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Entry version 167 (02 Dec 2020)
Sequence version 2 (11 Jan 2001)
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Protein

Phosphoribosylformylglycinamidine synthase

Gene

Pfas

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway (PubMed:3086869). Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (PubMed:3086869). Because of its role in metabolisms, is involved in sleep regulation (PubMed:3086869).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.1 Publication
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase (Pfas)
  2. Trifunctional purine biosynthetic protein adenosine-3 (ade3-RA), AIR synthase (gart), Trifunctional purine biosynthetic protein adenosine-3 (Gart), Trifunctional purine biosynthetic protein adenosine-3 (Gart)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei714ATP; via carbonyl oxygenBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi715MagnesiumBy similarity1
Metal bindingi754MagnesiumBy similarity1
Metal bindingi758MagnesiumBy similarity1
Metal bindingi918MagnesiumBy similarity1
Binding sitei920ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1180NucleophileBy similarity1
Active sitei1310By similarity1
Active sitei1312By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi327 – 338ATPSequence analysisAdd BLAST12
Nucleotide bindingi407 – 409ATPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-73817, Purine ribonucleoside monophosphate biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00074;UER00128

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine synthaseImported (EC:6.3.5.31 Publication)
Short name:
FGAM synthase
Short name:
FGAMS
Alternative name(s):
Formylglycinamide ribonucleotide amidotransferase
Short name:
FGAR amidotransferase
Short name:
FGAR-AT
Formylglycinamide ribotide amidotransferase
Protein adenosine-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PfasImported
Synonyms:ade2Imported
ORF Names:CG9127Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000052, Pfas

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Pupal lethal (PubMed:21441212). RNAi-mediated knockdown in the fat body reduces energy storage of both triglyceride and free glucose, increases waking activity during the day and the night, reduces sleep bout length, with total sleep bout number reduced during the day and increased during the night (PubMed:30249751).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001004031 – 1354Phosphoribosylformylglycinamidine synthaseAdd BLAST1354

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35421

PRoteomics IDEntifications database

More...
PRIDEi
P35421

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000052, Expressed in arthropod fat body and 52 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35421, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
60012, 4 interactors

Database of interacting proteins

More...
DIPi
DIP-22769N

Protein interaction database and analysis system

More...
IntActi
P35421, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0078850

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35421

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1087 – 1337Glutamine amidotransferase type-1Add BLAST251

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the FGAMS family.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1907, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007600

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001031_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35421

Identification of Orthologs from Complete Genome Data

More...
OMAi
LSANWMW

Database of Orthologous Groups

More...
OrthoDBi
38224at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35421

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1330.10, 2 hits
3.40.50.880, 1 hit
3.90.650.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00419, PurL_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029062, Class_I_gatase-like
IPR040707, FGAR-AT_N
IPR017926, GATASE
IPR010073, PurL_large
IPR041609, PurL_linker
IPR010918, PurM-like_C_dom
IPR036676, PurM-like_C_sf
IPR016188, PurM-like_N
IPR036921, PurM-like_N_sf
IPR036604, PurS-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00586, AIRS, 1 hit
PF02769, AIRS_C, 2 hits
PF18072, FGAR-AT_linker, 1 hit
PF18076, FGAR-AT_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52317, SSF52317, 1 hit
SSF55326, SSF55326, 2 hits
SSF56042, SSF56042, 2 hits
SSF82697, SSF82697, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01735, FGAM_synt, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51273, GATASE_TYPE_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P35421-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVILRYYDVQ AHSAAEEESV LRRLREEDGA VVSVRMERCY HLEYSAQAEH
60 70 80 90 100
SLALDELLVW LVKQPLSKGQ SLSRQPALQS TGSSQLLLEI GPRFNFSTPY
110 120 130 140 150
STNCVNIFQN LGYSEVRRME TSTRYLVTFG EGSKAPEAAR FVPLLGDRMT
160 170 180 190 200
QCLYTEENTP KASFDEQLPE RQANWHFVPV LEEGRAALER INQELGLAFN
210 220 230 240 250
DYDLDYYHDL FAKELGRNPT TVELFDCAQS NSEHSRHWFF RGRMVIDGVE
260 270 280 290 300
QPKSLIRMIM DTQAHTNPNN TIKFSDNSSA MVGFDHQTIV PSSVVAPGAV
310 320 330 340 350
RLQSVQSDLI FTAETHNMPT AVAPFSGATT GTGGRLRDVQ GVGRGGVPIA
360 370 380 390 400
GTAGYCVGAL HIPGYKQPYE PLDFKYPATF APPLQVLIEA SNGASDYGNK
410 420 430 440 450
FGEPVISGFA LSYGLNSAAD ASQRDEYVKP IMFSGGLGTM PATMREKLPP
460 470 480 490 500
ARGQLLAKIG GPVYRIGVGG GAASSVEIQG SGDAELDFNA VQRGDAEMEN
510 520 530 540 550
KLNRVVRACL DLGEQNPILA IHDQGAGGNG NVLKELVEPG FAGAVIFSKE
560 570 580 590 600
FQLGDPTITA LELWGAEYQE NNAILCNADQ RELLEKICRR ERCPISFVGV
610 620 630 640 650
VTGDGRVTLL EKPAPKDLEQ ALNASNRSEV SPFDLELKYV LGDMPKRTYD
660 670 680 690 700
LKREQTPLKE LSLPKGLLLD EALERVLSLV AVGSKRFLTN KVDRCVGGLI
710 720 730 740 750
AQQQCVGPLQ APLADYALTT VSHFSHSGIA TSIGTQPLKG LLDPAAMARM
760 770 780 790 800
CVAEALSNLV FVKISELADV KCSGNWMWAA KLPGEGARMF DACKELCQIL
810 820 830 840 850
EELHIAIDGG KDSLSMAAKV GGETIKSPGT LVISTYAPCP DVRLKVTPDL
860 870 880 890 900
KGPGAGSKTS LLWINLENSA RLGGSALAQA YAQQGKDTPN LTRSDVLGKA
910 920 930 940 950
FAVTQSLLGD GLIQAGHDVS DGGLLVCVLE MAIGGLSGLR VDLSEPLAKL
960 970 980 990 1000
KNFDKSVEKL NRPELAVLFA EECGWVVEVL DTDLERVRST YEKAGVPNYY
1010 1020 1030 1040 1050
LGVTEGFGLD SRVVLKNGKS ELLDQPLRVL YKKWERTSYE LEKLQANPEC
1060 1070 1080 1090 1100
AEAEYNSLEY RQAPQYRGPQ NVQAELTLKR SSAPVRVAVL REEGVNSERE
1110 1120 1130 1140 1150
MMACLLRANF EVHDVTMSDL LQGTASVSQY RGLIFPGGFS YADTLGSAKG
1160 1170 1180 1190 1200
WAANILHNPR LLPQFEAFKR RQDVFSLGIC NGCQLMTLIG FVGSAKSEVG
1210 1220 1230 1240 1250
ADPDVALLHN KSQRFECRWA TVKIPSNRSI MLGSMKDLVL GCWVAHGEGR
1260 1270 1280 1290 1300
FAFRDEKLIS HLQSEQLVTL QYVDDVGKPT ELYPLNPNGS PQGIAGLCSS
1310 1320 1330 1340 1350
DGRHLALMPH PERCSSMYQW PYVPSSFEVS PTQSESPWQI MFNNAYNWCV

KSNQ
Length:1,354
Mass (Da):148,085
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8AA167C2D2920B2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti558I → Y in AAC46468 (PubMed:8270203).Curated1
Sequence conflicti625S → F in AAC46468 (PubMed:8270203).Curated1
Sequence conflicti766E → V in AAR82811 (Ref. 4) Curated1
Sequence conflicti910D → E in AAR82811 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00683 Unassigned DNA Translation: AAC46468.1
AE014134 Genomic DNA Translation: AAF52329.1
AE014134 Genomic DNA Translation: AAN10573.1
AE014134 Genomic DNA Translation: AAN10574.1
BT011143 mRNA Translation: AAR82811.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T13363

NCBI Reference Sequences

More...
RefSeqi
NP_477212.1, NM_057864.4
NP_723146.1, NM_164675.2
NP_723147.1, NM_164676.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0079219; FBpp0078850; FBgn0000052
FBtr0079220; FBpp0078851; FBgn0000052
FBtr0079221; FBpp0078852; FBgn0000052

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9127

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00683 Unassigned DNA Translation: AAC46468.1
AE014134 Genomic DNA Translation: AAF52329.1
AE014134 Genomic DNA Translation: AAN10573.1
AE014134 Genomic DNA Translation: AAN10574.1
BT011143 mRNA Translation: AAR82811.1
PIRiT13363
RefSeqiNP_477212.1, NM_057864.4
NP_723146.1, NM_164675.2
NP_723147.1, NM_164676.2

3D structure databases

SMRiP35421
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi60012, 4 interactors
DIPiDIP-22769N
IntActiP35421, 2 interactors
STRINGi7227.FBpp0078850

Proteomic databases

PaxDbiP35421
PRIDEiP35421

Genome annotation databases

EnsemblMetazoaiFBtr0079219; FBpp0078850; FBgn0000052
FBtr0079220; FBpp0078851; FBgn0000052
FBtr0079221; FBpp0078852; FBgn0000052
GeneIDi33847
KEGGidme:Dmel_CG9127

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5198
FlyBaseiFBgn0000052, Pfas

Phylogenomic databases

eggNOGiKOG1907, Eukaryota
GeneTreeiENSGT00390000007600
HOGENOMiCLU_001031_0_0_1
InParanoidiP35421
OMAiLSANWMW
OrthoDBi38224at2759
PhylomeDBiP35421

Enzyme and pathway databases

UniPathwayiUPA00074;UER00128
ReactomeiR-DME-73817, Purine ribonucleoside monophosphate biosynthesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33847, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33847

Protein Ontology

More...
PROi
PR:P35421

Gene expression databases

BgeeiFBgn0000052, Expressed in arthropod fat body and 52 other tissues
GenevisibleiP35421, DM

Family and domain databases

Gene3Di3.30.1330.10, 2 hits
3.40.50.880, 1 hit
3.90.650.10, 2 hits
HAMAPiMF_00419, PurL_1, 1 hit
InterProiView protein in InterPro
IPR029062, Class_I_gatase-like
IPR040707, FGAR-AT_N
IPR017926, GATASE
IPR010073, PurL_large
IPR041609, PurL_linker
IPR010918, PurM-like_C_dom
IPR036676, PurM-like_C_sf
IPR016188, PurM-like_N
IPR036921, PurM-like_N_sf
IPR036604, PurS-like_sf
PfamiView protein in Pfam
PF00586, AIRS, 1 hit
PF02769, AIRS_C, 2 hits
PF18072, FGAR-AT_linker, 1 hit
PF18076, FGAR-AT_N, 1 hit
SUPFAMiSSF52317, SSF52317, 1 hit
SSF55326, SSF55326, 2 hits
SSF56042, SSF56042, 2 hits
SSF82697, SSF82697, 1 hit
TIGRFAMsiTIGR01735, FGAM_synt, 1 hit
PROSITEiView protein in PROSITE
PS51273, GATASE_TYPE_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPUR4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35421
Secondary accession number(s): A4V099, Q6NNY9, Q9VMI7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 11, 2001
Last modified: December 2, 2020
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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