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Protein

5-hydroxytryptamine receptor 5A

Gene

Htr5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functioni

  • G-protein coupled serotonin receptor activity Source: RGD
  • neurotransmitter receptor activity Source: GO_Central
  • serotonin binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390666 Serotonin receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5A
Short name:
5-HT-5A
Short name:
5-HT5A
Alternative name(s):
REC17
Serotonin receptor 5A
Gene namesi
Name:Htr5a
Synonyms:5ht5a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2851 Htr5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularBy similarityAdd BLAST40
Transmembranei41 – 63Helical; Name=1By similarityAdd BLAST23
Topological domaini64 – 78CytoplasmicBy similarityAdd BLAST15
Transmembranei79 – 99Helical; Name=2By similarityAdd BLAST21
Topological domaini100 – 115ExtracellularBy similarityAdd BLAST16
Transmembranei116 – 137Helical; Name=3By similarityAdd BLAST22
Topological domaini138 – 158CytoplasmicBy similarityAdd BLAST21
Transmembranei159 – 181Helical; Name=4By similarityAdd BLAST23
Topological domaini182 – 198ExtracellularBy similarityAdd BLAST17
Transmembranei199 – 219Helical; Name=5By similarityAdd BLAST21
Topological domaini220 – 282CytoplasmicBy similarityAdd BLAST63
Transmembranei283 – 303Helical; Name=6By similarityAdd BLAST21
Topological domaini304 – 320ExtracellularBy similarityAdd BLAST17
Transmembranei321 – 341Helical; Name=7By similarityAdd BLAST21
Topological domaini342 – 357CytoplasmicBy similarityAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4655
GuidetoPHARMACOLOGYi10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689711 – 3575-hydroxytryptamine receptor 5AAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP35364
PRIDEiP35364

PTM databases

PhosphoSitePlusiP35364

Expressioni

Tissue specificityi

Central nervous system.

Gene expression databases

BgeeiENSRNOG00000007066 Expressed in 2 organ(s), highest expression level in brain
GenevisibleiP35364 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009317

Chemistry databases

BindingDBiP35364

Structurei

3D structure databases

ProteinModelPortaliP35364
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP35364
KOiK04161
OMAiQKAALMV
OrthoDBiEOG091G06VI
PhylomeDBiP35364
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR001397 5HT5A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF108 PTHR24247:SF108, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00518 5HT5ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P35364-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLPINLTSF SLSTPSTLEP NRSLDTEALR TSQSFLSAFR VLVLTLLGFL
60 70 80 90 100
AAATFTWNLL VLATILRVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH
110 120 130 140 150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHLEYT
160 170 180 190 200
LRARKRVSNV MILLTWALSA VISLAPLLFG WGETYSELSE ECQVSREPSY
210 220 230 240 250
TVFSTVGAFY LPLCVVLFVY WKIYKAAKFR MGSRKTNSVS PIPEAVEVKD
260 270 280 290 300
ASQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP
310 320 330 340 350
FFVTELISPL CSWDIPALWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK

VFFSKQQ
Length:357
Mass (Da):40,673
Last modified:June 1, 1994 - v1
Checksum:i8C498A50C88408B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10072 mRNA Translation: AAA40615.1
PIRiB47472
RefSeqiNP_037280.1, NM_013148.1
UniGeneiRn.10569

Genome annotation databases

EnsembliENSRNOT00000009317; ENSRNOP00000009317; ENSRNOG00000007066
GeneIDi25689
KEGGirno:25689

Similar proteinsi

Entry informationi

Entry namei5HT5A_RAT
AccessioniPrimary (citable) accession number: P35364
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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