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Entry version 143 (07 Oct 2020)
Sequence version 2 (17 Apr 2007)
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Protein

Cartilage oligomeric matrix protein

Gene

COMP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarityNote: Binds 11-14 calcium ions per subunit.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processApoptosis, Cell adhesion
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cartilage oligomeric matrix protein
Short name:
COMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COMP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:27590, COMP

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000018646021 – 756Cartilage oligomeric matrix proteinAdd BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69InterchainPROSITE-ProRule annotation
Disulfide bondi72InterchainPROSITE-ProRule annotation
Disulfide bondi90 ↔ 101PROSITE-ProRule annotation
Disulfide bondi95 ↔ 110PROSITE-ProRule annotation
Disulfide bondi113 ↔ 124PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 141PROSITE-ProRule annotation
Disulfide bondi135 ↔ 150PROSITE-ProRule annotation
Disulfide bondi183 ↔ 196PROSITE-ProRule annotation
Disulfide bondi190 ↔ 205PROSITE-ProRule annotation
Disulfide bondi228 ↔ 242PROSITE-ProRule annotation
Disulfide bondi236 ↔ 252PROSITE-ProRule annotation
Disulfide bondi254 ↔ 265PROSITE-ProRule annotation
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
P35445

PRoteomics IDEntifications database

More...
PRIDEi
P35445

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35445, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium.

Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca2+, Mg2+ or Mn2+). The greatest amount of binding is seen in the presence of Mn2+.

Interacts with MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate.

Interacts with collagen I, II and IX and interaction with these collagens is dependent on the presence of zinc ions (By similarity).

Interacts with MATN1.

Interacts with ADAMTS12.

Interacts with ITGA7 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P35445, 1 interactor

Molecular INTeraction database

More...
MINTi
P35445

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000006074

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35445

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini86 – 125EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini126 – 178EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST53
Domaini179 – 218EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
Domaini224 – 266EGF-like 4PROSITE-ProRule annotationAdd BLAST43
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati267 – 299TSP type-3 1Add BLAST33
Repeati300 – 335TSP type-3 2Add BLAST36
Repeati336 – 358TSP type-3 3Add BLAST23
Repeati359 – 394TSP type-3 4Add BLAST36
Repeati395 – 417TSP type-3 5Add BLAST23
Repeati418 – 455TSP type-3 6Add BLAST38
Repeati456 – 491TSP type-3 7Add BLAST36
Repeati492 – 527TSP type-3 8Add BLAST36
Domaini531 – 745TSP C-terminalPROSITE-ProRule annotationAdd BLAST215

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni22 – 85COMP N-terminalAdd BLAST64
Regioni526 – 756Mediates cell survival and induction of the IAP family of survival proteinsBy similarityAdd BLAST231

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi366 – 368Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cell attachment motif mediates the attachment to chondrocytes. It mediates the induction of both the IAP family of survival proteins and the antiapoptotic response (By similarity).By similarity
The TSP C-terminal domain mediates interaction with FN1 and ACAN.By similarity
Each of the eight TSP type-3 repeats binds two calcium ions. The TSP C-terminal domain binds three calcium ions (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QRK8, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162169

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35445

Database of Orthologous Groups

More...
OrthoDBi
120983at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16077, TSP-5cc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1080.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR024665, Thbs/COMP_coiled-coil
IPR003367, Thrombospondin_3-like_rpt
IPR017897, Thrombospondin_3_rpt
IPR008859, Thrombospondin_C
IPR028492, TSP-5
IPR039081, TSP-5_cc
IPR028974, TSP_type-3_rpt

The PANTHER Classification System

More...
PANTHERi
PTHR10199:SF88, PTHR10199:SF88, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11598, COMP, 1 hit
PF07645, EGF_CA, 2 hits
PF02412, TSP_3, 5 hits
PF05735, TSP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 4 hits
SM00179, EGF_CA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103647, SSF103647, 3 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 3 hits
PS01187, EGF_CA, 2 hits
PS51234, TSP3, 8 hits
PS51236, TSP_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P35445-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLAAARVLL LTLAALGASG QGQMPLGGDL GPQMLRELQE TNAALQDVRD
60 70 80 90 100
LLRQQVKEIT FLKNTVMECD ACGMQPARTP KLTVRPLSQC SPGFCFPGVA
110 120 130 140 150
CTETANGARC GPCPEGFTGN GSHCADVNEC TAHPCFPRVR CINTSPGFRC
160 170 180 190 200
EACPPGFSGP THEGVGLAFA KANKQVCTDI NECETGQHNC VPNSVCVNTV
210 220 230 240 250
GSFQCGPCQP GFVGDQASGC RRRPQRFCPD GTPSPCHEKA DCVLERDGSR
260 270 280 290 300
SCVCAVGWAG NGLICGRDTD LDGFPDEKLR CSERQCRKDN CVTVPNSGQE
310 320 330 340 350
DVDQDGIGDA CDPDADGDGV LNEKDNCPLV RNPDQRNTDG DKWGDACDNC
360 370 380 390 400
RSQKNDDQKD TDKDGRGDAC DDDIDGDRIR NPVDNCPKVP NSDQKDTDGD
410 420 430 440 450
GVGDACDNCP QKSNADQRDV DHDFVGDACD SDQDQDGDGH QDSKDNCPTV
460 470 480 490 500
PNSAQQDSDH DGQGDACDDD DDNDGVPDSR DNCRLVPNPG QEDMDRDGVG
510 520 530 540 550
DACQGDFDAD KVVDKIDVCP ENAEVTLTDF RAFQTVVLDP EGDAQIDPNW
560 570 580 590 600
VVLNQGMEIV QTMNSDPGLA VGYTAFNGVD FEGTFHVNTA TDDDYAGFIF
610 620 630 640 650
GYQDSSSFYV VMWKQMEQTY WQANPFRAVA EPGIQLKAVK SSTGPGEQLR
660 670 680 690 700
NALWHTGDTA SQVRLLWKDP RNVGWKDKTS YRWFLQHRPQ VGYIRVRFYE
710 720 730 740 750
GPELVADSNV ILDTTMRGGR LGVFCFSQEN IIWANLRYRC NDTIPEDYEA

QRLLQA
Length:756
Mass (Da):82,362
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC2D84FE1C18FCA2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti570A → C in CAA52374 (PubMed:1429587).Curated1
Sequence conflicti584T → P in CAA52374 (PubMed:1429587).Curated1
Sequence conflicti603 – 604QD → HH in CAA52374 (PubMed:1429587).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X74326 mRNA Translation: CAA52374.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B44315

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBTAT00000006074; ENSBTAP00000006074; ENSBTAG00000004630

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74326 mRNA Translation: CAA52374.1
PIRiB44315

3D structure databases

SMRiP35445
ModBaseiSearch...

Protein-protein interaction databases

IntActiP35445, 1 interactor
MINTiP35445
STRINGi9913.ENSBTAP00000006074

Proteomic databases

PeptideAtlasiP35445
PRIDEiP35445

Genome annotation databases

EnsembliENSBTAT00000006074; ENSBTAP00000006074; ENSBTAG00000004630

Organism-specific databases

VGNCiVGNC:27590, COMP

Phylogenomic databases

eggNOGiENOG502QRK8, Eukaryota
GeneTreeiENSGT00940000162169
InParanoidiP35445
OrthoDBi120983at2759

Gene expression databases

ExpressionAtlasiP35445, baseline and differential

Family and domain databases

CDDicd16077, TSP-5cc, 1 hit
Gene3Di4.10.1080.10, 3 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR018097, EGF_Ca-bd_CS
IPR024665, Thbs/COMP_coiled-coil
IPR003367, Thrombospondin_3-like_rpt
IPR017897, Thrombospondin_3_rpt
IPR008859, Thrombospondin_C
IPR028492, TSP-5
IPR039081, TSP-5_cc
IPR028974, TSP_type-3_rpt
PANTHERiPTHR10199:SF88, PTHR10199:SF88, 1 hit
PfamiView protein in Pfam
PF11598, COMP, 1 hit
PF07645, EGF_CA, 2 hits
PF02412, TSP_3, 5 hits
PF05735, TSP_C, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 4 hits
SM00179, EGF_CA, 2 hits
SUPFAMiSSF103647, SSF103647, 3 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 3 hits
PS01187, EGF_CA, 2 hits
PS51234, TSP3, 8 hits
PS51236, TSP_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOMP_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35445
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 17, 2007
Last modified: October 7, 2020
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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