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Protein

Thrombospondin-2

Gene

THBS2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • negative regulation of angiogenesis Source: GO_Central
  • positive regulation of synapse assembly Source: GO_Central

Keywordsi

Molecular functionHeparin-binding
Biological processCell adhesion
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Thrombospondin-2
Gene namesi
Name:THBS2
Synonyms:TSP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003584823 – 1178Thrombospondin-2Add BLAST1156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi272InterchainBy similarity
Disulfide bondi276InterchainBy similarity
Glycosylationi317N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi322N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi399 ↔ 431By similarity
Disulfide bondi403 ↔ 436By similarity
Disulfide bondi414 ↔ 421By similarity
Disulfide bondi455 ↔ 492By similarity
Disulfide bondi459 ↔ 497By similarity
Glycosylationi463N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi470 ↔ 482By similarity
Disulfide bondi512 ↔ 549By similarity
Disulfide bondi516 ↔ 554By similarity
Disulfide bondi527 ↔ 539By similarity
Disulfide bondi559 ↔ 570By similarity
Disulfide bondi564 ↔ 580By similarity
Disulfide bondi583 ↔ 594By similarity
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi600 ↔ 616By similarity
Disulfide bondi607 ↔ 625By similarity
Disulfide bondi628 ↔ 652By similarity
Disulfide bondi658 ↔ 671By similarity
Disulfide bondi665 ↔ 684By similarity
Disulfide bondi686 ↔ 697By similarity
Disulfide bondi713 ↔ 721By similarity
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi726 ↔ 746By similarity
Disulfide bondi762 ↔ 782By similarity
Disulfide bondi785 ↔ 805By similarity
Disulfide bondi821 ↔ 841By similarity
Disulfide bondi844 ↔ 864By similarity
Disulfide bondi882 ↔ 902By similarity
Disulfide bondi918 ↔ 938By similarity
Disulfide bondi954 ↔ 1175By similarity
Glycosylationi1075N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35440
PRIDEiP35440

Expressioni

Gene expression databases

BgeeiENSGALG00000011200 Expressed in 7 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036892

Structurei

3D structure databases

ProteinModelPortaliP35440
SMRiP35440
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 221Laminin G-likeAdd BLAST197
Domaini324 – 381VWFCPROSITE-ProRule annotationAdd BLAST58
Domaini387 – 437TSP type-1 1PROSITE-ProRule annotationAdd BLAST51
Domaini443 – 498TSP type-1 2PROSITE-ProRule annotationAdd BLAST56
Domaini500 – 555TSP type-1 3PROSITE-ProRule annotationAdd BLAST56
Domaini555 – 595EGF-like 1PROSITE-ProRule annotationAdd BLAST41
Domaini654 – 698EGF-like 2PROSITE-ProRule annotationAdd BLAST45
Repeati699 – 734TSP type-3 1Add BLAST36
Repeati735 – 770TSP type-3 2Add BLAST36
Repeati771 – 793TSP type-3 3Add BLAST23
Repeati794 – 829TSP type-3 4Add BLAST36
Repeati830 – 852TSP type-3 5Add BLAST23
Repeati853 – 890TSP type-3 6Add BLAST38
Repeati891 – 926TSP type-3 7Add BLAST36
Repeati927 – 962TSP type-3 8Add BLAST36
Domaini966 – 1178TSP C-terminalPROSITE-ProRule annotationAdd BLAST213

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni? – 232Heparin-bindingSequence analysis

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi934 – 936Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the thrombospondin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
HOGENOMiHOG000007542
HOVERGENiHBG018006
InParanoidiP35440
KOiK04659
OrthoDBiEOG091G00TV
PhylomeDBiP35440

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35440-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQRSRLLWL AVFITLWVSS DAQDDAKEEE NTFDLLQISN INRKTIGAKL
60 70 80 90 100
FRGPDPAIPA YRFIRFDHIP PFKPEKLKKI VKLIRQNEGF ILSATLRQDR
110 120 130 140 150
QSRGTILALE GPGISERQFE IISNGRANTL DLIYWVDGFQ NVISLEDVDL
160 170 180 190 200
ADSQWKNLTV QVTGENYNLY VGCDLIDSFI LEEPFYEQLK AENSRMYVAK
210 220 230 240 250
GSIRENHFRG LLQNIHLIFD TSIEDVLRKK GCQRSQSTEV NTINESTEIL
260 270 280 290 300
HLSPAVTTEY VGEKTEKKAE FCDRSCEELG TMFTELTGLR IVVNNLADNL
310 320 330 340 350
QKVSEENQIM WELIGPNKTL KNQSVCWQDG RVFADSESWI VDSCTKCTCQ
360 370 380 390 400
DSKIVCHQIT CPPVSCADPS FIEGECCPVC SHSDDSEEGW SPWSDWTKCS
410 420 430 440 450
VTCGSGTQMR GRSCDVTRSA CTGPHIQTRM CSFKKCDHRI RQDGGWSHWS
460 470 480 490 500
PWSSCSVTCG VGNITRIRLC NSPIPQMGGK NCVGNGRETE KCEKAPCPVN
510 520 530 540 550
GQWGPWSPWS ACTVTCGGGI RERSRLCNSP EPQYGGKPCV GDTKQHDMCN
560 570 580 590 600
KRDCPIDGCL SNPCFPGAEC NSYPDGSWSC GPCPAGFLGN GTVCEDLDEC
610 620 630 640 650
IAVSDVCFKV NQVHRCVNTN PGFHCLPCPP RYKGSQPYGV GLEVAKTEKQ
660 670 680 690 700
VCEPENPCKD KTHSCHKSAE CIYLGHFSDP MYKCECRTGY AGDGRICGED
710 720 730 740 750
SDLDGWPNNN LVCAANATYH CVKDNCPLLP NSGQEDFDKD GKGDACDEDD
760 770 780 790 800
DNDGVEDDKD NCPLLFNPRQ FDYDKDEVGD RCDNCPYVHN PAQIDTDNNG
810 820 830 840 850
EGDSCAVDID GDDIFNERDN CPYVYNTDQS DTDGDGVGDQ CDNCPLMHNP
860 870 880 890 900
DQTDADNDLV GDQCDNNEDI DEDGHQNNQD NCPYIPNANQ ADHDKDGKGD
910 920 930 940 950
ACDPDDDNDG IPDDRDNCRL RYNPEQEDSD GDGRGDICKD DFDDDNVPDI
960 970 980 990 1000
FDVCPENNAI SETDFRKFQM VPLDPKGTAQ IDPNWVIRHQ GKELVQTANS
1010 1020 1030 1040 1050
DPGIAVGYDE FSSVDFSGTF YVNTDRDDDY AGFVFGYQSS SRFYVLMWKQ
1060 1070 1080 1090 1100
VTQTYWEDKP TRAYGYSGVS LKVVNSTTGT GEHLRNALWH TGNTPGQVRT
1110 1120 1130 1140 1150
LWHDPKNIGW KDYTAYRWHL IHRPKTGLIK VLVYEGKQVM VDSGPIYDTT
1160 1170
FAGGRLGLFV FSQEMVYFSD LKYECRDA
Length:1,178
Mass (Da):131,817
Last modified:June 1, 1994 - v1
Checksum:iF37E02F42C8717A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60853 mRNA Translation: AAA51437.1
PIRiA39804
RefSeqiNP_001001755.1, NM_001001755.1
XP_015139539.1, XM_015284053.1
UniGeneiGga.797

Genome annotation databases

GeneIDi414837
KEGGigga:414837

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60853 mRNA Translation: AAA51437.1
PIRiA39804
RefSeqiNP_001001755.1, NM_001001755.1
XP_015139539.1, XM_015284053.1
UniGeneiGga.797

3D structure databases

ProteinModelPortaliP35440
SMRiP35440
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036892

Proteomic databases

PaxDbiP35440
PRIDEiP35440

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414837
KEGGigga:414837

Organism-specific databases

CTDi7058

Phylogenomic databases

eggNOGiENOG410IFQQ Eukaryota
ENOG410XQKE LUCA
HOGENOMiHOG000007542
HOVERGENiHBG018006
InParanoidiP35440
KOiK04659
OrthoDBiEOG091G00TV
PhylomeDBiP35440

Miscellaneous databases

PROiPR:P35440

Gene expression databases

BgeeiENSGALG00000011200 Expressed in 7 organ(s), highest expression level in heart

Family and domain databases

Gene3Di2.20.100.10, 3 hits
4.10.1080.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024731 EGF_dom
IPR001791 Laminin_G
IPR037349 Thrombospondin
IPR003367 Thrombospondin_3-like_rpt
IPR017897 Thrombospondin_3_rpt
IPR008859 Thrombospondin_C
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015455 TSP2
IPR028974 TSP_type-3_rpt
IPR001007 VWF_dom
PANTHERiPTHR10199 PTHR10199, 2 hits
PTHR10199:SF10 PTHR10199:SF10, 2 hits
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF00090 TSP_1, 3 hits
PF02412 TSP_3, 7 hits
PF05735 TSP_C, 1 hit
PF00093 VWC, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00209 TSP1, 3 hits
SM00210 TSPN, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF103647 SSF103647, 3 hits
SSF49899 SSF49899, 2 hits
SSF82895 SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS50092 TSP1, 3 hits
PS51234 TSP3, 8 hits
PS51236 TSP_CTER, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSP2_CHICK
AccessioniPrimary (citable) accession number: P35440
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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