Oxt

Functionⁱ

Neurophysin 1 specifically binds oxytocin.

Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).By similarity

GO - Molecular functionⁱ

neurohypophyseal hormone activity Source: InterPro
neuropeptide hormone activity Source: MGI
oxytocin receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

drinking behavior Source: MGI
eating behavior Source: MGI
female pregnancy Source: Ensembl
grooming behavior Source: MGI
heart development Source: Ensembl
hyperosmotic salinity response Source: Ensembl
male mating behavior Source: Ensembl
maternal aggressive behavior Source: Ensembl
maternal behavior Source: MGI
memory Source: Ensembl
negative regulation of blood pressure Source: MGI
negative regulation of gastric acid secretion Source: MGI
negative regulation of urine volume Source: MGI
positive regulation of blood pressure Source: MGI
positive regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from mutant phenotypeⁱ
- 18071238
positive regulation of cytosolic calcium ion concentration Source: MGI
positive regulation of female receptivity Source: MGI
positive regulation of hindgut contraction Source: MGI
positive regulation of norepinephrine secretion Source: MGI
positive regulation of ossification Source: MGI
positive regulation of penile erection Source: MGI
positive regulation of prostaglandin secretion Source: MGI
positive regulation of renal sodium excretion Source: MGI
positive regulation of synapse assembly Source: MGI
positive regulation of synaptic transmission Source: MGI
positive regulation of uterine smooth muscle contraction Source: MGI
regulation of digestive system process Source: MGI
regulation of heart rate Source: MGI
regulation of sensory perception of pain Source: MGI
response to activity Source: Ensembl
response to amphetamine Source: Ensembl
response to cAMP Source: Ensembl
response to cocaine Source: Ensembl
response to electrical stimulus Source: Ensembl
response to estradiol Source: Ensembl
response to ether Source: Ensembl
response to external biotic stimulus Source: AgBase
response to food Source: AgBase
response to glucocorticoid Source: Ensembl
response to mechanical stimulus Source: AgBase
response to organic cyclic compound Source: MGI
response to peptide hormone Source: Ensembl
response to progesterone Source: MGI
response to prostaglandin E Source: Ensembl
response to retinoic acid Source: Ensembl
response to sucrose Source: Ensembl
sleep Source: MGI
social behavior Source: MGI
sperm ejaculation Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-MMU-388479 Vasopressin-like receptors R-MMU-416476 G alpha (q) signalling events

Reactomeⁱ

R-MMU-388479 Vasopressin-like receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Oxytocin-neurophysin 1 Short name: OT-NPI Cleaved into the following 2 chains: Oxytocin Alternative name(s): Ocytocin Neurophysin 1
Gene namesⁱ	Name:Oxt
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:97453 Oxt

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 19	By similarityAdd BLAST	19
PeptideⁱPRO_0000020497	20 – 28	Oxytocin	9
ChainⁱPRO_0000020498	32 – 125	Neurophysin 1Add BLAST	94

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	20 ↔ 25	By similarity
Modified residueⁱ	28	Glycine amideBy similarity	1
Disulfide bondⁱ	41 ↔ 85	By similarity
Disulfide bondⁱ	44 ↔ 58	By similarity
Disulfide bondⁱ	52 ↔ 75	By similarity
Disulfide bondⁱ	59 ↔ 65	By similarity
Disulfide bondⁱ	92 ↔ 104	By similarity
Disulfide bondⁱ	98 ↔ 116	By similarity
Disulfide bondⁱ	105 ↔ 110	By similarity

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbⁱ	P35454
PeptideAtlas More...PeptideAtlasⁱ	P35454
PRIDEⁱ	P35454

Miscellaneous databases

PMAP-CutDBⁱ

P35454

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027301 Expressed in 63 organ(s), highest expression level in supraoptic nucleus
CleanExⁱ	MM_OXT
ExpressionAtlasⁱ	P35454 baseline and differential
Genevisibleⁱ	P35454 MM

Interactionⁱ

Subunit structureⁱ

Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity). Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).By similarity

GO - Molecular functionⁱ

neurohypophyseal hormone activity Source: InterPro
neuropeptide hormone activity Source: MGI
oxytocin receptor binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000028764

STRINGⁱ

10090.ENSMUSP00000028764

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35454
SMRⁱ	P35454
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the vasopressin/oxytocin family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J3A8 Eukaryota ENOG41124QF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004511
HOGENOMⁱ	HOG000113768
HOVERGENⁱ	HBG004462
InParanoidⁱ	P35454
KEGG Orthology (KO) More...KOⁱ	K05243
OMAⁱ	GLCCDAE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0V8Z
PhylomeDBⁱ	P35454
TreeFamⁱ	TF333018

Family and domain databases

Gene3Dⁱ	2.60.9.10, 1 hit
InterProⁱ	View protein in InterPro IPR000981 Neurhyp_horm IPR036387 Neurhyp_horm_dom_sf IPR022423 Neurohypophysial_hormone_CS
PANTHERⁱ	PTHR11681 PTHR11681, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00220 Hormone_4, 1 hit PF00184 Hormone_5, 1 hit
PIRSFⁱ	PIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSⁱ	PR00831 NEUROPHYSIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD001676 Neurhyp_horm, 1 hit
SMARTⁱ	View protein in SMART SM00003 NH, 1 hit
SUPFAMⁱ	SSF49606 SSF49606, 1 hit
PROSITEⁱ	View protein in PROSITE PS00264 NEUROHYPOPHYS_HORM, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P35454-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG 
        60         70         80         90        100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA 
       110        120 
TGICCSPDGC RTDPACDPES AFSER

Length:125

Mass (Da):12,851

Last modified:June 1, 1994 - v1

Checksum:ⁱ96D3135EBBA2436E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M88355 Genomic DNA Translation: AAC42024.1 AF483508 mRNA Translation: AAL90782.1 AF483509 mRNA Translation: AAL90783.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16745.1
PIRⁱ	A43755
NCBI Reference Sequences More...RefSeqⁱ	NP_035155.1, NM_011025.4
UniGeneⁱ	Mm.16745

Genome annotation databases

Ensemblⁱ	ENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301
GeneIDⁱ	18429
KEGGⁱ	mmu:18429
UCSC genome browser More...UCSCⁱ	uc008mjg.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
P35454	Oxytocin		MOUSE		125	UniRef100_P35454
Oxytocin (Fragment)		MOUSE		101

Protein	Similar proteins		Species	Score	Length	Source
P35454	Oxytocin		MOUSE		125	UniRef90_P35454
Oxytocin (Fragment)		MOUSE		101
Oxytocin (Fragment)		MOUSE		99
UPI0003D6F91C		MOUSE		129

Protein	Similar proteins		Species	Score	Length	Source
P35454	Oxytocin		MOUSE		125	UniRef50_P35454
UPI0004ED5826		NANGA		125
UPI00077DAE2D		PERMB		129
UPI0001DEABA4		AILME		140
UPI000333BF04		ECHTE		161
+4

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M88355 Genomic DNA Translation: AAC42024.1 AF483508 mRNA Translation: AAL90782.1 AF483509 mRNA Translation: AAL90783.1
CCDSⁱ	CCDS16745.1
PIRⁱ	A43755
RefSeqⁱ	NP_035155.1, NM_011025.4
UniGeneⁱ	Mm.16745

3D structure databases

ProteinModelPortalⁱ	P35454
SMRⁱ	P35454
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000028764

STRINGⁱ

10090.ENSMUSP00000028764

Proteomic databases

PaxDbⁱ	P35454
PeptideAtlasⁱ	P35454
PRIDEⁱ	P35454

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301
GeneIDⁱ	18429
KEGGⁱ	mmu:18429
UCSCⁱ	uc008mjg.2 mouse

Organism-specific databases

CTDⁱ	5020
MGIⁱ	MGI:97453 Oxt

Phylogenomic databases

eggNOGⁱ	ENOG410J3A8 Eukaryota ENOG41124QF LUCA
GeneTreeⁱ	ENSGT00390000004511
HOGENOMⁱ	HOG000113768
HOVERGENⁱ	HBG004462
InParanoidⁱ	P35454
KOⁱ	K05243
OMAⁱ	GLCCDAE
OrthoDBⁱ	EOG091G0V8Z
PhylomeDBⁱ	P35454
TreeFamⁱ	TF333018

Enzyme and pathway databases

Reactomeⁱ	R-MMU-388479 Vasopressin-like receptors R-MMU-416476 G alpha (q) signalling events

Reactomeⁱ

R-MMU-388479 Vasopressin-like receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PMAP-CutDBⁱ	P35454
Protein Ontology More...PROⁱ	PR:P35454
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027301 Expressed in 63 organ(s), highest expression level in supraoptic nucleus
CleanExⁱ	MM_OXT
ExpressionAtlasⁱ	P35454 baseline and differential
Genevisibleⁱ	P35454 MM

Family and domain databases

Gene3Dⁱ	2.60.9.10, 1 hit
InterProⁱ	View protein in InterPro IPR000981 Neurhyp_horm IPR036387 Neurhyp_horm_dom_sf IPR022423 Neurohypophysial_hormone_CS
PANTHERⁱ	PTHR11681 PTHR11681, 1 hit
Pfamⁱ	View protein in Pfam PF00220 Hormone_4, 1 hit PF00184 Hormone_5, 1 hit
PIRSFⁱ	PIRSF001815 Nonapeptide_hormone_precursor, 1 hit
PRINTSⁱ	PR00831 NEUROPHYSIN
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD001676 Neurhyp_horm, 1 hit
SMARTⁱ	View protein in SMART SM00003 NH, 1 hit
SUPFAMⁱ	SSF49606 SSF49606, 1 hit
PROSITEⁱ	View protein in PROSITE PS00264 NEUROHYPOPHYS_HORM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEU1_MOUSE
Accessionⁱ	P35454Primary (citable) accession number: P35454
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35454 (NEU1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Oxytocin-neurophysin 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ