		CHLSB		403
D(3) dopamine receptor isoform a		CALJA		400
Uncharacterized protein		COLAP		400
Uncharacterized protein		AOTNA		400
+20
P35462-3	Dopamine receptor D3		CALJA		367	UniRef90_P35462-3
D(3) dopamine receptor		PANTR		367
Uncharacterized protein		PANPA		367
D(3) dopamine receptor isoform X2		DIPOR		367
D(3) dopamine receptor		HUMAN		367
+17

Protein	Similar proteins		Species	Score	Length	Source
P35462	D(3) dopamine receptor		MOUSE		446	UniRef50_P35462
D(3) dopamine receptor		RAT		446
D(3) dopamine receptor		PANTR		400
D(3) dopamine receptor		CHLAE		400
Dopamine D3 receptor (Fragment)		HUMAN		90
+282
P35462-3	DRD3 isoform 3		PONAB		367	UniRef50_P35462-3
Uncharacterized protein		AOTNA		367
Dopamine receptor D3		CALJA		367
Uncharacterized protein		PANPA		367
Uncharacterized protein		NOMLE		367
+38

Cross-referencesⁱ

Web resourcesⁱ

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L20469 mRNA Translation: AAA03543.1 Frameshift. AH003061 Genomic DNA Translation: AAA64369.1 Sequence problems. U32499 mRNA Translation: AAA73929.1 AC092896 Genomic DNA No translation available. CH471052 Genomic DNA Translation: EAW79610.1 BC095510 mRNA Translation: AAH95510.1 BC128123 mRNA Translation: AAI28124.1
CCDSⁱ	CCDS2978.1 [P35462-1] CCDS33829.1 [P35462-3]
PIRⁱ	A48258 A55419 G01977
RefSeqⁱ	NP_000787.2, NM_000796.5 NP_001269492.1, NM_001282563.2 NP_001277738.1, NM_001290809.1 NP_387512.3, NM_033663.5
UniGeneⁱ	Hs.121478

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3PBL	X-ray	2.89	A/B	2-221	[»]
				A/B	319-400	[»]
ProteinModelPortalⁱ	P35462
SMRⁱ	P35462
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108148, 10 interactors
DIPⁱ	DIP-5976N
IntActⁱ	P35462, 6 interactors
STRINGⁱ	9606.ENSP00000373169

Chemistry databases

BindingDBⁱ	P35462
ChEMBLⁱ	CHEMBL234
DrugBankⁱ	DB05766 ACP-104 DB06288 Amisulpride DB00543 Amoxapine DB00714 Apomorphine DB01238 Aripiprazole DB09207 AS-8112 DB06216 Asenapine DB01200 Bromocriptine DB00248 Cabergoline DB09014 Captodiame DB06016 Cariprazine DB00477 Chlorpromazine DB01239 Chlorprothixene DB00363 Clozapine DB01184 Domperidone DB00988 Dopamine DB00502 Haloperidol DB04946 Iloperidone DB01235 Levodopa DB00589 Lisuride DB00408 Loxapine DB01403 Methotrimeprazine DB06148 Mianserin DB00370 Mirtazapine DB00334 Olanzapine DB01267 Paliperidone DB01186 Pergolide DB01100 Pimozide DB00413 Pramipexole DB01224 Quetiapine DB00409 Remoxipride DB00734 Risperidone DB00268 Ropinirole DB05271 Rotigotine DB05280 SLV 308 DB00391 Sulpiride DB13025 Tiapride DB01392 Yohimbine DB00246 Ziprasidone
GuidetoPHARMACOLOGYⁱ	216

Protein family/group databases

TCDBⁱ	9.A.14.3.9 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	P35462
PhosphoSitePlusⁱ	P35462
SwissPalmⁱ	P35462

Polymorphism and mutation databases

DMDMⁱ	1169206

DMDMⁱ

1169206

Proteomic databases

PaxDbⁱ	P35462
PeptideAtlasⁱ	P35462
PRIDEⁱ	P35462
ProteomicsDBⁱ	55066 55067 [P35462-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1814
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000383673; ENSP00000373169; ENSG00000151577 ENST00000460779; ENSP00000419402; ENSG00000151577 ENST00000467632; ENSP00000420662; ENSG00000151577
GeneIDⁱ	1814
KEGGⁱ	hsa:1814

Organism-specific databases

CTDⁱ	1814
DisGeNETⁱ	1814
EuPathDBⁱ	HostDB:ENSG00000151577.12
GeneCardsⁱ	DRD3
H-InvDBⁱ	HIX0030774 HIX0163472
HGNCⁱ	HGNC:3024 DRD3
MalaCardsⁱ	DRD3
MIMⁱ	126451 gene 181500 phenotype 190300 phenotype
neXtProtⁱ	NX_P35462
Orphanetⁱ	862 NON RARE IN EUROPE: Hereditary essential tremor
PharmGKBⁱ	PA27479
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P35462
KOⁱ	K04146
OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P35462
TreeFamⁱ	TF334382

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390651 Dopamine receptors R-HSA-418594 G alpha (i) signalling events
SignaLinkⁱ	P35462

Miscellaneous databases

ChiTaRSⁱ	DRD3 human
GenomeRNAiⁱ	1814
Protein Ontology More...PROⁱ	PR:P35462
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151577 Expressed in 11 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_DRD3
ExpressionAtlasⁱ	P35462 baseline and differential
Genevisibleⁱ	P35462 HS

Family and domain databases

CDDⁱ	cd15310 7tmA_D3_dopamine_R, 1 hit
InterProⁱ	View protein in InterPro IPR001620 Dopamine_D3_rcpt IPR000929 Dopamine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00568 DOPAMINED3R PR00242 DOPAMINER PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DRD3_HUMAN
Accessionⁱ	P35462Primary (citable) accession number: P35462 Secondary accession number(s): A1A4V5, Q4VBM8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	November 1, 1995
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35462 (DRD3_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

D(3) dopamine receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ