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Protein

5-hydroxytryptamine receptor 5B

Gene

Htr5b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5B
Short name:
5-HT-5B
Short name:
5-HT5B
Alternative name(s):
MR22
Serotonin receptor 5B
Gene namesi
Name:Htr5b
Synonyms:5ht5b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi62388 Htr5b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularBy similarityAdd BLAST52
Transmembranei53 – 75Helical; Name=1By similarityAdd BLAST23
Topological domaini76 – 90CytoplasmicBy similarityAdd BLAST15
Transmembranei91 – 111Helical; Name=2By similarityAdd BLAST21
Topological domaini112 – 128ExtracellularBy similarityAdd BLAST17
Transmembranei129 – 150Helical; Name=3By similarityAdd BLAST22
Topological domaini151 – 171CytoplasmicBy similarityAdd BLAST21
Transmembranei172 – 194Helical; Name=4By similarityAdd BLAST23
Topological domaini195 – 211ExtracellularBy similarityAdd BLAST17
Transmembranei212 – 232Helical; Name=5By similarityAdd BLAST21
Topological domaini233 – 295CytoplasmicBy similarityAdd BLAST63
Transmembranei296 – 316Helical; Name=6By similarityAdd BLAST21
Topological domaini317 – 333ExtracellularBy similarityAdd BLAST17
Transmembranei334 – 354Helical; Name=7By similarityAdd BLAST21
Topological domaini355 – 370CytoplasmicBy similarityAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2619

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689731 – 3705-hydroxytryptamine receptor 5BAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 205PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35365

PTM databases

PhosphoSitePlusiP35365

Expressioni

Tissue specificityi

Brain; in the CA1 region of hippocampus, the medial habenula, and raphe nuclei.

Gene expression databases

BgeeiENSRNOG00000002549 Expressed in 3 organ(s), highest expression level in Ammon's horn
GenevisibleiP35365 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003441

Chemistry databases

BindingDBiP35365

Structurei

3D structure databases

ProteinModelPortaliP35365
SMRiP35365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP35365
KOiK04161
OMAiRCQVSQE
OrthoDBiEOG091G06VI
PhylomeDBiP35365
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR000431 5HT5B_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF14 PTHR24247:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00519 5HT5BRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35365-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVSNLSGAT PGIAFPPGPE SCSDSPSSGR SMGSTPGGLI LSGREPPFSA
60 70 80 90 100
FTVLVVTLLV LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL
110 120 130 140 150
VAALVMPLSL VSELSAGRRW QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL
160 170 180 190 200
DRYWTITRHL QYTLRTRRRA SALMIAITWA LSALIALAPL LFGWGEAYDA
210 220 230 240 250
RLQRCQVSQE PSYAVFSTCG AFYVPLAVVL FVYWKIYKAA KFRFGRRRRA
260 270 280 290 300
VVPLPATTQA KEAPQESETV FTARCRATVA FQTSGDSWRE QKEKRAAMMV
310 320 330 340 350
GILIGVFVLC WIPFFLTELV SPLCACSLPP IWKSIFLWLG YSNSFFNPLI
360 370
YTAFNKNYNN AFKSLFTKQR
Length:370
Mass (Da):41,122
Last modified:June 1, 1994 - v1
Checksum:i8EC5F789BFD647E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10073 mRNA Translation: AAA40616.1
PIRiS38744
RefSeqiNP_077371.1, NM_024395.1
UniGeneiRn.202942

Genome annotation databases

EnsembliENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549
GeneIDi79247
KEGGirno:79247
UCSCiRGD:62388 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10073 mRNA Translation: AAA40616.1
PIRiS38744
RefSeqiNP_077371.1, NM_024395.1
UniGeneiRn.202942

3D structure databases

ProteinModelPortaliP35365
SMRiP35365
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003441

Chemistry databases

BindingDBiP35365
ChEMBLiCHEMBL2619

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP35365

Proteomic databases

PaxDbiP35365

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549
GeneIDi79247
KEGGirno:79247
UCSCiRGD:62388 rat

Organism-specific databases

CTDi15564
RGDi62388 Htr5b

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP35365
KOiK04161
OMAiRCQVSQE
OrthoDBiEOG091G06VI
PhylomeDBiP35365
TreeFamiTF316350

Miscellaneous databases

PROiPR:P35365

Gene expression databases

BgeeiENSRNOG00000002549 Expressed in 3 organ(s), highest expression level in Ammon's horn
GenevisibleiP35365 RN

Family and domain databases

InterProiView protein in InterPro
IPR000431 5HT5B_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF14 PTHR24247:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00519 5HT5BRECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei5HT5B_RAT
AccessioniPrimary (citable) accession number: P35365
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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