UniProtKB - P35442 (TSP2_HUMAN)
Thrombospondin-2
THBS2
Functioni
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.
1 PublicationGO - Molecular functioni
- calcium ion binding Source: InterPro
- heparin binding Source: ProtInc
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- negative regulation of angiogenesis Source: UniProtKB
- positive regulation of synapse assembly Source: Ensembl
Keywordsi
Molecular function | Heparin-binding |
Biological process | Cell adhesion |
Ligand | Calcium |
Enzyme and pathway databases
PathwayCommonsi | P35442 |
Reactomei | R-HSA-186797, Signaling by PDGF R-HSA-5083635, Defective B3GALTL causes PpS R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
SignaLinki | P35442 |
SIGNORi | P35442 |
Names & Taxonomyi
Protein namesi | Recommended name: Thrombospondin-2 |
Gene namesi | Name:THBS2 Synonyms:TSP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11786, THBS2 |
MIMi | 188061, gene |
neXtProti | NX_P35442 |
VEuPathDBi | HostDB:ENSG00000186340 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: BHF-UCL
Other locations
- basement membrane Source: Ensembl
- collagen-containing extracellular matrix Source: BHF-UCL
- platelet alpha granule Source: UniProtKB
Pathology & Biotechi
Involvement in diseasei
Intervertebral disc disease (IDD)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 702 | N → S: Alters protein stability. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7058 |
MalaCardsi | THBS2 |
MIMi | 603932, phenotype |
OpenTargetsi | ENSG00000186340 |
PharmGKBi | PA36498 |
Miscellaneous databases
Pharosi | P35442, Tbio |
Genetic variation databases
BioMutai | THBS2 |
DMDMi | 215273908 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000035846 | 19 – 1172 | Thrombospondin-2Add BLAST | 1154 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 151 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 266 | InterchainCurated | ||
Disulfide bondi | 270 | InterchainCurated | ||
Glycosylationi | 316 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 330 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 393 ↔ 425 | By similarity | ||
Disulfide bondi | 397 ↔ 430 | By similarity | ||
Disulfide bondi | 408 ↔ 415 | By similarity | ||
Disulfide bondi | 449 ↔ 486 | By similarity | ||
Disulfide bondi | 453 ↔ 491 | By similarity | ||
Glycosylationi | 457 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 464 ↔ 476 | By similarity | ||
Disulfide bondi | 506 ↔ 543 | By similarity | ||
Disulfide bondi | 510 ↔ 548 | By similarity | ||
Disulfide bondi | 521 ↔ 533 | By similarity | ||
Disulfide bondi | 553 ↔ 564 | Combined sources2 Publications | ||
Disulfide bondi | 558 ↔ 574 | Combined sources2 Publications | ||
Disulfide bondi | 577 ↔ 588 | Combined sources2 Publications | ||
Glycosylationi | 584 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 594 ↔ 610 | Combined sources2 Publications | ||
Disulfide bondi | 601 ↔ 619 | Combined sources2 Publications | ||
Disulfide bondi | 622 ↔ 646 | Combined sources2 Publications | ||
Disulfide bondi | 652 ↔ 665 | Combined sources2 Publications | ||
Disulfide bondi | 659 ↔ 678 | Combined sources2 Publications | ||
Disulfide bondi | 680 ↔ 691 | Combined sources2 Publications | ||
Disulfide bondi | 707 ↔ 715 | Combined sources2 Publications | ||
Glycosylationi | 710 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 720 ↔ 740 | Combined sources2 Publications | ||
Disulfide bondi | 756 ↔ 776 | Combined sources2 Publications | ||
Disulfide bondi | 779 ↔ 799 | Combined sources2 Publications | ||
Disulfide bondi | 815 ↔ 835 | Combined sources2 Publications | ||
Disulfide bondi | 838 ↔ 858 | Combined sources2 Publications | ||
Disulfide bondi | 876 ↔ 896 | Combined sources2 Publications | ||
Disulfide bondi | 912 ↔ 932 | Combined sources2 Publications | ||
Disulfide bondi | 948 ↔ 1169 | Combined sources2 Publications | ||
Glycosylationi | 1069 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | CPTAC-1186 |
EPDi | P35442 |
jPOSTi | P35442 |
MassIVEi | P35442 |
MaxQBi | P35442 |
PaxDbi | P35442 |
PeptideAtlasi | P35442 |
PRIDEi | P35442 |
ProteomicsDBi | 55062 |
PTM databases
GlyConnecti | 1805, 24 N-Linked glycans (4 sites) |
GlyGeni | P35442, 7 sites, 23 N-linked glycans (4 sites) |
iPTMneti | P35442 |
PhosphoSitePlusi | P35442 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000186340, Expressed in left coronary artery and 239 other tissues |
ExpressionAtlasi | P35442, baseline and differential |
Genevisiblei | P35442, HS |
Organism-specific databases
HPAi | ENSG00000186340, Low tissue specificity |
Interactioni
Subunit structurei
Homotrimer; disulfide-linked.
Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect.
Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36 (By similarity). Can bind to fibrinogen, fibronectin, laminin and type V collagen.
By similarity3 PublicationsBinary interactionsi
P35442
With | #Exp. | IntAct |
---|---|---|
Cacna2d1 [P54290] from Rattus norvegicus. | 2 | EBI-2466249,EBI-2466294 |
Protein-protein interaction databases
BioGRIDi | 112916, 22 interactors |
ComplexPortali | CPX-1788, Thrombospondin 2 complex |
CORUMi | P35442 |
IntActi | P35442, 12 interactors |
STRINGi | 9606.ENSP00000355751 |
Miscellaneous databases
RNActi | P35442, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P35442 |
SMRi | P35442 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35442 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 215 | Laminin G-likeAdd BLAST | 197 | |
Domaini | 318 – 375 | VWFCPROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 381 – 431 | TSP type-1 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Domaini | 437 – 492 | TSP type-1 2PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 494 – 549 | TSP type-1 3PROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 549 – 589 | EGF-like 1PROSITE-ProRule annotationAdd BLAST | 41 | |
Domaini | 648 – 692 | EGF-like 2PROSITE-ProRule annotationAdd BLAST | 45 | |
Repeati | 693 – 728 | TSP type-3 1Add BLAST | 36 | |
Repeati | 729 – 764 | TSP type-3 2Add BLAST | 36 | |
Repeati | 765 – 787 | TSP type-3 3Add BLAST | 23 | |
Repeati | 788 – 823 | TSP type-3 4Add BLAST | 36 | |
Repeati | 824 – 846 | TSP type-3 5Add BLAST | 23 | |
Repeati | 847 – 884 | TSP type-3 6Add BLAST | 38 | |
Repeati | 885 – 920 | TSP type-3 7Add BLAST | 36 | |
Repeati | 921 – 956 | TSP type-3 8Add BLAST | 36 | |
Domaini | 960 – 1172 | TSP C-terminalPROSITE-ProRule annotationAdd BLAST | 213 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 232 | Heparin-bindingSequence analysisAdd BLAST | 214 | |
Regioni | 843 – 931 | DisorderedSequence analysisAdd BLAST | 89 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 928 – 930 | Cell attachment siteSequence analysis | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 871 – 886 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 906 – 931 | Basic and acidic residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Keywords - Domaini
EGF-like domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QRK8, Eukaryota |
GeneTreei | ENSGT00940000157846 |
HOGENOMi | CLU_009257_0_0_1 |
InParanoidi | P35442 |
OMAi | PPVTCAN |
OrthoDBi | 120983at2759 |
PhylomeDBi | P35442 |
TreeFami | TF324917 |
Family and domain databases
Gene3Di | 2.20.100.10, 3 hits 4.10.1080.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR024731, EGF_dom IPR001791, Laminin_G IPR003367, Thrombospondin_3-like_rpt IPR017897, Thrombospondin_3_rpt IPR008859, Thrombospondin_C IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR015455, TSP2 IPR028974, TSP_type-3_rpt IPR001007, VWF_dom |
PANTHERi | PTHR10199:SF10, PTHR10199:SF10, 1 hit |
Pfami | View protein in Pfam PF12947, EGF_3, 1 hit PF07645, EGF_CA, 1 hit PF00090, TSP_1, 3 hits PF02412, TSP_3, 6 hits PF05735, TSP_C, 1 hit PF00093, VWC, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00179, EGF_CA, 2 hits SM00209, TSP1, 3 hits SM00210, TSPN, 1 hit SM00214, VWC, 1 hit |
SUPFAMi | SSF103647, SSF103647, 3 hits SSF49899, SSF49899, 2 hits SSF82895, SSF82895, 3 hits |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS50092, TSP1, 3 hits PS51234, TSP3, 8 hits PS51236, TSP_CTER, 1 hit PS01208, VWFC_1, 1 hit PS50184, VWFC_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MVWRLVLLAL WVWPSTQAGH QDKDTTFDLF SISNINRKTI GAKQFRGPDP
60 70 80 90 100
GVPAYRFVRF DYIPPVNADD LSKITKIMRQ KEGFFLTAQL KQDGKSRGTL
110 120 130 140 150
LALEGPGLSQ RQFEIVSNGP ADTLDLTYWI DGTRHVVSLE DVGLADSQWK
160 170 180 190 200
NVTVQVAGET YSLHVGCDLI DSFALDEPFY EHLQAEKSRM YVAKGSARES
210 220 230 240 250
HFRGLLQNVH LVFENSVEDI LSKKGCQQGQ GAEINAISEN TETLRLGPHV
260 270 280 290 300
TTEYVGPSSE RRPEVCERSC EELGNMVQEL SGLHVLVNQL SENLKRVSND
310 320 330 340 350
NQFLWELIGG PPKTRNMSAC WQDGRFFAEN ETWVVDSCTT CTCKKFKTIC
360 370 380 390 400
HQITCPPATC ASPSFVEGEC CPSCLHSVDG EEGWSPWAEW TQCSVTCGSG
410 420 430 440 450
TQQRGRSCDV TSNTCLGPSI QTRACSLSKC DTRIRQDGGW SHWSPWSSCS
460 470 480 490 500
VTCGVGNITR IRLCNSPVPQ MGGKNCKGSG RETKACQGAP CPIDGRWSPW
510 520 530 540 550
SPWSACTVTC AGGIRERTRV CNSPEPQYGG KACVGDVQER QMCNKRSCPV
560 570 580 590 600
DGCLSNPCFP GAQCSSFPDG SWSCGSCPVG FLGNGTHCED LDECALVPDI
610 620 630 640 650
CFSTSKVPRC VNTQPGFHCL PCPPRYRGNQ PVGVGLEAAK TEKQVCEPEN
660 670 680 690 700
PCKDKTHNCH KHAECIYLGH FSDPMYKCEC QTGYAGDGLI CGEDSDLDGW
710 720 730 740 750
PNLNLVCATN ATYHCIKDNC PHLPNSGQED FDKDGIGDAC DDDDDNDGVT
760 770 780 790 800
DEKDNCQLLF NPRQADYDKD EVGDRCDNCP YVHNPAQIDT DNNGEGDACS
810 820 830 840 850
VDIDGDDVFN ERDNCPYVYN TDQRDTDGDG VGDHCDNCPL VHNPDQTDVD
860 870 880 890 900
NDLVGDQCDN NEDIDDDGHQ NNQDNCPYIS NANQADHDRD GQGDACDPDD
910 920 930 940 950
DNDGVPDDRD NCRLVFNPDQ EDLDGDGRGD ICKDDFDNDN IPDIDDVCPE
960 970 980 990 1000
NNAISETDFR NFQMVPLDPK GTTQIDPNWV IRHQGKELVQ TANSDPGIAV
1010 1020 1030 1040 1050
GFDEFGSVDF SGTFYVNTDR DDDYAGFVFG YQSSSRFYVV MWKQVTQTYW
1060 1070 1080 1090 1100
EDQPTRAYGY SGVSLKVVNS TTGTGEHLRN ALWHTGNTPG QVRTLWHDPR
1110 1120 1130 1140 1150
NIGWKDYTAY RWHLTHRPKT GYIRVLVHEG KQVMADSGPI YDQTYAGGRL
1160 1170
GLFVFSQEMV YFSDLKYECR DI
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITK0 | A0A3B3ITK0_HUMAN | Thrombospondin-2 | THBS2 | 1,177 | Annotation score: | ||
A0A7I2V585 | A0A7I2V585_HUMAN | Thrombospondin-2 | THBS2 | 1,114 | Annotation score: | ||
A0A7I2YQT6 | A0A7I2YQT6_HUMAN | Thrombospondin-2 | THBS2 | 1,115 | Annotation score: | ||
A0A7I2YQ86 | A0A7I2YQ86_HUMAN | Thrombospondin-2 | THBS2 | 827 | Annotation score: | ||
Q5RI53 | Q5RI53_HUMAN | Thrombospondin-2 | THBS2 | 83 | Annotation score: | ||
A0A7I2V344 | A0A7I2V344_HUMAN | Thrombospondin-2 | THBS2 | 197 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | V → A in AAI50176 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 171 – 173 | DSF → GPV in AAA03703 (PubMed:8406456).Curated | 3 | |
Sequence conflicti | 576 | S → F in AAA03703 (PubMed:8406456).Curated | 1 | |
Sequence conflicti | 1111 | R → G in AAI46677 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045842 | 133 | T → S. Corresponds to variant dbSNP:rs36088849EnsemblClinVar. | 1 | |
Natural variantiVAR_045843 | 375 | L → F. Corresponds to variant dbSNP:rs35404985Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12350 mRNA Translation: AAA03703.1 M81339 mRNA No translation available. AK292429 mRNA Translation: BAF85118.1 BX322234 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47455.1 BC146676 mRNA Translation: AAI46677.1 BC150175 mRNA Translation: AAI50176.1 |
CCDSi | CCDS34574.1 |
PIRi | A47379, TSHUP2 |
RefSeqi | NP_003238.2, NM_003247.3 |
Genome annotation databases
Ensembli | ENST00000366787.7; ENSP00000355751.3; ENSG00000186340.17 ENST00000617924.6; ENSP00000482784.1; ENSG00000186340.17 ENST00000676498.1; ENSP00000504820.1; ENSG00000186340.17 ENST00000676760.1; ENSP00000503020.1; ENSG00000186340.17 |
GeneIDi | 7058 |
KEGGi | hsa:7058 |
MANE-Selecti | ENST00000617924.6; ENSP00000482784.1; NM_003247.5; NP_003238.2 |
UCSCi | uc003qwt.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12350 mRNA Translation: AAA03703.1 M81339 mRNA No translation available. AK292429 mRNA Translation: BAF85118.1 BX322234 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW47455.1 BC146676 mRNA Translation: AAI46677.1 BC150175 mRNA Translation: AAI50176.1 |
CCDSi | CCDS34574.1 |
PIRi | A47379, TSHUP2 |
RefSeqi | NP_003238.2, NM_003247.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1YO8 | X-ray | 2.60 | A | 551-1172 | [»] | |
2RHP | X-ray | 2.90 | A | 551-1172 | [»] | |
AlphaFoldDBi | P35442 | |||||
SMRi | P35442 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112916, 22 interactors |
ComplexPortali | CPX-1788, Thrombospondin 2 complex |
CORUMi | P35442 |
IntActi | P35442, 12 interactors |
STRINGi | 9606.ENSP00000355751 |
PTM databases
GlyConnecti | 1805, 24 N-Linked glycans (4 sites) |
GlyGeni | P35442, 7 sites, 23 N-linked glycans (4 sites) |
iPTMneti | P35442 |
PhosphoSitePlusi | P35442 |
Genetic variation databases
BioMutai | THBS2 |
DMDMi | 215273908 |
Proteomic databases
CPTACi | CPTAC-1186 |
EPDi | P35442 |
jPOSTi | P35442 |
MassIVEi | P35442 |
MaxQBi | P35442 |
PaxDbi | P35442 |
PeptideAtlasi | P35442 |
PRIDEi | P35442 |
ProteomicsDBi | 55062 |
Protocols and materials databases
Antibodypediai | 33564, 252 antibodies from 25 providers |
DNASUi | 7058 |
Genome annotation databases
Ensembli | ENST00000366787.7; ENSP00000355751.3; ENSG00000186340.17 ENST00000617924.6; ENSP00000482784.1; ENSG00000186340.17 ENST00000676498.1; ENSP00000504820.1; ENSG00000186340.17 ENST00000676760.1; ENSP00000503020.1; ENSG00000186340.17 |
GeneIDi | 7058 |
KEGGi | hsa:7058 |
MANE-Selecti | ENST00000617924.6; ENSP00000482784.1; NM_003247.5; NP_003238.2 |
UCSCi | uc003qwt.5, human |
Organism-specific databases
CTDi | 7058 |
DisGeNETi | 7058 |
GeneCardsi | THBS2 |
HGNCi | HGNC:11786, THBS2 |
HPAi | ENSG00000186340, Low tissue specificity |
MalaCardsi | THBS2 |
MIMi | 188061, gene 603932, phenotype |
neXtProti | NX_P35442 |
OpenTargetsi | ENSG00000186340 |
PharmGKBi | PA36498 |
VEuPathDBi | HostDB:ENSG00000186340 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRK8, Eukaryota |
GeneTreei | ENSGT00940000157846 |
HOGENOMi | CLU_009257_0_0_1 |
InParanoidi | P35442 |
OMAi | PPVTCAN |
OrthoDBi | 120983at2759 |
PhylomeDBi | P35442 |
TreeFami | TF324917 |
Enzyme and pathway databases
PathwayCommonsi | P35442 |
Reactomei | R-HSA-186797, Signaling by PDGF R-HSA-5083635, Defective B3GALTL causes PpS R-HSA-5173214, O-glycosylation of TSR domain-containing proteins |
SignaLinki | P35442 |
SIGNORi | P35442 |
Miscellaneous databases
BioGRID-ORCSi | 7058, 10 hits in 1074 CRISPR screens |
ChiTaRSi | THBS2, human |
EvolutionaryTracei | P35442 |
GeneWikii | THBS2 |
GenomeRNAii | 7058 |
Pharosi | P35442, Tbio |
PROi | PR:P35442 |
RNActi | P35442, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186340, Expressed in left coronary artery and 239 other tissues |
ExpressionAtlasi | P35442, baseline and differential |
Genevisiblei | P35442, HS |
Family and domain databases
Gene3Di | 2.20.100.10, 3 hits 4.10.1080.10, 2 hits |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR024731, EGF_dom IPR001791, Laminin_G IPR003367, Thrombospondin_3-like_rpt IPR017897, Thrombospondin_3_rpt IPR008859, Thrombospondin_C IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR015455, TSP2 IPR028974, TSP_type-3_rpt IPR001007, VWF_dom |
PANTHERi | PTHR10199:SF10, PTHR10199:SF10, 1 hit |
Pfami | View protein in Pfam PF12947, EGF_3, 1 hit PF07645, EGF_CA, 1 hit PF00090, TSP_1, 3 hits PF02412, TSP_3, 6 hits PF05735, TSP_C, 1 hit PF00093, VWC, 1 hit |
SMARTi | View protein in SMART SM00181, EGF, 3 hits SM00179, EGF_CA, 2 hits SM00209, TSP1, 3 hits SM00210, TSPN, 1 hit SM00214, VWC, 1 hit |
SUPFAMi | SSF103647, SSF103647, 3 hits SSF49899, SSF49899, 2 hits SSF82895, SSF82895, 3 hits |
PROSITEi | View protein in PROSITE PS01186, EGF_2, 1 hit PS50026, EGF_3, 2 hits PS50092, TSP1, 3 hits PS51234, TSP3, 8 hits PS51236, TSP_CTER, 1 hit PS01208, VWFC_1, 1 hit PS50184, VWFC_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TSP2_HUMAN | |
Accessioni | P35442Primary (citable) accession number: P35442 Secondary accession number(s): A6H8N1, A7E232, Q5RI52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | November 25, 2008 | |
Last modified: | May 25, 2022 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families