Type-2 angiotensin II receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• angiotensin type II receptor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption."
    Daubert D.L., Meadows G.G., Wang J.H., Sanchez P.J., Speth R.C.
    Brain Res. 816:8-16(1999) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: MGI

GO - Biological processⁱ

• aldosterone secretion Source: MGI
• angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Increased vasoconstrictor response of the mouse lacking angiotensin II type 2 receptor."
    Akishita M., Yamada H., Dzau V.J., Horiuchi M.
    Biochem. Biophys. Res. Commun. 261:345-349(1999) [PubMed] [Europe PMC] [Abstract]
• brain renin-angiotensin system Source: MGIInferred from direct assayⁱ
  • "Changes in angiotensin II receptors in dopamine-rich regions of the mouse brain with age and ethanol consumption."
    Daubert D.L., Meadows G.G., Wang J.H., Sanchez P.J., Speth R.C.
    Brain Res. 816:8-16(1999) [PubMed] [Europe PMC] [Abstract]
• cell growth involved in cardiac muscle cell development Source: MGI
• cell surface receptor signaling pathway Source: MGI
• cellular response to dexamethasone stimulus Source: MGI
• cellular sodium ion homeostasis Source: MGI
• cerebellar cortex development Source: MGI
• dopamine biosynthetic process Source: MGI
• exploration behavior Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor."
    Ichiki T., Labosky P.A., Shiota C., Okuyama S., Imagawa Y., Fogo A., Niimura F., Ichikawa I., Hogan B.L., Inagami T.
    Nature 377:748-750(1995) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor."
    Yayama K., Hiyoshi H., Imazu D., Okamoto H.
    Hypertension 48:958-964(2006) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation."
    Esteban V., Heringer-Walther S., Sterner-Kock A., de Bruin R., van den Engel S., Wang Y., Mezzano S., Egido J., Schultheiss H.P., Ruiz-Ortega M., Walther T.
    PLoS ONE 4:e5406-e5406(2009) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor."
    Yayama K., Hiyoshi H., Imazu D., Okamoto H.
    Hypertension 48:958-964(2006) [PubMed] [Europe PMC] [Abstract]
• kidney morphogenesis Source: MGI
• negative regulation of fibroblast proliferation Source: MGI
• negative regulation of heart rate Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects."
    Masaki H., Kurihara T., Yamaki A., Inomata N., Nozawa Y., Mori Y., Murasawa S., Kizima K., Maruyama K., Horiuchi M., Dzau V.J., Takahashi H., Iwasaka T., Inada M., Matsubara H.
    J. Clin. Invest. 101:527-535(1998) [PubMed] [Europe PMC] [Abstract]
• negative regulation of icosanoid secretion Source: MGI
• negative regulation of neurotrophin TRK receptor signaling pathway Source: MGI
• negative regulation of norepinephrine secretion Source: MGI
• positive regulation of blood vessel diameter Source: MGI
• positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis."
    Chen Y.W., Tran S., Chenier I., Chan J.S., Ingelfinger J.R., Inagami T., Zhang S.L.
    Pediatr. Nephrol. 23:1769-1777(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: MGI
• positive regulation of cytokine secretion Source: MGI
• positive regulation of extrinsic apoptotic signaling pathway Source: MGI
• positive regulation of metanephric glomerulus development Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis."
    Chen Y.W., Tran S., Chenier I., Chan J.S., Ingelfinger J.R., Inagami T., Zhang S.L.
    Pediatr. Nephrol. 23:1769-1777(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of nitric-oxide synthase activity Source: BHF-UCLInferred from direct assayⁱ
  • "Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor."
    Yayama K., Hiyoshi H., Imazu D., Okamoto H.
    Hypertension 48:958-964(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of phosphoprotein phosphatase activity Source: MGI
• positive regulation of renal sodium excretion Source: MGI
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor."
    Zhang S.L., Moini B., Ingelfinger J.R.
    J. Am. Soc. Nephrol. 15:1452-1465(2004) [PubMed] [Europe PMC] [Abstract]
  • "Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis."
    Chen Y.W., Tran S., Chenier I., Chan J.S., Ingelfinger J.R., Inagami T., Zhang S.L.
    Pediatr. Nephrol. 23:1769-1777(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of metanephros size Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Deficiency of intrarenal angiotensin II type 2 receptor impairs paired homeo box-2 and N-myc expression during nephrogenesis."
    Chen Y.W., Tran S., Chenier I., Chan J.S., Ingelfinger J.R., Inagami T., Zhang S.L.
    Pediatr. Nephrol. 23:1769-1777(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of protein import into nucleus Source: MGI
• regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor."
    Ichiki T., Labosky P.A., Shiota C., Okuyama S., Imagawa Y., Fogo A., Niimura F., Ichikawa I., Hogan B.L., Inagami T.
    Nature 377:748-750(1995) [PubMed] [Europe PMC] [Abstract]
• renin-angiotensin regulation of aldosterone production Source: MGI
• vasodilation Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• transcription factor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKDNFSFAAT SRNITSSRPF DNLNATGTNE SAFNCSHKPS DKHLEAIPVL 
        60         70         80         90        100
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLALAD LLLLATLPLW 
       110        120        130        140        150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 
       160        170        180        190        200
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP 
       210        220        230        240        250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT 
       260        270        280        290        300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 
       310        320        330        340        350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR 
       360 
KGSSLREMDT FVS                                         

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot