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Entry version 177 (31 Jul 2019)
Sequence version 3 (10 Feb 2009)
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Protein

Homeobox protein Hox-D13

Gene

HOXD13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific transcription factor that binds gene promoters and activates their transcription (PubMed:24789103). Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity).By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi276 – 335HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P35453

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Hox-D13
Alternative name(s):
Homeobox protein Hox-4I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOXD13
Synonyms:HOX4I
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5136 HOXD13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142989 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35453

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Synpolydactyly 1 (SPD1)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionLimb malformation that shows a characteristic manifestation in both hands and feet. This condition is inherited as an autosomal dominant trait with reduced penetrance.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00381857A → AAAAAAAAAA in SPD1. 2 Publications1
Natural variantiVAR_076833306R → G in SPD1; decreases the transcriptional activator activity. 1 PublicationCorresponds to variant dbSNP:rs28933082EnsemblClinVar.1
Natural variantiVAR_076834306R → Q in SPD1; decreases the transcriptional activator activity. 1 PublicationCorresponds to variant dbSNP:rs879255265EnsemblClinVar.1
Natural variantiVAR_031651306R → W in SPD1. 1 PublicationCorresponds to variant dbSNP:rs28933082EnsemblClinVar.1
Natural variantiVAR_075400313T → R in SPD1; disrupts interaction with DNA. 1 Publication1
Brachydactyly D (BDD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type D is characterized by short and broad terminal phalanges of the thumbs and big toes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015952316S → C in BDE1 and BDD. 1 PublicationCorresponds to variant dbSNP:rs28928892EnsemblClinVar.1
Syndactyly 5 (SDTY5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of syndactyly, a congenital anomaly of the hand or foot marked by persistence of the webbing between adjacent digits that are more or less completely attached. The characteristic finding in SDTY5 is the presence of an associated metacarpal and metatarsal fusion. The metacarpals and metatarsals most commonly fused are the 4th and 5th or the 3rd and 4th. Soft tissue syndactyly usually affects the 3rd and 4th fingers and the 2nd and 3rd toes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031652325Q → R in SDTY5; impairs capacity to transactivate EPHA7 promoter. 2 PublicationsCorresponds to variant dbSNP:rs104893635EnsemblClinVar.1
Brachydactyly-syndactyly syndrome (BDSD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by generalized shortening of the hands and feet, broad and short distal phalanges of the thumbs, and cutaneous syndactyly of toes 2 and 3. The limb phenotypes observed in this syndrome overlap those of brachydactyly types A4, D, E and syndactyly type 1.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03164957 – 63Missing in BDSD; does not affect capacity to transactivate EPHA7 promoter. 7
Brachydactyly E1 (BDE1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type E is characterized by shortening of the fingers mainly in the metacarpals and metatarsals. Wide variability in the number of digits affected occurs from person to person, even in the same family. Some individuals are moderately short of stature. Brachydactyly type E1 is characterized by shortening limited to fourth metacarpals and/or metatarsals.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015952316S → C in BDE1 and BDD. 1 PublicationCorresponds to variant dbSNP:rs28928892EnsemblClinVar.1
Natural variantiVAR_015953322I → L in BDE1; decreases the transcriptional activator activity. 2 PublicationsCorresponds to variant dbSNP:rs28928891EnsemblClinVar.1
VACTERL association (VACTERL)1 Publication
The gene represented in this entry may be involved in disease pathogenesis.
Disease descriptionVACTERL is an acronym for vertebral anomalies, anal atresia, congenital cardiac disease, tracheoesophageal fistula, renal anomalies, radial dysplasia, and other limb defects.
Related information in OMIM
Brachydactyly-syndactyly-oligodactyly syndrome (BDSDO)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by a complex brachydactyly-syndactyly-oligodactyly phenotype. Limb anomalies include reduced number of digits that are severely shortened, camptodactyly, syndactyly, absence of terminal phalanges of the thumbs, and absence of nails of the thumbs and toes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076835325Q → K in BDSDO. 1 PublicationCorresponds to variant dbSNP:rs875989842EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3239

MalaCards human disease database

More...
MalaCardsi
HOXD13
MIMi113200 phenotype
113300 phenotype
186000 phenotype
186300 phenotype
192350 phenotype
610713 phenotype

Open Targets

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OpenTargetsi
ENSG00000128714

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93387 Brachydactyly type E
93409 Brachydactyly-syndactyly, Zhao type
93385 NON RARE IN EUROPE: Brachydactyly type D
93406 Syndactyly type 5
295195 Synpolydactyly type 1
887 VACTERL/VATER association
295191 Zygodactyly type 3

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29410

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
HOXD13

Domain mapping of disease mutations (DMDM)

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DMDMi
223590221

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002002441 – 343Homeobox protein Hox-D13Add BLAST343

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P35453

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P35453

MaxQB - The MaxQuant DataBase

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MaxQBi
P35453

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P35453

PeptideAtlas

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PeptideAtlasi
P35453

PRoteomics IDEntifications database

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PRIDEi
P35453

ProteomicsDB human proteome resource

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ProteomicsDBi
55065

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P35453

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P35453

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000128714 Expressed in 36 organ(s), highest expression level in ectocervix

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P35453 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA064064

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109479, 54 interactors

Protein interaction database and analysis system

More...
IntActi
P35453, 17 interactors

Molecular INTeraction database

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MINTi
P35453

STRING: functional protein association networks

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STRINGi
9606.ENSP00000376322

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35453

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 30Poly-Ser6
Compositional biasi32 – 36Poly-Ala5
Compositional biasi57 – 71Poly-AlaAdd BLAST15
Compositional biasi85 – 92Poly-Ser8
Compositional biasi113 – 118Poly-Ala6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0487 Eukaryota
ENOG4111FJP LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161457

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231176

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P35453

KEGG Orthology (KO)

More...
KOi
K09298

Identification of Orthologs from Complete Genome Data

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OMAi
FAYPGTS

Database of Orthologous Groups

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OrthoDBi
1042780at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P35453

TreeFam database of animal gene trees

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TreeFami
TF330813

Family and domain databases

Conserved Domains Database

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CDDi
cd00086 homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046 Homeodomain, 1 hit
PF12284 HoxA13_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00389 HOX, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P35453-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRAGSWDMD GLRADGGGAG GAPASSSSSS VAAAAASGQC RGFLSAPVFA
60 70 80 90 100
GTHSGRAAAA AAAAAAAAAA ASGFAYPGTS ERTGSSSSSS SSAVVAARPE
110 120 130 140 150
APPAKECPAP TPAAAAAAPP SAPALGYGYH FGNGYYSCRM SHGVGLQQNA
160 170 180 190 200
LKSSPHASLG GFPVEKYMDV SGLASSSVPA NEVPARAKEV SFYQGYTSPY
210 220 230 240 250
QHVPGYIDMV STFGSGEPRH EAYISMEGYQ SWTLANGWNS QVYCTKDQPQ
260 270 280 290 300
GSHFWKSSFP GDVALNQPDM CVYRRGRKKR VPYTKLQLKE LENEYAINKF
310 320 330 340
INKDKRRRIS AATNLSERQV TIWFQNRRVK DKKIVSKLKD TVS
Length:343
Mass (Da):36,101
Last modified:February 10, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF34D0319021430A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC51635 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA95352 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA95352 differs from that shown. Reason: Erroneous initiation.Curated

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-Ala region is polymorphic (11 to 15 residues) in the normal population and is expanded to about 22-29 residues in SPD1 and syndactyly type 5 patients.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03164957 – 63Missing in BDSD; does not affect capacity to transactivate EPHA7 promoter. 7
Natural variantiVAR_03164857 – 58Missing 1 Publication2
Natural variantiVAR_00381857A → AAAAAAAAAA in SPD1. 2 Publications1
Natural variantiVAR_031650252S → A. Corresponds to variant dbSNP:rs35290213Ensembl.1
Natural variantiVAR_076833306R → G in SPD1; decreases the transcriptional activator activity. 1 PublicationCorresponds to variant dbSNP:rs28933082EnsemblClinVar.1
Natural variantiVAR_076834306R → Q in SPD1; decreases the transcriptional activator activity. 1 PublicationCorresponds to variant dbSNP:rs879255265EnsemblClinVar.1
Natural variantiVAR_031651306R → W in SPD1. 1 PublicationCorresponds to variant dbSNP:rs28933082EnsemblClinVar.1
Natural variantiVAR_075400313T → R in SPD1; disrupts interaction with DNA. 1 Publication1
Natural variantiVAR_015952316S → C in BDE1 and BDD. 1 PublicationCorresponds to variant dbSNP:rs28928892EnsemblClinVar.1
Natural variantiVAR_015953322I → L in BDE1; decreases the transcriptional activator activity. 2 PublicationsCorresponds to variant dbSNP:rs28928891EnsemblClinVar.1
Natural variantiVAR_076835325Q → K in BDSDO. 1 PublicationCorresponds to variant dbSNP:rs875989842EnsemblClinVar.1
Natural variantiVAR_031652325Q → R in SDTY5; impairs capacity to transactivate EPHA7 promoter. 2 PublicationsCorresponds to variant dbSNP:rs104893635EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF005220, AF005219 Genomic DNA Translation: AAC51635.1 Different initiation.
AB032481 Genomic DNA Translation: BAA95352.1 Different initiation.
AC009336 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2264.2

Protein sequence database of the Protein Information Resource

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PIRi
B39065

NCBI Reference Sequences

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RefSeqi
NP_000514.2, NM_000523.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392539; ENSP00000376322; ENSG00000128714

Database of genes from NCBI RefSeq genomes

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GeneIDi
3239

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3239

UCSC genome browser

More...
UCSCi
uc002ukf.2 human

Keywords - Coding sequence diversityi

Polymorphism, Triplet repeat expansion

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF005220, AF005219 Genomic DNA Translation: AAC51635.1 Different initiation.
AB032481 Genomic DNA Translation: BAA95352.1 Different initiation.
AC009336 Genomic DNA No translation available.
CCDSiCCDS2264.2
PIRiB39065
RefSeqiNP_000514.2, NM_000523.3

3D structure databases

SMRiP35453
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109479, 54 interactors
IntActiP35453, 17 interactors
MINTiP35453
STRINGi9606.ENSP00000376322

PTM databases

iPTMnetiP35453
PhosphoSitePlusiP35453

Polymorphism and mutation databases

BioMutaiHOXD13
DMDMi223590221

Proteomic databases

EPDiP35453
jPOSTiP35453
MaxQBiP35453
PaxDbiP35453
PeptideAtlasiP35453
PRIDEiP35453
ProteomicsDBi55065

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3239
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392539; ENSP00000376322; ENSG00000128714
GeneIDi3239
KEGGihsa:3239
UCSCiuc002ukf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3239
DisGeNETi3239

GeneCards: human genes, protein and diseases

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GeneCardsi
HOXD13
HGNCiHGNC:5136 HOXD13
HPAiHPA064064
MalaCardsiHOXD13
MIMi113200 phenotype
113300 phenotype
142989 gene
186000 phenotype
186300 phenotype
192350 phenotype
610713 phenotype
neXtProtiNX_P35453
OpenTargetsiENSG00000128714
Orphaneti93387 Brachydactyly type E
93409 Brachydactyly-syndactyly, Zhao type
93385 NON RARE IN EUROPE: Brachydactyly type D
93406 Syndactyly type 5
295195 Synpolydactyly type 1
887 VACTERL/VATER association
295191 Zygodactyly type 3
PharmGKBiPA29410

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00940000161457
HOGENOMiHOG000231176
InParanoidiP35453
KOiK09298
OMAiFAYPGTS
OrthoDBi1042780at2759
PhylomeDBiP35453
TreeFamiTF330813

Enzyme and pathway databases

SIGNORiP35453

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
HOXD13 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
HOXD13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3239

Protein Ontology

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PROi
PR:P35453

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000128714 Expressed in 36 organ(s), highest expression level in ectocervix
GenevisibleiP35453 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR022067 HoxA13_N
PfamiView protein in Pfam
PF00046 Homeodomain, 1 hit
PF12284 HoxA13_N, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXD13_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35453
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: February 10, 2009
Last modified: July 31, 2019
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
UniProt is an ELIXIR core data resource
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