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Protein

Spondin-1

Gene

Spon1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi325CalciumBy similarity1
Metal bindingi354CalciumBy similarity1
Metal bindingi358Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesion
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spondin-1
Alternative name(s):
F-spondin
Gene namesi
Name:Spon1
Synonyms:Sponf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi619918 Spon1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000003586729 – 807Spondin-1Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 128PROSITE-ProRule annotation
Disulfide bondi156 ↔ 182PROSITE-ProRule annotation
Disulfide bondi199 ↔ 336By similarity
Disulfide bondi200 ↔ 340By similarity
Disulfide bondi202 ↔ 415By similarity
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi443 ↔ 480PROSITE-ProRule annotation1 Publication
Disulfide bondi454 ↔ 489PROSITE-ProRule annotation1 Publication
Disulfide bondi459 ↔ 494PROSITE-ProRule annotation1 Publication
Disulfide bondi502 ↔ 538PROSITE-ProRule annotation
Disulfide bondi513 ↔ 517PROSITE-ProRule annotation
Disulfide bondi548 ↔ 554PROSITE-ProRule annotation
Disulfide bondi559 ↔ 595PROSITE-ProRule annotation
Disulfide bondi570 ↔ 574PROSITE-ProRule annotation
Disulfide bondi605 ↔ 610PROSITE-ProRule annotation
Disulfide bondi615 ↔ 650PROSITE-ProRule annotation1 Publication
Disulfide bondi626 ↔ 630PROSITE-ProRule annotation1 Publication
Disulfide bondi660 ↔ 665PROSITE-ProRule annotation1 Publication
Glycosylationi681N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35446
PRIDEiP35446

Expressioni

Tissue specificityi

Expressed at high levels in the floor plate.

Interactioni

Subunit structurei

Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.

Protein-protein interaction databases

IntActiP35446, 1 interactor
STRINGi10116.ENSRNOP00000046944

Structurei

Secondary structure

1807
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35446
SMRiP35446
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP35446

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 194ReelinPROSITE-ProRule annotationAdd BLAST166
Domaini195 – 388SpondinPROSITE-ProRule annotationAdd BLAST194
Domaini442 – 495TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini501 – 555TSP type-1 2PROSITE-ProRule annotationAdd BLAST55
Domaini558 – 611TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini614 – 666TSP type-1 4PROSITE-ProRule annotationAdd BLAST53
Domaini668 – 721TSP type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini754 – 806TSP type-1 6PROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3539 Eukaryota
ENOG410XQHP LUCA
HOGENOMiHOG000124667
HOVERGENiHBG052920
InParanoidiP35446
PhylomeDBiP35446

Family and domain databases

CDDicd08544 Reeler, 1 hit
Gene3Di2.20.100.10, 6 hits
2.60.40.2130, 2 hits
InterProiView protein in InterPro
IPR002861 Reeler_dom
IPR009465 Spondin_N
IPR038678 Spondin_N_sf
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PfamiView protein in Pfam
PF02014 Reeler, 1 hit
PF06468 Spond_N, 1 hit
PF00090 TSP_1, 6 hits
SMARTiView protein in SMART
SM00209 TSP1, 6 hits
SUPFAMiSSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS51019 REELIN, 1 hit
PS51020 SPONDIN, 1 hit
PS50092 TSP1, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P35446-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSPAPLRL SRGPALLALA LPLAAALAFS DETLDKVAKS EGYCSRILRA
60 70 80 90 100
QGTRREGYTE FSLRVEGDPD FYKPGSSYRV TLSAAPPSYF RGFTLIALKE
110 120 130 140 150
NREGDKEEDH AGTFQIIDEE ETQFMSNCPV AVTESTPRRR TRIQVFWIAP
160 170 180 190 200
PTGTGCVILK ASIVQKRIIY FQDEGSLTKK LCEQDPTLDG VTDRPILDCC
210 220 230 240 250
ACGTAKYRLT FYGNWSEKTH PKDYPRRANH WSAIIGGSHS KNYVLWEYGG
260 270 280 290 300
YASEGVKQVA ELGSPVKMEE EIRQQSDEVL TVIKAKAQWP SWQPVNVRAA
310 320 330 340 350
PSAEFSVDRT RHLMSFLTMM GPSPDWNVGL SAEDLCTKEC GWVQKVVQDL
360 370 380 390 400
IPWDAGTDSG VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSITQV
410 420 430 440 450
ARVVIERIAR KGEQCNIVPD NVDDIVADLA PEEKDEDDTP ETCIYSNWSP
460 470 480 490 500
WSACSSSTCE KGKRMRQRML KAQLDLSVPC PDTQDFQPCM GPGCSDEDGS
510 520 530 540 550
TCTMSEWITW SPCSVSCGMG MRSRERYVKQ FPEDGSVCML PTEETEKCTV
560 570 580 590 600
NEECSPSSCL VTEWGEWDDC SATCGMGMKK RHRMVKMSPA DGSMCKAETS
610 620 630 640 650
QAEKCMMPEC HTIPCLLSPW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC
660 670 680 690 700
NEDLEQAEKC MLPECPIDCE LSEWSQWSEC NKSCGKGHMI RTRTIQMEPQ
710 720 730 740 750
FGGAPCPETV QRKKCRARKC LRSPSIQKLR WREARESRRS EQLREESDGE
760 770 780 790 800
QFPGCRMRPW TAWSECTKLC GGGIQERYMT VKKRFKSSQF TSCKDKKEIR

ACNVHPC
Length:807
Mass (Da):90,773
Last modified:June 1, 1994 - v1
Checksum:i309525F9EAFEA89A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3B7D6Q3B7D6_RAT
RCG39552, isoform CRA_a
Spon1 rCG_39552
807Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M88469 mRNA Translation: AAA41174.1
PIRiA38152
RefSeqiNP_742064.1, NM_172067.1
UniGeneiRn.7546

Genome annotation databases

GeneIDi64456
KEGGirno:64456
UCSCiRGD:619918 rat

Similar proteinsi

Entry informationi

Entry nameiSPON1_RAT
AccessioniPrimary (citable) accession number: P35446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: June 20, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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