ADRA1B

Functionⁱ

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.2 Publications

GO - Molecular functionⁱ

alpha1-adrenergic receptor activity Source: GO_Central
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22120526

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 10820200
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 1328250
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 10820200
glucose homeostasis Source: GO_Central
G-protein coupled receptor signaling pathway Source: Reactome
intracellular signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10820200
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 10820200
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: GO_Central
phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
positive regulation of cytosolic calcium ion concentration Source: GO_Central
positive regulation of MAPK cascade
Source: UniProtKB
Inferred from direct assayⁱ
- 22120526
positive regulation of smooth muscle contraction Source: GO_Central
positive regulation of vasoconstriction Source: GO_Central
regulation of cardiac muscle contraction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390696 Adrenoceptors R-HSA-416476 G alpha (q) signalling events R-HSA-416482 G alpha (12/13) signalling events
SignaLinkⁱ	P35368
SIGNORⁱ	P35368

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-1B adrenergic receptor Alternative name(s): Alpha-1B adrenoreceptor Short name: Alpha-1B adrenoceptor
Gene namesⁱ	Name:ADRA1B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170214.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:278 ADRA1B
MIMⁱ	104220 gene
neXtProtⁱ	NX_P35368

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 45	ExtracellularBy similarityAdd BLAST	45
Transmembraneⁱ	46 – 70	Helical; Name=1By similarityAdd BLAST	25
Topological domainⁱ	71 – 83	CytoplasmicBy similarityAdd BLAST	13
Transmembraneⁱ	84 – 105	Helical; Name=2By similarityAdd BLAST	22
Topological domainⁱ	106 – 115	ExtracellularBy similarity	10
Transmembraneⁱ	116 – 141	Helical; Name=3By similarityAdd BLAST	26
Topological domainⁱ	142 – 161	CytoplasmicBy similarityAdd BLAST	20
Transmembraneⁱ	162 – 184	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	185 – 201	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	202 – 224	Helical; Name=5By similarityAdd BLAST	23
Topological domainⁱ	225 – 295	CytoplasmicBy similarityAdd BLAST	71
Transmembraneⁱ	296 – 319	Helical; Name=6By similarityAdd BLAST	24
Topological domainⁱ	320 – 326	ExtracellularBy similarity	7
Transmembraneⁱ	327 – 351	Helical; Name=7By similarityAdd BLAST	25
Topological domainⁱ	352 – 520	CytoplasmicBy similarityAdd BLAST	169

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	368 – 380	RGRGR…RRRRR → AGAGAAAAAAAAA: Abolishes targeting to the nuclear membrane of cardiac myocytes. 1 PublicationAdd BLAST		13

Organism-specific databases

DisGeNET More...DisGeNETⁱ	147
Open Targets More...OpenTargetsⁱ	ENSG00000170214
PharmGKBⁱ	PA33

Chemistry databases

ChEMBLⁱ	CHEMBL232
Drug and drug target database More...DrugBankⁱ	DB01614 Acepromazine DB00346 Alfuzosin DB00321 Amitriptyline DB00543 Amoxapine DB00182 Amphetamine DB01238 Aripiprazole DB09128 Brexpiprazole DB01200 Bromocriptine DB00248 Cabergoline DB01136 Carvedilol DB00477 Chlorpromazine DB09202 Cirazoline DB00575 Clonidine DB00363 Clozapine DB00298 Dapiprazole DB01151 Desipramine DB01576 Dextroamphetamine DB00590 Doxazosin DB01142 Doxepin DB04855 Dronedarone DB06262 Droxidopa DB05492 Epicept NP-1 DB00668 Epinephrine DB01049 Ergoloid mesylate DB00696 Ergotamine DB00800 Fenoldopam DB00458 Imipramine DB00598 Labetalol DB01255 Lisdexamfetamine DB00408 Loxapine DB00934 Maprotiline DB01365 Mephentermine DB01403 Methotrimeprazine DB00723 Methoxamine DB06148 Mianserin DB00211 Midodrine DB00370 Mirtazapine DB00745 Modafinil DB01149 Nefazodone DB00622 Nicardipine DB00368 Norepinephrine DB00540 Nortriptyline DB00334 Olanzapine DB00935 Oxymetazoline DB01267 Paliperidone DB01186 Pergolide DB01579 Phendimetrazine DB00925 Phenoxybenzamine DB00388 Phenylephrine DB00457 Prazosin DB00420 Promazine DB01608 Propericiazine DB00777 Propiomazine DB01224 Quetiapine DB05469 R450 DB00734 Risperidone DB06144 Sertindole DB06207 Silodosin DB00706 Tamsulosin DB01162 Terazosin DB01622 Thioproperazine DB00679 Thioridazine DB13025 Tiapride DB00726 Trimipramine DB06694 Xylometazoline DB00246 Ziprasidone
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	23

Polymorphism and mutation databases

BioMutaⁱ	ADRA1B
DMDMⁱ	116241241

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069069	1 – 520	Alpha-1B adrenergic receptorAdd BLAST		520

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	10	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	24	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	29	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	34	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	118 ↔ 195	PROSITE-ProRule annotation
Modified residueⁱ	264	PhosphothreonineBy similarity	1
Lipidationⁱ	365	S-palmitoyl cysteineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35368
PaxDbⁱ	P35368
PeptideAtlas More...PeptideAtlasⁱ	P35368
PRIDEⁱ	P35368
ProteomicsDBⁱ	55037

PTM databases

iPTMnetⁱ	P35368
PhosphoSitePlusⁱ	P35368

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170214 Expressed in 84 organ(s), highest expression level in thoracic aorta
CleanExⁱ	HS_ADRA1B
Genevisibleⁱ	P35368 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA074416

HPAⁱ

HPA074416

Interactionⁱ

Subunit structureⁱ

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes (PubMed:22120526). Interacts with CAVIN4 (PubMed:24567387).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DRD4	P21917	2	EBI-490017,EBI-8592297

With

Entry

#Exp.

IntAct

Notes

DRD4

P21917

2

EBI-490017,EBI-8592297

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22120526

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106657, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-33399N
IntActⁱ	P35368, 5 interactors
Molecular INTeraction database More...MINTⁱ	P35368
STRINGⁱ	9606.ENSP00000306662

Chemistry databases

BindingDBⁱ	P35368

BindingDBⁱ

P35368

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35368
SMRⁱ	P35368
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	368 – 380	Nuclear localization signalAdd BLAST		13

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	370 – 380	Poly-ArgAdd BLAST		11

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239244
HOVERGENⁱ	HBG106962
InParanoidⁱ	P35368
KEGG Orthology (KO) More...KOⁱ	K04136
OMAⁱ	WVLGRIF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P35368
TreeFamⁱ	TF331895

Family and domain databases

InterProⁱ	View protein in InterPro IPR002233 ADR_fam IPR001115 ADRA1B_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24248:SF17 PTHR24248:SF17, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01103 ADRENERGICR PR00556 ADRENRGCA1BR PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.ⁱShow all

P35368-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL 
        60         70         80         90        100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP 
       110        120        130        140        150
FSAALEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS 
       160        170        180        190        200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE 
       210        220        230        240        250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE 
       260        270        280        290        300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 
       310        320        330        340        350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC 
       360        370        380        390        400
SSKEFKRAFV RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS 
       410        420        430        440        450
QSRKDSLDDS GSCLSGSQRT LPSASPSPGY LGRGAPPPVE LCAFPEWKAP 
       460        470        480        490        500
GALLSLPAPE PPGRRGRHDS GPLFTFKLLT EPESPGTDGG ASNGGCEAAA 
       510        520
DVANGQPGFK SNMPLAPGQF

Length:520

Mass (Da):56,836

Last modified:October 17, 2006 - v3

Checksum:ⁱF081A23D2F943F7F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	A0A286YF88	A0A286YF88_HUMAN		Alpha-1B adrenergic receptor Alpha-1B adrenergic receptor	ADRA1B	35	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	371	Missing (PubMed:1328250).Curated	1
Sequence conflictⁱ	371	Missing in AAB59485 (PubMed:7815325).Curated	1
Sequence conflictⁱ	498 – 501	AAAD → PRH (PubMed:1328250).Curated	4

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019510	51	V → G. Corresponds to variant dbSNP:rs8192448Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M99589 Genomic DNA No translation available. M99590 Genomic DNA No translation available. U03865 mRNA Translation: AAB60352.1 L31773 mRNA Translation: AAB59485.1 EU332831 Genomic DNA Translation: ABY87520.1 BC136568 mRNA Translation: AAI36569.1 BC136569 mRNA Translation: AAI36570.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4347.1
PIRⁱ	A45121
NCBI Reference Sequences More...RefSeqⁱ	NP_000670.1, NM_000679.3
UniGeneⁱ	Hs.368632 Hs.670012

Genome annotation databases

Ensemblⁱ	ENST00000306675; ENSP00000306662; ENSG00000170214
GeneIDⁱ	147
KEGGⁱ	hsa:147
UCSC genome browser More...UCSCⁱ	uc003lxt.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35368	Uncharacterized protein (Fragment)		MACMU		367	UniRef100_P35368
Uncharacterized protein (Fragment)		MACFA		361

Protein	Similar proteins		Species	Score	Length	Source
P35368	Alpha-1B adrenergic receptor		MOUSE		514	UniRef90_P97717
Alpha-1B adrenergic receptor		MESAU		515
Alpha-1B adrenergic receptor		RAT		515
Alpha-1B adrenergic receptor (Fragment)		CANLF		417
Uncharacterized protein (Fragment)		MACMU		367
+81

Protein	Similar proteins		Species	Score	Length	Source
P35368	Alpha-1B adrenergic receptor		MOUSE		514	UniRef50_P97717
Alpha-1B adrenergic receptor		RAT		515
Alpha-1B adrenergic receptor		MESAU		515
Alpha-1B adrenergic receptor (Fragment)		CANLF		417
Uncharacterized protein (Fragment)		MACMU		367
+184

Entry informationⁱ

Entry nameⁱ	ADA1B_HUMAN
Accessionⁱ	P35368Primary (citable) accession number: P35368 Secondary accession number(s): B0LPE1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	October 17, 2006
	Last modified:	September 12, 2018
	This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35368 (ADA1B_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Alpha-1B adrenergic receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Other locations

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ