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Protein

D(3) dopamine receptor

Gene

DRD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei110Agonist1

GO - Molecular functioni

  • adrenergic receptor activity Source: GO_Central
  • D1 dopamine receptor binding Source: Ensembl
  • dopamine binding Source: GO_Central
  • dopamine neurotransmitter receptor activity, coupled via Gi/Go Source: BHF-UCL
  • drug binding Source: BHF-UCL
  • protein domain specific binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390651 Dopamine receptors
R-HSA-418594 G alpha (i) signalling events
SignaLinkiP35462

Protein family/group databases

TCDBi9.A.14.3.9 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
D(3) dopamine receptor
Alternative name(s):
Dopamine D3 receptor
Gene namesi
Name:DRD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000151577.12
HGNCiHGNC:3024 DRD3
MIMi126451 gene
neXtProtiNX_P35462

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32Extracellular1 PublicationAdd BLAST32
Transmembranei33 – 55Helical; Name=11 PublicationAdd BLAST23
Topological domaini56 – 65Cytoplasmic1 Publication10
Transmembranei66 – 88Helical; Name=21 PublicationAdd BLAST23
Topological domaini89 – 104Extracellular1 PublicationAdd BLAST16
Transmembranei105 – 126Helical; Name=31 PublicationAdd BLAST22
Topological domaini127 – 149Cytoplasmic1 PublicationAdd BLAST23
Transmembranei150 – 170Helical; Name=41 PublicationAdd BLAST21
Topological domaini171 – 187Extracellular1 PublicationAdd BLAST17
Transmembranei188 – 209Helical; Name=51 PublicationAdd BLAST22
Topological domaini210 – 329Cytoplasmic1 PublicationAdd BLAST120
Transmembranei330 – 351Helical; Name=61 PublicationAdd BLAST22
Topological domaini352 – 366Extracellular1 PublicationAdd BLAST15
Transmembranei367 – 386Helical; Name=71 PublicationAdd BLAST20
Topological domaini387 – 400Cytoplasmic1 PublicationAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Tremor, hereditary essential 1 (ETM1)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
See also OMIM:190300
Schizophrenia (SCZD)2 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
See also OMIM:181500

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNETi1814
MalaCardsiDRD3
MIMi181500 phenotype
190300 phenotype
Orphaneti862 NON RARE IN EUROPE: Hereditary essential tremor
PharmGKBiPA27479

Chemistry databases

ChEMBLiCHEMBL234
DrugBankiDB05766 ACP-104
DB06288 Amisulpride
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB09207 AS-8112
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB09014 Captodiame
DB06016 Cariprazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00363 Clozapine
DB01184 Domperidone
DB00988 Dopamine
DB00502 Haloperidol
DB04946 Iloperidone
DB01235 Levodopa
DB00589 Lisuride
DB00408 Loxapine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB01100 Pimozide
DB00413 Pramipexole
DB01224 Quetiapine
DB00409 Remoxipride
DB00734 Risperidone
DB00268 Ropinirole
DB05271 Rotigotine
DB05280 SLV 308
DB00391 Sulpiride
DB13025 Tiapride
DB01392 Yohimbine
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi216

Polymorphism and mutation databases

DMDMi1169206

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693971 – 400D(3) dopamine receptorAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 181PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi355 ↔ 358PROSITE-ProRule annotationCombined sources1 Publication

Post-translational modificationi

Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).1 Publication
Palmitoylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP35462
PeptideAtlasiP35462
PRIDEiP35462
ProteomicsDBi55066
55067 [P35462-3]

PTM databases

iPTMnetiP35462
PhosphoSitePlusiP35462
SwissPalmiP35462

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000151577 Expressed in 11 organ(s), highest expression level in nucleus accumbens
CleanExiHS_DRD3
ExpressionAtlasiP35462 baseline and differential
GenevisibleiP35462 HS

Interactioni

Subunit structurei

Interacts with CLIC6 (By similarity). Interacts with GRK4 (PubMed:19520868). Interacts with PALM (PubMed:16386234). Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA (PubMed:26460884).By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108148, 10 interactors
DIPiDIP-5976N
IntActiP35462, 6 interactors
STRINGi9606.ENSP00000373169

Chemistry databases

BindingDBiP35462

Structurei

Secondary structure

1400
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35462
SMRiP35462
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni189 – 196Agonist binding8
Regioni342 – 350Agonist binding9

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP35462
KOiK04146
OrthoDBiEOG091G06VI
PhylomeDBiP35462
TreeFamiTF334382

Family and domain databases

CDDicd15310 7tmA_D3_dopamine_R, 1 hit
InterProiView protein in InterPro
IPR001620 Dopamine_D3_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00568 DOPAMINED3R
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P35462-1) [UniParc]FASTAAdd to basket
Also known as: D3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLSQLSSH LNYTCGAENS TGASQARPHA YYALSYCALI LAIVFGNGLV
60 70 80 90 100
CMAVLKERAL QTTTNYLVVS LAVADLLVAT LVMPWVVYLE VTGGVWNFSR
110 120 130 140 150
ICCDVFVTLD VMMCTASILN LCAISIDRYT AVVMPVHYQH GTGQSSCRRV
160 170 180 190 200
ALMITAVWVL AFAVSCPLLF GFNTTGDPTV CSISNPDFVI YSSVVSFYLP
210 220 230 240 250
FGVTVLVYAR IYVVLKQRRR KRILTRQNSQ CNSVRPGFPQ QTLSPDPAHL
260 270 280 290 300
ELKRYYSICQ DTALGGPGFQ ERGGELKREE KTRNSLSPTI APKLSLEVRK
310 320 330 340 350
LSNGRLSTSL KLGPLQPRGV PLREKKATQM VAIVLGAFIV CWLPFFLTHV
360 370 380 390 400
LNTHCQTCHV SPELYSATTW LGYVNSALNP VIYTTFNIEF RKAFLKILSC
Length:400
Mass (Da):44,225
Last modified:November 1, 1995 - v2
Checksum:i2CDA789D78378DDA
GO
Isoform 3 (identifier: P35462-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     287-320: SPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGV → M

Show »
Length:367
Mass (Da):40,760
Checksum:i40F7FFA4519042FD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PCM4E9PCM4_HUMAN
D(3) dopamine receptor
DRD3
367Annotation score:

Sequence cautioni

The sequence AAA03543 differs from that shown. Reason: Frameshift at position 288.Curated
The sequence AAA64369 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti396K → L in AAH95510 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0034639S → G Polymorphism; associated with susceptibility to essential tremor; risk factor for schizophrenia; gain of function. 9 PublicationsCorresponds to variant dbSNP:rs6280Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040570287 – 320SPTIA…QPRGV → M in isoform 3. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20469 mRNA Translation: AAA03543.1 Frameshift.
AH003061 Genomic DNA Translation: AAA64369.1 Sequence problems.
U32499 mRNA Translation: AAA73929.1
AC092896 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79610.1
BC095510 mRNA Translation: AAH95510.1
BC128123 mRNA Translation: AAI28124.1
CCDSiCCDS2978.1 [P35462-1]
CCDS33829.1 [P35462-3]
PIRiA48258
A55419
G01977
RefSeqiNP_000787.2, NM_000796.5
NP_001269492.1, NM_001282563.2
NP_001277738.1, NM_001290809.1
NP_387512.3, NM_033663.5
UniGeneiHs.121478

Genome annotation databases

EnsembliENST00000383673; ENSP00000373169; ENSG00000151577
ENST00000460779; ENSP00000419402; ENSG00000151577
ENST00000467632; ENSP00000420662; ENSG00000151577
GeneIDi1814
KEGGihsa:1814

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20469 mRNA Translation: AAA03543.1 Frameshift.
AH003061 Genomic DNA Translation: AAA64369.1 Sequence problems.
U32499 mRNA Translation: AAA73929.1
AC092896 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79610.1
BC095510 mRNA Translation: AAH95510.1
BC128123 mRNA Translation: AAI28124.1
CCDSiCCDS2978.1 [P35462-1]
CCDS33829.1 [P35462-3]
PIRiA48258
A55419
G01977
RefSeqiNP_000787.2, NM_000796.5
NP_001269492.1, NM_001282563.2
NP_001277738.1, NM_001290809.1
NP_387512.3, NM_033663.5
UniGeneiHs.121478

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PBLX-ray2.89A/B2-221[»]
A/B319-400[»]
ProteinModelPortaliP35462
SMRiP35462
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108148, 10 interactors
DIPiDIP-5976N
IntActiP35462, 6 interactors
STRINGi9606.ENSP00000373169

Chemistry databases

BindingDBiP35462
ChEMBLiCHEMBL234
DrugBankiDB05766 ACP-104
DB06288 Amisulpride
DB00543 Amoxapine
DB00714 Apomorphine
DB01238 Aripiprazole
DB09207 AS-8112
DB06216 Asenapine
DB01200 Bromocriptine
DB00248 Cabergoline
DB09014 Captodiame
DB06016 Cariprazine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00363 Clozapine
DB01184 Domperidone
DB00988 Dopamine
DB00502 Haloperidol
DB04946 Iloperidone
DB01235 Levodopa
DB00589 Lisuride
DB00408 Loxapine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00334 Olanzapine
DB01267 Paliperidone
DB01186 Pergolide
DB01100 Pimozide
DB00413 Pramipexole
DB01224 Quetiapine
DB00409 Remoxipride
DB00734 Risperidone
DB00268 Ropinirole
DB05271 Rotigotine
DB05280 SLV 308
DB00391 Sulpiride
DB13025 Tiapride
DB01392 Yohimbine
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi216

Protein family/group databases

TCDBi9.A.14.3.9 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiP35462
PhosphoSitePlusiP35462
SwissPalmiP35462

Polymorphism and mutation databases

DMDMi1169206

Proteomic databases

PaxDbiP35462
PeptideAtlasiP35462
PRIDEiP35462
ProteomicsDBi55066
55067 [P35462-3]

Protocols and materials databases

DNASUi1814
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383673; ENSP00000373169; ENSG00000151577
ENST00000460779; ENSP00000419402; ENSG00000151577
ENST00000467632; ENSP00000420662; ENSG00000151577
GeneIDi1814
KEGGihsa:1814

Organism-specific databases

CTDi1814
DisGeNETi1814
EuPathDBiHostDB:ENSG00000151577.12
GeneCardsiDRD3
H-InvDBiHIX0030774
HIX0163472
HGNCiHGNC:3024 DRD3
MalaCardsiDRD3
MIMi126451 gene
181500 phenotype
190300 phenotype
neXtProtiNX_P35462
Orphaneti862 NON RARE IN EUROPE: Hereditary essential tremor
PharmGKBiPA27479
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP35462
KOiK04146
OrthoDBiEOG091G06VI
PhylomeDBiP35462
TreeFamiTF334382

Enzyme and pathway databases

ReactomeiR-HSA-390651 Dopamine receptors
R-HSA-418594 G alpha (i) signalling events
SignaLinkiP35462

Miscellaneous databases

ChiTaRSiDRD3 human
GenomeRNAii1814
PROiPR:P35462
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151577 Expressed in 11 organ(s), highest expression level in nucleus accumbens
CleanExiHS_DRD3
ExpressionAtlasiP35462 baseline and differential
GenevisibleiP35462 HS

Family and domain databases

CDDicd15310 7tmA_D3_dopamine_R, 1 hit
InterProiView protein in InterPro
IPR001620 Dopamine_D3_rcpt
IPR000929 Dopamine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00568 DOPAMINED3R
PR00242 DOPAMINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRD3_HUMAN
AccessioniPrimary (citable) accession number: P35462
Secondary accession number(s): A1A4V5, Q4VBM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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