UniProtKB - P35378 (FSHR_MOUSE)
Protein
Follicle-stimulating hormone receptor
Gene
Fshr
Organism
Mus musculus (Mouse)
Status
Functioni
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.By similarity
GO - Molecular functioni
- follicle-stimulating hormone receptor activity Source: MGI
- G protein-coupled peptide receptor activity Source: GO_Central
- peptide hormone binding Source: MGI
GO - Biological processi
- activation of adenylate cyclase activity Source: GO_Central
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGI
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: MGI
- basement membrane organization Source: MGI
- cellular response to follicle-stimulating hormone stimulus Source: UniProtKB
- cellular water homeostasis Source: MGI
- follicle-stimulating hormone signaling pathway Source: MGI
- G protein-coupled receptor signaling pathway Source: MGI
- hormone-mediated signaling pathway Source: GO_Central
- locomotory behavior Source: MGI
- male gonad development Source: GO_Central
- negative regulation of bone resorption Source: MGI
- neuron projection development Source: MGI
- ovarian follicle development Source: MGI
- ovulation cycle process Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of intracellular estrogen receptor signaling pathway Source: MGI
- positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
- primary ovarian follicle growth Source: MGI
- regulation of acetylcholine metabolic process Source: MGI
- regulation of chromosome organization Source: MGI
- regulation of hormone metabolic process Source: MGI
- regulation of intracellular estrogen receptor signaling pathway Source: MGI
- regulation of MAPK cascade Source: MGI
- regulation of osteoclast differentiation Source: MGI
- regulation of platelet-derived growth factor receptor signaling pathway Source: MGI
- regulation of protein kinase A signaling Source: UniProtKB
- regulation of protein phosphorylation Source: MGI
- regulation of systemic arterial blood pressure Source: MGI
- Sertoli cell development Source: MGI
- Sertoli cell proliferation Source: MGI
- spermatid development Source: MGI
- spermatogenesis Source: MGI
- spermatogenesis, exchange of chromosomal proteins Source: MGI
- sperm chromatin condensation Source: MGI
- transcytosis Source: MGI
- uterus development Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375281, Hormone ligand-binding receptors R-MMU-418555, G alpha (s) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Follicle-stimulating hormone receptorShort name: FSH-R Alternative name(s): Follitropin receptor |
Gene namesi | Name:Fshr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95583, Fshr |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Endosome
- endosome Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB
- receptor complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 18 – 365 | ExtracellularSequence analysisAdd BLAST | 348 | |
Transmembranei | 366 – 386 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 387 – 397 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 398 – 420 | Helical; Name=2Sequence analysisAdd BLAST | 23 | |
Topological domaini | 421 – 442 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 443 – 464 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 465 – 484 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 485 – 507 | Helical; Name=4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 508 – 527 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 528 – 549 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 550 – 572 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 573 – 596 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 597 – 607 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 608 – 629 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 630 – 692 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000012773 | 18 – 692 | Follicle-stimulating hormone receptorAdd BLAST | 675 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 18 ↔ 25 | PROSITE-ProRule annotation | ||
Disulfide bondi | 23 ↔ 32 | PROSITE-ProRule annotation | ||
Glycosylationi | 191 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Glycosylationi | 199 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 275 ↔ 345 | By similarity | ||
Disulfide bondi | 276 ↔ 355 | By similarity | ||
Disulfide bondi | 276 ↔ 292 | By similarity | ||
Disulfide bondi | 292 ↔ 337 | By similarity | ||
Glycosylationi | 293 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Modified residuei | 334 | SulfotyrosineBy similarity | 1 | |
Disulfide bondi | 441 ↔ 516 | PROSITE-ProRule annotation |
Post-translational modificationi
N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.By similarity
Sulfated.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, SulfationProteomic databases
PaxDbi | P35378 |
PRIDEi | P35378 |
PTM databases
GlyGeni | P35378, 3 sites |
PhosphoSitePlusi | P35378 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000032937, Expressed in cumulus cell and 33 other tissues |
ExpressionAtlasi | P35378, baseline and differential |
Genevisiblei | P35378, MM |
Interactioni
Subunit structurei
Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity).
Interacts with ARRB2 (By similarity).
Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000040477 |
Miscellaneous databases
RNActi | P35378, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 46 | LRRNTAdd BLAST | 29 | |
Repeati | 49 – 72 | LRR 1Add BLAST | 24 | |
Repeati | 73 – 97 | LRR 2Add BLAST | 25 | |
Repeati | 98 – 118 | LRR 3Add BLAST | 21 | |
Repeati | 119 – 143 | LRR 4Add BLAST | 25 | |
Repeati | 144 – 169 | LRR 5Add BLAST | 26 | |
Repeati | 170 – 192 | LRR 6Add BLAST | 23 | |
Repeati | 193 – 216 | LRR 7Add BLAST | 24 | |
Repeati | 217 – 240 | LRR 8Add BLAST | 24 | |
Repeati | 241 – 259 | LRR 9Add BLAST | 19 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2087, Eukaryota |
GeneTreei | ENSGT00940000158952 |
HOGENOMi | CLU_006130_1_1_1 |
InParanoidi | P35378 |
OMAi | HNFHTRN |
OrthoDBi | 257031at2759 |
PhylomeDBi | P35378 |
TreeFami | TF316814 |
Family and domain databases
InterProi | View protein in InterPro IPR002272, FSH_rcpt IPR024635, GnHR_TM IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002131, Gphrmn_rcpt_fam IPR026906, LRR_5 IPR000372, LRRNT |
PANTHERi | PTHR24372:SF5, PTHR24372:SF5, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF12369, GnHR_trans, 1 hit PF13306, LRR_5, 2 hits PF01462, LRRNT, 1 hit |
PRINTSi | PR01143, FSHRECEPTOR PR00373, GLYCHORMONER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35378-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLLVSLLA FLGSGSGCHH WLCHCSNRVF LCQDSKVTEI PPDLPRNAIE
60 70 80 90 100
LRFVLTKLRV IPKGSFSGFG DLEKIEISQN DVLEVIEADV FSNLPNLHEI
110 120 130 140 150
RIEKANNLLY INPEAFQNLP SLRYLLISNT GIKHLPAFHK IQSLQKVLLD
160 170 180 190 200
IQDNINIHII ARNSFMGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL
210 220 230 240 250
SDNNNLEELP DDVFQGASGP VVLDISRTKV YSLPNHGLEN LKKLRARSTY
260 270 280 290 300
RLKKLPSLDK FVMLIEASLT YPSHCCAFAN WRRQTSELHP ICNKSISRQD
310 320 330 340 350
IDDMTQPGDQ RVSLVDDEPS YGKGSDMLYS EFDYDLCNEF VDVTCSPKPD
360 370 380 390 400
AFNPCEDIMG YNILRVLIWF ISILAITGNT TVLVVLTTSQ YKLTVPRFLM
410 420 430 440 450
CNLAFADLCI GIYLLLIASV DIHTKSQYHN YAIDWQTGAG CDAAGFFTVF
460 470 480 490 500
ASELSVYTLA AITLERWHTI THAMQLECKV QLCHAASIMV LGWAFAFAAA
510 520 530 540 550
LFPIFGISSY MKVSICLPMD IDSPLSQLYV MALLVLNALA FVVICGCYTH
560 570 580 590 600
IYLTVRNPNI VSSSRDTKIA KRMATLIFTD FLCMAPILFF AISASLKVPL
610 620 630 640 650
ITVSKAKILL VLFYPINSCA NPFLYAIFTK NFRRDFFVLM SKFGCYEVQA
660 670 680 690
QIYKTETSSI THNFHSRKNP CSSAPRVTNS YVLVPLNHSV QN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 436 | Q → K in BAB30351 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095642 mRNA Translation: AAC67559.1 AK016635 mRNA Translation: BAB30351.1 S49632 Genomic DNA Translation: AAB24401.1 M87570 Genomic DNA Translation: AAA37641.1 |
CCDSi | CCDS29026.1 |
PIRi | I57670 |
RefSeqi | NP_038551.3, NM_013523.3 |
Genome annotation databases
Ensembli | ENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937 |
GeneIDi | 14309 |
KEGGi | mmu:14309 |
UCSCi | uc008dvx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF095642 mRNA Translation: AAC67559.1 AK016635 mRNA Translation: BAB30351.1 S49632 Genomic DNA Translation: AAB24401.1 M87570 Genomic DNA Translation: AAA37641.1 |
CCDSi | CCDS29026.1 |
PIRi | I57670 |
RefSeqi | NP_038551.3, NM_013523.3 |
3D structure databases
SMRi | P35378 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000040477 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35378, 3 sites |
PhosphoSitePlusi | P35378 |
Proteomic databases
PaxDbi | P35378 |
PRIDEi | P35378 |
Protocols and materials databases
Antibodypediai | 15300, 675 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937 |
GeneIDi | 14309 |
KEGGi | mmu:14309 |
UCSCi | uc008dvx.1, mouse |
Organism-specific databases
CTDi | 2492 |
MGIi | MGI:95583, Fshr |
Phylogenomic databases
eggNOGi | KOG2087, Eukaryota |
GeneTreei | ENSGT00940000158952 |
HOGENOMi | CLU_006130_1_1_1 |
InParanoidi | P35378 |
OMAi | HNFHTRN |
OrthoDBi | 257031at2759 |
PhylomeDBi | P35378 |
TreeFami | TF316814 |
Enzyme and pathway databases
Reactomei | R-MMU-375281, Hormone ligand-binding receptors R-MMU-418555, G alpha (s) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 14309, 1 hit in 17 CRISPR screens |
ChiTaRSi | Fshr, mouse |
PROi | PR:P35378 |
RNActi | P35378, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032937, Expressed in cumulus cell and 33 other tissues |
ExpressionAtlasi | P35378, baseline and differential |
Genevisiblei | P35378, MM |
Family and domain databases
InterProi | View protein in InterPro IPR002272, FSH_rcpt IPR024635, GnHR_TM IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR002131, Gphrmn_rcpt_fam IPR026906, LRR_5 IPR000372, LRRNT |
PANTHERi | PTHR24372:SF5, PTHR24372:SF5, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit PF12369, GnHR_trans, 1 hit PF13306, LRR_5, 2 hits PF01462, LRRNT, 1 hit |
PRINTSi | PR01143, FSHRECEPTOR PR00373, GLYCHORMONER PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM00013, LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FSHR_MOUSE | |
Accessioni | P35378Primary (citable) accession number: P35378 Secondary accession number(s): Q9D4C2, Q9QWV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | September 26, 2001 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries