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Entry version 134 (10 Feb 2021)
Sequence version 1 (01 Jun 1994)
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Protein

ER lumen protein-retaining receptor A

Gene

ERD2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes H-D-E-L.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ER lumen protein-retaining receptor A
Alternative name(s):
HDEL receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERD2A
Ordered Locus Names:At1g29330
ORF Names:F15D2.26, F28N24.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G29330

The Arabidopsis Information Resource

More...
TAIRi
locus:2013683, AT1G29330

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2LumenalSequence analysis2
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 98CytoplasmicSequence analysisAdd BLAST16
Transmembranei99 – 112HelicalSequence analysisAdd BLAST14
Topological domaini113 – 119LumenalSequence analysis7
Transmembranei120 – 139HelicalSequence analysisAdd BLAST20
Topological domaini140 – 151CytoplasmicSequence analysisAdd BLAST12
Transmembranei152 – 170HelicalSequence analysisAdd BLAST19
Topological domaini171 – 181LumenalSequence analysisAdd BLAST11
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Topological domaini203 – 215CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001941671 – 215ER lumen protein-retaining receptor AAdd BLAST215

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35402

PRoteomics IDEntifications database

More...
PRIDEi
P35402

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
220667

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P35402, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35402, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
25042, 34 interactors

Protein interaction database and analysis system

More...
IntActi
P35402, 29 interactors

STRING: functional protein association networks

More...
STRINGi
3702.AT1G29330.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35402

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3106, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_057784_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35402

Identification of Orthologs from Complete Genome Data

More...
OMAi
TVYLMFF

Database of Orthologous Groups

More...
OrthoDBi
1186269at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35402

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000133, ER_ret_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR10585, PTHR10585, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00810, ER_lumen_recept, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00660, ERLUMENR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00951, ER_LUMEN_RECEPTOR_1, 1 hit
PS00952, ER_LUMEN_RECEPTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35402-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNIFRFAGDM SHLISVLILL LKIYATKSCA GISLKTQELY ALVFLTRYLD
60 70 80 90 100
LFTDYVSLYN SIMKIVFIAS SLAIVWCMRR HPLVRRSYDK DLDTFRHQYV
110 120 130 140 150
VLACFVLGLI LNEKFTVQEV FWAFSIYLEA VAILPQLVLL QRSGNVDNLT
160 170 180 190 200
GQYVVFLGAY RGLYIINWIY RYFTEDHFTR WIACVSGLVQ TALYADFFYY
210
YYISWKTNTK LKLPA
Length:215
Mass (Da):25,204
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD379FA8E4ECC9BC2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A178WIU4A0A178WIU4_ARATH
ER lumen protein-retaining receptor
ERD2 AERD2, ATERD2, At1g29330, F28N24.1
153Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L23573 mRNA No translation available.
AC021043 Genomic DNA Translation: AAF88108.1
AC068667 Genomic DNA Translation: AAG51724.1
CP002684 Genomic DNA Translation: AEE31073.1
AY093240 mRNA Translation: AAM13239.1
BT009655 mRNA Translation: AAP75805.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A49677

NCBI Reference Sequences

More...
RefSeqi
NP_564326.1, NM_102673.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G29330.1; AT1G29330.1; AT1G29330

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
839807

Gramene; a comparative resource for plants

More...
Gramenei
AT1G29330.1; AT1G29330.1; AT1G29330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G29330

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23573 mRNA No translation available.
AC021043 Genomic DNA Translation: AAF88108.1
AC068667 Genomic DNA Translation: AAG51724.1
CP002684 Genomic DNA Translation: AEE31073.1
AY093240 mRNA Translation: AAM13239.1
BT009655 mRNA Translation: AAP75805.1
PIRiA49677
RefSeqiNP_564326.1, NM_102673.6

3D structure databases

SMRiP35402
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi25042, 34 interactors
IntActiP35402, 29 interactors
STRINGi3702.AT1G29330.1

Proteomic databases

PaxDbiP35402
PRIDEiP35402
ProteomicsDBi220667

Genome annotation databases

EnsemblPlantsiAT1G29330.1; AT1G29330.1; AT1G29330
GeneIDi839807
GrameneiAT1G29330.1; AT1G29330.1; AT1G29330
KEGGiath:AT1G29330

Organism-specific databases

AraportiAT1G29330
TAIRilocus:2013683, AT1G29330

Phylogenomic databases

eggNOGiKOG3106, Eukaryota
HOGENOMiCLU_057784_0_0_1
InParanoidiP35402
OMAiTVYLMFF
OrthoDBi1186269at2759
PhylomeDBiP35402

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P35402

Gene expression databases

ExpressionAtlasiP35402, baseline and differential
GenevisibleiP35402, AT

Family and domain databases

InterProiView protein in InterPro
IPR000133, ER_ret_rcpt
PANTHERiPTHR10585, PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810, ER_lumen_recept, 1 hit
PRINTSiPR00660, ERLUMENR
PROSITEiView protein in PROSITE
PS00951, ER_LUMEN_RECEPTOR_1, 1 hit
PS00952, ER_LUMEN_RECEPTOR_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERD2A_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35402
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: February 10, 2021
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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