Htr5a

Functionⁱ

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functionⁱ

G-protein coupled serotonin receptor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 7682702
neurotransmitter receptor activity Source: GO_Central
serotonin binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
brain development
Source: RGD
Inferred from expression patternⁱ
- 15823424
cAMP-mediated signaling Source: Ensembl
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Source: RGD
Inferred from mutant phenotypeⁱ
- 10861802
hippocampus development
Source: RGD
Inferred from expression patternⁱ
- 16572590
response to estradiol
Source: RGD
Inferred from expression patternⁱ
- 17122082

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390666 Serotonin receptors R-RNO-418594 G alpha (i) signalling events

Reactomeⁱ

R-RNO-390666 Serotonin receptors
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 5A Short name: 5-HT-5A Short name: 5-HT5A Alternative name(s): REC17 Serotonin receptor 5A
Gene namesⁱ	Name:Htr5a Synonyms:5ht5a
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 4

Organism-specific databases

Rat genome database More...RGDⁱ	2851 Htr5a

RGDⁱ

2851 Htr5a

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 40	ExtracellularBy similarityAdd BLAST	40
Transmembraneⁱ	41 – 63	Helical; Name=1By similarityAdd BLAST	23
Topological domainⁱ	64 – 78	CytoplasmicBy similarityAdd BLAST	15
Transmembraneⁱ	79 – 99	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	100 – 115	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	116 – 137	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	138 – 158	CytoplasmicBy similarityAdd BLAST	21
Transmembraneⁱ	159 – 181	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	182 – 198	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	199 – 219	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	220 – 282	CytoplasmicBy similarityAdd BLAST	63
Transmembraneⁱ	283 – 303	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	304 – 320	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	321 – 341	Helical; Name=7By similarityAdd BLAST	21
Topological domainⁱ	342 – 357	CytoplasmicBy similarityAdd BLAST	16

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL4655
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	10

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068971	1 – 357	5-hydroxytryptamine receptor 5AAdd BLAST		357

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	120 ↔ 192	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P35364
PRIDEⁱ	P35364

PTM databases

PhosphoSitePlusⁱ	P35364

PhosphoSitePlusⁱ

P35364

Expressionⁱ

Tissue specificityⁱ

Central nervous system.

Gene expression databases

Bgeeⁱ	ENSRNOG00000007066 Expressed in 2 organ(s), highest expression level in brain
Genevisibleⁱ	P35364 RN

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000009317

STRINGⁱ

10116.ENSRNOP00000009317

Chemistry databases

BindingDBⁱ	P35364

BindingDBⁱ

P35364

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35364
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P35364
KEGG Orthology (KO) More...KOⁱ	K04161
OMAⁱ	QKAALMV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P35364
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR001397 5HT5A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF108 PTHR24247:SF108, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00518 5HT5ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P35364-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDLPINLTSF SLSTPSTLEP NRSLDTEALR TSQSFLSAFR VLVLTLLGFL 
        60         70         80         90        100
AAATFTWNLL VLATILRVRT FHRVPHNLVA SMAISDVLVA VLVMPLSLVH 
       110        120        130        140        150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHLEYT 
       160        170        180        190        200
LRARKRVSNV MILLTWALSA VISLAPLLFG WGETYSELSE ECQVSREPSY 
       210        220        230        240        250
TVFSTVGAFY LPLCVVLFVY WKIYKAAKFR MGSRKTNSVS PIPEAVEVKD 
       260        270        280        290        300
ASQHPQMVFT VRHATVTFQT EGDTWREQKE QRAALMVGIL IGVFVLCWFP 
       310        320        330        340        350
FFVTELISPL CSWDIPALWK SIFLWLGYSN SFFNPLIYTA FNRSYSSAFK 

VFFSKQQ

Length:357

Mass (Da):40,673

Last modified:June 1, 1994 - v1

Checksum:ⁱ8C498A50C88408B5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L10072 mRNA Translation: AAA40615.1
PIRⁱ	B47472
NCBI Reference Sequences More...RefSeqⁱ	NP_037280.1, NM_013148.1
UniGeneⁱ	Rn.10569

Genome annotation databases

Ensemblⁱ	ENSRNOT00000009317; ENSRNOP00000009317; ENSRNOG00000007066
GeneIDⁱ	25689
KEGGⁱ	rno:25689

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35364	5-hydroxytryptamine receptor 5A		MOUSE		357	UniRef90_P35364
UPI000A314BC9		MUSCR		357
UPI000A30C4AE		MUSPA		357
Uncharacterized protein (Fragment)		MOUSE		149
UPI0003D6E7F5		MOUSE		380

Protein	Similar proteins		Species	Score	Length	Source
P35364	5-hydroxytryptamine receptor 5A		MOUSE		357	UniRef50_P35364
5-hydroxytryptamine receptor 5A		HUMAN		357
5-hydroxytryptamine receptor 5A		TUPCH		405
5-hydroxytryptamine receptor 5A-like		Asian bonytongue		342
5-hydroxytryptamine receptor 5A		CANLF		360
+118

Entry informationⁱ

Entry nameⁱ	5HT5A_RAT
Accessionⁱ	P35364Primary (citable) accession number: P35364
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	September 12, 2018
	This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P35364 (5HT5A_RAT)

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5-hydroxytryptamine receptor 5A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ