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Entry version 190 (13 Feb 2019)
Sequence version 2 (25 Nov 2008)
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Protein

Thrombospondin-2

Gene

THBS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • extracellular matrix structural constituent Source: BHF-UCL
  • heparin binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-186797 Signaling by PDGF
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins

SIGNOR Signaling Network Open Resource

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SIGNORi
P35442

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thrombospondin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THBS2
Synonyms:TSP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000186340.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11786 THBS2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
188061 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P35442

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Intervertebral disc disease (IDD)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain.
See also OMIM:603932

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi702N → S: Alters protein stability. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7058

MalaCards human disease database

More...
MalaCardsi
THBS2
MIMi603932 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000186340

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36498

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
THBS2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215273908

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003584619 – 1172Thrombospondin-2Add BLAST1154

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi266InterchainCurated
Disulfide bondi270InterchainCurated
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi330N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi393 ↔ 425By similarity
Disulfide bondi397 ↔ 430By similarity
Disulfide bondi408 ↔ 415By similarity
Disulfide bondi449 ↔ 486By similarity
Disulfide bondi453 ↔ 491By similarity
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi464 ↔ 476By similarity
Disulfide bondi506 ↔ 543By similarity
Disulfide bondi510 ↔ 548By similarity
Disulfide bondi521 ↔ 533By similarity
Disulfide bondi553 ↔ 564Combined sources2 Publications
Disulfide bondi558 ↔ 574Combined sources2 Publications
Disulfide bondi577 ↔ 588Combined sources2 Publications
Glycosylationi584N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi594 ↔ 610Combined sources2 Publications
Disulfide bondi601 ↔ 619Combined sources2 Publications
Disulfide bondi622 ↔ 646Combined sources2 Publications
Disulfide bondi652 ↔ 665Combined sources2 Publications
Disulfide bondi659 ↔ 678Combined sources2 Publications
Disulfide bondi680 ↔ 691Combined sources2 Publications
Disulfide bondi707 ↔ 715Combined sources2 Publications
Glycosylationi710N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi720 ↔ 740Combined sources2 Publications
Disulfide bondi756 ↔ 776Combined sources2 Publications
Disulfide bondi779 ↔ 799Combined sources2 Publications
Disulfide bondi815 ↔ 835Combined sources2 Publications
Disulfide bondi838 ↔ 858Combined sources2 Publications
Disulfide bondi876 ↔ 896Combined sources2 Publications
Disulfide bondi912 ↔ 932Combined sources2 Publications
Disulfide bondi948 ↔ 1169Combined sources2 Publications
Glycosylationi1069N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P35442

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P35442

MaxQB - The MaxQuant DataBase

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MaxQBi
P35442

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35442

PeptideAtlas

More...
PeptideAtlasi
P35442

PRoteomics IDEntifications database

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PRIDEi
P35442

ProteomicsDB human proteome resource

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ProteomicsDBi
55062

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
1805

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35442

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35442

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in invertebral disk tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000186340 Expressed in 227 organ(s), highest expression level in left coronary artery

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P35442 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P35442 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017716
HPA044304

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; disulfide-linked. Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Cacna2d1P542902EBI-2466249,EBI-2466294From Rattus norvegicus.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112916, 13 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-1788 Thrombospondin 2 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P35442

Protein interaction database and analysis system

More...
IntActi
P35442, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355751

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YO8X-ray2.60A551-1172[»]
2RHPX-ray2.90A551-1172[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P35442

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35442

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P35442

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 215Laminin G-likeAdd BLAST197
Domaini318 – 375VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini381 – 431TSP type-1 1PROSITE-ProRule annotationAdd BLAST51
Domaini437 – 492TSP type-1 2PROSITE-ProRule annotationAdd BLAST56
Domaini494 – 549TSP type-1 3PROSITE-ProRule annotationAdd BLAST56
Domaini549 – 589EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini648 – 692EGF-like 2PROSITE-ProRule annotationAdd BLAST45
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati693 – 728TSP type-3 1Add BLAST36
Repeati729 – 764TSP type-3 2Add BLAST36
Repeati765 – 787TSP type-3 3Add BLAST23
Repeati788 – 823TSP type-3 4Add BLAST36
Repeati824 – 846TSP type-3 5Add BLAST23
Repeati847 – 884TSP type-3 6Add BLAST38
Repeati885 – 920TSP type-3 7Add BLAST36
Repeati921 – 956TSP type-3 8Add BLAST36
Domaini960 – 1172TSP C-terminalPROSITE-ProRule annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 232Heparin-bindingSequence analysisAdd BLAST214

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi928 – 930Cell attachment siteSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFQQ Eukaryota
ENOG410XQKE LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157846

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000007542

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG018006

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P35442

KEGG Orthology (KO)

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KOi
K04659

Identification of Orthologs from Complete Genome Data

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OMAi
KEGFFLT

Database of Orthologous Groups

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OrthoDBi
120983at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P35442

TreeFam database of animal gene trees

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TreeFami
TF324917

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.20.100.10, 3 hits
4.10.1080.10, 2 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits

Pfam protein domain database

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Pfami
View protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P35442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVWRLVLLAL WVWPSTQAGH QDKDTTFDLF SISNINRKTI GAKQFRGPDP
60 70 80 90 100
GVPAYRFVRF DYIPPVNADD LSKITKIMRQ KEGFFLTAQL KQDGKSRGTL
110 120 130 140 150
LALEGPGLSQ RQFEIVSNGP ADTLDLTYWI DGTRHVVSLE DVGLADSQWK
160 170 180 190 200
NVTVQVAGET YSLHVGCDLI DSFALDEPFY EHLQAEKSRM YVAKGSARES
210 220 230 240 250
HFRGLLQNVH LVFENSVEDI LSKKGCQQGQ GAEINAISEN TETLRLGPHV
260 270 280 290 300
TTEYVGPSSE RRPEVCERSC EELGNMVQEL SGLHVLVNQL SENLKRVSND
310 320 330 340 350
NQFLWELIGG PPKTRNMSAC WQDGRFFAEN ETWVVDSCTT CTCKKFKTIC
360 370 380 390 400
HQITCPPATC ASPSFVEGEC CPSCLHSVDG EEGWSPWAEW TQCSVTCGSG
410 420 430 440 450
TQQRGRSCDV TSNTCLGPSI QTRACSLSKC DTRIRQDGGW SHWSPWSSCS
460 470 480 490 500
VTCGVGNITR IRLCNSPVPQ MGGKNCKGSG RETKACQGAP CPIDGRWSPW
510 520 530 540 550
SPWSACTVTC AGGIRERTRV CNSPEPQYGG KACVGDVQER QMCNKRSCPV
560 570 580 590 600
DGCLSNPCFP GAQCSSFPDG SWSCGSCPVG FLGNGTHCED LDECALVPDI
610 620 630 640 650
CFSTSKVPRC VNTQPGFHCL PCPPRYRGNQ PVGVGLEAAK TEKQVCEPEN
660 670 680 690 700
PCKDKTHNCH KHAECIYLGH FSDPMYKCEC QTGYAGDGLI CGEDSDLDGW
710 720 730 740 750
PNLNLVCATN ATYHCIKDNC PHLPNSGQED FDKDGIGDAC DDDDDNDGVT
760 770 780 790 800
DEKDNCQLLF NPRQADYDKD EVGDRCDNCP YVHNPAQIDT DNNGEGDACS
810 820 830 840 850
VDIDGDDVFN ERDNCPYVYN TDQRDTDGDG VGDHCDNCPL VHNPDQTDVD
860 870 880 890 900
NDLVGDQCDN NEDIDDDGHQ NNQDNCPYIS NANQADHDRD GQGDACDPDD
910 920 930 940 950
DNDGVPDDRD NCRLVFNPDQ EDLDGDGRGD ICKDDFDNDN IPDIDDVCPE
960 970 980 990 1000
NNAISETDFR NFQMVPLDPK GTTQIDPNWV IRHQGKELVQ TANSDPGIAV
1010 1020 1030 1040 1050
GFDEFGSVDF SGTFYVNTDR DDDYAGFVFG YQSSSRFYVV MWKQVTQTYW
1060 1070 1080 1090 1100
EDQPTRAYGY SGVSLKVVNS TTGTGEHLRN ALWHTGNTPG QVRTLWHDPR
1110 1120 1130 1140 1150
NIGWKDYTAY RWHLTHRPKT GYIRVLVHEG KQVMADSGPI YDQTYAGGRL
1160 1170
GLFVFSQEMV YFSDLKYECR DI
Length:1,172
Mass (Da):129,991
Last modified:November 25, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i415BF376F4669F6A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITK0A0A3B3ITK0_HUMAN
Thrombospondin-2
THBS2
1,177Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5RI53Q5RI53_HUMAN
Thrombospondin-2
THBS2
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2V → A in AAI50176 (PubMed:15489334).Curated1
Sequence conflicti171 – 173DSF → GPV in AAA03703 (PubMed:8406456).Curated3
Sequence conflicti576S → F in AAA03703 (PubMed:8406456).Curated1
Sequence conflicti1111R → G in AAI46677 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045842133T → S. Corresponds to variant dbSNP:rs36088849Ensembl.1
Natural variantiVAR_045843375L → F. Corresponds to variant dbSNP:rs35404985Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L12350 mRNA Translation: AAA03703.1
M81339 mRNA No translation available.
AK292429 mRNA Translation: BAF85118.1
BX322234 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47455.1
BC146676 mRNA Translation: AAI46677.1
BC150175 mRNA Translation: AAI50176.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS34574.1

Protein sequence database of the Protein Information Resource

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PIRi
A47379 TSHUP2

NCBI Reference Sequences

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RefSeqi
NP_003238.2, NM_003247.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.371147

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000366787; ENSP00000355751; ENSG00000186340
ENST00000617924; ENSP00000482784; ENSG00000186340

Database of genes from NCBI RefSeq genomes

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GeneIDi
7058

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7058

UCSC genome browser

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UCSCi
uc003qwt.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12350 mRNA Translation: AAA03703.1
M81339 mRNA No translation available.
AK292429 mRNA Translation: BAF85118.1
BX322234 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47455.1
BC146676 mRNA Translation: AAI46677.1
BC150175 mRNA Translation: AAI50176.1
CCDSiCCDS34574.1
PIRiA47379 TSHUP2
RefSeqiNP_003238.2, NM_003247.3
UniGeneiHs.371147

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YO8X-ray2.60A551-1172[»]
2RHPX-ray2.90A551-1172[»]
ProteinModelPortaliP35442
SMRiP35442
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112916, 13 interactors
ComplexPortaliCPX-1788 Thrombospondin 2 complex
CORUMiP35442
IntActiP35442, 1 interactor
STRINGi9606.ENSP00000355751

PTM databases

GlyConnecti1805
iPTMnetiP35442
PhosphoSitePlusiP35442

Polymorphism and mutation databases

BioMutaiTHBS2
DMDMi215273908

Proteomic databases

EPDiP35442
jPOSTiP35442
MaxQBiP35442
PaxDbiP35442
PeptideAtlasiP35442
PRIDEiP35442
ProteomicsDBi55062

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366787; ENSP00000355751; ENSG00000186340
ENST00000617924; ENSP00000482784; ENSG00000186340
GeneIDi7058
KEGGihsa:7058
UCSCiuc003qwt.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7058
DisGeNETi7058
EuPathDBiHostDB:ENSG00000186340.14

GeneCards: human genes, protein and diseases

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GeneCardsi
THBS2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0025092
HIX0165050
HGNCiHGNC:11786 THBS2
HPAiCAB017716
HPA044304
MalaCardsiTHBS2
MIMi188061 gene
603932 phenotype
neXtProtiNX_P35442
OpenTargetsiENSG00000186340
PharmGKBiPA36498

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
GeneTreeiENSGT00940000157846
HOGENOMiHOG000007542
HOVERGENiHBG018006
InParanoidiP35442
KOiK04659
OMAiKEGFFLT
OrthoDBi120983at2759
PhylomeDBiP35442
TreeFamiTF324917

Enzyme and pathway databases

ReactomeiR-HSA-186797 Signaling by PDGF
R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-5173214 O-glycosylation of TSR domain-containing proteins
SIGNORiP35442

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
THBS2 human
EvolutionaryTraceiP35442

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
THBS2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7058

Protein Ontology

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PROi
PR:P35442

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000186340 Expressed in 227 organ(s), highest expression level in left coronary artery
ExpressionAtlasiP35442 baseline and differential
GenevisibleiP35442 HS

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35442
Secondary accession number(s): A6H8N1, A7E232, Q5RI52
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: February 13, 2019
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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