Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Follicle-stimulating hormone receptor

Gene

Fshr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.By similarity

GO - Molecular functioni

  • follicle-stimulating hormone receptor activity Source: MGI
  • G protein-coupled peptide receptor activity Source: GO_Central
  • peptide hormone binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Follicle-stimulating hormone receptor
Short name:
FSH-R
Alternative name(s):
Follitropin receptor
Gene namesi
Name:Fshr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95583 Fshr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 365ExtracellularSequence analysisAdd BLAST348
Transmembranei366 – 386Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini387 – 397CytoplasmicSequence analysisAdd BLAST11
Transmembranei398 – 420Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini421 – 442ExtracellularSequence analysisAdd BLAST22
Transmembranei443 – 464Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini465 – 484CytoplasmicSequence analysisAdd BLAST20
Transmembranei485 – 507Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini508 – 527ExtracellularSequence analysisAdd BLAST20
Transmembranei528 – 549Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini550 – 572CytoplasmicSequence analysisAdd BLAST23
Transmembranei573 – 596Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini597 – 607ExtracellularSequence analysisAdd BLAST11
Transmembranei608 – 629Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini630 – 692CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001277318 – 692Follicle-stimulating hormone receptorAdd BLAST675

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 25PROSITE-ProRule annotation
Disulfide bondi23 ↔ 32PROSITE-ProRule annotation
Glycosylationi191N-linked (GlcNAc...) asparagineBy similarity1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi275 ↔ 345By similarity
Disulfide bondi276 ↔ 355By similarity
Disulfide bondi276 ↔ 292By similarity
Disulfide bondi292 ↔ 337By similarity
Glycosylationi293N-linked (GlcNAc...) asparagineBy similarity1
Modified residuei334SulfotyrosineBy similarity1
Disulfide bondi441 ↔ 516PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone.By similarity
Sulfated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbiP35378
PRIDEiP35378

PTM databases

PhosphoSitePlusiP35378

Expressioni

Gene expression databases

BgeeiENSMUSG00000032937 Expressed in 24 organ(s), highest expression level in cumulus cell
CleanExiMM_FSHR
ExpressionAtlasiP35378 baseline and differential
GenevisibleiP35378 MM

Interactioni

Subunit structurei

Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040477

Structurei

3D structure databases

ProteinModelPortaliP35378
SMRiP35378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 46LRRNTAdd BLAST29
Repeati49 – 72LRR 1Add BLAST24
Repeati73 – 97LRR 2Add BLAST25
Repeati98 – 118LRR 3Add BLAST21
Repeati119 – 143LRR 4Add BLAST25
Repeati144 – 169LRR 5Add BLAST26
Repeati170 – 192LRR 6Add BLAST23
Repeati193 – 216LRR 7Add BLAST24
Repeati217 – 240LRR 8Add BLAST24
Repeati241 – 259LRR 9Add BLAST19

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087 Eukaryota
ENOG410XR1T LUCA
GeneTreeiENSGT00760000119088
HOGENOMiHOG000045902
HOVERGENiHBG003521
InParanoidiP35378
KOiK04247
OMAiFGCYEMQ
OrthoDBiEOG091G02BV
PhylomeDBiP35378
TreeFamiTF316814

Family and domain databases

InterProiView protein in InterPro
IPR002272 FSH_rcpt
IPR024635 GnHR_TM
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002131 Gphrmn_rcpt_fam
IPR026906 LRR_5
IPR000372 LRRNT
IPR034298 TSHR/LHCGR/FSHR
PANTHERiPTHR24372 PTHR24372, 1 hit
PTHR24372:SF5 PTHR24372:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF12369 GnHR_trans, 1 hit
PF13306 LRR_5, 2 hits
PF01462 LRRNT, 1 hit
PRINTSiPR01143 FSHRECEPTOR
PR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P35378-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLLVSLLA FLGSGSGCHH WLCHCSNRVF LCQDSKVTEI PPDLPRNAIE
60 70 80 90 100
LRFVLTKLRV IPKGSFSGFG DLEKIEISQN DVLEVIEADV FSNLPNLHEI
110 120 130 140 150
RIEKANNLLY INPEAFQNLP SLRYLLISNT GIKHLPAFHK IQSLQKVLLD
160 170 180 190 200
IQDNINIHII ARNSFMGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL
210 220 230 240 250
SDNNNLEELP DDVFQGASGP VVLDISRTKV YSLPNHGLEN LKKLRARSTY
260 270 280 290 300
RLKKLPSLDK FVMLIEASLT YPSHCCAFAN WRRQTSELHP ICNKSISRQD
310 320 330 340 350
IDDMTQPGDQ RVSLVDDEPS YGKGSDMLYS EFDYDLCNEF VDVTCSPKPD
360 370 380 390 400
AFNPCEDIMG YNILRVLIWF ISILAITGNT TVLVVLTTSQ YKLTVPRFLM
410 420 430 440 450
CNLAFADLCI GIYLLLIASV DIHTKSQYHN YAIDWQTGAG CDAAGFFTVF
460 470 480 490 500
ASELSVYTLA AITLERWHTI THAMQLECKV QLCHAASIMV LGWAFAFAAA
510 520 530 540 550
LFPIFGISSY MKVSICLPMD IDSPLSQLYV MALLVLNALA FVVICGCYTH
560 570 580 590 600
IYLTVRNPNI VSSSRDTKIA KRMATLIFTD FLCMAPILFF AISASLKVPL
610 620 630 640 650
ITVSKAKILL VLFYPINSCA NPFLYAIFTK NFRRDFFVLM SKFGCYEVQA
660 670 680 690
QIYKTETSSI THNFHSRKNP CSSAPRVTNS YVLVPLNHSV QN
Length:692
Mass (Da):77,769
Last modified:September 26, 2001 - v2
Checksum:i4B57229180563A44
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti436Q → K in BAB30351 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095642 mRNA Translation: AAC67559.1
AK016635 mRNA Translation: BAB30351.1
S49632 Genomic DNA Translation: AAB24401.1
M87570 Genomic DNA Translation: AAA37641.1
CCDSiCCDS29026.1
PIRiI57670
RefSeqiNP_038551.3, NM_013523.3
UniGeneiMm.57155

Genome annotation databases

EnsembliENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937
GeneIDi14309
KEGGimmu:14309
UCSCiuc008dvx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095642 mRNA Translation: AAC67559.1
AK016635 mRNA Translation: BAB30351.1
S49632 Genomic DNA Translation: AAB24401.1
M87570 Genomic DNA Translation: AAA37641.1
CCDSiCCDS29026.1
PIRiI57670
RefSeqiNP_038551.3, NM_013523.3
UniGeneiMm.57155

3D structure databases

ProteinModelPortaliP35378
SMRiP35378
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040477

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP35378

Proteomic databases

PaxDbiP35378
PRIDEiP35378

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035701; ENSMUSP00000040477; ENSMUSG00000032937
GeneIDi14309
KEGGimmu:14309
UCSCiuc008dvx.1 mouse

Organism-specific databases

CTDi2492
MGIiMGI:95583 Fshr

Phylogenomic databases

eggNOGiKOG2087 Eukaryota
ENOG410XR1T LUCA
GeneTreeiENSGT00760000119088
HOGENOMiHOG000045902
HOVERGENiHBG003521
InParanoidiP35378
KOiK04247
OMAiFGCYEMQ
OrthoDBiEOG091G02BV
PhylomeDBiP35378
TreeFamiTF316814

Enzyme and pathway databases

ReactomeiR-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:P35378
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032937 Expressed in 24 organ(s), highest expression level in cumulus cell
CleanExiMM_FSHR
ExpressionAtlasiP35378 baseline and differential
GenevisibleiP35378 MM

Family and domain databases

InterProiView protein in InterPro
IPR002272 FSH_rcpt
IPR024635 GnHR_TM
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002131 Gphrmn_rcpt_fam
IPR026906 LRR_5
IPR000372 LRRNT
IPR034298 TSHR/LHCGR/FSHR
PANTHERiPTHR24372 PTHR24372, 1 hit
PTHR24372:SF5 PTHR24372:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF12369 GnHR_trans, 1 hit
PF13306 LRR_5, 2 hits
PF01462 LRRNT, 1 hit
PRINTSiPR01143 FSHRECEPTOR
PR00373 GLYCHORMONER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFSHR_MOUSE
AccessioniPrimary (citable) accession number: P35378
Secondary accession number(s): Q9D4C2, Q9QWV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: September 26, 2001
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again