UniProtKB - P35444 (COMP_RAT)
Cartilage oligomeric matrix protein
Comp
Functioni
Cofactori
GO - Molecular functioni
- BMP binding Source: RGD
- calcium ion binding Source: RGD
- collagen binding Source: RGD
- extracellular matrix structural constituent Source: RGD
- fibronectin binding Source: RGD
- heparan sulfate proteoglycan binding Source: RGD
- heparin binding Source: RGD
- integrin binding Source: RGD
- protease binding Source: RGD
- proteoglycan binding Source: RGD
- vitamin D binding Source: RGD
GO - Biological processi
- animal organ senescence Source: RGD
- apoptotic process Source: RGD
- artery morphogenesis Source: RGD
- blood coagulation Source: RGD
- BMP signaling pathway Source: RGD
- bone growth Source: RGD
- bone mineralization Source: RGD
- bone morphogenesis Source: RGD
- cartilage development Source: RGD
- chondrocyte development Source: RGD
- chondrocyte proliferation Source: RGD
- collagen fibril organization Source: RGD
- endochondral bone growth Source: RGD
- growth plate cartilage development Source: RGD
- limb development Source: RGD
- multicellular organism aging Source: RGD
- multicellular organism growth Source: RGD
- muscle fiber development Source: RGD
- musculoskeletal movement Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of hemostasis Source: RGD
- neuromuscular process Source: RGD
- ossification Source: RGD
- platelet aggregation Source: RGD
- positive regulation of chondrocyte proliferation Source: RGD
- protein processing Source: RGD
- protein secretion Source: RGD
- regulation of bone mineralization Source: RGD
- regulation of gene expression Source: RGD
- response to unfolded protein Source: RGD
- skeletal system development Source: RGD
- skin development Source: RGD
- tendon development Source: RGD
- vascular associated smooth muscle cell development Source: RGD
- vascular associated smooth muscle contraction Source: RGD
Keywordsi
Molecular function | Heparin-binding |
Biological process | Apoptosis, Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
Reactomei | R-RNO-216083, Integrin cell surface interactions R-RNO-3000178, ECM proteoglycans |
Names & Taxonomyi
Protein namesi | Recommended name: Cartilage oligomeric matrix proteinShort name: COMP |
Gene namesi | Name:Comp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2378, Comp |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- collagen-containing extracellular matrix Source: RGD
- extracellular space Source: RGD
Other locations
- protein-containing complex Source: RGD
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000035859 | 20 – 755 | Cartilage oligomeric matrix proteinAdd BLAST | 736 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 68 | Interchain (with C-71)Combined sources1 Publication | ||
Disulfide bondi | 71 | Interchain (with C-68)Combined sources1 Publication | ||
Disulfide bondi | 89 ↔ 100 | PROSITE-ProRule annotation | ||
Disulfide bondi | 94 ↔ 109 | PROSITE-ProRule annotation | ||
Disulfide bondi | 112 ↔ 123 | PROSITE-ProRule annotation | ||
Glycosylationi | 119 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 129 ↔ 140 | PROSITE-ProRule annotation | ||
Disulfide bondi | 134 ↔ 149 | PROSITE-ProRule annotation | ||
Disulfide bondi | 152 ↔ 176 | PROSITE-ProRule annotation | ||
Disulfide bondi | 182 ↔ 195 | PROSITE-ProRule annotation | ||
Disulfide bondi | 189 ↔ 204 | PROSITE-ProRule annotation | ||
Disulfide bondi | 207 ↔ 219 | PROSITE-ProRule annotation | ||
Disulfide bondi | 227 ↔ 241 | PROSITE-ProRule annotation | ||
Disulfide bondi | 235 ↔ 251 | PROSITE-ProRule annotation | ||
Disulfide bondi | 253 ↔ 264 | PROSITE-ProRule annotation | ||
Disulfide bondi | 280 ↔ 285 | PROSITE-ProRule annotation | ||
Disulfide bondi | 290 ↔ 310 | PROSITE-ProRule annotation | ||
Disulfide bondi | 326 ↔ 346 | PROSITE-ProRule annotation | ||
Disulfide bondi | 349 ↔ 369 | PROSITE-ProRule annotation | ||
Disulfide bondi | 385 ↔ 405 | PROSITE-ProRule annotation | ||
Modified residuei | 394 | PhosphoserineBy similarity | 1 | |
Disulfide bondi | 408 ↔ 428 | PROSITE-ProRule annotation | ||
Disulfide bondi | 446 ↔ 466 | PROSITE-ProRule annotation | ||
Disulfide bondi | 482 ↔ 502 | PROSITE-ProRule annotation | ||
Disulfide bondi | 518 ↔ 739 | PROSITE-ProRule annotation | ||
Glycosylationi | 740 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P35444 |
PRIDEi | P35444 |
PTM databases
GlyGeni | P35444, 2 sites |
Expressioni
Tissue specificityi
Interactioni
Subunit structurei
Pentamer; disulfide-linked. Exists in a more compact conformation in the presence of calcium and shows a more extended conformation in the absence of calcium.
Interacts with ITGB3, ITGA5 and FN1. Binding to FN1 requires the presence of divalent cations (Ca2+, Mg2+ or Mn2+). The greatest amount of binding is seen in the presence of Mn2+.
Interacts with MATN1, MATN3, MATN4 and ACAN. Binds heparin, heparan sulfate and chondroitin sulfate. EDTA dimishes significantly its binding to ACAN and abolishes its binding to MATN3, MATN4 and chondroitin sulfate.
Interacts with collagen I, II and IX and interaction with these collagens is dependent on the presence of zinc ions (By similarity).
Interacts with ADAMTS12 (By similarity).
Interacts with ITGA7.
By similarity1 PublicationGO - Molecular functioni
- BMP binding Source: RGD
- fibronectin binding Source: RGD
- heparan sulfate proteoglycan binding Source: RGD
- integrin binding Source: RGD
- protease binding Source: RGD
- proteoglycan binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 247343, 2 interactors |
STRINGi | 10116.ENSRNOP00000067037 |
Structurei
Secondary structure
3D structure databases
SMRi | P35444 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35444 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 85 – 124 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 125 – 177 | EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 53 | |
Domaini | 178 – 220 | EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST | 43 | |
Domaini | 223 – 265 | EGF-like 4PROSITE-ProRule annotationAdd BLAST | 43 | |
Repeati | 266 – 298 | TSP type-3 1Add BLAST | 33 | |
Repeati | 299 – 334 | TSP type-3 2Add BLAST | 36 | |
Repeati | 335 – 357 | TSP type-3 3Add BLAST | 23 | |
Repeati | 358 – 393 | TSP type-3 4Add BLAST | 36 | |
Repeati | 394 – 416 | TSP type-3 5Add BLAST | 23 | |
Repeati | 417 – 454 | TSP type-3 6Add BLAST | 38 | |
Repeati | 455 – 490 | TSP type-3 7Add BLAST | 36 | |
Repeati | 491 – 526 | TSP type-3 8Add BLAST | 36 | |
Domaini | 530 – 744 | TSP C-terminalPROSITE-ProRule annotationAdd BLAST | 215 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 21 – 84 | COMP N-terminalAdd BLAST | 64 | |
Regioni | 525 – 755 | Mediates cell survival and induction of the IAP family of survival proteinsBy similarityAdd BLAST | 231 |
Domaini
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QRK8, Eukaryota |
InParanoidi | P35444 |
OrthoDBi | 120983at2759 |
PhylomeDBi | P35444 |
Family and domain databases
CDDi | cd16077, TSP-5cc, 1 hit |
Gene3Di | 4.10.1080.10, 3 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR024665, Thbs/COMP_coiled-coil IPR003367, Thrombospondin_3-like_rpt IPR017897, Thrombospondin_3_rpt IPR008859, Thrombospondin_C IPR028492, TSP-5 IPR039081, TSP-5_cc IPR028974, TSP_type-3_rpt |
PANTHERi | PTHR10199:SF88, PTHR10199:SF88, 1 hit |
Pfami | View protein in Pfam PF11598, COMP, 1 hit PF07645, EGF_CA, 2 hits PF02412, TSP_3, 6 hits PF05735, TSP_C, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00179, EGF_CA, 2 hits |
SUPFAMi | SSF103647, SSF103647, 3 hits SSF49899, SSF49899, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS50026, EGF_3, 3 hits PS01187, EGF_CA, 2 hits PS51234, TSP3, 8 hits PS51236, TSP_CTER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MSPTACVLVL ALAALRATGQ GQIPLGGDLA PQMLRELQET NAALQDVREL
60 70 80 90 100
LRHRVKEITF LKNTVMECDA CGMQPARTPG LSVRPVALCA PGSCFPGVVC
110 120 130 140 150
TETATGARCG PCPPGYTGNG SHCTDVNECN AHPCFPRVRC INTSPGFHCE
160 170 180 190 200
ACPPGFSGPT HEGVGLTFAK TNKQVCTDIN ECETGQHNCV PNSVCVNTRG
210 220 230 240 250
SFQCGPCQPG FVGDQRSGCQ RRGQHFCPDG SPSPCHEKAD CILERDGSRS
260 270 280 290 300
CVCAVGWAGN GLLCGRDTDL DGFPDEKLRC SERQCRKDNC VTVPNSGQED
310 320 330 340 350
VDRDRIGDAC DPDADGDGVP NEQDNCPLVR NPDQRNSDKD KWGDACDNCR
360 370 380 390 400
SQKNDDQKDT DRDGQGDACD DDIDGDRIRN VADNCPRVPN FDQSDSDGDG
410 420 430 440 450
VGDACDNCPQ KDNPDQRDVD HDFVGDACDS DQDQDGDGHQ DSRDNCPTVP
460 470 480 490 500
NSAQQDSDHD GKGDACDDDD DNDGVPDSRD NCRLVPNPGQ EDNDRDGVGD
510 520 530 540 550
ACQGDFDADK VIDKIDVCPE NAEVTLTDFR AFQTVVLDPE GDAQIDPNWV
560 570 580 590 600
VLNQGMEIVQ TMNSDPGLAV GYTAFNGVDF EGTFHVNTAT DDDYAGFIFG
610 620 630 640 650
YQDSSSFYVV MWKQMEQTYW QANPFRAVAE PGIQLKAVKS STGPGEQLRN
660 670 680 690 700
ALWHTGDTAS QVRLLWKDPR NVGWKDKTSY RWFLQHRPQV GYIRVRFYEG
710 720 730 740 750
PELVADSNVV LDTAMRGGRL GVFCFSQENI IWANLRYRCN DTIPEDYERH
RLRRA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0RBU0 | M0RBU0_RAT | Cartilage oligomeric matrix protein | Comp rCG_38834 | 755 | Annotation score: | ||
A0A0G2JXN9 | A0A0G2JXN9_RAT | Cartilage oligomeric matrix protein | Comp | 109 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X72914 mRNA Translation: CAA51419.1 |
PIRi | A44315 |
RefSeqi | NP_036966.1, NM_012834.1 |
Genome annotation databases
GeneIDi | 25304 |
KEGGi | rno:25304 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X72914 mRNA Translation: CAA51419.1 |
PIRi | A44315 |
RefSeqi | NP_036966.1, NM_012834.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FBM | X-ray | 2.70 | A/B/C/D/E | 28-72 | [»] | |
1VDF | X-ray | 2.05 | A/B/C/D/E | 28-72 | [»] | |
6SF6 | X-ray | 1.90 | C/D | 232-250 | [»] | |
SMRi | P35444 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 247343, 2 interactors |
STRINGi | 10116.ENSRNOP00000067037 |
PTM databases
GlyGeni | P35444, 2 sites |
Proteomic databases
PaxDbi | P35444 |
PRIDEi | P35444 |
Protocols and materials databases
ABCDi | P35444, 1 sequenced antibody |
Genome annotation databases
GeneIDi | 25304 |
KEGGi | rno:25304 |
Organism-specific databases
CTDi | 1311 |
RGDi | 2378, Comp |
Phylogenomic databases
eggNOGi | ENOG502QRK8, Eukaryota |
InParanoidi | P35444 |
OrthoDBi | 120983at2759 |
PhylomeDBi | P35444 |
Enzyme and pathway databases
Reactomei | R-RNO-216083, Integrin cell surface interactions R-RNO-3000178, ECM proteoglycans |
Miscellaneous databases
EvolutionaryTracei | P35444 |
PROi | PR:P35444 |
Family and domain databases
CDDi | cd16077, TSP-5cc, 1 hit |
Gene3Di | 4.10.1080.10, 3 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR024665, Thbs/COMP_coiled-coil IPR003367, Thrombospondin_3-like_rpt IPR017897, Thrombospondin_3_rpt IPR008859, Thrombospondin_C IPR028492, TSP-5 IPR039081, TSP-5_cc IPR028974, TSP_type-3_rpt |
PANTHERi | PTHR10199:SF88, PTHR10199:SF88, 1 hit |
Pfami | View protein in Pfam PF11598, COMP, 1 hit PF07645, EGF_CA, 2 hits PF02412, TSP_3, 6 hits PF05735, TSP_C, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 4 hits SM00179, EGF_CA, 2 hits |
SUPFAMi | SSF103647, SSF103647, 3 hits SSF49899, SSF49899, 1 hit SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS50026, EGF_3, 3 hits PS01187, EGF_CA, 2 hits PS51234, TSP3, 8 hits PS51236, TSP_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COMP_RAT | |
Accessioni | P35444Primary (citable) accession number: P35444 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families