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Protein

Lymphocyte antigen 6D

Gene

Ly6d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification.1 Publication

GO - Biological processi

  • lymphocyte differentiation Source: UniProtKB
  • response to stilbenoid Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6D
Short name:
Ly-6D
Alternative name(s):
Thymocyte B-cell antigen
Short name:
ThB
Gene namesi
Name:Ly6d
Synonyms:Ly61, Thb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96881 Ly6d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003613621 – 98Lymphocyte antigen 6DAdd BLAST78
PropeptideiPRO_000003613799 – 127Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 45By similarity
Disulfide bondi26 ↔ 32By similarity
Disulfide bondi38 ↔ 63By similarity
Disulfide bondi67 ↔ 86By similarity
Disulfide bondi87 ↔ 92By similarity
Lipidationi98GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP35459
PaxDbiP35459
PeptideAtlasiP35459
PRIDEiP35459

PTM databases

iPTMnetiP35459
PhosphoSitePlusiP35459

Expressioni

Tissue specificityi

Lymphoid cells lacking Ly6d, called ALP (all-lymphoid progenitor), retain full lymphoid potential and early thymic seeding activity, whereas cells containing Ly6d, called BLP (B-cell-biased lymphoid progenitor), up-regulate the B-cell specifying factors Ebf1 and Pax5 and behave essentially as B-cell progenitors (at protein level). Thymocytes and B-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000034634 Expressed in 97 organ(s), highest expression level in tail skin
CleanExiMM_LY6D
GenevisibleiP35459 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047419

Structurei

3D structure databases

ProteinModelPortaliP35459
SMRiP35459
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 108UPAR/Ly6Add BLAST88

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2E2 Eukaryota
ENOG4111DU7 LUCA
GeneTreeiENSGT00730000111514
HOGENOMiHOG000035114
HOVERGENiHBG096383
InParanoidiP35459
KOiK06846
OMAiLRCHVCT
OrthoDBiEOG091G0TV7
PhylomeDBiP35459
TreeFamiTF336080

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35459-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTALLVLLV LAVATSPAWA LRCHVCTNSA NCKNPQVCPS NFYFCKTVTS
60 70 80 90 100
VEPLNGNLVR KECANSCTSD YSQQGHVSSG SEVTQCCQTD LCNERLVSAA
110 120
PGHALLSSVT LGLATSLSLL TVMALCL
Length:127
Mass (Da):13,396
Last modified:June 1, 1994 - v1
Checksum:i0AF039B77D105917
GO

Sequence cautioni

The sequence AAA79249 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63782 mRNA Translation: CAA45317.1
L40419 Genomic DNA Translation: AAA79249.1 Different initiation.
BC025135 mRNA Translation: AAH25135.1
CCDSiCCDS27531.1
PIRiA46528
I54553
RefSeqiNP_034872.1, NM_010742.1
UniGeneiMm.878

Genome annotation databases

EnsembliENSMUST00000040404; ENSMUSP00000047419; ENSMUSG00000034634
GeneIDi17068
KEGGimmu:17068
UCSCiuc007wfx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63782 mRNA Translation: CAA45317.1
L40419 Genomic DNA Translation: AAA79249.1 Different initiation.
BC025135 mRNA Translation: AAH25135.1
CCDSiCCDS27531.1
PIRiA46528
I54553
RefSeqiNP_034872.1, NM_010742.1
UniGeneiMm.878

3D structure databases

ProteinModelPortaliP35459
SMRiP35459
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047419

PTM databases

iPTMnetiP35459
PhosphoSitePlusiP35459

Proteomic databases

MaxQBiP35459
PaxDbiP35459
PeptideAtlasiP35459
PRIDEiP35459

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040404; ENSMUSP00000047419; ENSMUSG00000034634
GeneIDi17068
KEGGimmu:17068
UCSCiuc007wfx.1 mouse

Organism-specific databases

CTDi8581
MGIiMGI:96881 Ly6d

Phylogenomic databases

eggNOGiENOG410J2E2 Eukaryota
ENOG4111DU7 LUCA
GeneTreeiENSGT00730000111514
HOGENOMiHOG000035114
HOVERGENiHBG096383
InParanoidiP35459
KOiK06846
OMAiLRCHVCT
OrthoDBiEOG091G0TV7
PhylomeDBiP35459
TreeFamiTF336080

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

PROiPR:P35459
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034634 Expressed in 97 organ(s), highest expression level in tail skin
CleanExiMM_LY6D
GenevisibleiP35459 MM

Family and domain databases

InterProiView protein in InterPro
IPR018363 CD59_antigen_CS
IPR016054 LY6_UPA_recep-like
PfamiView protein in Pfam
PF00021 UPAR_LY6, 1 hit
SMARTiView protein in SMART
SM00134 LU, 1 hit
PROSITEiView protein in PROSITE
PS00983 LY6_UPAR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLY6D_MOUSE
AccessioniPrimary (citable) accession number: P35459
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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