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Protein

Histamine H1 receptor

Gene

HRH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390650 Histamine receptors
R-HSA-416476 G alpha (q) signalling events

SIGNOR Signaling Network Open Resource

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SIGNORi
P35367

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histamine H1 receptor
Short name:
H1R
Short name:
HH1R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HRH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000196639.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5182 HRH1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600167 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35367

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 29Extracellular1 PublicationAdd BLAST29
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei30 – 52Helical; Name=1Add BLAST23
Topological domaini53 – 62Cytoplasmic1 Publication10
Transmembranei63 – 83Helical; Name=2Add BLAST21
Topological domaini84 – 101Extracellular1 PublicationAdd BLAST18
Transmembranei102 – 123Helical; Name=3Add BLAST22
Topological domaini124 – 143Cytoplasmic1 PublicationAdd BLAST20
Transmembranei144 – 164Helical; Name=4Add BLAST21
Topological domaini165 – 189Extracellular1 PublicationAdd BLAST25
Transmembranei190 – 210Helical; Name=5Add BLAST21
Topological domaini211 – 416Cytoplasmic1 PublicationAdd BLAST206
Transmembranei417 – 438Helical; Name=6Add BLAST22
Topological domaini439 – 450Extracellular1 PublicationAdd BLAST12
Transmembranei451 – 470Helical; Name=7Add BLAST20
Topological domaini471 – 487Cytoplasmic1 PublicationAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3269

Open Targets

More...
OpenTargetsi
ENSG00000196639

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29456

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL231

Drug and drug target database

More...
DrugBanki
DB01615 Aceprometazine
DB09488 Acrivastine
DB06766 Alcaftadine
DB01246 Alimemazine
DB00321 Amitriptyline
DB00543 Amoxapine
DB08799 Antazoline
DB01238 Aripiprazole
DB06216 Asenapine
DB00637 Astemizole
DB00719 Azatadine
DB00972 Azelastine
DB00245 Benzatropine
DB00767 Benzquinamide
DB04890 Bepotastine
DB06698 Betahistine
DB11591 Bilastine
DB01237 Bromodiphenhydramine
DB00835 Brompheniramine
DB00354 Buclizine
DB09016 Butriptyline
DB00748 Carbinoxamine
DB06016 Cariprazine
DB00341 Cetirizine
DB08936 Chlorcyclizine
DB08800 Chloropyramine
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00215 Citalopram
DB00283 Clemastine
DB04837 Clofedanol
DB00363 Clozapine
DB01176 Cyclizine
DB00434 Cyproheptadine
DB01151 Desipramine
DB00967 Desloratadine
DB00405 Dexbrompheniramine
DB09555 Dexchlorpheniramine maleate
DB00985 Dimenhydrinate
DB08801 Dimetindene
DB01075 Diphenhydramine
DB01146 Diphenylpyraline
DB01142 Doxepin
DB00366 Doxylamine
DB01084 Emedastine
DB05492 Epicept NP-1
DB00751 Epinastine
DB01175 Escitalopram
DB06678 Esmirtazapine
DB00950 Fexofenadine
DB04841 Flunarizine
DB05381 Histamine
DB05079 HY10275
DB00557 Hydroxyzine
DB04946 Iloperidone
DB00458 Imipramine
DB08802 Isothipendyl
DB00920 Ketotifen
DB01106 Levocabastine
DB06282 Levocetirizine
DB00455 Loratadine
DB00408 Loxapine
DB00934 Maprotiline
DB00737 Meclizine
DB06691 Mepyramine
DB01071 Mequitazine
DB00902 Methdilazine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00540 Nortriptyline
DB05080 OBE101
DB00334 Olanzapine
DB00768 Olopatadine
DB01173 Orphenadrine
DB01267 Paliperidone
DB01619 Phenindamine
DB01620 Pheniramine
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB05345 SO-101
DB00342 Terfenadine
DB04905 Tesmilifene
DB13025 Tiapride
DB00797 Tolazoline
DB00656 Trazodone
DB00726 Trimipramine
DB00792 Tripelennamine
DB00427 Triprolidine
DB00246 Ziprasidone
DB01624 Zuclopenthixol

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
262

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HRH1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
547645

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696761 – 487Histamine H1 receptorAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi100 ↔ 180PROSITE-ProRule annotation1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei140Phosphothreonine1 Publication1
Modified residuei142Phosphothreonine1 Publication1
Modified residuei230PhosphoserineCombined sources1
Modified residuei279PhosphothreonineCombined sources1
Modified residuei344PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei396Phosphoserine1 Publication1
Modified residuei398Phosphoserine1 Publication1
Disulfide bondi441 ↔ 444PROSITE-ProRule annotation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P35367

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P35367

MaxQB - The MaxQuant DataBase

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MaxQBi
P35367

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P35367

PeptideAtlas

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PeptideAtlasi
P35367

PRoteomics IDEntifications database

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PRIDEi
P35367

ProteomicsDB human proteome resource

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ProteomicsDBi
55036

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P35367

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35367

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196639 Expressed in 170 organ(s), highest expression level in layer of synovial tissue

CleanEx database of gene expression profiles

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CleanExi
HS_HRH1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P35367 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P35367 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029740

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109505, 1 interactor

Database of interacting proteins

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DIPi
DIP-41996N

Protein interaction database and analysis system

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IntActi
P35367, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000380247

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P35367

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RZEX-ray3.10A20-221[»]
A405-487[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P35367

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P35367

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni107 – 112Important for agonist binding6
Regioni424 – 428Important for agonist binding5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4220 Eukaryota
ENOG410YCQR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000160690

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000273869

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG101103

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P35367

KEGG Orthology (KO)

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KOi
K04149

Identification of Orthologs from Complete Genome Data

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OMAi
HMFTIWL

Database of Orthologous Groups

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OrthoDBi
1245472at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P35367

TreeFam database of animal gene trees

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TreeFami
TF333432

Family and domain databases

Conserved Domains Database

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CDDi
cd15050 7tmA_Histamine_H1R, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000921 Histamine_H1_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00237 GPCRRHODOPSN
PR00530 HISTAMINEH1R

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35367-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY
60 70 80 90 100
AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC
110 120 130 140 150
LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLKYRT KTRASATILG
160 170 180 190 200
AWFLSFLWVI PILGWNHFMQ QTSVRREDKC ETDFYDVTWF KVMTAIINFY
210 220 230 240 250
LPTLLMLWFY AKIYKAVRQH CQHRELINRS LPSFSEIKLR PENPKGDAKK
260 270 280 290 300
PGKESPWEVL KRKPKDAGGG SVLKSPSQTP KEMKSPVVFS QEDDREVDKL
310 320 330 340 350
YCFPLDIVHM QAAAEGSSRD YVAVNRSHGQ LKTDEQGLNT HGASEISEDQ
360 370 380 390 400
MLGDSQSFSR TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ
410 420 430 440 450
YVSGLHMNRE RKAAKQLGFI MAAFILCWIP YFIFFMVIAF CKNCCNEHLH
460 470 480
MFTIWLGYIN STLNPLIYPL CNENFKKTFK RILHIRS
Length:487
Mass (Da):55,784
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5DB418A4C17A985
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J2E6C9J2E6_HUMAN
Histamine H1 receptor
HRH1
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti308V → E in AAH60802 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04941019K → N. Corresponds to variant dbSNP:rs2067466Ensembl.1
Natural variantiVAR_033476270G → E. Corresponds to variant dbSNP:rs7651620Ensembl.1
Natural variantiVAR_035761385D → E in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1370695377Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z34897 mRNA Translation: CAA84380.1
X76786 Genomic DNA Translation: CAA54182.1
D14436 Genomic DNA Translation: BAA03319.1
D28481 mRNA Translation: BAA05840.1
AF026261 mRNA Translation: AAB95156.1
AB041380 Genomic DNA Translation: BAA94465.1
AY136743 mRNA Translation: AAN01269.1
AK289412 mRNA Translation: BAF82101.1
CH471055 Genomic DNA Translation: EAW64092.1
BC060802 mRNA Translation: AAH60802.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2604.1

Protein sequence database of the Protein Information Resource

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PIRi
JC2495

NCBI Reference Sequences

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RefSeqi
NP_000852.1, NM_000861.3
NP_001091681.1, NM_001098211.1
NP_001091682.1, NM_001098212.1
NP_001091683.1, NM_001098213.1
XP_011531954.1, XM_011533652.1
XP_011531955.1, XM_011533653.2
XP_016861772.1, XM_017006283.1
XP_016861773.1, XM_017006284.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.1570

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000397056; ENSP00000380247; ENSG00000196639
ENST00000431010; ENSP00000397028; ENSG00000196639
ENST00000438284; ENSP00000406705; ENSG00000196639

Database of genes from NCBI RefSeq genomes

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GeneIDi
3269

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3269

UCSC genome browser

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UCSCi
uc003bwb.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34897 mRNA Translation: CAA84380.1
X76786 Genomic DNA Translation: CAA54182.1
D14436 Genomic DNA Translation: BAA03319.1
D28481 mRNA Translation: BAA05840.1
AF026261 mRNA Translation: AAB95156.1
AB041380 Genomic DNA Translation: BAA94465.1
AY136743 mRNA Translation: AAN01269.1
AK289412 mRNA Translation: BAF82101.1
CH471055 Genomic DNA Translation: EAW64092.1
BC060802 mRNA Translation: AAH60802.1
CCDSiCCDS2604.1
PIRiJC2495
RefSeqiNP_000852.1, NM_000861.3
NP_001091681.1, NM_001098211.1
NP_001091682.1, NM_001098212.1
NP_001091683.1, NM_001098213.1
XP_011531954.1, XM_011533652.1
XP_011531955.1, XM_011533653.2
XP_016861772.1, XM_017006283.1
XP_016861773.1, XM_017006284.1
UniGeneiHs.1570

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RZEX-ray3.10A20-221[»]
A405-487[»]
ProteinModelPortaliP35367
SMRiP35367
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109505, 1 interactor
DIPiDIP-41996N
IntActiP35367, 4 interactors
STRINGi9606.ENSP00000380247

Chemistry databases

BindingDBiP35367
ChEMBLiCHEMBL231
DrugBankiDB01615 Aceprometazine
DB09488 Acrivastine
DB06766 Alcaftadine
DB01246 Alimemazine
DB00321 Amitriptyline
DB00543 Amoxapine
DB08799 Antazoline
DB01238 Aripiprazole
DB06216 Asenapine
DB00637 Astemizole
DB00719 Azatadine
DB00972 Azelastine
DB00245 Benzatropine
DB00767 Benzquinamide
DB04890 Bepotastine
DB06698 Betahistine
DB11591 Bilastine
DB01237 Bromodiphenhydramine
DB00835 Brompheniramine
DB00354 Buclizine
DB09016 Butriptyline
DB00748 Carbinoxamine
DB06016 Cariprazine
DB00341 Cetirizine
DB08936 Chlorcyclizine
DB08800 Chloropyramine
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00215 Citalopram
DB00283 Clemastine
DB04837 Clofedanol
DB00363 Clozapine
DB01176 Cyclizine
DB00434 Cyproheptadine
DB01151 Desipramine
DB00967 Desloratadine
DB00405 Dexbrompheniramine
DB09555 Dexchlorpheniramine maleate
DB00985 Dimenhydrinate
DB08801 Dimetindene
DB01075 Diphenhydramine
DB01146 Diphenylpyraline
DB01142 Doxepin
DB00366 Doxylamine
DB01084 Emedastine
DB05492 Epicept NP-1
DB00751 Epinastine
DB01175 Escitalopram
DB06678 Esmirtazapine
DB00950 Fexofenadine
DB04841 Flunarizine
DB05381 Histamine
DB05079 HY10275
DB00557 Hydroxyzine
DB04946 Iloperidone
DB00458 Imipramine
DB08802 Isothipendyl
DB00920 Ketotifen
DB01106 Levocabastine
DB06282 Levocetirizine
DB00455 Loratadine
DB00408 Loxapine
DB00934 Maprotiline
DB00737 Meclizine
DB06691 Mepyramine
DB01071 Mequitazine
DB00902 Methdilazine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00540 Nortriptyline
DB05080 OBE101
DB00334 Olanzapine
DB00768 Olopatadine
DB01173 Orphenadrine
DB01267 Paliperidone
DB01619 Phenindamine
DB01620 Pheniramine
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB05345 SO-101
DB00342 Terfenadine
DB04905 Tesmilifene
DB13025 Tiapride
DB00797 Tolazoline
DB00656 Trazodone
DB00726 Trimipramine
DB00792 Tripelennamine
DB00427 Triprolidine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi262

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP35367
PhosphoSitePlusiP35367

Polymorphism and mutation databases

BioMutaiHRH1
DMDMi547645

Proteomic databases

EPDiP35367
jPOSTiP35367
MaxQBiP35367
PaxDbiP35367
PeptideAtlasiP35367
PRIDEiP35367
ProteomicsDBi55036

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3269
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397056; ENSP00000380247; ENSG00000196639
ENST00000431010; ENSP00000397028; ENSG00000196639
ENST00000438284; ENSP00000406705; ENSG00000196639
GeneIDi3269
KEGGihsa:3269
UCSCiuc003bwb.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3269
DisGeNETi3269
EuPathDBiHostDB:ENSG00000196639.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HRH1
HGNCiHGNC:5182 HRH1
HPAiHPA029740
MIMi600167 gene
neXtProtiNX_P35367
OpenTargetsiENSG00000196639
PharmGKBiPA29456

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00940000160690
HOGENOMiHOG000273869
HOVERGENiHBG101103
InParanoidiP35367
KOiK04149
OMAiHMFTIWL
OrthoDBi1245472at2759
PhylomeDBiP35367
TreeFamiTF333432

Enzyme and pathway databases

ReactomeiR-HSA-390650 Histamine receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP35367

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HRH1 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Histamine_H1_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3269

Protein Ontology

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PROi
PR:P35367

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196639 Expressed in 170 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_HRH1
ExpressionAtlasiP35367 baseline and differential
GenevisibleiP35367 HS

Family and domain databases

CDDicd15050 7tmA_Histamine_H1R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000921 Histamine_H1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00530 HISTAMINEH1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHRH1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35367
Secondary accession number(s): A8K047, Q6P9E5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: January 16, 2019
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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