UniProtKB - P35407 (CXCR2_RAT)
Protein
C-X-C chemokine receptor type 2
Gene
Cxcr2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity).By similarity
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- C-C chemokine receptor activity Source: GO_Central
- chemokine binding Source: GO_Central
- chemokine receptor activity Source: RGD
- C-X-C chemokine receptor activity Source: RGD
- G protein-coupled receptor activity Source: RGD
- interleukin-8 binding Source: RGD
- interleukin-8 receptor activity Source: RGD
GO - Biological processi
- acute inflammatory response to antigenic stimulus Source: RGD
- calcium-mediated signaling Source: GO_Central
- cell chemotaxis Source: GO_Central
- cell surface receptor signaling pathway Source: RGD
- cellular defense response Source: RGD
- chemotaxis Source: RGD
- immune response Source: GO_Central
- interleukin-8-mediated signaling pathway Source: RGD
- metanephric tubule morphogenesis Source: RGD
- midbrain development Source: RGD
- negative regulation of apoptotic process Source: RGD
- negative regulation of neutrophil apoptotic process Source: RGD
- neutrophil activation Source: RGD
- neutrophil chemotaxis Source: RGD
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of cardiac muscle cell apoptotic process Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of leukocyte chemotaxis Source: RGD
- positive regulation of neutrophil chemotaxis Source: RGD
- positive regulation of vascular permeability Source: RGD
- receptor internalization Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Chemotaxis |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events R-RNO-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C chemokine receptor type 2Short name: CXC-R2 Short name: CXCR-2 Alternative name(s): GRO/MGSA receptor High affinity interleukin-8 receptor B Short name: IL-8R B CD_antigen: CD182 |
Gene namesi | Name:Cxcr2 Synonyms:Il8rb |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2906, Cxcr2 |
Subcellular locationi
Plasma membrane
Cytoskeleton
- mitotic spindle Source: Ensembl
Lysosome
- mast cell granule Source: RGD
Nucleus
- nucleoplasm Source: Ensembl
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- cell surface Source: RGD
- integral component of membrane Source: UniProtKB-KW
- membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 47 | ExtracellularSequence analysisAdd BLAST | 47 | |
Transmembranei | 48 – 74 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 75 – 83 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 84 – 104 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 105 – 119 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 120 – 141 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 142 – 162 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 163 – 182 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 183 – 207 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 208 – 230 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 231 – 250 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 251 – 272 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 273 – 296 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 297 – 314 | Helical; Name=7Sequence analysisAdd BLAST | 18 | |
Topological domaini | 315 – 359 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069342 | 1 – 359 | C-X-C chemokine receptor type 2Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 8 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 23 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 118 ↔ 195 | PROSITE-ProRule annotation | ||
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 202 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated upon ligand binding; which is required for desensitization.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P35407 |
PTM databases
GlyGeni | P35407, 4 sites |
PhosphoSitePlusi | P35407 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000014269, Expressed in esophagus and 19 other tissues |
ExpressionAtlasi | P35407, baseline and differential |
Genevisiblei | P35407, RN |
Interactioni
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- chemokine binding Source: GO_Central
- interleukin-8 binding Source: RGD
Protein-protein interaction databases
IntActi | P35407, 1 interactor |
MINTi | P35407 |
STRINGi | 10116.ENSRNOP00000019109 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214381 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P35407 |
OMAi | FIFREAY |
OrthoDBi | 865441at2759 |
PhylomeDBi | P35407 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR000057, Chemokine_CXCR2 IPR000174, Chemokine_CXCR_1/2 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00427, INTRLEUKIN8R PR00573, INTRLEUKN8BR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P35407-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV
60 70 80 90 100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL
110 120 130 140 150
PVWAASKVNG WIFGSFLCKV FSFLQEITFY SSVLLLACIS MDRYLAIVHA
160 170 180 190 200
TSTLIQKRHL VKFVCITMWF LSLVLSLPIF ILRTTVKANP STVVCYENIG
210 220 230 240 250
NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA HMGQKHRAMR
260 270 280 290 300
VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI
310 320 330 340 350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS
SSANTSTTL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K0F0 | A0A0G2K0F0_RAT | C-X-C chemokine receptor type 2 | Cxcr2 | 160 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77797 mRNA Translation: CAA54824.1 D63584 Genomic DNA Translation: BAA09797.1 U70988 Genomic DNA Translation: AAC52961.1 |
PIRi | S42096 |
RefSeqi | NP_058879.1, NM_017183.1 XP_008765435.1, XM_008767213.2 |
Genome annotation databases
Ensembli | ENSRNOT00000019109; ENSRNOP00000019109; ENSRNOG00000014269 |
GeneIDi | 29385 |
KEGGi | rno:29385 |
UCSCi | RGD:2906, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77797 mRNA Translation: CAA54824.1 D63584 Genomic DNA Translation: BAA09797.1 U70988 Genomic DNA Translation: AAC52961.1 |
PIRi | S42096 |
RefSeqi | NP_058879.1, NM_017183.1 XP_008765435.1, XM_008767213.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P35407, 1 interactor |
MINTi | P35407 |
STRINGi | 10116.ENSRNOP00000019109 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35407, 4 sites |
PhosphoSitePlusi | P35407 |
Proteomic databases
PaxDbi | P35407 |
Genome annotation databases
Ensembli | ENSRNOT00000019109; ENSRNOP00000019109; ENSRNOG00000014269 |
GeneIDi | 29385 |
KEGGi | rno:29385 |
UCSCi | RGD:2906, rat |
Organism-specific databases
CTDi | 3579 |
RGDi | 2906, Cxcr2 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214381 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P35407 |
OMAi | FIFREAY |
OrthoDBi | 865441at2759 |
PhylomeDBi | P35407 |
TreeFami | TF330966 |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-418594, G alpha (i) signalling events R-RNO-6798695, Neutrophil degranulation |
Miscellaneous databases
PROi | PR:P35407 |
Gene expression databases
Bgeei | ENSRNOG00000014269, Expressed in esophagus and 19 other tissues |
ExpressionAtlasi | P35407, baseline and differential |
Genevisiblei | P35407, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000057, Chemokine_CXCR2 IPR000174, Chemokine_CXCR_1/2 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00427, INTRLEUKIN8R PR00573, INTRLEUKN8BR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCR2_RAT | |
Accessioni | P35407Primary (citable) accession number: P35407 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries