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Protein

Alpha-1B adrenergic receptor

Gene

ADRA1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.2 Publications

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: GO_Central
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390696 Adrenoceptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-416482 G alpha (12/13) signalling events
SignaLinkiP35368
SIGNORiP35368

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1B adrenergic receptor
Alternative name(s):
Alpha-1B adrenoreceptor
Short name:
Alpha-1B adrenoceptor
Gene namesi
Name:ADRA1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170214.3
HGNCiHGNC:278 ADRA1B
MIMi104220 gene
neXtProtiNX_P35368

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularBy similarityAdd BLAST45
Transmembranei46 – 70Helical; Name=1By similarityAdd BLAST25
Topological domaini71 – 83CytoplasmicBy similarityAdd BLAST13
Transmembranei84 – 105Helical; Name=2By similarityAdd BLAST22
Topological domaini106 – 115ExtracellularBy similarity10
Transmembranei116 – 141Helical; Name=3By similarityAdd BLAST26
Topological domaini142 – 161CytoplasmicBy similarityAdd BLAST20
Transmembranei162 – 184Helical; Name=4By similarityAdd BLAST23
Topological domaini185 – 201ExtracellularBy similarityAdd BLAST17
Transmembranei202 – 224Helical; Name=5By similarityAdd BLAST23
Topological domaini225 – 295CytoplasmicBy similarityAdd BLAST71
Transmembranei296 – 319Helical; Name=6By similarityAdd BLAST24
Topological domaini320 – 326ExtracellularBy similarity7
Transmembranei327 – 351Helical; Name=7By similarityAdd BLAST25
Topological domaini352 – 520CytoplasmicBy similarityAdd BLAST169

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi368 – 380RGRGR…RRRRR → AGAGAAAAAAAAA: Abolishes targeting to the nuclear membrane of cardiac myocytes. 1 PublicationAdd BLAST13

Organism-specific databases

DisGeNETi147
OpenTargetsiENSG00000170214
PharmGKBiPA33

Chemistry databases

ChEMBLiCHEMBL232
DrugBankiDB01614 Acepromazine
DB00346 Alfuzosin
DB00321 Amitriptyline
DB00543 Amoxapine
DB00182 Amphetamine
DB01238 Aripiprazole
DB09128 Brexpiprazole
DB01200 Bromocriptine
DB00248 Cabergoline
DB01136 Carvedilol
DB00477 Chlorpromazine
DB09202 Cirazoline
DB00575 Clonidine
DB00363 Clozapine
DB00298 Dapiprazole
DB01151 Desipramine
DB01576 Dextroamphetamine
DB00590 Doxazosin
DB01142 Doxepin
DB04855 Dronedarone
DB06262 Droxidopa
DB05492 Epicept NP-1
DB00668 Epinephrine
DB01049 Ergoloid mesylate
DB00696 Ergotamine
DB00800 Fenoldopam
DB00458 Imipramine
DB00598 Labetalol
DB01255 Lisdexamfetamine
DB00408 Loxapine
DB00934 Maprotiline
DB01365 Mephentermine
DB01403 Methotrimeprazine
DB00723 Methoxamine
DB06148 Mianserin
DB00211 Midodrine
DB00370 Mirtazapine
DB00745 Modafinil
DB01149 Nefazodone
DB00622 Nicardipine
DB00368 Norepinephrine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00935 Oxymetazoline
DB01267 Paliperidone
DB01186 Pergolide
DB01579 Phendimetrazine
DB00925 Phenoxybenzamine
DB00388 Phenylephrine
DB00457 Prazosin
DB00420 Promazine
DB01608 Propericiazine
DB00777 Propiomazine
DB01224 Quetiapine
DB05469 R450
DB00734 Risperidone
DB06144 Sertindole
DB06207 Silodosin
DB00706 Tamsulosin
DB01162 Terazosin
DB01622 Thioproperazine
DB00679 Thioridazine
DB13025 Tiapride
DB00726 Trimipramine
DB06694 Xylometazoline
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi23

Polymorphism and mutation databases

BioMutaiADRA1B
DMDMi116241241

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690691 – 520Alpha-1B adrenergic receptorAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 195PROSITE-ProRule annotation
Modified residuei264PhosphothreonineBy similarity1
Lipidationi365S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP35368
PaxDbiP35368
PeptideAtlasiP35368
PRIDEiP35368
ProteomicsDBi55037

PTM databases

iPTMnetiP35368
PhosphoSitePlusiP35368

Expressioni

Gene expression databases

BgeeiENSG00000170214
CleanExiHS_ADRA1B
GenevisibleiP35368 HS

Organism-specific databases

HPAiHPA074416

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes (PubMed:22120526). Interacts with CAVIN4 (PubMed:24567387).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DRD4P219172EBI-490017,EBI-8592297

GO - Molecular functioni

  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi106657, 5 interactors
DIPiDIP-33399N
IntActiP35368, 5 interactors
MINTiP35368
STRINGi9606.ENSP00000306662

Chemistry databases

BindingDBiP35368

Structurei

3D structure databases

ProteinModelPortaliP35368
SMRiP35368
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi368 – 380Nuclear localization signalAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi370 – 380Poly-ArgAdd BLAST11

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiP35368
KOiK04136
OMAiWVLGRIF
OrthoDBiEOG091G06VI
PhylomeDBiP35368
TreeFamiTF331895

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001115 ADRA1B_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24248:SF17 PTHR24248:SF17, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00556 ADRENRGCA1BR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KNANFTGPNQ TSSNSTLPQL DITRAISVGL
60 70 80 90 100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAMA DLLLSFTVLP
110 120 130 140 150
FSAALEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS
160 170 180 190 200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE
210 220 230 240 250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE
260 270 280 290 300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV
310 320 330 340 350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC
360 370 380 390 400
SSKEFKRAFV RILGCQCRGR GRRRRRRRRR LGGCAYTYRP WTRGGSLERS
410 420 430 440 450
QSRKDSLDDS GSCLSGSQRT LPSASPSPGY LGRGAPPPVE LCAFPEWKAP
460 470 480 490 500
GALLSLPAPE PPGRRGRHDS GPLFTFKLLT EPESPGTDGG ASNGGCEAAA
510 520
DVANGQPGFK SNMPLAPGQF
Length:520
Mass (Da):56,836
Last modified:October 17, 2006 - v3
Checksum:iF081A23D2F943F7F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti371Missing (PubMed:1328250).Curated1
Sequence conflicti371Missing in AAB59485 (PubMed:7815325).Curated1
Sequence conflicti498 – 501AAAD → PRH (PubMed:1328250).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01951051V → G. Corresponds to variant dbSNP:rs8192448Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99589 Genomic DNA No translation available.
M99590 Genomic DNA No translation available.
U03865 mRNA Translation: AAB60352.1
L31773 mRNA Translation: AAB59485.1
EU332831 Genomic DNA Translation: ABY87520.1
BC136568 mRNA Translation: AAI36569.1
BC136569 mRNA Translation: AAI36570.1
CCDSiCCDS4347.1
PIRiA45121
RefSeqiNP_000670.1, NM_000679.3
UniGeneiHs.368632
Hs.670012

Genome annotation databases

EnsembliENST00000306675; ENSP00000306662; ENSG00000170214
GeneIDi147
KEGGihsa:147
UCSCiuc003lxt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADA1B_HUMAN
AccessioniPrimary (citable) accession number: P35368
Secondary accession number(s): B0LPE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: October 17, 2006
Last modified: June 20, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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