C-X-C chemokine receptor type 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• C-C chemokine binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• C-C chemokine receptor activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine receptor activity Source: RGD
• C-X-C chemokine receptor activity Source: RGD
• G protein-coupled receptor activity Source: RGD
• interleukin-8 binding Source: RGD
• interleukin-8 receptor activity Source: RGD

GO - Biological processⁱ

• acute inflammatory response to antigenic stimulus Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect."
    Stevenson C.S., Coote K., Webster R., Johnston H., Atherton H.C., Nicholls A., Giddings J., Sugar R., Jackson A., Press N.J., Brown Z., Butler K., Danahay H.
    Am J Physiol Lung Cell Mol Physiol 288:L514-22(2005) [PubMed] [Europe PMC] [Abstract]
• calcium-mediated signaling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell surface receptor signaling pathway Source: RGD
• cellular defense response Source: RGD
• chemotaxis Source: RGD
• immune response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• interleukin-8-mediated signaling pathway Source: RGD
• metanephric tubule morphogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "ELR+-CXC chemokines and their receptors in early metanephric development."
    Levashova Z.B., Sharma N., Timofeeva O.A., Dome J.S., Perantoni A.O.
    J Am Soc Nephrol 18:2359-2370(2007) [PubMed] [Europe PMC] [Abstract]
• midbrain development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres."
    Edman L.C., Mira H., Erices A., Malmersjo S., Andersson E., Uhlen P., Arenas E.
    Stem Cells 26:1891-1900(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "ELR+-CXC chemokines and their receptors in early metanephric development."
    Levashova Z.B., Sharma N., Timofeeva O.A., Dome J.S., Perantoni A.O.
    J Am Soc Nephrol 18:2359-2370(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neutrophil apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Virus-infected alveolar epithelial cells direct neutrophil chemotaxis and inhibit their apoptosis."
    Rzepka J.P., Haick A.K., Miura T.A.
    Am J Respir Cell Mol Biol 46:833-841(2012) [PubMed] [Europe PMC] [Abstract]
• neutrophil activation Source: RGD
• neutrophil chemotaxis Source: RGDInferred from mutant phenotypeⁱ
  • "Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs)."
    Shibata F., Konishi K., Nakagawa H.
    Cytokine 12:1368-1373(2000) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: RGD
• positive regulation of angiogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages."
    Gelati M., Aplin A.C., Fogel E., Smith K.D., Nicosia R.F.
    J Immunol 181:5711-5719(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle cell apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell-released chemokines."
    Lee A.S., Wang G.J., Chan H.C., Chen F.Y., Chang C.M., Yang C.Y., Lee Y.T., Chang K.C., Chen C.H.
    Apoptosis 17:1009-1018(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGD
• positive regulation of cytosolic calcium ion concentration Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Identification of a common receptor for three types of rat cytokine-induced neutrophil chemoattractants (CINCs)."
    Shibata F., Konishi K., Nakagawa H.
    Cytokine 12:1368-1373(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of leukocyte chemotaxis Source: RGDInferred from mutant phenotypeⁱ
  • "CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration."
    Abu Nabah Y.N., Losada M., Estelles R., Mateo T., Company C., Piqueras L., Lopez-Gines C., Sarau H., Cortijo J., Morcillo E.J., Jose P.J., Sanz M.J.
    Arterioscler Thromb Vasc Biol 27:2370-2376(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil chemotaxis Source: RGDInferred from mutant phenotypeⁱ
  • "Rho-kinase inhibitor prevents bleomycin-induced injury in neonatal rats independent of effects on lung inflammation."
    Lee A.H., Dhaliwal R., Kantores C., Ivanovska J., Gosal K., McNamara P.J., Letarte M., Jankov R.P.
    Am J Respir Cell Mol Biol 50:61-73(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of vascular permeability Source: RGDInferred from mutant phenotypeⁱ
  • "A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability."
    Gavard J., Hou X., Qu Y., Masedunskas A., Martin D., Weigert R., Li X., Gutkind J.S.
    Mol Cell Biol 29:2469-2480(2009) [PubMed] [Europe PMC] [Abstract]
• receptor internalization Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• C-C chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• interleukin-8 binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MGEIRVDNFS LEDFFSGDID SYNYSSDPPF TLSDAAPCPS ANLDINRYAV 
        60         70         80         90        100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL 
       110        120        130        140        150
PVWAASKVNG WIFGSFLCKV FSFLQEITFY SSVLLLACIS MDRYLAIVHA 
       160        170        180        190        200
TSTLIQKRHL VKFVCITMWF LSLVLSLPIF ILRTTVKANP STVVCYENIG 
       210        220        230        240        250
NNTSKWRVVL RILPQTYGFL LPLLIMLFCY GFTLRTLFKA HMGQKHRAMR 
       260        270        280        290        300
VIFAVVLVFL LCWLPYNIVL FTDTLMRTKL IKETCERQNE INKALEATEI 
       310        320        330        340        350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAN YGLVSKEFLA KEGRPSFVGS 

SSANTSTTL                                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries