UniProtKB - P35396 (PPARD_MOUSE)
Peroxisome proliferator-activated receptor delta
Ppard
Functioni
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 70 – 144 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 75 | |
Zinc fingeri | 73 – 93 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 110 – 132 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
- enzyme activator activity Source: UniProtKB
- fatty acid binding Source: MGI
- linoleic acid binding Source: UniProtKB
- lipid binding Source: UniProtKB
- NF-kappaB binding Source: MGI
- nuclear receptor activity Source: UniProtKB
- prostacyclin receptor activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
- transcription coactivator binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- adipose tissue development Source: MGI
- apoptotic process Source: MGI
- apoptotic signaling pathway Source: MGI
- axon ensheathment Source: MGI
- cell differentiation Source: MGI
- cell-substrate adhesion Source: MGI
- cellular response to hypoxia Source: MGI
- cellular response to lipopolysaccharide Source: MGI
- decidualization Source: Ensembl
- embryo implantation Source: MGI
- epidermis development Source: MGI
- fatty acid beta-oxidation Source: UniProtKB
- fatty acid metabolic process Source: GO_Central
- fatty acid oxidation Source: MGI
- fatty acid transport Source: UniProtKB
- heart development Source: Ensembl
- hormone-mediated signaling pathway Source: GO_Central
- keratinocyte migration Source: MGI
- keratinocyte proliferation Source: MGI
- lipid metabolic process Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cell growth Source: MGI
- negative regulation of cholesterol storage Source: GO_Central
- negative regulation of collagen biosynthetic process Source: MGI
- negative regulation of epithelial cell proliferation Source: MGI
- negative regulation of inflammatory response Source: MGI
- negative regulation of myoblast differentiation Source: CACAO
- negative regulation of pri-miRNA transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of smooth muscle cell migration Source: MGI
- negative regulation of smooth muscle cell proliferation Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- phospholipid biosynthetic process Source: MGI
- placenta development Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of epidermis development Source: MGI
- positive regulation of fatty acid metabolic process Source: GO_Central
- positive regulation of fatty acid oxidation Source: MGI
- positive regulation of gene expression Source: CACAO
- positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
- positive regulation of myoblast proliferation Source: CACAO
- positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
- positive regulation of skeletal muscle tissue regeneration Source: CACAO
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- proteoglycan metabolic process Source: MGI
- regulation of cell population proliferation Source: MGI
- regulation of fat cell differentiation Source: MGI
- regulation of insulin secretion Source: UniProtKB
- regulation of lipid metabolic process Source: GO_Central
- regulation of skeletal muscle satellite cell proliferation Source: CACAO
- response to activity Source: Ensembl
- response to glucose Source: Ensembl
- response to lipid Source: GO_Central
- response to vitamin A Source: Ensembl
- vasodilation Source: MGI
- vitamin A metabolic process Source: MGI
- wound healing Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-200425, Carnitine metabolism R-MMU-204174, Regulation of pyruvate dehydrogenase (PDH) complex R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-5362517, Signaling by Retinoic Acid |
Chemistry databases
SwissLipidsi | SLP:000000397 |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisome proliferator-activated receptor deltaShort name: PPAR-delta Alternative name(s): Nuclear hormone receptor 1 Short name: NUC1 Nuclear receptor subfamily 1 group C member 2 Peroxisome proliferator-activated receptor beta Short name: PPAR-beta |
Gene namesi | Name:Ppard Synonyms:Nr1c2, Pparb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:101884, Ppard |
VEuPathDBi | HostDB:ENSMUSG00000002250 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053487 | 1 – 440 | Peroxisome proliferator-activated receptor deltaAdd BLAST | 440 |
Proteomic databases
EPDi | P35396 |
PaxDbi | P35396 |
PRIDEi | P35396 |
ProteomicsDBi | 291646 |
PTM databases
PhosphoSitePlusi | P35396 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000002250, Expressed in intestine and 220 other tissues |
ExpressionAtlasi | P35396, baseline and differential |
Genevisiblei | P35396, MM |
Interactioni
Subunit structurei
GO - Molecular functioni
- NF-kappaB binding Source: MGI
- transcription coactivator binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202319, 12 interactors |
DIPi | DIP-29851N |
IntActi | P35396, 6 interactors |
STRINGi | 10090.ENSMUSP00000002320 |
Chemistry databases
BindingDBi | P35396 |
Miscellaneous databases
RNActi | P35396, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 210 – 438 | NR LBDPROSITE-ProRule annotationAdd BLAST | 229 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 53 | DisorderedSequence analysisAdd BLAST | 53 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 22 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 33 – 53 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 73 – 93 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 110 – 132 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156676 |
HOGENOMi | CLU_007368_4_1_1 |
InParanoidi | P35396 |
OMAi | YEKCDRS |
OrthoDBi | 1240230at2759 |
PhylomeDBi | P35396 |
TreeFami | TF316304 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR003075, 1Cnucl_rcpt_B IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01290, PROXISOMPABR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEQPQEETPE AREEEKEEVA MGDGAPELNG GPEHTLPSSS CADLSQNSSP
60 70 80 90 100
SSLLDQLQMG CDGASGGSLN MECRVCGDKA SGFHYGVHAC EGCKGFFRRT
110 120 130 140 150
IRMKLEYEKC DRICKIQKKN RNKCQYCRFQ KCLALGMSHN AIRFGRMPEA
160 170 180 190 200
EKRKLVAGLT ASEGCQHNPQ LADLKAFSKH IYNAYLKNFN MTKKKARSIL
210 220 230 240 250
TGKSSHNAPF VIHDIETLWQ AEKGLVWKQL VNGLPPYNEI SVHVFYRCQS
260 270 280 290 300
TTVETVRELT EFAKNIPNFS SLFLNDQVTL LKYGVHEAIF AMLASIVNKD
310 320 330 340 350
GLLVANGSGF VTHEFLRSLR KPFSDIIEPK FEFAVKFNAL ELDDSDLALF
360 370 380 390 400
IAAIILCGDR PGLMNVPQVE AIQDTILRAL EFHLQVNHPD SQYLFPKLLQ
410 420 430 440
KMADLRQLVT EHAQMMQWLK KTESETLLHP LLQEIYKDMY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B2W7W2 | A0A3B2W7W2_MOUSE | Peroxisome proliferator-activated r... | Ppard | 382 | Annotation score: | ||
A0A3B2WD72 | A0A3B2WD72_MOUSE | Peroxisome proliferator-activated r... | Ppard | 342 | Annotation score: | ||
E9PV57 | E9PV57_MOUSE | Peroxisome proliferator-activated r... | Ppard | 252 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 149 – 150 | EA → DG in AAA19972 (PubMed:8041794).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L28116 mRNA Translation: AAA63394.1 U10375 mRNA Translation: AAA19972.1 BC070398 mRNA Translation: AAH70398.1 U01665 mRNA Translation: AAA03332.1 Different initiation. |
CCDSi | CCDS28575.1 |
PIRi | I55442 |
RefSeqi | NP_035275.1, NM_011145.3 |
Genome annotation databases
Ensembli | ENSMUST00000002320; ENSMUSP00000002320; ENSMUSG00000002250 |
GeneIDi | 19015 |
KEGGi | mmu:19015 |
UCSCi | uc008bqk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L28116 mRNA Translation: AAA63394.1 U10375 mRNA Translation: AAA19972.1 BC070398 mRNA Translation: AAH70398.1 U01665 mRNA Translation: AAA03332.1 Different initiation. |
CCDSi | CCDS28575.1 |
PIRi | I55442 |
RefSeqi | NP_035275.1, NM_011145.3 |
3D structure databases
SMRi | P35396 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202319, 12 interactors |
DIPi | DIP-29851N |
IntActi | P35396, 6 interactors |
STRINGi | 10090.ENSMUSP00000002320 |
Chemistry databases
BindingDBi | P35396 |
ChEMBLi | CHEMBL2458 |
SwissLipidsi | SLP:000000397 |
PTM databases
PhosphoSitePlusi | P35396 |
Proteomic databases
EPDi | P35396 |
PaxDbi | P35396 |
PRIDEi | P35396 |
ProteomicsDBi | 291646 |
Protocols and materials databases
Antibodypediai | 4322, 635 antibodies from 43 providers |
DNASUi | 19015 |
Genome annotation databases
Ensembli | ENSMUST00000002320; ENSMUSP00000002320; ENSMUSG00000002250 |
GeneIDi | 19015 |
KEGGi | mmu:19015 |
UCSCi | uc008bqk.1, mouse |
Organism-specific databases
CTDi | 5467 |
MGIi | MGI:101884, Ppard |
VEuPathDBi | HostDB:ENSMUSG00000002250 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000156676 |
HOGENOMi | CLU_007368_4_1_1 |
InParanoidi | P35396 |
OMAi | YEKCDRS |
OrthoDBi | 1240230at2759 |
PhylomeDBi | P35396 |
TreeFami | TF316304 |
Enzyme and pathway databases
Reactomei | R-MMU-200425, Carnitine metabolism R-MMU-204174, Regulation of pyruvate dehydrogenase (PDH) complex R-MMU-383280, Nuclear Receptor transcription pathway R-MMU-5362517, Signaling by Retinoic Acid |
Miscellaneous databases
BioGRID-ORCSi | 19015, 3 hits in 66 CRISPR screens |
ChiTaRSi | Ppard, mouse |
PROi | PR:P35396 |
RNActi | P35396, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000002250, Expressed in intestine and 220 other tissues |
ExpressionAtlasi | P35396, baseline and differential |
Genevisiblei | P35396, MM |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR003075, 1Cnucl_rcpt_B IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01290, PROXISOMPABR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PPARD_MOUSE | |
Accessioni | P35396Primary (citable) accession number: P35396 Secondary accession number(s): P37239 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families