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Protein

Heat shock protein beta-7

Gene

Hspb7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • filamin binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-7
Short name:
HspB7
Alternative name(s):
Cardiovascular heat shock protein
Short name:
cvHsp
Heat shock protein 25 kDa 2
Protein p19/6.8
Gene namesi
Name:Hspb7
Synonyms:Cvhsp, Hsp25-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1352494 Hspb7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259421 – 169Heat shock protein beta-7Add BLAST169

Proteomic databases

PaxDbiP35385
PeptideAtlasiP35385
PRIDEiP35385

PTM databases

iPTMnetiP35385
PhosphoSitePlusiP35385

Expressioni

Tissue specificityi

Found in both cardiac and slow skeletal (soleus) muscle.

Gene expression databases

BgeeiENSMUSG00000006221
GenevisibleiP35385 MM

Interactioni

Subunit structurei

Interacts with C-terminal domain of actin-binding protein 280.

GO - Molecular functioni

  • filamin binding Source: MGI

Protein-protein interaction databases

IntActiP35385, 1 interactor
MINTiP35385
STRINGi10090.ENSMUSP00000099544

Structurei

3D structure databases

ProteinModelPortaliP35385
SMRiP35385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 169sHSPPROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 70Required for localization to SC35 splicing specklesBy similarityAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi17 – 30Poly-SerAdd BLAST14

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00390000010674
HOGENOMiHOG000072715
HOVERGENiHBG052040
InParanoidiP35385
KOiK09546
OMAiMNTFTHK
OrthoDBiEOG091G0R4Y
TreeFamiTF350564

Family and domain databases

CDDicd06479 ACD_HspB7_like, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037885 ACD_HspB7
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P35385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHRTSSAFR AERSFRSSSS SSSSSSSSAS RALPAQDPPM EKALSMFSDD
60 70 80 90 100
FGSFMLPHSE PLAFPARPGG QGNIKTLGDA YEFTVDMRDF SPEDIIVTTF
110 120 130 140 150
NNHIEVRAEK LAADGTVMNT FAHKCQLPED VDPTSVTSAL REDGSLTIRA
160
RRHPHTEHVQ QTFRTEIKI
Length:169
Mass (Da):18,635
Last modified:October 3, 2012 - v3
Checksum:i15E45C854BF09E7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23S → P in CAB63266 (PubMed:10593960).Curated1
Sequence conflicti23S → P in AAF20023 (PubMed:10593960).Curated1
Sequence conflicti60 – 61EP → GD AA sequence (Ref. 6) Curated2
Sequence conflicti153H → N in CAB63266 (PubMed:10593960).Curated1
Sequence conflicti153H → N in AAF20023 (PubMed:10593960).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ243192 mRNA Translation: CAB63266.1
AF155909 mRNA Translation: AAF20023.1
AK030025 mRNA Translation: BAC26743.1
AL670285 Genomic DNA Translation: CAM20400.1
CH466615 Genomic DNA Translation: EDL13373.1
BC089584 mRNA Translation: AAH89584.1
CCDSiCCDS18873.1
RefSeqiNP_038896.2, NM_013868.4
UniGeneiMm.46181

Genome annotation databases

EnsembliENSMUST00000102486; ENSMUSP00000099544; ENSMUSG00000006221
GeneIDi29818
KEGGimmu:29818
UCSCiuc008voj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHSPB7_MOUSE
AccessioniPrimary (citable) accession number: P35385
Secondary accession number(s): Q5FW72, Q8CDI0, Q9QUS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 3, 2012
Last modified: June 20, 2018
This is version 120 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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