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Protein

Transcription factor HES-2

Gene

Hes2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor of genes that require a bHLH protein for their transcription.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor HES-2
Alternative name(s):
Hairy and enhancer of split 2
Gene namesi
Name:Hes2
Synonyms:Hes-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi62082 Hes2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272081 – 157Transcription factor HES-2Add BLAST157

Proteomic databases

PaxDbiP35429
PRIDEiP35429

Expressioni

Gene expression databases

BgeeiENSRNOG00000010490 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiP35429 RN

Interactioni

Subunit structurei

Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family.By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiP35429
STRINGi10116.ENSRNOP00000014035

Structurei

3D structure databases

ProteinModelPortaliP35429
SMRiP35429
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 70bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini86 – 119OrangePROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi154 – 157WRPW motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi139 – 148Pro-rich10

Domaini

Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG).
The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins.By similarity

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104168
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiP35429
KOiK09087
OMAiPVPCDSY
OrthoDBiEOG091G0GBN
PhylomeDBiP35429
TreeFamiTF351373

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

P35429-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLPRGVGDA AELRKSLKPL LEKRRRARIN ESLSQLKGLV LPLLGAETSR
60 70 80 90 100
YSKLEKADIL EMTVRFLREQ PASVCSTEAP GSLDSYLEGY RACLARLARV
110 120 130 140 150
LPACSVLEPA VSARLLEHLR QRTVSGGPPS LTPASASAPA PSPPVPPPSS

LGLWRPW
Length:157
Mass (Da):17,028
Last modified:June 1, 1994 - v1
Checksum:iB5D621E814AE0369
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14029 mRNA Translation: BAA03118.1
PIRiS35037
RefSeqiNP_062109.1, NM_019236.1
UniGeneiRn.44655

Genome annotation databases

EnsembliENSRNOT00000014035; ENSRNOP00000014035; ENSRNOG00000010490
GeneIDi29567
KEGGirno:29567
UCSCiRGD:62082 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14029 mRNA Translation: BAA03118.1
PIRiS35037
RefSeqiNP_062109.1, NM_019236.1
UniGeneiRn.44655

3D structure databases

ProteinModelPortaliP35429
SMRiP35429
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP35429
STRINGi10116.ENSRNOP00000014035

Proteomic databases

PaxDbiP35429
PRIDEiP35429

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000014035; ENSRNOP00000014035; ENSRNOG00000010490
GeneIDi29567
KEGGirno:29567
UCSCiRGD:62082 rat

Organism-specific databases

CTDi54626
RGDi62082 Hes2

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104168
HOGENOMiHOG000236346
HOVERGENiHBG005960
InParanoidiP35429
KOiK09087
OMAiPVPCDSY
OrthoDBiEOG091G0GBN
PhylomeDBiP35429
TreeFamiTF351373

Miscellaneous databases

PROiPR:P35429

Gene expression databases

BgeeiENSRNOG00000010490 Expressed in 9 organ(s), highest expression level in heart
GenevisibleiP35429 RN

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00511 ORANGE, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHES2_RAT
AccessioniPrimary (citable) accession number: P35429
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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