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Protein

Prostaglandin G/H synthase 2

Gene

PTGS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis (PubMed:26859324, PubMed:27226593). Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.3 Publications

Miscellaneous

The conversion of arachidonate to prostaglandin H2 is a 2 step reaction: a cyclooxygenase (COX) reaction which converts arachidonate to prostaglandin G2 (PGG2) and a peroxidase reaction in which PGG2 is reduced to prostaglandin H2 (PGH2). The cyclooxygenase reaction occurs in a hydrophobic channel in the core of the enzyme. The peroxidase reaction occurs at a heme-containing active site located near the protein surface. The nonsteroidal anti-inflammatory drugs (NSAIDs) binding site corresponds to the cyclooxygenase active site.
Conversion of arachidonate to prostaglandin H2 is mediated by 2 different isozymes: the constitutive PTGS1 and the inducible PTGS2. PGHS1 is expressed constitutively and generally produces prostanoids acutely in response to hormonal stimuli to fine-tune physiological processes requiring instantaneous, continuous regulation (e.g. hemostasis). PGHS2 is inducible and typically produces prostanoids that mediate responses to physiological stresses such as infection and inflammation.
PTGS1 and PTGS2 are the targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin and ibuprofen (PubMed:27710942, PubMed:26859324, PubMed:27226593). Aspirin is able to produce an irreversible inactivation of the enzyme through a serine acetylation (PubMed:26859324). Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic events, as well as the development of colon cancer and Alzheimer's disease. PTGS2 is the principal isozyme responsible for production of inflammatory prostaglandins. New generation PTGSs inhibitors strive to be selective for PTGS2, to avoid side effects such as gastrointestinal complications and ulceration.3 Publications

Catalytic activityi

Arachidonate + AH2 + 2 O2 = prostaglandin H2 + A + H2O.3 Publications

Cofactori

heme b3 PublicationsNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.3 Publications

Activity regulationi

Inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, ibuprofen, flurbiprofen and celecoxib (PubMed:26859324). Inhibited by flufenamic acid, mefenamic acid and tolfenamic acid (PubMed:27226593).2 Publications

Kineticsi

  1. KM=16.2 µM for arachidonate (in absence of sodium nitroprusside NO donor)1 Publication
  2. KM=12 µM for arachidonic acid1 Publication
  3. KM=17.0 µM for arachidonate (in presence of sodium nitroprusside NO donor)1 Publication
  1. Vmax=81.3 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor)1 Publication
  2. Vmax=132 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor)1 Publication

Pathwayi: prostaglandin biosynthesis

This protein is involved in the pathway prostaglandin biosynthesis, which is part of Lipid metabolism.2 Publications
View all proteins of this organism that are known to be involved in the pathway prostaglandin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106SubstrateBy similarity1
Active sitei193Proton acceptorPROSITE-ProRule annotation1
Binding sitei341SubstrateBy similarity1
Active sitei371For cyclooxygenase activityBy similarity1
Metal bindingi374Iron (heme axial ligand)PROSITE-ProRule annotation1
Sitei516Aspirin-acetylated serine1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase, Peroxidase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS01115-MONOMER
BRENDAi1.14.99.1 2681
ReactomeiR-HSA-197264 Nicotinamide salvaging
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-9018679 Biosynthesis of EPA-derived SPMs
R-HSA-9025094 Biosynthesis of DPAn-3 SPMs
R-HSA-9027604 Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives
SABIO-RKiP35354
SIGNORiP35354
UniPathwayi
UPA00662

Protein family/group databases

PeroxiBasei3321 HsPGHS02

Chemistry databases

SwissLipidsiSLP:000000830

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin G/H synthase 2 (EC:1.14.99.13 Publications)
Alternative name(s):
Cyclooxygenase-2
Short name:
COX-2
PHS II
Prostaglandin H2 synthase 2
Short name:
PGH synthase 2
Short name:
PGHS-2
Prostaglandin-endoperoxide synthase 2
Gene namesi
Name:PTGS2
Synonyms:COX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000073756.11
HGNCiHGNC:9605 PTGS2
MIMi600262 gene
neXtProtiNX_P35354

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi371Y → A: Decreased protein stability. Increased decrease of protein stability; when associated with A-516. 1 Publication1
Mutagenesisi516S → A: No effect on protein stability. Increased decrease of protein stability; when associated with A-371. 1 Publication1
Mutagenesisi516S → T: Decreased enzyme activity with arachidonic acid. Loss of cyclooxygenase activity; when associated with V-519. 1 Publication1
Mutagenesisi519G → V: Loss of cyclooxygenase activity. Loss of cyclooxygenase activity; when associated with T-516. 1 Publication1
Mutagenesisi526C → S: Prevents activation by nitric oxid (NO). 1 Publication1
Mutagenesisi555C → S: Abolishes enzyme activity. 1 Publication1
Mutagenesisi561C → S: Does not affect activation by nitric oxid (NO). 1 Publication1

Organism-specific databases

DisGeNETi5743
OpenTargetsiENSG00000073756
PharmGKBiPA293

Chemistry databases

ChEMBLiCHEMBL230
DrugBankiDB03477 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
DB00316 Acetaminophen
DB00945 Acetylsalicylic acid
DB00041 Aldesleukin
DB00233 Aminosalicylic Acid
DB01435 Antipyrine
DB01419 Antrafenine
DB01014 Balsalazide
DB00963 Bromfenac
DB00887 Bumetanide
DB06774 Capsaicin
DB00821 Carprofen
DB00482 Celecoxib
DB00856 Chlorphenesin
DB05095 Cimicoxib
DB00515 Cisplatin
DB00720 Clodronate
DB00250 Dapsone
DB05804 dehydroepiandrosterone sulfate
DB00035 Desmopressin
DB00586 Diclofenac
DB00861 Diflunisal
DB00154 Dihomo-gamma-linolenic acid
DB01395 Drospirenone
DB00005 Etanercept
DB00749 Etodolac
DB00773 Etoposide
DB01628 Etoricoxib
DB00573 Fenoprofen
DB09217 Firocoxib
DB02266 Flufenamic Acid
DB00712 Flurbiprofen
DB01404 Ginseng
DB01050 Ibuprofen
DB00159 Icosapent
DB00328 Indomethacin
DB01009 Ketoprofen
DB00465 Ketorolac
DB00480 Lenalidomide
DB04725 Licofelone
DB06725 Lornoxicam
DB01283 Lumiracoxib
DB01397 Magnesium salicylate
DB00939 Meclofenamic acid
DB00784 Mefenamic acid
DB00814 Meloxicam
DB00244 Mesalazine
DB00461 Nabumetone
DB00788 Naproxen
DB06802 Nepafenac
DB04552 Niflumic Acid
DB04743 Nimesulide
DB06804 Nonoxynol-9
DB00991 Oxaprozin
DB08439 Parecoxib
DB00812 Phenylbutazone
DB00554 Piroxicam
DB08910 Pomalidomide
DB03866 Prostaglandin G2
DB02709 Resveratrol
DB00884 Risedronate
DB00533 Rofecoxib
DB00936 Salicylic acid
DB01399 Salsalate
DB00360 Sapropterin
DB05875 substance P
DB00795 Sulfasalazine
DB00605 Sulindac
DB00870 Suprofen
DB08819 Tafluprost
DB00469 Tenoxicam
DB01041 Thalidomide
DB01600 Tiaprofenic acid
DB00500 Tolmetin
DB00620 Triamcinolone
DB01401 Trisalicylate-choline
DB00580 Valdecoxib
GuidetoPHARMACOLOGYi1376

Polymorphism and mutation databases

BioMutaiPTGS2
DMDMi3915797

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002387518 – 604Prostaglandin G/H synthase 2Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi21 ↔ 32Combined sources3 Publications
Disulfide bondi22 ↔ 145Combined sources3 Publications
Disulfide bondi26 ↔ 42Combined sources3 Publications
Disulfide bondi44 ↔ 54Combined sources3 Publications
Glycosylationi53N-linked (GlcNAc...) asparagineCombined sources2 Publications1
Glycosylationi130N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Glycosylationi396N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Modified residuei526S-nitrosocysteine1 Publication1
Disulfide bondi555 ↔ 561Combined sources3 Publications
Glycosylationi580N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

S-nitrosylation by NOS2 (iNOS) activates enzyme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-526.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, S-nitrosylation

Proteomic databases

EPDiP35354
MaxQBiP35354
PaxDbiP35354
PeptideAtlasiP35354
PRIDEiP35354
ProteomicsDBi55035

PTM databases

GlyConnecti1649
iPTMnetiP35354
PhosphoSitePlusiP35354

Expressioni

Inductioni

By cytokines and mitogens.

Gene expression databases

BgeeiENSG00000073756 Expressed in 186 organ(s), highest expression level in seminal vesicle
CleanExiHS_PTGS2
ExpressionAtlasiP35354 baseline and differential
GenevisibleiP35354 HS

Organism-specific databases

HPAiCAB000113
HPA001335

Interactioni

Subunit structurei

Homodimer.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111715, 36 interactors
CORUMiP35354
DIPiDIP-28131N
IntActiP35354, 2 interactors
STRINGi9606.ENSP00000356438

Chemistry databases

BindingDBiP35354

Structurei

Secondary structure

1604
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP35354
SMRiP35354
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 55EGF-likePROSITE-ProRule annotationAdd BLAST38

Sequence similaritiesi

Belongs to the prostaglandin G/H synthase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00390000010743
HOGENOMiHOG000013149
HOVERGENiHBG000366
InParanoidiP35354
KOiK11987
OMAiKGCPFTA
OrthoDBiEOG091G03CD
PhylomeDBiP35354
TreeFamiTF329675

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR029576 COX-2
IPR000742 EGF-like_dom
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
PANTHERiPTHR11903:SF8 PTHR11903:SF8, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00008 EGF, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 1 hit
PS50292 PEROXIDASE_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P35354-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARALLLCA VLALSHTANP CCSHPCQNRG VCMSVGFDQY KCDCTRTGFY
60 70 80 90 100
GENCSTPEFL TRIKLFLKPT PNTVHYILTH FKGFWNVVNN IPFLRNAIMS
110 120 130 140 150
YVLTSRSHLI DSPPTYNADY GYKSWEAFSN LSYYTRALPP VPDDCPTPLG
160 170 180 190 200
VKGKKQLPDS NEIVEKLLLR RKFIPDPQGS NMMFAFFAQH FTHQFFKTDH
210 220 230 240 250
KRGPAFTNGL GHGVDLNHIY GETLARQRKL RLFKDGKMKY QIIDGEMYPP
260 270 280 290 300
TVKDTQAEMI YPPQVPEHLR FAVGQEVFGL VPGLMMYATI WLREHNRVCD
310 320 330 340 350
VLKQEHPEWG DEQLFQTSRL ILIGETIKIV IEDYVQHLSG YHFKLKFDPE
360 370 380 390 400
LLFNKQFQYQ NRIAAEFNTL YHWHPLLPDT FQIHDQKYNY QQFIYNNSIL
410 420 430 440 450
LEHGITQFVE SFTRQIAGRV AGGRNVPPAV QKVSQASIDQ SRQMKYQSFN
460 470 480 490 500
EYRKRFMLKP YESFEELTGE KEMSAELEAL YGDIDAVELY PALLVEKPRP
510 520 530 540 550
DAIFGETMVE VGAPFSLKGL MGNVICSPAY WKPSTFGGEV GFQIINTASI
560 570 580 590 600
QSLICNNVKG CPFTSFSVPD PELIKTVTIN ASSSRSGLDD INPTVLLKER

STEL
Length:604
Mass (Da):68,996
Last modified:December 15, 1998 - v2
Checksum:i72FBD699F6128519
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZYK7Q6ZYK7_HUMAN
Prostaglandin G/H synthase 2
PTGS2 COX-2
163Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165E → G in AAA58433 (PubMed:1380156).Curated1
Sequence conflicti438I → T in AAA35803 (PubMed:8473346).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016262228R → H1 PublicationCorresponds to variant dbSNP:rs3218622Ensembl.1
Natural variantiVAR_016263428P → A1 PublicationCorresponds to variant dbSNP:rs4648279Ensembl.1
Natural variantiVAR_011980488E → G. Corresponds to variant dbSNP:rs5272Ensembl.1
Natural variantiVAR_011981511V → A2 PublicationsCorresponds to variant dbSNP:rs5273Ensembl.1
Natural variantiVAR_016264587G → R1 PublicationCorresponds to variant dbSNP:rs3218625Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15326 mRNA Translation: AAA35803.1
M90100 mRNA Translation: AAA58433.1
D28235 Genomic DNA Translation: BAA05698.1
U04636 Genomic DNA Translation: AAA57317.1
AY462100 mRNA Translation: AAR23927.1
AY229989 Genomic DNA Translation: AAO38056.1
AY382629 Genomic DNA Translation: AAQ75702.1
AK292167 mRNA Translation: BAF84856.1
AL033533 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91216.1
BC013734 mRNA Translation: AAH13734.1
CCDSiCCDS1371.1
PIRiA46150
RefSeqiNP_000954.1, NM_000963.3
UniGeneiHs.196384

Genome annotation databases

EnsembliENST00000367468; ENSP00000356438; ENSG00000073756
GeneIDi5743
KEGGihsa:5743
UCSCiuc001gsb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15326 mRNA Translation: AAA35803.1
M90100 mRNA Translation: AAA58433.1
D28235 Genomic DNA Translation: BAA05698.1
U04636 Genomic DNA Translation: AAA57317.1
AY462100 mRNA Translation: AAR23927.1
AY229989 Genomic DNA Translation: AAO38056.1
AY382629 Genomic DNA Translation: AAQ75702.1
AK292167 mRNA Translation: BAF84856.1
AL033533 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91216.1
BC013734 mRNA Translation: AAH13734.1
CCDSiCCDS1371.1
PIRiA46150
RefSeqiNP_000954.1, NM_000963.3
UniGeneiHs.196384

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V0Xmodel-A1-604[»]
5F19X-ray2.04A/B19-569[»]
5F1AX-ray2.38A/B19-570[»]
5IKQX-ray2.41A/B19-569[»]
5IKRX-ray2.34A/B19-569[»]
5IKTX-ray2.45A/B19-569[»]
5IKVX-ray2.51A/B19-569[»]
5KIRX-ray2.70A/B19-569[»]
ProteinModelPortaliP35354
SMRiP35354
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111715, 36 interactors
CORUMiP35354
DIPiDIP-28131N
IntActiP35354, 2 interactors
STRINGi9606.ENSP00000356438

Chemistry databases

BindingDBiP35354
ChEMBLiCHEMBL230
DrugBankiDB03477 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole
DB00316 Acetaminophen
DB00945 Acetylsalicylic acid
DB00041 Aldesleukin
DB00233 Aminosalicylic Acid
DB01435 Antipyrine
DB01419 Antrafenine
DB01014 Balsalazide
DB00963 Bromfenac
DB00887 Bumetanide
DB06774 Capsaicin
DB00821 Carprofen
DB00482 Celecoxib
DB00856 Chlorphenesin
DB05095 Cimicoxib
DB00515 Cisplatin
DB00720 Clodronate
DB00250 Dapsone
DB05804 dehydroepiandrosterone sulfate
DB00035 Desmopressin
DB00586 Diclofenac
DB00861 Diflunisal
DB00154 Dihomo-gamma-linolenic acid
DB01395 Drospirenone
DB00005 Etanercept
DB00749 Etodolac
DB00773 Etoposide
DB01628 Etoricoxib
DB00573 Fenoprofen
DB09217 Firocoxib
DB02266 Flufenamic Acid
DB00712 Flurbiprofen
DB01404 Ginseng
DB01050 Ibuprofen
DB00159 Icosapent
DB00328 Indomethacin
DB01009 Ketoprofen
DB00465 Ketorolac
DB00480 Lenalidomide
DB04725 Licofelone
DB06725 Lornoxicam
DB01283 Lumiracoxib
DB01397 Magnesium salicylate
DB00939 Meclofenamic acid
DB00784 Mefenamic acid
DB00814 Meloxicam
DB00244 Mesalazine
DB00461 Nabumetone
DB00788 Naproxen
DB06802 Nepafenac
DB04552 Niflumic Acid
DB04743 Nimesulide
DB06804 Nonoxynol-9
DB00991 Oxaprozin
DB08439 Parecoxib
DB00812 Phenylbutazone
DB00554 Piroxicam
DB08910 Pomalidomide
DB03866 Prostaglandin G2
DB02709 Resveratrol
DB00884 Risedronate
DB00533 Rofecoxib
DB00936 Salicylic acid
DB01399 Salsalate
DB00360 Sapropterin
DB05875 substance P
DB00795 Sulfasalazine
DB00605 Sulindac
DB00870 Suprofen
DB08819 Tafluprost
DB00469 Tenoxicam
DB01041 Thalidomide
DB01600 Tiaprofenic acid
DB00500 Tolmetin
DB00620 Triamcinolone
DB01401 Trisalicylate-choline
DB00580 Valdecoxib
GuidetoPHARMACOLOGYi1376
SwissLipidsiSLP:000000830

Protein family/group databases

PeroxiBasei3321 HsPGHS02

PTM databases

GlyConnecti1649
iPTMnetiP35354
PhosphoSitePlusiP35354

Polymorphism and mutation databases

BioMutaiPTGS2
DMDMi3915797

Proteomic databases

EPDiP35354
MaxQBiP35354
PaxDbiP35354
PeptideAtlasiP35354
PRIDEiP35354
ProteomicsDBi55035

Protocols and materials databases

DNASUi5743
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367468; ENSP00000356438; ENSG00000073756
GeneIDi5743
KEGGihsa:5743
UCSCiuc001gsb.4 human

Organism-specific databases

CTDi5743
DisGeNETi5743
EuPathDBiHostDB:ENSG00000073756.11
GeneCardsiPTGS2
HGNCiHGNC:9605 PTGS2
HPAiCAB000113
HPA001335
MIMi600262 gene
neXtProtiNX_P35354
OpenTargetsiENSG00000073756
PharmGKBiPA293
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00390000010743
HOGENOMiHOG000013149
HOVERGENiHBG000366
InParanoidiP35354
KOiK11987
OMAiKGCPFTA
OrthoDBiEOG091G03CD
PhylomeDBiP35354
TreeFamiTF329675

Enzyme and pathway databases

UniPathwayi
UPA00662

BioCyciMetaCyc:HS01115-MONOMER
BRENDAi1.14.99.1 2681
ReactomeiR-HSA-197264 Nicotinamide salvaging
R-HSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9018677 Biosynthesis of DHA-derived SPMs
R-HSA-9018679 Biosynthesis of EPA-derived SPMs
R-HSA-9025094 Biosynthesis of DPAn-3 SPMs
R-HSA-9027604 Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives
SABIO-RKiP35354
SIGNORiP35354

Miscellaneous databases

GeneWikiiProstaglandin-endoperoxide_synthase_2
PTGS2
GenomeRNAii5743
PROiPR:P35354
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000073756 Expressed in 186 organ(s), highest expression level in seminal vesicle
CleanExiHS_PTGS2
ExpressionAtlasiP35354 baseline and differential
GenevisibleiP35354 HS

Family and domain databases

Gene3Di1.10.640.10, 1 hit
InterProiView protein in InterPro
IPR029576 COX-2
IPR000742 EGF-like_dom
IPR010255 Haem_peroxidase
IPR019791 Haem_peroxidase_animal
IPR037120 Haem_peroxidase_sf
PANTHERiPTHR11903:SF8 PTHR11903:SF8, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF00008 EGF, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS50026 EGF_3, 1 hit
PS50292 PEROXIDASE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGH2_HUMAN
AccessioniPrimary (citable) accession number: P35354
Secondary accession number(s): A8K802, Q16876
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 199 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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