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Protein

Oxytocin-neurophysin 1

Gene

Oxt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-388479 Vasopressin-like receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytocin-neurophysin 1
Short name:
OT-NPI
Cleaved into the following 2 chains:
Alternative name(s):
Ocytocin
Gene namesi
Name:Oxt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:97453 Oxt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
PeptideiPRO_000002049720 – 28Oxytocin9
ChainiPRO_000002049832 – 125Neurophysin 1Add BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi20 ↔ 25By similarity
Modified residuei28Glycine amideBy similarity1
Disulfide bondi41 ↔ 85By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi52 ↔ 75By similarity
Disulfide bondi59 ↔ 65By similarity
Disulfide bondi92 ↔ 104By similarity
Disulfide bondi98 ↔ 116By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP35454
PeptideAtlasiP35454
PRIDEiP35454

Miscellaneous databases

PMAP-CutDBiP35454

Expressioni

Gene expression databases

BgeeiENSMUSG00000027301 Expressed in 63 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_OXT
ExpressionAtlasiP35454 baseline and differential
GenevisibleiP35454 MM

Interactioni

Subunit structurei

Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028764

Structurei

3D structure databases

ProteinModelPortaliP35454
SMRiP35454
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3A8 Eukaryota
ENOG41124QF LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP35454
KOiK05243
OMAiGLCCDAE
OrthoDBiEOG091G0V8Z
PhylomeDBiP35454
TreeFamiTF333018

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35454-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA
110 120
TGICCSPDGC RTDPACDPES AFSER
Length:125
Mass (Da):12,851
Last modified:June 1, 1994 - v1
Checksum:i96D3135EBBA2436E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88355 Genomic DNA Translation: AAC42024.1
AF483508 mRNA Translation: AAL90782.1
AF483509 mRNA Translation: AAL90783.1
CCDSiCCDS16745.1
PIRiA43755
RefSeqiNP_035155.1, NM_011025.4
UniGeneiMm.16745

Genome annotation databases

EnsembliENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301
GeneIDi18429
KEGGimmu:18429
UCSCiuc008mjg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88355 Genomic DNA Translation: AAC42024.1
AF483508 mRNA Translation: AAL90782.1
AF483509 mRNA Translation: AAL90783.1
CCDSiCCDS16745.1
PIRiA43755
RefSeqiNP_035155.1, NM_011025.4
UniGeneiMm.16745

3D structure databases

ProteinModelPortaliP35454
SMRiP35454
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028764

Proteomic databases

PaxDbiP35454
PeptideAtlasiP35454
PRIDEiP35454

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301
GeneIDi18429
KEGGimmu:18429
UCSCiuc008mjg.2 mouse

Organism-specific databases

CTDi5020
MGIiMGI:97453 Oxt

Phylogenomic databases

eggNOGiENOG410J3A8 Eukaryota
ENOG41124QF LUCA
GeneTreeiENSGT00390000004511
HOGENOMiHOG000113768
HOVERGENiHBG004462
InParanoidiP35454
KOiK05243
OMAiGLCCDAE
OrthoDBiEOG091G0V8Z
PhylomeDBiP35454
TreeFamiTF333018

Enzyme and pathway databases

ReactomeiR-MMU-388479 Vasopressin-like receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PMAP-CutDBiP35454
PROiPR:P35454
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027301 Expressed in 63 organ(s), highest expression level in supraoptic nucleus
CleanExiMM_OXT
ExpressionAtlasiP35454 baseline and differential
GenevisibleiP35454 MM

Family and domain databases

Gene3Di2.60.9.10, 1 hit
InterProiView protein in InterPro
IPR000981 Neurhyp_horm
IPR036387 Neurhyp_horm_dom_sf
IPR022423 Neurohypophysial_hormone_CS
PANTHERiPTHR11681 PTHR11681, 1 hit
PfamiView protein in Pfam
PF00220 Hormone_4, 1 hit
PF00184 Hormone_5, 1 hit
PIRSFiPIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSiPR00831 NEUROPHYSIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001676 Neurhyp_horm, 1 hit
SMARTiView protein in SMART
SM00003 NH, 1 hit
SUPFAMiSSF49606 SSF49606, 1 hit
PROSITEiView protein in PROSITE
PS00264 NEUROHYPOPHYS_HORM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEU1_MOUSE
AccessioniPrimary (citable) accession number: P35454
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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