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Protein

Vasopressin-neurophysin 2-copeptin

Gene

Avp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Neurophysin 2 specifically binds vasopressin.
Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei32Important for agonist activity on V1aR/AVPR1ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone, Vasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-MMU-388479 Vasopressin-like receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-418555 G alpha (s) signalling events
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-879518 Transport of organic anions
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin-neurophysin 2-copeptin
Alternative name(s):
AVP-NPII
Cleaved into the following 3 chains:
Alternative name(s):
Arginine-vasopressin
Alternative name(s):
Neurophysin-I
Gene namesi
Name:Avp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88121 Avp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PeptideiPRO_000002051824 – 32Arg-vasopressin9
ChainiPRO_000002051936 – 128Neurophysin 2Add BLAST93
PeptideiPRO_0000020520130 – 168CopeptinAdd BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 29By similarity
Modified residuei32Glycine amideBy similarity1
Disulfide bondi45 ↔ 89By similarity
Disulfide bondi48 ↔ 62By similarity
Disulfide bondi56 ↔ 79By similarity
Disulfide bondi63 ↔ 69By similarity
Disulfide bondi96 ↔ 108By similarity
Disulfide bondi102 ↔ 120By similarity
Disulfide bondi109 ↔ 114By similarity
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35455
PeptideAtlasiP35455
PRIDEiP35455

PTM databases

PhosphoSitePlusiP35455

Expressioni

Gene expression databases

BgeeiENSMUSG00000037727 Expressed in 85 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_AVP
ExpressionAtlasiP35455 baseline and differential
GenevisibleiP35455 MM

Interactioni

Subunit structurei

Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035551

Structurei

3D structure databases

ProteinModelPortaliP35455
SMRiP35455
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXM5 Eukaryota
ENOG4111S8B LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP35455
KOiK05242
OMAiSGLCCNS
OrthoDBiEOG091G0V8Z
PhylomeDBiP35455
TreeFamiTF333018

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35455-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARMLNTTL SACFLSLLAF SSACYFQNCP RGGKRAISDM ELRQCLPCGP
60 70 80 90 100
GGKGRCFGPS ICCADELGCF VGTAEALRCQ EENYLPSPCQ SGQKPCGSGG
110 120 130 140 150
RCAAVGICCS DESCVAEPEC HDGFFRLTRA REPSNATQLD GPARALLLRL
160
VQLAGTRESV DSAKPRVY
Length:168
Mass (Da):17,900
Last modified:June 1, 1994 - v1
Checksum:i234F6D826E0BBEE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88354 Genomic DNA Translation: AAC42027.1
BC051997 mRNA Translation: AAH51997.1
CCDSiCCDS16746.1
PIRiB43755
RefSeqiNP_033862.1, NM_009732.2
UniGeneiMm.6190

Genome annotation databases

EnsembliENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727
GeneIDi11998
KEGGimmu:11998
UCSCiuc008mjh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88354 Genomic DNA Translation: AAC42027.1
BC051997 mRNA Translation: AAH51997.1
CCDSiCCDS16746.1
PIRiB43755
RefSeqiNP_033862.1, NM_009732.2
UniGeneiMm.6190

3D structure databases

ProteinModelPortaliP35455
SMRiP35455
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035551

PTM databases

PhosphoSitePlusiP35455

Proteomic databases

PaxDbiP35455
PeptideAtlasiP35455
PRIDEiP35455

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046001; ENSMUSP00000035551; ENSMUSG00000037727
GeneIDi11998
KEGGimmu:11998
UCSCiuc008mjh.1 mouse

Organism-specific databases

CTDi551
MGIiMGI:88121 Avp

Phylogenomic databases

eggNOGiENOG410IXM5 Eukaryota
ENOG4111S8B LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP35455
KOiK05242
OMAiSGLCCNS
OrthoDBiEOG091G0V8Z
PhylomeDBiP35455
TreeFamiTF333018

Enzyme and pathway databases

ReactomeiR-MMU-388479 Vasopressin-like receptors
R-MMU-416476 G alpha (q) signalling events
R-MMU-418555 G alpha (s) signalling events
R-MMU-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-MMU-879518 Transport of organic anions
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

PROiPR:P35455
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037727 Expressed in 85 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_AVP
ExpressionAtlasiP35455 baseline and differential
GenevisibleiP35455 MM

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEU2_MOUSE
AccessioniPrimary (citable) accession number: P35455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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