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UniProtKB - P35368 (ADA1B_HUMAN)

Entry version 186 (25 May 2022)
Sequence version 3 (17 Oct 2006)
Previous versions | rss
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Protein

Alpha-1B adrenergic receptor

Gene

ADRA1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P35368

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390696, Adrenoceptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P35368

SIGNOR Signaling Network Open Resource

More...SIGNORi		P35368

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADRA1B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:278, ADRA1B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		104220, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P35368

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170214

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 45ExtracellularBy similarityAdd BLAST45
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei46 – 70Helical; Name=1By similarityAdd BLAST25
Topological domaini71 – 83CytoplasmicBy similarityAdd BLAST13
Transmembranei84 – 105Helical; Name=2By similarityAdd BLAST22
Topological domaini106 – 115ExtracellularBy similarity10
Transmembranei116 – 141Helical; Name=3By similarityAdd BLAST26
Topological domaini142 – 161CytoplasmicBy similarityAdd BLAST20
Transmembranei162 – 184Helical; Name=4By similarityAdd BLAST23
Topological domaini185 – 201ExtracellularBy similarityAdd BLAST17
Transmembranei202 – 224Helical; Name=5By similarityAdd BLAST23
Topological domaini225 – 295CytoplasmicBy similarityAdd BLAST71
Transmembranei296 – 319Helical; Name=6By similarityAdd BLAST24
Topological domaini320 – 326ExtracellularBy similarity7
Transmembranei327 – 351Helical; Name=7By similarityAdd BLAST25
Topological domaini352 – 520CytoplasmicBy similarityAdd BLAST169

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi368 – 380RGRGR…RRRRR → AGAGAAAAAAAAA: Abolishes targeting to the nuclear membrane of cardiac myocytes. 1 PublicationAdd BLAST13

Organism-specific databases

DisGeNET

More...DisGeNETi		147

Open Targets

More...OpenTargetsi		ENSG00000170214

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P35368, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL232

Drug and drug target database

More...DrugBanki		DB01614, Acepromazine
DB00346, Alfuzosin
DB00321, Amitriptyline
DB00543, Amoxapine
DB00182, Amphetamine
DB09229, Aranidipine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB09204, Arotinolol
DB09128, Brexpiprazole
DB01200, Bromocriptine
DB00490, Buspirone
DB00248, Cabergoline
DB01136, Carvedilol
DB00477, Chlorpromazine
DB09202, Cirazoline
DB00575, Clonidine
DB00363, Clozapine
DB00298, Dapiprazole
DB01151, Desipramine
DB01576, Dextroamphetamine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB00320, Dihydroergotamine
DB11278, DL-Methylephedrine
DB00841, Dobutamine
DB09167, Dosulepin
DB00590, Doxazosin
DB01142, Doxepin
DB04855, Dronedarone
DB06262, Droxidopa
DB05492, Epicept NP-1
DB00668, Epinephrine
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB09194, Etoperidone
DB00800, Fenoldopam
DB00458, Imipramine
DB11577, Indigotindisulfonic acid
DB00598, Labetalol
DB09195, Lorpiprazole
DB00408, Loxapine
DB00934, Maprotiline
DB01365, Mephentermine
DB01403, Methotrimeprazine
DB00723, Methoxamine
DB06148, Mianserin
DB00211, Midodrine
DB00370, Mirtazapine
DB00745, Modafinil
DB09205, Moxisylyte
DB01149, Nefazodone
DB00622, Nicardipine
DB00368, Norepinephrine
DB00540, Nortriptyline
DB06229, Ocaperidone
DB00334, Olanzapine
DB00935, Oxymetazoline
DB01267, Paliperidone
DB00715, Paroxetine
DB01186, Pergolide
DB01608, Periciazine
DB08922, Perospirone
DB01579, Phendimetrazine
DB00925, Phenoxybenzamine
DB00692, Phentolamine
DB00388, Phenylephrine
DB09286, Pipamperone
DB06153, Pizotifen
DB00457, Prazosin
DB00433, Prochlorperazine
DB01069, Promethazine
DB01224, Quetiapine
DB00908, Quinidine
DB05469, R450
DB11124, Racepinephrine
DB00243, Ranolazine
DB00734, Risperidone
DB00268, Ropinirole
DB06144, Sertindole
DB06207, Silodosin
DB09203, Synephrine
DB00706, Tamsulosin
DB01162, Terazosin
DB06764, Tetryzoline
DB01622, Thioproperazine
DB00679, Thioridazine
DB13025, Tiapride
DB00697, Tizanidine
DB00726, Trimipramine
DB00661, Verapamil
DB06694, Xylometazoline
DB00246, Ziprasidone

DrugCentral

More...DrugCentrali		P35368

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		23

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADRA1B

Domain mapping of disease mutations (DMDM)

More...DMDMi		116241241

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690691 – 520Alpha-1B adrenergic receptorAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei264PhosphothreonineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi365S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P35368

MaxQB - The MaxQuant DataBase

More...MaxQBi		P35368

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P35368

PeptideAtlas

More...PeptideAtlasi		P35368

PRoteomics IDEntifications database

More...PRIDEi		P35368

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55037

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P35368, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P35368

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P35368

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170214, Expressed in thoracic aorta and 106 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P35368, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P35368, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170214, Tissue enhanced (brain, liver, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes (PubMed:22120526).

Interacts with CAVIN4 (PubMed:24567387).

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106657, 6 interactors

Database of interacting proteins

More...DIPi		DIP-33399N

Protein interaction database and analysis system

More...IntActi		P35368, 9 interactors

Molecular INTeraction database

More...MINTi		P35368

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000306662

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P35368

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P35368, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P35368

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P35368

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni394 – 432DisorderedSequence analysisAdd BLAST39
Regioni479 – 520DisorderedSequence analysisAdd BLAST42

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi368 – 380Nuclear localization signalAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi407 – 425Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3656, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009579_11_6_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P35368

Identification of Orthologs from Complete Genome Data

More...OMAi		STRAKGH

Database of Orthologous Groups

More...OrthoDBi		1095345at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P35368

TreeFam database of animal gene trees

More...TreeFami		TF331895

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002233, ADR_fam
IPR001115, ADRA1B_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...PANTHERi		PTHR24248:SF17, PTHR24248:SF17, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01103, ADRENERGICR
PR00556, ADRENRGCA1BR
PR00237, GPCRRHODOPSN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35368-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL 
        60         70         80         90        100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP 
       110        120        130        140        150
FSAALEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS 
       160        170        180        190        200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE 
       210        220        230        240        250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE 
       260        270        280        290        300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 
       310        320        330        340        350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC 
       360        370        380        390        400
SSKEFKRAFV RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS 
       410        420        430        440        450
QSRKDSLDDS GSCLSGSQRT LPSASPSPGY LGRGAPPPVE LCAFPEWKAP 
       460        470        480        490        500
GALLSLPAPE PPGRRGRHDS GPLFTFKLLT EPESPGTDGG ASNGGCEAAA 
       510        520
DVANGQPGFK SNMPLAPGQF
Length:520
Mass (Da):56,836
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF081A23D2F943F7F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YF88A0A286YF88_HUMAN
Alpha-1B adrenergic receptor
ADRA1B
35Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti371Missing (PubMed:1328250).Curated1
Sequence conflicti371Missing in AAB59485 (PubMed:7815325).Curated1
Sequence conflicti498 – 501AAAD → PRH (PubMed:1328250).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01951051V → G. Corresponds to variant dbSNP:rs8192448Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M99589 Genomic DNA No translation available.
M99590 Genomic DNA No translation available.
U03865 mRNA Translation: AAB60352.1
L31773 mRNA Translation: AAB59485.1
EU332831 Genomic DNA Translation: ABY87520.1
BC136568 mRNA Translation: AAI36569.1
BC136569 mRNA Translation: AAI36570.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4347.1

Protein sequence database of the Protein Information Resource

More...PIRi		A45121

NCBI Reference Sequences

More...RefSeqi		NP_000670.1, NM_000679.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306675.5; ENSP00000306662.3; ENSG00000170214.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		147

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:147

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000306675.5; ENSP00000306662.3; NM_000679.4; NP_000670.1

UCSC genome browser

More...UCSCi		uc003lxt.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99589 Genomic DNA No translation available.
M99590 Genomic DNA No translation available.
U03865 mRNA Translation: AAB60352.1
L31773 mRNA Translation: AAB59485.1
EU332831 Genomic DNA Translation: ABY87520.1
BC136568 mRNA Translation: AAI36569.1
BC136569 mRNA Translation: AAI36570.1
CCDSiCCDS4347.1
PIRiA45121
RefSeqiNP_000670.1, NM_000679.3

3D structure databases

AlphaFoldDBiP35368
SMRiP35368
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi106657, 6 interactors
DIPiDIP-33399N
IntActiP35368, 9 interactors
MINTiP35368
STRINGi9606.ENSP00000306662

Chemistry databases

BindingDBiP35368
ChEMBLiCHEMBL232
DrugBankiDB01614, Acepromazine
DB00346, Alfuzosin
DB00321, Amitriptyline
DB00543, Amoxapine
DB00182, Amphetamine
DB09229, Aranidipine
DB01238, Aripiprazole
DB14185, Aripiprazole lauroxil
DB09204, Arotinolol
DB09128, Brexpiprazole
DB01200, Bromocriptine
DB00490, Buspirone
DB00248, Cabergoline
DB01136, Carvedilol
DB00477, Chlorpromazine
DB09202, Cirazoline
DB00575, Clonidine
DB00363, Clozapine
DB00298, Dapiprazole
DB01151, Desipramine
DB01576, Dextroamphetamine
DB11273, Dihydroergocornine
DB13345, Dihydroergocristine
DB00320, Dihydroergotamine
DB11278, DL-Methylephedrine
DB00841, Dobutamine
DB09167, Dosulepin
DB00590, Doxazosin
DB01142, Doxepin
DB04855, Dronedarone
DB06262, Droxidopa
DB05492, Epicept NP-1
DB00668, Epinephrine
DB01049, Ergoloid mesylate
DB00696, Ergotamine
DB01175, Escitalopram
DB09194, Etoperidone
DB00800, Fenoldopam
DB00458, Imipramine
DB11577, Indigotindisulfonic acid
DB00598, Labetalol
DB09195, Lorpiprazole
DB00408, Loxapine
DB00934, Maprotiline
DB01365, Mephentermine
DB01403, Methotrimeprazine
DB00723, Methoxamine
DB06148, Mianserin
DB00211, Midodrine
DB00370, Mirtazapine
DB00745, Modafinil
DB09205, Moxisylyte
DB01149, Nefazodone
DB00622, Nicardipine
DB00368, Norepinephrine
DB00540, Nortriptyline
DB06229, Ocaperidone
DB00334, Olanzapine
DB00935, Oxymetazoline
DB01267, Paliperidone
DB00715, Paroxetine
DB01186, Pergolide
DB01608, Periciazine
DB08922, Perospirone
DB01579, Phendimetrazine
DB00925, Phenoxybenzamine
DB00692, Phentolamine
DB00388, Phenylephrine
DB09286, Pipamperone
DB06153, Pizotifen
DB00457, Prazosin
DB00433, Prochlorperazine
DB01069, Promethazine
DB01224, Quetiapine
DB00908, Quinidine
DB05469, R450
DB11124, Racepinephrine
DB00243, Ranolazine
DB00734, Risperidone
DB00268, Ropinirole
DB06144, Sertindole
DB06207, Silodosin
DB09203, Synephrine
DB00706, Tamsulosin
DB01162, Terazosin
DB06764, Tetryzoline
DB01622, Thioproperazine
DB00679, Thioridazine
DB13025, Tiapride
DB00697, Tizanidine
DB00726, Trimipramine
DB00661, Verapamil
DB06694, Xylometazoline
DB00246, Ziprasidone
DrugCentraliP35368
GuidetoPHARMACOLOGYi23

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniP35368, 4 sites
iPTMnetiP35368
PhosphoSitePlusiP35368

Genetic variation databases

BioMutaiADRA1B
DMDMi116241241

Proteomic databases

MassIVEiP35368
MaxQBiP35368
PaxDbiP35368
PeptideAtlasiP35368
PRIDEiP35368
ProteomicsDBi55037

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		16635, 507 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		147

Genome annotation databases

EnsembliENST00000306675.5; ENSP00000306662.3; ENSG00000170214.5
GeneIDi147
KEGGihsa:147
MANE-SelectiENST00000306675.5; ENSP00000306662.3; NM_000679.4; NP_000670.1
UCSCiuc003lxt.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		147
DisGeNETi147

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADRA1B
HGNCiHGNC:278, ADRA1B
HPAiENSG00000170214, Tissue enhanced (brain, liver, lymphoid tissue)
MIMi104220, gene
neXtProtiNX_P35368
OpenTargetsiENSG00000170214
PharmGKBiPA33
VEuPathDBiHostDB:ENSG00000170214

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3656, Eukaryota
GeneTreeiENSGT00940000156944
HOGENOMiCLU_009579_11_6_1
InParanoidiP35368
OMAiSTRAKGH
OrthoDBi1095345at2759
PhylomeDBiP35368
TreeFamiTF331895

Enzyme and pathway databases

PathwayCommonsiP35368
ReactomeiR-HSA-390696, Adrenoceptors
R-HSA-416476, G alpha (q) signalling events
R-HSA-416482, G alpha (12/13) signalling events
SignaLinkiP35368
SIGNORiP35368

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		147, 11 hits in 1078 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADRA1B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Alpha-1B_adrenergic_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		147
PharosiP35368, Tclin

Protein Ontology

More...PROi		PR:P35368
RNActiP35368, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170214, Expressed in thoracic aorta and 106 other tissues
ExpressionAtlasiP35368, baseline and differential
GenevisibleiP35368, HS

Family and domain databases

InterProiView protein in InterPro
IPR002233, ADR_fam
IPR001115, ADRA1B_rcpt
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF17, PTHR24248:SF17, 1 hit
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR01103, ADRENERGICR
PR00556, ADRENRGCA1BR
PR00237, GPCRRHODOPSN
SMARTiView protein in SMART
SM01381, 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADA1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35368
Secondary accession number(s): B0LPE1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 17, 2006
Last modified: May 25, 2022
This is version 186 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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