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UniProtKB - P35365 (5HT5B_RAT)
Protein
5-hydroxytryptamine receptor 5B
Gene
Htr5b
Organism
Rattus norvegicus (Rat)
Status
Functioni
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins. Probably involved in anxiety and depression.
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
- G protein-coupled serotonin receptor activity Source: GO_Central
- neurotransmitter receptor activity Source: GO_Central
- serotonin binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 5BShort name: 5-HT-5B Short name: 5-HT5B Alternative name(s): MR22 Serotonin receptor 5B |
Gene namesi | Name:Htr5b Synonyms:5ht5b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 62388, Htr5b |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 52 | ExtracellularBy similarityAdd BLAST | 52 | |
Transmembranei | 53 – 75 | Helical; Name=1By similarityAdd BLAST | 23 | |
Topological domaini | 76 – 90 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 91 – 111 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 112 – 128 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 129 – 150 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 151 – 171 | CytoplasmicBy similarityAdd BLAST | 21 | |
Transmembranei | 172 – 194 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 195 – 211 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 212 – 232 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 233 – 295 | CytoplasmicBy similarityAdd BLAST | 63 | |
Transmembranei | 296 – 316 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 317 – 333 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 334 – 354 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 355 – 370 | CytoplasmicBy similarityAdd BLAST | 16 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068973 | 1 – 370 | 5-hydroxytryptamine receptor 5BAdd BLAST | 370 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 127 ↔ 205 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P35365 |
PTM databases
GlyGeni | P35365, 1 site |
PhosphoSitePlusi | P35365 |
Expressioni
Tissue specificityi
Brain; in the CA1 region of hippocampus, the medial habenula, and raphe nuclei.
Gene expression databases
Bgeei | ENSRNOG00000002549, Expressed in brain and 10 other tissues |
Genevisiblei | P35365, RN |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003441 |
Chemistry databases
BindingDBi | P35365 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 35 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234619 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P35365 |
OMAi | RYWTITR |
OrthoDBi | 817833at2759 |
PhylomeDBi | P35365 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR000431, 5HT5B_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00519, 5HT5BRECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P35365-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVSNLSGAT PGIAFPPGPE SCSDSPSSGR SMGSTPGGLI LSGREPPFSA
60 70 80 90 100
FTVLVVTLLV LLIAATFLWN LLVLVTILRV RAFHRVPHNL VASTAVSDVL
110 120 130 140 150
VAALVMPLSL VSELSAGRRW QLGRSLCHVW ISFDVLCCTA SIWNVAAIAL
160 170 180 190 200
DRYWTITRHL QYTLRTRRRA SALMIAITWA LSALIALAPL LFGWGEAYDA
210 220 230 240 250
RLQRCQVSQE PSYAVFSTCG AFYVPLAVVL FVYWKIYKAA KFRFGRRRRA
260 270 280 290 300
VVPLPATTQA KEAPQESETV FTARCRATVA FQTSGDSWRE QKEKRAAMMV
310 320 330 340 350
GILIGVFVLC WIPFFLTELV SPLCACSLPP IWKSIFLWLG YSNSFFNPLI
360 370
YTAFNKNYNN AFKSLFTKQR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10073 mRNA Translation: AAA40616.1 |
PIRi | S38744 |
RefSeqi | NP_077371.1, NM_024395.1 |
Genome annotation databases
Ensembli | ENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549 |
GeneIDi | 79247 |
KEGGi | rno:79247 |
UCSCi | RGD:62388, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L10073 mRNA Translation: AAA40616.1 |
PIRi | S38744 |
RefSeqi | NP_077371.1, NM_024395.1 |
3D structure databases
SMRi | P35365 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003441 |
Chemistry databases
BindingDBi | P35365 |
ChEMBLi | CHEMBL2619 |
DrugCentrali | P35365 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35365, 1 site |
PhosphoSitePlusi | P35365 |
Proteomic databases
PaxDbi | P35365 |
Genome annotation databases
Ensembli | ENSRNOT00000003441; ENSRNOP00000003441; ENSRNOG00000002549 |
GeneIDi | 79247 |
KEGGi | rno:79247 |
UCSCi | RGD:62388, rat |
Organism-specific databases
CTDi | 15564 |
RGDi | 62388, Htr5b |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234619 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P35365 |
OMAi | RYWTITR |
OrthoDBi | 817833at2759 |
PhylomeDBi | P35365 |
TreeFami | TF316350 |
Miscellaneous databases
PROi | PR:P35365 |
Gene expression databases
Bgeei | ENSRNOG00000002549, Expressed in brain and 10 other tissues |
Genevisiblei | P35365, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000431, 5HT5B_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00519, 5HT5BRECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT5B_RAT | |
Accessioni | P35365Primary (citable) accession number: P35365 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families