UniProtKB - P35351 (AGTR2_RAT)
Protein
Type-2 angiotensin II receptor
Gene
Agtr2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation (By similarity).By similarity
GO - Molecular functioni
- angiotensin type II receptor activity Source: RGD
- G-protein alpha-subunit binding Source: RGD
- G protein-coupled receptor activity Source: GO_Central
- transcription factor binding Source: RGD
GO - Biological processi
- aldosterone secretion Source: RGD
- angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: RGD
- brain renin-angiotensin system Source: RGD
- cell growth involved in cardiac muscle cell development Source: RGD
- cell surface receptor signaling pathway Source: RGD
- cellular response to dexamethasone stimulus Source: UniProtKB
- cellular sodium ion homeostasis Source: RGD
- cerebellar cortex development Source: RGD
- dopamine biosynthetic process Source: RGD
- exploration behavior Source: RGD
- G protein-coupled receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RGD
- inflammatory response Source: RGD
- intracellular signal transduction Source: RGD
- kidney development Source: RGD
- kidney morphogenesis Source: RGD
- negative regulation of fibroblast proliferation Source: RGD
- negative regulation of heart rate Source: RGD
- negative regulation of icosanoid secretion Source: RGD
- negative regulation of neurotrophin TRK receptor signaling pathway Source: RGD
- negative regulation of norepinephrine secretion Source: RGD
- neuron differentiation Source: RGD
- positive regulation of blood vessel diameter Source: RGD
- positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
- positive regulation of cell population proliferation Source: RGD
- positive regulation of extrinsic apoptotic signaling pathway Source: RGD
- positive regulation of metanephric glomerulus development Source: RGD
- positive regulation of nitric-oxide synthase activity Source: RGD
- positive regulation of phosphoprotein phosphatase activity Source: RGD
- positive regulation of renal sodium excretion Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- regulation of metanephros size Source: RGD
- regulation of protein import into nucleus Source: RGD
- regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: RGD
- renin-angiotensin regulation of aldosterone production Source: RGD
- response to organonitrogen compound Source: RGD
- vasodilation Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-418594, G alpha (i) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Type-2 angiotensin II receptorAlternative name(s): Angiotensin II type-2 receptor Short name: AT2 |
Gene namesi | Name:Agtr2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2072, Agtr2 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 45 | ExtracellularSequence analysisAdd BLAST | 45 | |
Transmembranei | 46 – 71 | Helical; Name=1Sequence analysisAdd BLAST | 26 | |
Topological domaini | 72 – 80 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 81 – 102 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 103 – 119 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 120 – 140 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 141 – 160 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 161 – 179 | Helical; Name=4Sequence analysisAdd BLAST | 19 | |
Topological domaini | 180 – 208 | ExtracellularSequence analysisAdd BLAST | 29 | |
Transmembranei | 209 – 234 | Helical; Name=5Sequence analysisAdd BLAST | 26 | |
Topological domaini | 235 – 256 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 257 – 278 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 279 – 297 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 298 – 318 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 319 – 363 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069170 | 1 – 363 | Type-2 angiotensin II receptorAdd BLAST | 363 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 24 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 35 ↔ 290 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 117 ↔ 195 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 354 | Phosphoserine; by PKCSequence analysis | 1 |
Post-translational modificationi
C-terminal Ser or Thr residues may be phosphorylated.
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P35351 |
PTM databases
GlyGeni | P35351, 5 sites |
iPTMneti | P35351 |
PhosphoSitePlusi | P35351 |
Expressioni
Tissue specificityi
Abundant expression in fetal tissues, immature brain, skin wound and atretic ovarian follicles.
Developmental stagei
Abundant in whole fetus but decreases rapidly after birth. In adults is highly expressed in the adrenal, present in the brain and uterus but undetectable in the heart.
Gene expression databases
Bgeei | ENSRNOG00000050006, Expressed in esophagus and 12 other tissues |
ExpressionAtlasi | P35351, baseline and differential |
Genevisiblei | P35351, RN |
Interactioni
Subunit structurei
Interacts with MTUS1.
By similarityGO - Molecular functioni
- G-protein alpha-subunit binding Source: RGD
- transcription factor binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 246372, 1 interactor |
STRINGi | 10116.ENSRNOP00000064709 |
Chemistry databases
BindingDBi | P35351 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222500 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P35351 |
OMAi | LYCFIGN |
OrthoDBi | 685818at2759 |
PhylomeDBi | P35351 |
Family and domain databases
InterProi | View protein in InterPro IPR000147, ATII_AT2_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00636, ANGIOTENSN2R PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P35351-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL
60 70 80 90 100
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW
110 120 130 140 150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF
160 170 180 190 200
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP
210 220 230 240 250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT
260 270 280 290 300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL
310 320 330 340 350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR
360
KSSSLREMDT FVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16840 mRNA Translation: BAA04116.1 U01908 Genomic DNA Translation: AAC52126.1 U22663 Genomic DNA Translation: AAA86509.1 D43778 Genomic DNA Translation: BAA07833.1 |
PIRi | A49092 |
RefSeqi | NP_036626.1, NM_012494.3 XP_006257494.1, XM_006257432.3 |
Genome annotation databases
Ensembli | ENSRNOT00000074269; ENSRNOP00000064709; ENSRNOG00000050006 |
GeneIDi | 24182 |
KEGGi | rno:24182 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D16840 mRNA Translation: BAA04116.1 U01908 Genomic DNA Translation: AAC52126.1 U22663 Genomic DNA Translation: AAA86509.1 D43778 Genomic DNA Translation: BAA07833.1 |
PIRi | A49092 |
RefSeqi | NP_036626.1, NM_012494.3 XP_006257494.1, XM_006257432.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2G2A | model | - | A | 1-363 | [»] | |
SMRi | P35351 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 246372, 1 interactor |
STRINGi | 10116.ENSRNOP00000064709 |
Chemistry databases
BindingDBi | P35351 |
ChEMBLi | CHEMBL257 |
DrugCentrali | P35351 |
GuidetoPHARMACOLOGYi | 35 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35351, 5 sites |
iPTMneti | P35351 |
PhosphoSitePlusi | P35351 |
Proteomic databases
PaxDbi | P35351 |
Genome annotation databases
Ensembli | ENSRNOT00000074269; ENSRNOP00000064709; ENSRNOG00000050006 |
GeneIDi | 24182 |
KEGGi | rno:24182 |
Organism-specific databases
CTDi | 186 |
RGDi | 2072, Agtr2 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222500 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P35351 |
OMAi | LYCFIGN |
OrthoDBi | 685818at2759 |
PhylomeDBi | P35351 |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-418594, G alpha (i) signalling events |
Miscellaneous databases
PROi | PR:P35351 |
Gene expression databases
Bgeei | ENSRNOG00000050006, Expressed in esophagus and 12 other tissues |
ExpressionAtlasi | P35351, baseline and differential |
Genevisiblei | P35351, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000147, ATII_AT2_rcpt IPR000248, ATII_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00241, ANGIOTENSINR PR00636, ANGIOTENSN2R PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGTR2_RAT | |
Accessioni | P35351Primary (citable) accession number: P35351 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families