UniProtKB - P35452 (HXD12_HUMAN)
Protein
Homeobox protein Hox-D12
Gene
HOXD12
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 202 – 261 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- embryonic digit morphogenesis Source: Ensembl
- pattern specification process Source: Ensembl
- skeletal system development Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P35452 |
SIGNORi | P35452 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-D12Alternative name(s): Homeobox protein Hox-4H |
Gene namesi | Name:HOXD12 Synonyms:HOX4H |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5135, HOXD12 |
MIMi | 142988, gene |
neXtProti | NX_P35452 |
VEuPathDBi | HostDB:ENSG00000170178.6 |
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chromatin Source: NTNU_SB
- transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3238 |
OpenTargetsi | ENSG00000170178 |
PharmGKBi | PA29409 |
Miscellaneous databases
Pharosi | P35452, Tbio |
Genetic variation databases
BioMutai | HOXD12 |
DMDMi | 259016345 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200238 | 1 – 270 | Homeobox protein Hox-D12Add BLAST | 270 |
Proteomic databases
MassIVEi | P35452 |
PaxDbi | P35452 |
PeptideAtlasi | P35452 |
PRIDEi | P35452 |
ProteomicsDBi | 55064 [P35452-1] |
PTM databases
iPTMneti | P35452 |
PhosphoSitePlusi | P35452 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170178, Expressed in ectocervix and 9 other tissues |
ExpressionAtlasi | P35452, baseline and differential |
Genevisiblei | P35452, HS |
Organism-specific databases
HPAi | ENSG00000170178, Tissue enhanced (brain, intestine, seminal vesicle, vagina) |
Interactioni
Binary interactionsi
Hide detailsP35452
With | #Exp. | IntAct |
---|---|---|
TRAF1 [Q13077] | 3 | EBI-10206752,EBI-359224 |
Isoform 2 [P35452-2]
Protein-protein interaction databases
BioGRIDi | 109478, 16 interactors |
IntActi | P35452, 10 interactors |
STRINGi | 9606.ENSP00000385586 |
Miscellaneous databases
RNActi | P35452, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Abd-B homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000159938 |
HOGENOMi | CLU_087968_0_0_1 |
InParanoidi | P35452 |
OMAi | YRSGYVG |
OrthoDBi | 1154178at2759 |
PhylomeDBi | P35452 |
TreeFami | TF351604 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P35452-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MCERSLYRAG YVGSLLNLQS PDSFYFSNLR PNGGQLAALP PISYPRGALP
60 70 80 90 100
WAATPASCAP AQPAGATAFG GFSQPYLAGS GPLGLQPPTA KDGPEEQAKF
110 120 130 140 150
YAPEAAAGPE ERGRTRPSFA PESSLAPAVA ALKAAKYDYA GVGRATPGST
160 170 180 190 200
TLLQGAPCAP GFKDDTKGPL NLNMTVQAAG VASCLRPSLP DGLPWGAAPG
210 220 230 240 250
RARKKRKPYT KQQIAELENE FLVNEFINRQ KRKELSNRLN LSDQQVKIWF
260 270
QNRRMKKKRV VLREQALALY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB5MCD3 | B5MCD3_HUMAN | Homeobox D12, isoform CRA_a | HOXD12 hCG_1778464 | 246 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 – 47 | GGQLA…SYPRG → AASLAFPLSPTRA in AAF79044 (Ref. 1) CuratedAdd BLAST | 15 | |
Sequence conflicti | 50 | P → S in AAI21105 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 62 – 64 | QPA → TC in AAF79044 (Ref. 1) Curated | 3 | |
Sequence conflicti | 81 – 84 | GPLG → ASR in AAF79044 (Ref. 1) Curated | 4 | |
Sequence conflicti | 193 – 201 | LPWGAAPGR → KRCPCSPGRPAVGGGPGE in AAF79044 (Ref. 1) Curated | 9 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071211 | 186 | R → Q1 PublicationCorresponds to variant dbSNP:rs35817516Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056816 | 193 – 270 | LPWGA…ALALY → KRCPCSPGRFGPGWEVGFKG ECKGR in isoform 2. 1 PublicationAdd BLAST | 78 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF154915 Genomic DNA Translation: AAF79044.1 AC009336 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX11094.1 BC121103 mRNA Translation: AAI21104.1 BC121104 mRNA Translation: AAI21105.1 |
CCDSi | CCDS46456.1 [P35452-1] |
PIRi | C39065 |
RefSeqi | NP_067016.3, NM_021193.3 [P35452-1] |
Genome annotation databases
Ensembli | ENST00000406506; ENSP00000385586; ENSG00000170178 [P35452-1] |
GeneIDi | 3238 |
KEGGi | hsa:3238 |
UCSCi | uc010zev.2, human [P35452-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF154915 Genomic DNA Translation: AAF79044.1 AC009336 Genomic DNA No translation available. CH471058 Genomic DNA Translation: EAX11094.1 BC121103 mRNA Translation: AAI21104.1 BC121104 mRNA Translation: AAI21105.1 |
CCDSi | CCDS46456.1 [P35452-1] |
PIRi | C39065 |
RefSeqi | NP_067016.3, NM_021193.3 [P35452-1] |
3D structure databases
SMRi | P35452 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109478, 16 interactors |
IntActi | P35452, 10 interactors |
STRINGi | 9606.ENSP00000385586 |
PTM databases
iPTMneti | P35452 |
PhosphoSitePlusi | P35452 |
Genetic variation databases
BioMutai | HOXD12 |
DMDMi | 259016345 |
Proteomic databases
MassIVEi | P35452 |
PaxDbi | P35452 |
PeptideAtlasi | P35452 |
PRIDEi | P35452 |
ProteomicsDBi | 55064 [P35452-1] |
Protocols and materials databases
Antibodypediai | 10810, 240 antibodies |
Genome annotation databases
Ensembli | ENST00000406506; ENSP00000385586; ENSG00000170178 [P35452-1] |
GeneIDi | 3238 |
KEGGi | hsa:3238 |
UCSCi | uc010zev.2, human [P35452-1] |
Organism-specific databases
CTDi | 3238 |
DisGeNETi | 3238 |
GeneCardsi | HOXD12 |
HGNCi | HGNC:5135, HOXD12 |
HPAi | ENSG00000170178, Tissue enhanced (brain, intestine, seminal vesicle, vagina) |
MIMi | 142988, gene |
neXtProti | NX_P35452 |
OpenTargetsi | ENSG00000170178 |
PharmGKBi | PA29409 |
VEuPathDBi | HostDB:ENSG00000170178.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0487, Eukaryota |
GeneTreei | ENSGT00940000159938 |
HOGENOMi | CLU_087968_0_0_1 |
InParanoidi | P35452 |
OMAi | YRSGYVG |
OrthoDBi | 1154178at2759 |
PhylomeDBi | P35452 |
TreeFami | TF351604 |
Enzyme and pathway databases
PathwayCommonsi | P35452 |
SIGNORi | P35452 |
Miscellaneous databases
BioGRID-ORCSi | 3238, 5 hits in 1002 CRISPR screens |
GeneWikii | HOXD12 |
GenomeRNAii | 3238 |
Pharosi | P35452, Tbio |
PROi | PR:P35452 |
RNActi | P35452, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170178, Expressed in ectocervix and 9 other tissues |
ExpressionAtlasi | P35452, baseline and differential |
Genevisiblei | P35452, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXD12_HUMAN | |
Accessioni | P35452Primary (citable) accession number: P35452 Secondary accession number(s): B5MCP0 Q9NS03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | September 22, 2009 | |
Last modified: | April 7, 2021 | |
This is version 176 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families