UniProtKB - P35372 (OPRM_HUMAN)
Mu-type opioid receptor
OPRM1
Functioni
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:7905839, PubMed:7957926, PubMed:7891175, PubMed:12589820, PubMed:9689128).
Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors (PubMed:7905839).
The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15 (PubMed:12068084).
They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G-proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G-protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G-protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G-protein coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G-protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling whereas morphine induces only low desensitization and endocytosis. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis. Isoform 12 couples to GNAS and is proposed to be involved in excitatory effects (PubMed:20525224).
Isoform 16 and isoform 17 do not bind agonists but may act through oligomerization with binding-competent OPRM1 isoforms and reduce their ligand binding activity (PubMed:16580639).
2 PublicationsBy similarity9 PublicationsMiscellaneous
GO - Molecular functioni
- beta-endorphin receptor activity Source: UniProtKB
- filamin binding Source: Ensembl
- G-protein alpha-subunit binding Source: UniProtKB
- G-protein beta-subunit binding Source: GO_Central
- G protein-coupled receptor activity Source: UniProtKB
- morphine receptor activity Source: UniProtKB
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: Ensembl
- voltage-gated calcium channel activity Source: UniProtKB
GO - Biological processi
- acute inflammatory response to antigenic stimulus Source: Ensembl
- adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway Source: UniProtKB
- adenylate cyclase-inhibiting opioid receptor signaling pathway Source: Ensembl
- behavioral response to ethanol Source: UniProtKB
- eating behavior Source: Ensembl
- estrous cycle Source: Ensembl
- excitatory postsynaptic potential Source: Ensembl
- G protein-coupled opioid receptor signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- negative regulation of cAMP-mediated signaling Source: UniProtKB
- negative regulation of cell population proliferation Source: ProtInc
- negative regulation of cytosolic calcium ion concentration Source: UniProtKB
- negative regulation of nitric oxide biosynthetic process Source: UniProtKB
- negative regulation of Wnt protein secretion Source: UniProtKB
- neuropeptide signaling pathway Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of appetite Source: Ensembl
- positive regulation of cAMP-mediated signaling Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of neurogenesis Source: UniProtKB
- positive regulation of nitric oxide biosynthetic process Source: UniProtKB
- regulation of cellular response to stress Source: UniProtKB
- regulation of NMDA receptor activity Source: UniProtKB
- regulation of sensory perception of pain Source: Ensembl
- response to cocaine Source: Ensembl
- response to food Source: Ensembl
- response to growth factor Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
- response to radiation Source: Ensembl
- sensory perception Source: UniProtKB
- sensory perception of pain Source: UniProtKB
- wound healing Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P35372 |
Reactomei | R-HSA-111885, Opioid Signalling R-HSA-202040, G-protein activation R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9022699, MECP2 regulates neuronal receptors and channels |
SignaLinki | P35372 |
SIGNORi | P35372 |
Protein family/group databases
TCDBi | 9.A.14.13.18, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Mu-type opioid receptorShort name: M-OR-1 Short name: MOR-1 Alternative name(s): Mu opiate receptor Mu opioid receptor Short name: MOP Short name: hMOP |
Gene namesi | Name:OPRM1 Synonyms:MOR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8156, OPRM1 |
MIMi | 600018, gene |
neXtProti | NX_P35372 |
VEuPathDBi | HostDB:ENSG00000112038 |
Subcellular locationi
Endosome
- Endosome By similarity
Plasma membrane
- Cell membrane 7 Publications; Multi-pass membrane protein 1 Publication
Other locations
- axon By similarity
- Perikaryon By similarity
- dendrite By similarity
Note: Is rapidly internalized after agonist binding.By similarity
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: ProtInc
Endosome
- endosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: ProtInc
Plasma Membrane
- dendrite membrane Source: Ensembl
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: UniProtKB
- sarcolemma Source: Ensembl
Other locations
- axon Source: UniProtKB
- dendrite Source: UniProtKB
- dendrite cytoplasm Source: Ensembl
- focal adhesion Source: Ensembl
- membrane raft Source: Ensembl
- neuron projection Source: GO_Central
- perikaryon Source: UniProtKB-SubCell
- spine apparatus Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 68 | ExtracellularBy similarityAdd BLAST | 68 | |
Transmembranei | 69 – 93 | Helical; Name=1By similarityAdd BLAST | 25 | |
Topological domaini | 94 – 106 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 107 – 131 | Helical; Name=2By similarityAdd BLAST | 25 | |
Topological domaini | 132 – 142 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 143 – 165 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 166 – 185 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 186 – 207 | Helical; Name=4By similarityAdd BLAST | 22 | |
Topological domaini | 208 – 230 | ExtracellularBy similarityAdd BLAST | 23 | |
Transmembranei | 231 – 255 | Helical; Name=5By similarityAdd BLAST | 25 | |
Topological domaini | 256 – 279 | CytoplasmicBy similarityAdd BLAST | 24 | |
Transmembranei | 280 – 306 | Helical; Name=6By similarityAdd BLAST | 27 | |
Topological domaini | 307 – 314 | ExtracellularBy similarity | 8 | |
Transmembranei | 315 – 338 | Helical; Name=7By similarityAdd BLAST | 24 | |
Topological domaini | 339 – 400 | CytoplasmicBy similarityAdd BLAST | 62 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 142 | C → A or S: Abolishes ligand binding; when associated with A-219 or S-219. 1 Publication | 1 | |
Mutagenesisi | 219 | C → A or S: Abolishes ligand binding; when associated with A-142 or S-142. 1 Publication | 1 | |
Mutagenesisi | 273 | K → A: Impairs interaction with calmodulin. 2 Publications | 1 | |
Mutagenesisi | 275 | R → A: Impairs interaction with calmodulin. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4988 |
OpenTargetsi | ENSG00000112038 |
PharmGKBi | PA31945 |
Miscellaneous databases
Pharosi | P35372, Tclin |
Chemistry databases
ChEMBLi | CHEMBL233 |
DrugBanki | DB01571, 3-Methylfentanyl DB01439, 3-Methylthiofentanyl DB00802, Alfentanil DB06274, Alvimopan DB06288, Amisulpride DB00321, Amitriptyline DB00913, Anileridine DB01238, Aripiprazole DB00921, Buprenorphine DB00611, Butorphanol DB09173, Butyrfentanyl DB09061, Cannabidiol DB01535, Carfentanil DB00318, Codeine DB00514, Dextromethorphan DB00647, Dextropropoxyphene DB01209, Dezocine DB01452, Diamorphine DB01565, Dihydromorphine DB01444, Dimethylthiambutene DB01081, Diphenoxylate DB01548, Diprenorphine DB09272, Eluxadoline DB05492, Epicept NP-1 DB01466, Ethylmorphine DB01497, Etorphine DB00813, Fentanyl DB00956, Hydrocodone DB00327, Hydromorphone DB01221, Ketamine DB06738, Ketobemidone DB01227, Levacetylmethadol DB00504, Levallorphan DB00854, Levorphanol DB05509, LI-301 DB00836, Loperamide DB14146, Loxicodegol DB14009, Medical Cannabis DB00454, Meperidine DB12668, Metenkefalin DB00333, Methadone DB01433, Methadyl acetate DB06800, Methylnaltrexone DB00295, Morphine DB06409, Morphine glucuronide DB14011, Nabiximols DB00844, Nalbuphine DB11691, Naldemedine DB06230, Nalmefene DB09049, Naloxegol DB01183, Naloxone DB00704, Naltrexone DB14881, Oliceridine DB00904, Ondansetron DB11130, Opium DB00497, Oxycodone DB01192, Oxymorphone DB00652, Pentazocine DB11186, Pentoxyverine DB09209, Pholcodine DB00899, Remifentanil DB12543, Samidorphan DB00708, Sufentanil DB06204, Tapentadol DB09289, Tianeptine DB00193, Tramadol DB09089, Trimebutine DB05046, V1003 |
DrugCentrali | P35372 |
GuidetoPHARMACOLOGYi | 319 |
Genetic variation databases
BioMutai | OPRM1 |
DMDMi | 2851402 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069972 | 1 – 400 | Mu-type opioid receptorAdd BLAST | 400 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 12 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 33 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 40 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 48 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 142 ↔ 219 | PROSITE-ProRule annotation | ||
Modified residuei | 168 | PhosphotyrosineBy similarity | 1 | |
Lipidationi | 353 | S-palmitoyl cysteineSequence analysis | 1 | |
Modified residuei | 365 | PhosphoserineBy similarity | 1 | |
Modified residuei | 372 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 377 | PhosphoserineBy similarity | 1 | |
Modified residuei | 396 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
MassIVEi | P35372 |
PaxDbi | P35372 |
PeptideAtlasi | P35372 |
PRIDEi | P35372 |
ProteomicsDBi | 55039 [P35372-10] |
PTM databases
GlyGeni | P35372, 5 sites |
iPTMneti | P35372 |
PhosphoSitePlusi | P35372 |
SwissPalmi | P35372 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000112038, Expressed in right hemisphere of cerebellum and 54 other tissues |
ExpressionAtlasi | P35372, baseline and differential |
Genevisiblei | P35372, HS |
Organism-specific databases
HPAi | ENSG00000112038, Group enriched (brain, testis) |
Interactioni
Subunit structurei
Forms homooligomers and heterooligomers with other GPCRs, such as OPRD1, OPRK1, OPRL1, NPFFR2, ADRA2A, SSTR2, CNR1 and CCR5 (probably in dimeric forms) (PubMed:12413885, PubMed:15778451, PubMed:15967873, PubMed:17224450).
Interacts with heterotrimeric G proteins; interaction with a heterotrimeric complex containing GNAI1, GNB1 and GNG2 stabilizes the active conformation of the receptor and increases its affinity for endomorphin-2, the synthetic opioid peptide DAMGO and for morphinan agonists (By similarity).
Interacts with PPL; the interaction disrupts agonist-mediated G-protein activation (PubMed:12810704).
Interacts (via C-terminus) with DNAJB4 (via C-terminus) (PubMed:16542645).
Interacts with calmodulin; the interaction inhibits the constitutive activity of OPRM1; it abolishes basal and attenuates agonist-stimulated G-protein coupling (PubMed:10419536, PubMed:10899953).
Interacts with FLNA, PLD2, RANBP9 and WLS and GPM6A (PubMed:12519790, PubMed:14573758, PubMed:19788913, PubMed:20214800).
Interacts with RTP4 (By similarity).
Interacts with SYP and GNAS (By similarity).
Interacts with RGS9, RGS17, RGS20, RGS4, PPP1R9B and HINT1 (By similarity).
By similarity12 PublicationsBinary interactionsi
P35372
Isoform 10 [P35372-10]
GO - Molecular functioni
- filamin binding Source: Ensembl
- G-protein alpha-subunit binding Source: UniProtKB
- G-protein beta-subunit binding Source: GO_Central
- protein C-terminus binding Source: Ensembl
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 111033, 136 interactors |
IntActi | P35372, 123 interactors |
MINTi | P35372 |
STRINGi | 9606.ENSP00000394624 |
Chemistry databases
BindingDBi | P35372 |
Miscellaneous databases
RNActi | P35372, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 334 – 338 | NPxxY; plays a role in stabilizing the activated conformation of the receptorBy similarity | 5 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000158236 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P35372 |
OMAi | GNNMEID |
PhylomeDBi | P35372 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000105, Mu_opioid_rcpt IPR001418, Opioid_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00537, MUOPIOIDR PR00384, OPIOIDR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (18+)i Sequence
Sequence statusi: Complete.
This entry describes 18 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 18 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDSSAAPTNA SNCTDALAYS SCSPAPSPGS WVNLSHLDGN LSDPCGPNRT
60 70 80 90 100
DLGGRDSLCP PTGSPSMITA ITIMALYSIV CVVGLFGNFL VMYVIVRYTK
110 120 130 140 150
MKTATNIYIF NLALADALAT STLPFQSVNY LMGTWPFGTI LCKIVISIDY
160 170 180 190 200
YNMFTSIFTL CTMSVDRYIA VCHPVKALDF RTPRNAKIIN VCNWILSSAI
210 220 230 240 250
GLPVMFMATT KYRQGSIDCT LTFSHPTWYW ENLLKICVFI FAFIMPVLII
260 270 280 290 300
TVCYGLMILR LKSVRMLSGS KEKDRNLRRI TRMVLVVVAV FIVCWTPIHI
310 320 330 340 350
YVIIKALVTI PETTFQTVSW HFCIALGYTN SCLNPVLYAF LDENFKRCFR
360 370 380 390 400
EFCIPTSSNI EQQNSTRIRQ NTRDHPSTAN TVDRTNHQLE NLEAETAPLP
The sequence of this isoform differs from the canonical sequence as follows:
389-400: LENLEAETAPLP → IRDPISNLPRVSVF
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MCLHRRVPSE...SGARPAVSTM
The sequence of this isoform differs from the canonical sequence as follows:
389-400: LENLEAETAPLP → S
The sequence of this isoform differs from the canonical sequence as follows:
1-100: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-96: MDSSAAPTNA...GNFLVMYVIV → MMRAKSISTKAGKPS
The sequence of this isoform differs from the canonical sequence as follows:
1-100: Missing.
389-400: LENLEAETAPLP → NYYIIHRCCCNTPLISQKPVLLWFCD
The sequence of this isoform differs from the canonical sequence as follows:
1-100: Missing.
389-400: LENLEAETAPLP → VRSL
The sequence of this isoform differs from the canonical sequence as follows:
98-400: YTKMKTATNI...NLEAETAPLP → YSWFVIGGPEGRRKQRRLGEDKRARGCGEKG
The sequence of this isoform differs from the canonical sequence as follows:
97-400: RYTKMKTATN...NLEAETAPLP → SSSWF
The sequence of this isoform differs from the canonical sequence as follows:
98-186: YTKMKTATNI...ALDFRTPRNA → FHRLYTNILS...LDSHSHLRHH
187-400: Missing.
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketL0E130 | L0E130_HUMAN | Mu-type opioid receptor | OPRM1 | 476 | Annotation score: | ||
E7EW71 | E7EW71_HUMAN | Mu-type opioid receptor | OPRM1 | 162 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 26 | P → L in BAG36624 (PubMed:14702039).Curated | 1 | ||
Sequence conflicti | 51 | D → N in AAA20580 (PubMed:7905839).Curated | 1 | ||
Sequence conflicti | 109 | I → V in AAQ77391 (PubMed:15893644).Curated | 1 | ||
Sequence conflicti | 207 | M → I in AAB60354 (PubMed:7957926).Curated | 1 | ||
Sequence conflicti | 234 | L → V in AAA20580 (PubMed:7905839).Curated | 1 | ||
Isoform 3 (identifier: P35372-3) | |||||
Sequence conflicti | 402 | Q → H in AAK74189 (PubMed:12589820).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Natural variantiVAR_009525 | 6 | A → V4 PublicationsCorresponds to variant dbSNP:rs1799972Ensembl. | 1 | ||
Natural variantiVAR_009524 | 40 | N → D4 PublicationsCorresponds to variant dbSNP:rs1799971EnsemblClinVar. | 1 | ||
Natural variantiVAR_049426 | 63 | G → V. Corresponds to variant dbSNP:rs9282817Ensembl. | 1 | ||
Natural variantiVAR_049427 | 66 | S → F. Corresponds to variant dbSNP:rs9282819Ensembl. | 1 | ||
Natural variantiVAR_009526 | 147 | S → C2 PublicationsCorresponds to variant dbSNP:rs17174794EnsemblClinVar. | 1 | ||
Natural variantiVAR_019252 | 152 | N → D1 PublicationCorresponds to variant dbSNP:rs17174801Ensembl. | 1 | ||
Natural variantiVAR_009527 | 260 | R → H1 PublicationCorresponds to variant dbSNP:rs1799974Ensembl. | 1 | ||
Natural variantiVAR_019253 | 265 | R → C1 PublicationCorresponds to variant dbSNP:rs17174822Ensembl. | 1 | ||
Natural variantiVAR_019254 | 274 | D → N1 PublicationCorresponds to variant dbSNP:rs17174829Ensembl. | 1 | ||
Natural variantiVAR_082952 | 388 – 400 | Missing 1 PublicationAdd BLAST | 13 | ||
Isoform 9 (identifier: P35372-9) | |||||
Natural variantiVAR_082953 | 411 – 420 | Missing 1 Publication | 10 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042327 | 1 – 100 | Missing in isoform 12, isoform 14 and isoform 15. 4 PublicationsAdd BLAST | 100 | |
Alternative sequenceiVSP_042328 | 1 – 96 | MDSSA…MYVIV → MMRAKSISTKAGKPS in isoform 13. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_037693 | 1 | M → MCLHRRVPSEETYSLDRFAQ NPPLFPPPSLPASESRMAHA PLLQRCGAARTGFCKKQQEL WQRRKEAAEALGTRKVSVLL ATSHSGARPAVSTM in isoform 10. 2 Publications | 1 | |
Alternative sequenceiVSP_042329 | 97 – 400 | RYTKM…TAPLP → SSSWF in isoform 17. CuratedAdd BLAST | 304 | |
Alternative sequenceiVSP_042330 | 98 – 400 | YTKMK…TAPLP → YSWFVIGGPEGRRKQRRLGE DKRARGCGEKG in isoform 16. CuratedAdd BLAST | 303 | |
Alternative sequenceiVSP_047577 | 98 – 186 | YTKMK…TPRNA → FHRLYTNILSSNLVLGKPAE DLCFHLRLHYASAHHYRVLW TDDLAPQECPHALWLQRKGQ ESSKDHQDGAGGGGCVHRLL DSHSHLRHH in isoform 18. 1 PublicationAdd BLAST | 89 | |
Alternative sequenceiVSP_047578 | 187 – 400 | Missing in isoform 18. 1 PublicationAdd BLAST | 214 | |
Alternative sequenceiVSP_037694 | 389 – 400 | LENLE…TAPLP → S in isoform 11. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_042331 | 389 – 400 | LENLE…TAPLP → NYYIIHRCCCNTPLISQKPV LLWFCD in isoform 14. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_001896 | 389 – 400 | LENLE…TAPLP → VRSL in isoform 2 and isoform 15. 3 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_037695 | 389 – 400 | LENLE…TAPLP → CLPIPSLSCWALEQGCLVVY PGPLQGPLVRYDLPAILHSS CLRGNTAPSPSGGAFLLS in isoform 3. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_037696 | 389 – 400 | LENLE…TAPLP → GPPAKFVADQLAGSS in isoform 4. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_037697 | 389 – 400 | LENLE…TAPLP → PPLAVSMAQIFTRYPPPTHR EKTCNDYMKR in isoform 5. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_037698 | 389 – 400 | LENLE…TAPLP → IRDPISNLPRVSVF in isoform 6. 3 PublicationsAdd BLAST | 12 | |
Alternative sequenceiVSP_037699 | 389 – 400 | LENLE…TAPLP → KIDLFQKSSLLNCEHTKG in isoform 7. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_037700 | 389 – 400 | LENLE…TAPLP → RERRQKSDW in isoform 8. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_037701 | 389 – 400 | LENLE…TAPLP → VELNLDCHCENAKPWPLSYN AGQSPFPFPGRV in isoform 9. 1 PublicationAdd BLAST | 12 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Mu opioid receptor entry |
NIEHS-SNPs |
Sequence databases
3D structure databases
AlphaFoldDBi | P35372 |
SMRi | P35372 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 111033, 136 interactors |
IntActi | P35372, 123 interactors |
MINTi | P35372 |
STRINGi | 9606.ENSP00000394624 |
Chemistry databases
BindingDBi | P35372 |
ChEMBLi | CHEMBL233 |
DrugBanki | DB01571, 3-Methylfentanyl DB01439, 3-Methylthiofentanyl DB00802, Alfentanil DB06274, Alvimopan DB06288, Amisulpride DB00321, Amitriptyline DB00913, Anileridine DB01238, Aripiprazole DB00921, Buprenorphine DB00611, Butorphanol DB09173, Butyrfentanyl DB09061, Cannabidiol DB01535, Carfentanil DB00318, Codeine DB00514, Dextromethorphan DB00647, Dextropropoxyphene DB01209, Dezocine DB01452, Diamorphine DB01565, Dihydromorphine DB01444, Dimethylthiambutene DB01081, Diphenoxylate DB01548, Diprenorphine DB09272, Eluxadoline DB05492, Epicept NP-1 DB01466, Ethylmorphine DB01497, Etorphine DB00813, Fentanyl DB00956, Hydrocodone DB00327, Hydromorphone DB01221, Ketamine DB06738, Ketobemidone DB01227, Levacetylmethadol DB00504, Levallorphan DB00854, Levorphanol DB05509, LI-301 DB00836, Loperamide DB14146, Loxicodegol DB14009, Medical Cannabis DB00454, Meperidine DB12668, Metenkefalin DB00333, Methadone DB01433, Methadyl acetate DB06800, Methylnaltrexone DB00295, Morphine DB06409, Morphine glucuronide DB14011, Nabiximols DB00844, Nalbuphine DB11691, Naldemedine DB06230, Nalmefene DB09049, Naloxegol DB01183, Naloxone DB00704, Naltrexone DB14881, Oliceridine DB00904, Ondansetron DB11130, Opium DB00497, Oxycodone DB01192, Oxymorphone DB00652, Pentazocine DB11186, Pentoxyverine DB09209, Pholcodine DB00899, Remifentanil DB12543, Samidorphan DB00708, Sufentanil DB06204, Tapentadol DB09289, Tianeptine DB00193, Tramadol DB09089, Trimebutine DB05046, V1003 |
DrugCentrali | P35372 |
GuidetoPHARMACOLOGYi | 319 |
Protein family/group databases
TCDBi | 9.A.14.13.18, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | P35372, 5 sites |
iPTMneti | P35372 |
PhosphoSitePlusi | P35372 |
SwissPalmi | P35372 |
Genetic variation databases
BioMutai | OPRM1 |
DMDMi | 2851402 |
Proteomic databases
MassIVEi | P35372 |
PaxDbi | P35372 |
PeptideAtlasi | P35372 |
PRIDEi | P35372 |
ProteomicsDBi | 55039 [P35372-10] |
Protocols and materials databases
Antibodypediai | 2929, 592 antibodies from 40 providers |
DNASUi | 4988 |
Genome annotation databases
Organism-specific databases
CTDi | 4988 |
DisGeNETi | 4988 |
GeneCardsi | OPRM1 |
HGNCi | HGNC:8156, OPRM1 |
HPAi | ENSG00000112038, Group enriched (brain, testis) |
MIMi | 600018, gene |
neXtProti | NX_P35372 |
OpenTargetsi | ENSG00000112038 |
PharmGKBi | PA31945 |
VEuPathDBi | HostDB:ENSG00000112038 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000158236 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P35372 |
OMAi | GNNMEID |
PhylomeDBi | P35372 |
TreeFami | TF315737 |
Enzyme and pathway databases
PathwayCommonsi | P35372 |
Reactomei | R-HSA-111885, Opioid Signalling R-HSA-202040, G-protein activation R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9022699, MECP2 regulates neuronal receptors and channels |
SignaLinki | P35372 |
SIGNORi | P35372 |
Miscellaneous databases
BioGRID-ORCSi | 4988, 11 hits in 1073 CRISPR screens |
ChiTaRSi | OPRM1, human |
GeneWikii | %CE%9C-opioid_receptor |
GenomeRNAii | 4988 |
Pharosi | P35372, Tclin |
PROi | PR:P35372 |
RNActi | P35372, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112038, Expressed in right hemisphere of cerebellum and 54 other tissues |
ExpressionAtlasi | P35372, baseline and differential |
Genevisiblei | P35372, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000105, Mu_opioid_rcpt IPR001418, Opioid_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00537, MUOPIOIDR PR00384, OPIOIDR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | OPRM_HUMAN | |
Accessioni | P35372Primary (citable) accession number: P35372 Secondary accession number(s): B0FXJ1 Q9UN57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | July 15, 1998 | |
Last modified: | May 25, 2022 | |
This is version 208 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families