Follicle-stimulating hormone receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• follicle-stimulating hormone receptor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence."
    Tena-Sempere M., Manna P.R., Huhtaniemi I.T.
    Biol. Reprod. 60:1515-1527(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
  • "FSH directly regulates bone mass."
    Sun L., Peng Y., Sharrow A.C., Iqbal J., Zhang Z., Papachristou D.J., Zaidi S., Zhu L.L., Yaroslavskiy B.B., Zhou H., Zallone A., Sairam M.R., Kumar T.R., Bo W., Braun J., Cardoso-Landa L., Schaffler M.B., Moonga B.S., Blair H.C., Zaidi M.
    Cell 125:247-260(2006) [PubMed] [Europe PMC] [Abstract]
  • "Inhibitory role of prolactin in the downregulation of testicular follicle-stimulating hormone receptors in mice."
    Takase M., Tsutsui K.
    J Exp Zool 278:234-242(1997) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled peptide receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• peptide hormone binding Source: MGI

GO - Biological processⁱ

• activation of adenylate cyclase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: MGI
• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • "FSH directly regulates bone mass."
    Sun L., Peng Y., Sharrow A.C., Iqbal J., Zhang Z., Papachristou D.J., Zaidi S., Zhu L.L., Yaroslavskiy B.B., Zhou H., Zallone A., Sairam M.R., Kumar T.R., Bo W., Braun J., Cardoso-Landa L., Schaffler M.B., Moonga B.S., Blair H.C., Zaidi M.
    Cell 125:247-260(2006) [PubMed] [Europe PMC] [Abstract]
• adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence."
    Tena-Sempere M., Manna P.R., Huhtaniemi I.T.
    Biol. Reprod. 60:1515-1527(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• basement membrane organization Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance."
    Dierich A., Sairam M.R., Monaco L., Fimia G.M., Gansmuller A., LeMeur M., Sassone-Corsi P.
    Proc Natl Acad Sci U S A 95:13612-13617(1998) [PubMed] [Europe PMC] [Abstract]
• cellular response to follicle-stimulating hormone stimulus Source: UniProtKB
• cellular water homeostasis Source: MGIInferred from mutant phenotypeⁱ
  • "Structural and functional modifications of sertoli cells in the testis of adult follicle-stimulating hormone receptor knockout mice."
    Grover A., Sairam M.R., Smith C.E., Hermo L.
    Biol Reprod 71:117-129(2004) [PubMed] [Europe PMC] [Abstract]
• follicle-stimulating hormone signaling pathway Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence."
    Tena-Sempere M., Manna P.R., Huhtaniemi I.T.
    Biol. Reprod. 60:1515-1527(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• G protein-coupled receptor signaling pathway Source: MGI
• hormone-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• locomotory behavior Source: MGIInferred from mutant phenotypeⁱ
  • "The menopausal mouse: a new neural paradigm of a distressing human condition."
    Danilovich N., Sairam M.R., Maysinger D.
    Neuroreport 14:1617-1622(2003) [PubMed] [Europe PMC] [Abstract]
• male gonad development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of bone resorption Source: MGIInferred from mutant phenotypeⁱ
  • "Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice."
    Danilovich N., Babu P.S., Xing W., Gerdes M., Krishnamurthy H., Sairam M.R.
    Endocrinology 141:4295-4308(2000) [PubMed] [Europe PMC] [Abstract]
  • "Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone."
    Gao J., Tiwari-Pandey R., Samadfam R., Yang Y., Miao D., Karaplis A.C., Sairam M.R., Goltzman D.
    Endocrinology 148:2613-2621(2007) [PubMed] [Europe PMC] [Abstract]
• neuron projection development Source: MGIInferred from mutant phenotypeⁱ
  • "Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice."
    Tam J., Danilovich N., Nilsson K., Sairam M.R., Maysinger D.
    Neuroscience 114:493-506(2002) [PubMed] [Europe PMC] [Abstract]
• ovarian follicle development Source: MGIInferred from mutant phenotypeⁱ
  • "The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction."
    Abel M.H., Wootton A.N., Wilkins V., Huhtaniemi I., Knight P.G., Charlton H.M.
    Endocrinology 141:1795-1803(2000) [PubMed] [Europe PMC] [Abstract]
  • "Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice."
    Danilovich N., Babu P.S., Xing W., Gerdes M., Krishnamurthy H., Sairam M.R.
    Endocrinology 141:4295-4308(2000) [PubMed] [Europe PMC] [Abstract]
  • "Ovarian pathology and high incidence of sex cord tumors in follitropin receptor knockout (FORKO) mice."
    Danilovich N., Roy I., Sairam M.R.
    Endocrinology 142:3673-3684(2001) [PubMed] [Europe PMC] [Abstract]
  • "Haploinsufficiency of the follicle-stimulating hormone receptor accelerates oocyte loss inducing early reproductive senescence and biological aging in mice."
    Danilovich N., Sairam M.R.
    Biol Reprod 67:361-369(2002) [PubMed] [Europe PMC] [Abstract]
  • "Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve."
    Balla A., Danilovich N., Yang Y., Sairam M.R.
    Biol Reprod 69:1281-1293(2003) [PubMed] [Europe PMC] [Abstract]
  • "Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance."
    Dierich A., Sairam M.R., Monaco L., Fimia G.M., Gansmuller A., LeMeur M., Sassone-Corsi P.
    Proc Natl Acad Sci U S A 95:13612-13617(1998) [PubMed] [Europe PMC] [Abstract]
• ovulation cycle process Source: MGIInferred from mutant phenotypeⁱ
  • "Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice."
    Danilovich N., Babu P.S., Xing W., Gerdes M., Krishnamurthy H., Sairam M.R.
    Endocrinology 141:4295-4308(2000) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • Ref.1

    "Molecular cloning of the mouse follicle-stimulating hormone receptor complementary deoxyribonucleic acid: functional expression of alternatively spliced variants and receptor inactivation by a C566T transition in exon 7 of the coding sequence."
    Tena-Sempere M., Manna P.R., Huhtaniemi I.T.
    Biol. Reprod. 60:1515-1527(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE.
• positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
• positive regulation of intracellular estrogen receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Estrogen deficiency, obesity, and skeletal abnormalities in follicle-stimulating hormone receptor knockout (FORKO) female mice."
    Danilovich N., Babu P.S., Xing W., Gerdes M., Krishnamurthy H., Sairam M.R.
    Endocrinology 141:4295-4308(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
• primary ovarian follicle growth Source: MGIInferred from mutant phenotypeⁱ
  • "Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve."
    Balla A., Danilovich N., Yang Y., Sairam M.R.
    Biol Reprod 69:1281-1293(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of acetylcholine metabolic process Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice."
    Tam J., Danilovich N., Nilsson K., Sairam M.R., Maysinger D.
    Neuroscience 114:493-506(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of chromosome organization Source: MGIInferred from mutant phenotypeⁱ
  • "Role of follitropin receptor signaling in nuclear protein transitions and chromatin condensation during spermatogenesis."
    Xing W., Krishnamurthy H., Sairam M.R.
    Biochem Biophys Res Commun 312:697-701(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of hormone metabolic process Source: MGIInferred from mutant phenotypeⁱ
  • "Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice."
    Tam J., Danilovich N., Nilsson K., Sairam M.R., Maysinger D.
    Neuroscience 114:493-506(2002) [PubMed] [Europe PMC] [Abstract]
  • "Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve."
    Balla A., Danilovich N., Yang Y., Sairam M.R.
    Biol Reprod 69:1281-1293(2003) [PubMed] [Europe PMC] [Abstract]
  • "The menopausal mouse: a new neural paradigm of a distressing human condition."
    Danilovich N., Sairam M.R., Maysinger D.
    Neuroreport 14:1617-1622(2003) [PubMed] [Europe PMC] [Abstract]
  • "Age-related neurodegenerative changes in the central nervous system of estrogen-deficient follitropin receptor knockout mice."
    Danilovich N., Harada N., Sairam M.R., Maysinger D.
    Exp Neurol 183:559-572(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of intracellular estrogen receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Impairment of the natriuretic peptide system in follitropin receptor knockout mice and reversal by estradiol: implications for obesity-associated hypertension in menopause."
    Belo N.O., Sairam M.R., Dos Reis A.M.
    Endocrinology 149:1399-1406(2008) [PubMed] [Europe PMC] [Abstract]
  • "Cardiac hypertrophy is associated with altered thioredoxin and ASK-1 signaling in a mouse model of menopause."
    Ebrahimian T., Sairam M.R., Schiffrin E.L., Touyz R.M.
    Am J Physiol Heart Circ Physiol 295:H1481-8(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of MAPK cascade Source: MGIInferred from mutant phenotypeⁱ
  • "Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice."
    Tam J., Danilovich N., Nilsson K., Sairam M.R., Maysinger D.
    Neuroscience 114:493-506(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of osteoclast differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "FSH directly regulates bone mass."
    Sun L., Peng Y., Sharrow A.C., Iqbal J., Zhang Z., Papachristou D.J., Zaidi S., Zhu L.L., Yaroslavskiy B.B., Zhou H., Zallone A., Sairam M.R., Kumar T.R., Bo W., Braun J., Cardoso-Landa L., Schaffler M.B., Moonga B.S., Blair H.C., Zaidi M.
    Cell 125:247-260(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of platelet-derived growth factor receptor signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse."
    Chen X., Aravindakshan J., Yang Y., Tiwari-Pandey R., Sairam M.R.
    Carcinogenesis 27:903-915(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of protein kinase A signaling Source: UniProtKB
• regulation of protein phosphorylation Source: MGIInferred from mutant phenotypeⁱ
  • "Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice."
    Tam J., Danilovich N., Nilsson K., Sairam M.R., Maysinger D.
    Neuroscience 114:493-506(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of systemic arterial blood pressure Source: MGIInferred from mutant phenotypeⁱ
  • "Functional role of gap junctions in cytokine-induced leukocyte adhesion to endothelium in vivo."
    Veliz L.P., Gonzalez F.G., Duling B.R., Saez J.C., Boric M.P.
    Am J Physiol Heart Circ Physiol 295:H1056-H1066(2008) [PubMed] [Europe PMC] [Abstract]
• Sertoli cell development Source: MGIInferred from mutant phenotypeⁱ
  • "Structural and functional modifications of sertoli cells in the testis of adult follicle-stimulating hormone receptor knockout mice."
    Grover A., Sairam M.R., Smith C.E., Hermo L.
    Biol Reprod 71:117-129(2004) [PubMed] [Europe PMC] [Abstract]
• Sertoli cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Delay in sexual maturity of the follicle-stimulating hormone receptor knockout male mouse."
    Krishnamurthy H., Babu P.S., Morales C.R., Sairam M.R.
    Biol Reprod 65:522-531(2001) [PubMed] [Europe PMC] [Abstract]
  • "Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen."
    Abel M.H., Baker P.J., Charlton H.M., Monteiro A., Verhoeven G., De Gendt K., Guillou F., O'Shaughnessy P.J.
    Endocrinology 149:3279-3285(2008) [PubMed] [Europe PMC] [Abstract]
• spermatid development Source: MGIInferred from mutant phenotypeⁱ
  • "Delay in sexual maturity of the follicle-stimulating hormone receptor knockout male mouse."
    Krishnamurthy H., Babu P.S., Morales C.R., Sairam M.R.
    Biol Reprod 65:522-531(2001) [PubMed] [Europe PMC] [Abstract]
  • "Effects of FSH receptor deletion on epididymal tubules and sperm morphology, numbers, and motility."
    Grover A., Smith C.E., Gregory M., Cyr D.G., Sairam M.R., Hermo L.
    Mol Reprod Dev 72:135-144(2005) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Role of follitropin receptor signaling in nuclear protein transitions and chromatin condensation during spermatogenesis."
    Xing W., Krishnamurthy H., Sairam M.R.
    Biochem Biophys Res Commun 312:697-701(2003) [PubMed] [Europe PMC] [Abstract]
  • "Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen."
    Abel M.H., Baker P.J., Charlton H.M., Monteiro A., Verhoeven G., De Gendt K., Guillou F., O'Shaughnessy P.J.
    Endocrinology 149:3279-3285(2008) [PubMed] [Europe PMC] [Abstract]
  • "Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance."
    Dierich A., Sairam M.R., Monaco L., Fimia G.M., Gansmuller A., LeMeur M., Sassone-Corsi P.
    Proc Natl Acad Sci U S A 95:13612-13617(1998) [PubMed] [Europe PMC] [Abstract]
• spermatogenesis, exchange of chromosomal proteins Source: MGIInferred from mutant phenotypeⁱ
  • "Role of follitropin receptor signaling in nuclear protein transitions and chromatin condensation during spermatogenesis."
    Xing W., Krishnamurthy H., Sairam M.R.
    Biochem Biophys Res Commun 312:697-701(2003) [PubMed] [Europe PMC] [Abstract]
• sperm DNA condensation Source: MGIInferred from mutant phenotypeⁱ
  • "Qualitative and quantitative decline in spermatogenesis of the follicle-stimulating hormone receptor knockout (FORKO) mouse."
    Krishnamurthy H., Danilovich N., Morales C.R., Sairam M.R.
    Biol Reprod 62:1146-1159(2000) [PubMed] [Europe PMC] [Abstract]
• transcytosis Source: MGI
• uterus development Source: MGIInferred from mutant phenotypeⁱ
  • "The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction."
    Abel M.H., Wootton A.N., Wilkins V., Huhtaniemi I., Knight P.G., Charlton H.M.
    Endocrinology 141:1795-1803(2000) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MALLLVSLLA FLGSGSGCHH WLCHCSNRVF LCQDSKVTEI PPDLPRNAIE 
        60         70         80         90        100
LRFVLTKLRV IPKGSFSGFG DLEKIEISQN DVLEVIEADV FSNLPNLHEI 
       110        120        130        140        150
RIEKANNLLY INPEAFQNLP SLRYLLISNT GIKHLPAFHK IQSLQKVLLD 
       160        170        180        190        200
IQDNINIHII ARNSFMGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL 
       210        220        230        240        250
SDNNNLEELP DDVFQGASGP VVLDISRTKV YSLPNHGLEN LKKLRARSTY 
       260        270        280        290        300
RLKKLPSLDK FVMLIEASLT YPSHCCAFAN WRRQTSELHP ICNKSISRQD 
       310        320        330        340        350
IDDMTQPGDQ RVSLVDDEPS YGKGSDMLYS EFDYDLCNEF VDVTCSPKPD 
       360        370        380        390        400
AFNPCEDIMG YNILRVLIWF ISILAITGNT TVLVVLTTSQ YKLTVPRFLM 
       410        420        430        440        450
CNLAFADLCI GIYLLLIASV DIHTKSQYHN YAIDWQTGAG CDAAGFFTVF 
       460        470        480        490        500
ASELSVYTLA AITLERWHTI THAMQLECKV QLCHAASIMV LGWAFAFAAA 
       510        520        530        540        550
LFPIFGISSY MKVSICLPMD IDSPLSQLYV MALLVLNALA FVVICGCYTH 
       560        570        580        590        600
IYLTVRNPNI VSSSRDTKIA KRMATLIFTD FLCMAPILFF AISASLKVPL 
       610        620        630        640        650
ITVSKAKILL VLFYPINSCA NPFLYAIFTK NFRRDFFVLM SKFGCYEVQA 
       660        670        680        690 
QIYKTETSSI THNFHSRKNP CSSAPRVTNS YVLVPLNHSV QN         

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families