UniProtKB - P35454 (NEU1_MOUSE)
Protein
Oxytocin-neurophysin 1
Gene
Oxt
Organism
Mus musculus (Mouse)
Status
Functioni
Neurophysin 1 specifically binds oxytocin.
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR) (By similarity).By similarity
GO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
- neuropeptide hormone activity Source: MGI
- oxytocin receptor binding Source: MGI
GO - Biological processi
- drinking behavior Source: MGI
- eating behavior Source: MGI
- female pregnancy Source: Ensembl
- grooming behavior Source: MGI
- heart development Source: Ensembl
- hyperosmotic salinity response Source: Ensembl
- male mating behavior Source: Ensembl
- maternal aggressive behavior Source: Ensembl
- maternal behavior Source: MGI
- memory Source: Ensembl
- negative regulation of blood pressure Source: MGI
- negative regulation of gastric acid secretion Source: MGI
- negative regulation of urine volume Source: MGI
- positive regulation of blood pressure Source: MGI
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of female receptivity Source: MGI
- positive regulation of hindgut contraction Source: MGI
- positive regulation of norepinephrine secretion Source: MGI
- positive regulation of ossification Source: MGI
- positive regulation of penile erection Source: MGI
- positive regulation of prostaglandin secretion Source: MGI
- positive regulation of renal sodium excretion Source: MGI
- positive regulation of synapse assembly Source: MGI
- positive regulation of synaptic transmission Source: MGI
- positive regulation of uterine smooth muscle contraction Source: MGI
- regulation of digestive system process Source: MGI
- regulation of heart rate Source: MGI
- regulation of sensory perception of pain Source: MGI
- response to activity Source: Ensembl
- response to amphetamine Source: Ensembl
- response to cAMP Source: Ensembl
- response to cocaine Source: Ensembl
- response to electrical stimulus Source: Ensembl
- response to estradiol Source: Ensembl
- response to ether Source: Ensembl
- response to external biotic stimulus Source: AgBase
- response to food Source: AgBase
- response to glucocorticoid Source: Ensembl
- response to mechanical stimulus Source: AgBase
- response to organic cyclic compound Source: MGI
- response to peptide hormone Source: Ensembl
- response to progesterone Source: MGI
- response to prostaglandin E Source: Ensembl
- response to retinoic acid Source: Ensembl
- response to sucrose Source: Ensembl
- sleep Source: MGI
- social behavior Source: MGI
- sperm ejaculation Source: MGI
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
Reactomei | R-MMU-388479, Vasopressin-like receptors R-MMU-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Oxytocin-neurophysin 1Short name: OT-NPI Cleaved into the following 2 chains: |
Gene namesi | Name:Oxt |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97453, Oxt |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: AgBase
Other locations
- cytoplasm Source: MGI
- secretory granule Source: MGI
- terminal bouton Source: MGI
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | By similarityAdd BLAST | 19 | |
PeptideiPRO_0000020497 | 20 – 28 | Oxytocin | 9 | |
ChainiPRO_0000020498 | 32 – 125 | Neurophysin 1Add BLAST | 94 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 20 ↔ 25 | By similarity | ||
Modified residuei | 28 | Glycine amideBy similarity | 1 | |
Disulfide bondi | 41 ↔ 85 | By similarity | ||
Disulfide bondi | 44 ↔ 58 | By similarity | ||
Disulfide bondi | 52 ↔ 75 | By similarity | ||
Disulfide bondi | 59 ↔ 65 | By similarity | ||
Disulfide bondi | 92 ↔ 104 | By similarity | ||
Disulfide bondi | 98 ↔ 116 | By similarity | ||
Disulfide bondi | 105 ↔ 110 | By similarity |
Keywords - PTMi
Amidation, Cleavage on pair of basic residues, Disulfide bondProteomic databases
PaxDbi | P35454 |
PeptideAtlasi | P35454 |
PRIDEi | P35454 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000027301, Expressed in supraoptic nucleus and 82 other tissues |
ExpressionAtlasi | P35454, baseline and differential |
Genevisiblei | P35454, MM |
Interactioni
Subunit structurei
Interacts with oxytocin receptor (Ki=1.5 nM) (By similarity).
Interacts with vasopressin V1aR/AVPR1A (Ki=37 nM), V1bR/AVPR1B (Ki=222 nM), and V2R/AVPR2 receptors (Ki=823 nM) (By similarity).
By similarityGO - Molecular functioni
- neurohypophyseal hormone activity Source: InterPro
- neuropeptide hormone activity Source: MGI
- oxytocin receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201996, 3 interactors |
STRINGi | 10090.ENSMUSP00000028764 |
Miscellaneous databases
RNActi | P35454, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the vasopressin/oxytocin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S2CT, Eukaryota |
GeneTreei | ENSGT00390000004511 |
HOGENOMi | CLU_125770_1_0_1 |
InParanoidi | P35454 |
OMAi | DMRKCLP |
OrthoDBi | 1548839at2759 |
PhylomeDBi | P35454 |
TreeFami | TF333018 |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35454-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MACPSLACCL LGLLALTSAC YIQNCPLGGK RAVLDLDMRK CLPCGPGGKG
60 70 80 90 100
RCFGPSICCA DELGCFVGTA EALRCQEENY LPSPCQSGQK PCGSGGRCAA
110 120
TGICCSPDGC RTDPACDPES AFSER
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88355 Genomic DNA Translation: AAC42024.1 AF483508 mRNA Translation: AAL90782.1 AF483509 mRNA Translation: AAL90783.1 |
CCDSi | CCDS16745.1 |
PIRi | A43755 |
RefSeqi | NP_035155.1, NM_011025.4 |
Genome annotation databases
Ensembli | ENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301 |
GeneIDi | 18429 |
KEGGi | mmu:18429 |
UCSCi | uc008mjg.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M88355 Genomic DNA Translation: AAC42024.1 AF483508 mRNA Translation: AAL90782.1 AF483509 mRNA Translation: AAL90783.1 |
CCDSi | CCDS16745.1 |
PIRi | A43755 |
RefSeqi | NP_035155.1, NM_011025.4 |
3D structure databases
SMRi | P35454 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201996, 3 interactors |
STRINGi | 10090.ENSMUSP00000028764 |
Proteomic databases
PaxDbi | P35454 |
PeptideAtlasi | P35454 |
PRIDEi | P35454 |
Protocols and materials databases
Antibodypediai | 7257, 241 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028764; ENSMUSP00000028764; ENSMUSG00000027301 |
GeneIDi | 18429 |
KEGGi | mmu:18429 |
UCSCi | uc008mjg.2, mouse |
Organism-specific databases
CTDi | 5020 |
MGIi | MGI:97453, Oxt |
Phylogenomic databases
eggNOGi | ENOG502S2CT, Eukaryota |
GeneTreei | ENSGT00390000004511 |
HOGENOMi | CLU_125770_1_0_1 |
InParanoidi | P35454 |
OMAi | DMRKCLP |
OrthoDBi | 1548839at2759 |
PhylomeDBi | P35454 |
TreeFami | TF333018 |
Enzyme and pathway databases
Reactomei | R-MMU-388479, Vasopressin-like receptors R-MMU-416476, G alpha (q) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 18429, 0 hits in 17 CRISPR screens |
ChiTaRSi | Oxt, mouse |
PROi | PR:P35454 |
RNActi | P35454, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027301, Expressed in supraoptic nucleus and 82 other tissues |
ExpressionAtlasi | P35454, baseline and differential |
Genevisiblei | P35454, MM |
Family and domain databases
Gene3Di | 2.60.9.10, 1 hit |
InterProi | View protein in InterPro IPR000981, Neurhyp_horm IPR036387, Neurhyp_horm_dom_sf IPR022423, Neurohypophysial_hormone_CS |
PANTHERi | PTHR11681, PTHR11681, 1 hit |
Pfami | View protein in Pfam PF00220, Hormone_4, 1 hit PF00184, Hormone_5, 1 hit |
PIRSFi | PIRSF001815, Nonapeptide_hormone_precursor, 1 hit |
PRINTSi | PR00831, NEUROPHYSIN |
SMARTi | View protein in SMART SM00003, NH, 1 hit |
SUPFAMi | SSF49606, SSF49606, 1 hit |
PROSITEi | View protein in PROSITE PS00264, NEUROHYPOPHYS_HORM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NEU1_MOUSE | |
Accessioni | P35454Primary (citable) accession number: P35454 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families