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Protein

Histamine H1 receptor

Gene

HRH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

GO - Molecular functioni

  • G-protein coupled receptor activity Source: ProtInc
  • histamine receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390650 Histamine receptors
R-HSA-416476 G alpha (q) signalling events
SIGNORiP35367

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H1 receptor
Short name:
H1R
Short name:
HH1R
Gene namesi
Name:HRH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196639.6
HGNCiHGNC:5182 HRH1
MIMi600167 gene
neXtProtiNX_P35367

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29Extracellular1 PublicationAdd BLAST29
Transmembranei30 – 52Helical; Name=1Add BLAST23
Topological domaini53 – 62Cytoplasmic1 Publication10
Transmembranei63 – 83Helical; Name=2Add BLAST21
Topological domaini84 – 101Extracellular1 PublicationAdd BLAST18
Transmembranei102 – 123Helical; Name=3Add BLAST22
Topological domaini124 – 143Cytoplasmic1 PublicationAdd BLAST20
Transmembranei144 – 164Helical; Name=4Add BLAST21
Topological domaini165 – 189Extracellular1 PublicationAdd BLAST25
Transmembranei190 – 210Helical; Name=5Add BLAST21
Topological domaini211 – 416Cytoplasmic1 PublicationAdd BLAST206
Transmembranei417 – 438Helical; Name=6Add BLAST22
Topological domaini439 – 450Extracellular1 PublicationAdd BLAST12
Transmembranei451 – 470Helical; Name=7Add BLAST20
Topological domaini471 – 487Cytoplasmic1 PublicationAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3269
OpenTargetsiENSG00000196639
PharmGKBiPA29456

Chemistry databases

ChEMBLiCHEMBL231
DrugBankiDB01615 Aceprometazine
DB09488 Acrivastine
DB06766 Alcaftadine
DB01246 Alimemazine
DB00321 Amitriptyline
DB00543 Amoxapine
DB08799 Antazoline
DB01238 Aripiprazole
DB06216 Asenapine
DB00637 Astemizole
DB00719 Azatadine
DB00972 Azelastine
DB00245 Benzatropine
DB00767 Benzquinamide
DB04890 Bepotastine
DB06698 Betahistine
DB11591 Bilastine
DB01237 Bromodiphenhydramine
DB00835 Brompheniramine
DB00354 Buclizine
DB09016 Butriptyline
DB00748 Carbinoxamine
DB06016 Cariprazine
DB00341 Cetirizine
DB08936 Chlorcyclizine
DB08800 Chloropyramine
DB01114 Chlorphenamine
DB00477 Chlorpromazine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00215 Citalopram
DB00283 Clemastine
DB04837 Clofedanol
DB00363 Clozapine
DB01176 Cyclizine
DB00434 Cyproheptadine
DB01151 Desipramine
DB00967 Desloratadine
DB00405 Dexbrompheniramine
DB09555 Dexchlorpheniramine maleate
DB00985 Dimenhydrinate
DB08801 Dimetindene
DB01075 Diphenhydramine
DB01146 Diphenylpyraline
DB01142 Doxepin
DB00366 Doxylamine
DB01084 Emedastine
DB05492 Epicept NP-1
DB00751 Epinastine
DB01175 Escitalopram
DB06678 Esmirtazapine
DB00950 Fexofenadine
DB04841 Flunarizine
DB05381 Histamine
DB05079 HY10275
DB00557 Hydroxyzine
DB04946 Iloperidone
DB00458 Imipramine
DB08802 Isothipendyl
DB00920 Ketotifen
DB01106 Levocabastine
DB06282 Levocetirizine
DB00455 Loratadine
DB00408 Loxapine
DB00934 Maprotiline
DB00737 Meclizine
DB06691 Mepyramine
DB01071 Mequitazine
DB00902 Methdilazine
DB01403 Methotrimeprazine
DB06148 Mianserin
DB00370 Mirtazapine
DB00540 Nortriptyline
DB05080 OBE101
DB00334 Olanzapine
DB00768 Olopatadine
DB01173 Orphenadrine
DB01267 Paliperidone
DB01619 Phenindamine
DB01620 Pheniramine
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00734 Risperidone
DB05345 SO-101
DB00342 Terfenadine
DB04905 Tesmilifene
DB13025 Tiapride
DB00797 Tolazoline
DB00656 Trazodone
DB00726 Trimipramine
DB00792 Tripelennamine
DB00427 Triprolidine
DB00246 Ziprasidone
DB01624 Zuclopenthixol
GuidetoPHARMACOLOGYi262

Polymorphism and mutation databases

BioMutaiHRH1
DMDMi547645

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696761 – 487Histamine H1 receptorAdd BLAST487

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 180PROSITE-ProRule annotation1 Publication
Modified residuei140Phosphothreonine1 Publication1
Modified residuei142Phosphothreonine1 Publication1
Modified residuei230PhosphoserineCombined sources1
Modified residuei279PhosphothreonineCombined sources1
Modified residuei344PhosphoserineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei396Phosphoserine1 Publication1
Modified residuei398Phosphoserine1 Publication1
Disulfide bondi441 ↔ 444PROSITE-ProRule annotation1 Publication

Post-translational modificationi

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP35367
MaxQBiP35367
PaxDbiP35367
PeptideAtlasiP35367
PRIDEiP35367
ProteomicsDBi55036

PTM databases

iPTMnetiP35367
PhosphoSitePlusiP35367

Expressioni

Gene expression databases

BgeeiENSG00000196639
CleanExiHS_HRH1
ExpressionAtlasiP35367 baseline and differential
GenevisibleiP35367 HS

Organism-specific databases

HPAiHPA029740

Interactioni

Protein-protein interaction databases

BioGridi109505, 1 interactor
DIPiDIP-41996N
IntActiP35367, 4 interactors
STRINGi9606.ENSP00000380247

Chemistry databases

BindingDBiP35367

Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 31Combined sources3
Helixi33 – 54Combined sources22
Helixi61 – 63Combined sources3
Helixi64 – 78Combined sources15
Helixi80 – 89Combined sources10
Beta strandi90 – 92Combined sources3
Helixi96 – 130Combined sources35
Turni135 – 138Combined sources4
Helixi141 – 155Combined sources15
Helixi156 – 158Combined sources3
Helixi159 – 163Combined sources5
Beta strandi177 – 180Combined sources4
Helixi188 – 198Combined sources11
Helixi200 – 216Combined sources17
Helixi408 – 441Combined sources34
Turni447 – 449Combined sources3
Helixi450 – 471Combined sources22
Helixi473 – 483Combined sources11

3D structure databases

ProteinModelPortaliP35367
SMRiP35367
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 112Important for agonist binding6
Regioni424 – 428Important for agonist binding5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000273869
HOVERGENiHBG101103
InParanoidiP35367
KOiK04149
OMAiHMFTIWL
OrthoDBiEOG091G06VI
PhylomeDBiP35367
TreeFamiTF333432

Family and domain databases

CDDicd15050 7tmA_Histamine_H1R, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000921 Histamine_H1_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00530 HISTAMINEH1R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPNSSCLL EDKMCEGNKT TMASPQLMPL VVVLSTICLV TVGLNLLVLY
60 70 80 90 100
AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLLM SKWSLGRPLC
110 120 130 140 150
LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLKYRT KTRASATILG
160 170 180 190 200
AWFLSFLWVI PILGWNHFMQ QTSVRREDKC ETDFYDVTWF KVMTAIINFY
210 220 230 240 250
LPTLLMLWFY AKIYKAVRQH CQHRELINRS LPSFSEIKLR PENPKGDAKK
260 270 280 290 300
PGKESPWEVL KRKPKDAGGG SVLKSPSQTP KEMKSPVVFS QEDDREVDKL
310 320 330 340 350
YCFPLDIVHM QAAAEGSSRD YVAVNRSHGQ LKTDEQGLNT HGASEISEDQ
360 370 380 390 400
MLGDSQSFSR TDSDTTTETA PGKGKLRSGS NTGLDYIKFT WKRLRSHSRQ
410 420 430 440 450
YVSGLHMNRE RKAAKQLGFI MAAFILCWIP YFIFFMVIAF CKNCCNEHLH
460 470 480
MFTIWLGYIN STLNPLIYPL CNENFKKTFK RILHIRS
Length:487
Mass (Da):55,784
Last modified:June 1, 1994 - v1
Checksum:iE5DB418A4C17A985
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308V → E in AAH60802 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04941019K → N. Corresponds to variant dbSNP:rs2067466Ensembl.1
Natural variantiVAR_033476270G → E. Corresponds to variant dbSNP:rs7651620Ensembl.1
Natural variantiVAR_035761385D → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z34897 mRNA Translation: CAA84380.1
X76786 Genomic DNA Translation: CAA54182.1
D14436 Genomic DNA Translation: BAA03319.1
D28481 mRNA Translation: BAA05840.1
AF026261 mRNA Translation: AAB95156.1
AB041380 Genomic DNA Translation: BAA94465.1
AY136743 mRNA Translation: AAN01269.1
AK289412 mRNA Translation: BAF82101.1
CH471055 Genomic DNA Translation: EAW64092.1
BC060802 mRNA Translation: AAH60802.1
CCDSiCCDS2604.1
PIRiJC2495
RefSeqiNP_000852.1, NM_000861.3
NP_001091681.1, NM_001098211.1
NP_001091682.1, NM_001098212.1
NP_001091683.1, NM_001098213.1
XP_011531954.1, XM_011533652.1
XP_011531955.1, XM_011533653.2
XP_016861772.1, XM_017006283.1
XP_016861773.1, XM_017006284.1
UniGeneiHs.1570

Genome annotation databases

EnsembliENST00000397056; ENSP00000380247; ENSG00000196639
ENST00000431010; ENSP00000397028; ENSG00000196639
ENST00000438284; ENSP00000406705; ENSG00000196639
GeneIDi3269
KEGGihsa:3269
UCSCiuc003bwb.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHRH1_HUMAN
AccessioniPrimary (citable) accession number: P35367
Secondary accession number(s): A8K047, Q6P9E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: July 18, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

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