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Protein

Type-2 angiotensin II receptor

Gene

Agtr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Type-2 angiotensin II receptor
Alternative name(s):
Angiotensin II type-2 receptor
Short name:
AT2
Gene namesi
Name:Agtr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:87966 Agtr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 71Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini72 – 80CytoplasmicSequence analysis9
Transmembranei81 – 102Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini103 – 119ExtracellularSequence analysisAdd BLAST17
Transmembranei120 – 140Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini141 – 160CytoplasmicSequence analysisAdd BLAST20
Transmembranei161 – 179Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini180 – 208ExtracellularSequence analysisAdd BLAST29
Transmembranei209 – 234Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini235 – 256CytoplasmicSequence analysisAdd BLAST22
Transmembranei257 – 278Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini279 – 297ExtracellularSequence analysisAdd BLAST19
Transmembranei298 – 318Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini319 – 363CytoplasmicSequence analysisAdd BLAST45

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691691 – 363Type-2 angiotensin II receptorAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi35 ↔ 290PROSITE-ProRule annotation1 Publication
Disulfide bondi117 ↔ 195PROSITE-ProRule annotation1 Publication
Modified residuei354Phosphoserine; by PKCSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP35374
PRIDEiP35374

PTM databases

iPTMnetiP35374
PhosphoSitePlusiP35374

Expressioni

Tissue specificityi

Expressed at highest levels in adrenal gland and uterus.1 Publication

Gene expression databases

BgeeiENSMUSG00000068122 Expressed in 138 organ(s), highest expression level in efferent duct
CleanExiMM_AGTR2
GenevisibleiP35374 MM

Interactioni

Subunit structurei

Interacts with MTUS1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086592

Structurei

3D structure databases

ProteinModelPortaliP35374
SMRiP35374
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119055
HOVERGENiHBG104998
InParanoidiP35374
KOiK04167
OMAiNCSHKPS
OrthoDBiEOG091G0HEN
PhylomeDBiP35374
TreeFamiTF330024

Family and domain databases

CDDicd15191 7tmA_AT2R, 1 hit
InterProiView protein in InterPro
IPR000147 ATII_AT2_rcpt
IPR000248 ATII_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00241 ANGIOTENSINR
PR00636 ANGIOTENSN2R
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35374-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDNFSFAAT SRNITSSRPF DNLNATGTNE SAFNCSHKPS DKHLEAIPVL
60 70 80 90 100
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLALAD LLLLATLPLW
110 120 130 140 150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF
160 170 180 190 200
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP
210 220 230 240 250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT
260 270 280 290 300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL
310 320 330 340 350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR
360
KGSSLREMDT FVS
Length:363
Mass (Da):41,374
Last modified:June 1, 1994 - v1
Checksum:i6C7D6E3B026D1E80
GO

Sequence cautioni

The sequence AAB49539 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67465 mRNA Translation: AAB29336.1
U04828 mRNA Translation: AAC52128.1
U00766 mRNA Translation: AAC04933.1
L32840 mRNA Translation: AAB49539.1 Different initiation.
U11073 Genomic DNA Translation: AAA82184.1
AK086334 mRNA Translation: BAC39650.1
BC003811 mRNA Translation: AAH03811.1
CCDSiCCDS40889.1
PIRiI48261
RefSeqiNP_031455.1, NM_007429.5
UniGeneiMm.2679

Genome annotation databases

EnsembliENSMUST00000089188; ENSMUSP00000086592; ENSMUSG00000068122
GeneIDi11609
KEGGimmu:11609
UCSCiuc009suq.3 mouse

Similar proteinsi

Entry informationi

Entry nameiAGTR2_MOUSE
AccessioniPrimary (citable) accession number: P35374
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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