UniProtKB - P35400 (GRM7_RAT)
Protein
Metabotropic glutamate receptor 7
Gene
Grm7
Organism
Rattus norvegicus (Rat)
Status
Functioni
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 159 | GlutamateBy similarity | 1 | |
Binding sitei | 230 | GlutamateBy similarity | 1 | |
Binding sitei | 314 | GlutamateBy similarity | 1 | |
Binding sitei | 407 | GlutamateBy similarity | 1 |
GO - Molecular functioni
- adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Source: RGD
- adenylate cyclase inhibitor activity Source: RGD
- calcium channel regulator activity Source: RGD
- calcium-dependent protein binding Source: RGD
- calcium ion binding Source: RGD
- calmodulin binding Source: UniProtKB
- glutamate binding Source: RGD
- glutamate receptor activity Source: RGD
- group III metabotropic glutamate receptor activity Source: RGD
- identical protein binding Source: RGD
- PDZ domain binding Source: RGD
- serine binding Source: RGD
- voltage-gated calcium channel activity Source: RGD
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: RGD
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: RGD
- adult behavior Source: RGD
- associative learning Source: RGD
- behavioral fear response Source: RGD
- chemical synaptic transmission Source: RGD
- conditioned taste aversion Source: RGD
- G protein-coupled glutamate receptor signaling pathway Source: GO_Central
- learning or memory Source: UniProtKB
- memory Source: RGD
- multicellular organismal response to stress Source: RGD
- negative regulation of glutamate secretion Source: RGD
- negative regulation of neuron apoptotic process Source: RGD
- nervous system process Source: RGD
- regulation of synaptic transmission, glutamatergic Source: GO_Central
- regulation of synaptic vesicle exocytosis Source: RGD
- sensory perception of sound Source: RGD
- short-term memory Source: RGD
- transmission of nerve impulse Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Sensory transduction |
Enzyme and pathway databases
Reactomei | R-RNO-418594, G alpha (i) signalling events R-RNO-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Names & Taxonomyi
Protein namesi | Recommended name: Metabotropic glutamate receptor 7Short name: mGluR7 |
Gene namesi | Name:Grm7 Synonyms:Gprc1g, Mglur7 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 619857, Grm7 |
Subcellular locationi
Plasma membrane
Endoplasmic reticulum
- rough endoplasmic reticulum Source: RGD
Golgi apparatus
- Golgi apparatus Source: RGD
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of presynaptic active zone membrane Source: SynGO
- integral component of presynaptic membrane Source: SynGO
- postsynaptic membrane Source: UniProtKB
- presynaptic membrane Source: RGD
Other locations
- asymmetric synapse Source: RGD
- axon Source: RGD
- axon terminus Source: RGD
- cell cortex Source: RGD
- cell surface Source: UniProtKB
- dendrite Source: RGD
- dendritic shaft Source: RGD
- GABA-ergic synapse Source: SynGO
- glutamatergic synapse Source: SynGO
- integral component of membrane Source: RGD
- membrane Source: RGD
- neuronal cell body Source: RGD
- presynaptic active zone Source: UniProtKB
- protein-containing complex Source: RGD
- receptor complex Source: RGD
- synapse Source: RGD
- terminal bouton Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 35 – 590 | ExtracellularSequence analysisAdd BLAST | 556 | |
Transmembranei | 591 – 615 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 616 – 627 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 628 – 648 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 649 – 654 | ExtracellularSequence analysis | 6 | |
Transmembranei | 655 – 675 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 676 – 702 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 703 – 723 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 724 – 753 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 754 – 775 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 776 – 788 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 789 – 810 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 811 – 825 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 826 – 850 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 851 – 915 | CytoplasmicSequence analysisAdd BLAST | 65 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Sequence analysisAdd BLAST | 34 | |
ChainiPRO_0000012940 | 35 – 915 | Metabotropic glutamate receptor 7Add BLAST | 881 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 67 ↔ 109 | 1 Publication | ||
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 249 ↔ 541 | By similarity | ||
Disulfide bondi | 374 ↔ 390 | 1 Publication | ||
Disulfide bondi | 430 ↔ 437 | 1 Publication | ||
Glycosylationi | 458 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 486 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 523 ↔ 542 | By similarity | ||
Disulfide bondi | 527 ↔ 545 | By similarity | ||
Disulfide bondi | 548 ↔ 560 | By similarity | ||
Disulfide bondi | 563 ↔ 576 | By similarity | ||
Glycosylationi | 572 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 900 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P35400 |
PRIDEi | P35400 |
PTM databases
CarbonylDBi | P35400 |
GlyGeni | P35400, 4 sites |
iPTMneti | P35400 |
PhosphoSitePlusi | P35400 |
Expressioni
Tissue specificityi
Widely distributed throughout the brain.2 Publications
Interactioni
Subunit structurei
Interacts with PICK1.
1 PublicationBinary interactionsi
Hide detailsP35400
With | #Exp. | IntAct |
---|---|---|
Grip1 [P97879] | 3 | EBI-6936416,EBI-936113 |
Pick1 [Q9EP80] | 2 | EBI-6936416,EBI-77728 |
Ppp1cc [P63088] | 4 | EBI-6936416,EBI-80049 |
GO - Molecular functioni
- calcium-dependent protein binding Source: RGD
- calmodulin binding Source: UniProtKB
- identical protein binding Source: RGD
- PDZ domain binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 249569, 9 interactors |
DIPi | DIP-41145N |
IntActi | P35400, 7 interactors |
MINTi | P35400 |
STRINGi | 10116.ENSRNOP00000053411 |
Chemistry databases
BindingDBi | P35400 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P35400 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P35400 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 180 – 182 | Glutamate bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
InParanoidi | P35400 |
OrthoDBi | 483746at2759 |
PhylomeDBi | P35400 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001883, GPCR_3_mtglu_rcpt_7 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01057, MTABOTROPC7R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P35400-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVQLGKLLRV LTLMKFPCCV LEVLLCVLAA AARGQEMYAP HSIRIEGDVT
60 70 80 90 100
LGGLFPVHAK GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT
110 120 130 140 150
LGARILDTCS RDTYALEQSL TFVQALIQKD TSDVRCTNGE PPVFVKPEKV
160 170 180 190 200
VGVIGASGSS VSIMVANILR LFQIPQISYA STAPELSDDR RYDFFSRVVP
210 220 230 240 250
PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ ISKEAGGLCI
260 270 280 290 300
AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK
310 320 330 340 350
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF
360 370 380 390 400
TSRTLENNRR NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS
410 420 430 440 450
NYEQEGKVQF VIDAVYAMAH ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK
460 470 480 490 500
YIRHVNFNGS AGTPVMFNKN GDAPGRYDIF QYQTTNTTNP GYRLIGQWTD
510 520 530 540 550
ELQLNIEDMQ WGKGVREIPS SVCTLPCKPG QRKKTQKGTP CCWTCEPCDG
560 570 580 590 600
YQYQFDEMTC QHCPYDQRPN ENRTGCQNIP IIKLEWHSPW AVIPVFLAML
610 620 630 640 650
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP
660 670 680 690 700
DVAVCSFRRV FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT
710 720 730 740 750
SQLAITSSLI SVQLLGVFIW FGVDPPNIII DYDEHKTMNP EQARGVLKCD
760 770 780 790 800
ITDLQIICSL GYSILLMVTC TVYAIKTRGV PENFNEAKPI GFTMYTTCIV
810 820 830 840 850
WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML YMPKVYIIIF
860 870 880 890 900
HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS
910
PAAKKKYVSY NNLVI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1LZS5 | F1LZS5_RAT | Metabotropic glutamate receptor 7 | Grm7 | 744 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16817 mRNA Translation: BAA04092.1 U06832 mRNA Translation: AAA20655.1 |
PIRi | A49874 |
RefSeqi | NP_112302.1, NM_031040.1 |
Genome annotation databases
GeneIDi | 81672 |
KEGGi | rno:81672 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16817 mRNA Translation: BAA04092.1 U06832 mRNA Translation: AAA20655.1 |
PIRi | A49874 |
RefSeqi | NP_112302.1, NM_031040.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E4Z | X-ray | 3.30 | A | 33-521 | [»] | |
SMRi | P35400 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 249569, 9 interactors |
DIPi | DIP-41145N |
IntActi | P35400, 7 interactors |
MINTi | P35400 |
STRINGi | 10116.ENSRNOP00000053411 |
Chemistry databases
BindingDBi | P35400 |
ChEMBLi | CHEMBL3879 |
GuidetoPHARMACOLOGYi | 295 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
CarbonylDBi | P35400 |
GlyGeni | P35400, 4 sites |
iPTMneti | P35400 |
PhosphoSitePlusi | P35400 |
Proteomic databases
PaxDbi | P35400 |
PRIDEi | P35400 |
Genome annotation databases
GeneIDi | 81672 |
KEGGi | rno:81672 |
Organism-specific databases
CTDi | 2917 |
RGDi | 619857, Grm7 |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
InParanoidi | P35400 |
OrthoDBi | 483746at2759 |
PhylomeDBi | P35400 |
Enzyme and pathway databases
Reactomei | R-RNO-418594, G alpha (i) signalling events R-RNO-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Miscellaneous databases
EvolutionaryTracei | P35400 |
PROi | PR:P35400 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR001883, GPCR_3_mtglu_rcpt_7 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01057, MTABOTROPC7R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GRM7_RAT | |
Accessioni | P35400Primary (citable) accession number: P35400 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families