Type-2 angiotensin II receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• angiotensin type II receptor activity Source: RGD
• G-protein alpha-subunit binding Source: RGD <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy."
    Senbonmatsu T., Saito T., Landon E.J., Watanabe O., Price E. Jr., Roberts R.L., Imboden H., Fitzgerald T.G., Gaffney F.A., Inagami T.
    EMBO J 22:6471-6482(2003) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy."
    Senbonmatsu T., Saito T., Landon E.J., Watanabe O., Price E. Jr., Roberts R.L., Imboden H., Fitzgerald T.G., Gaffney F.A., Inagami T.
    EMBO J 22:6471-6482(2003) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• aldosterone secretion Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Overview of in vivo xenotransplantation studies: prospects for the future."
    Najarian J.S.
    Transplant Proc 24:733-738(1992) [PubMed] [Europe PMC] [Abstract]
• angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure Source: RGD
• brain renin-angiotensin system Source: RGD
• cell growth involved in cardiac muscle cell development Source: RGDInferred from mutant phenotypeⁱ
  • "Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor."
    Flores-Munoz M., Smith N.J., Haggerty C., Milligan G., Nicklin S.A.
    J Physiol 589:939-951(2011) [PubMed] [Europe PMC] [Abstract]
• cell surface receptor signaling pathway Source: RGD
• cellular response to dexamethasone stimulus Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies."
    Singh R.R., Moritz K.M., Bertram J.F., Cullen-McEwen L.A.
    Am J Physiol Renal Physiol 293:F548-54(2007) [PubMed] [Europe PMC] [Abstract]
• cellular sodium ion homeostasis Source: RGDInferred from mutant phenotypeⁱ
  • "Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat."
    Padia S.H., Howell N.L., Siragy H.M., Carey R.M.
    Hypertension 47:537-544(2006) [PubMed] [Europe PMC] [Abstract]
• cerebellar cortex development Source: RGDInferred from mutant phenotypeⁱ
  • "Prenatal blockade of Ang II receptors affects neonatal rat hindbrain structure and receptor localization."
    Sanchez S.I., Arce M.E., Fuentes L.B., Ciuffo G.M.
    Exp Neurol 220:246-254(2009) [PubMed] [Europe PMC] [Abstract]
• dopamine biosynthetic process Source: RGDInferred from mutant phenotypeⁱ
  • "Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum."
    Mertens B., Vanderheyden P., Michotte Y., Sarre S.
    Neuropharmacology 58:1038-1044(2010) [PubMed] [Europe PMC] [Abstract]
• exploration behavior Source: RGD
• G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger Source: RGD
• inflammatory response Source: RGDInferred from direct assayⁱ
  • "Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats."
    Sabuhi R., Ali Q., Asghar M., Al-Zamily N.R., Hussain T.
    Am J Physiol Renal Physiol 300:F700-6(2011) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: RGD
• kidney development Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Expression and role of angiotensin II type 2 receptor in the kidney and mesangial cells of spontaneously hypertensive rats."
    Goto M., Mukoyama M., Sugawara A., Suganami T., Kasahara M., Yahata K., Makino H., Suga S., Tanaka I., Nakao K.
    Hypertens Res 25:125-133(2002) [PubMed] [Europe PMC] [Abstract]
• kidney morphogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "Inhibition of Angiotensin II receptors during pregnancy induces malformations in developing rat kidney."
    Sanchez S.I., Seltzer A.M., Fuentes L.B., Forneris M.L., Ciuffo G.M.
    Eur J Pharmacol 588:114-123(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of fibroblast proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor."
    Flores-Munoz M., Work L.M., Douglas K., Denby L., Dominiczak A.F., Graham D., Nicklin S.A.
    Hypertension 59:300-307(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of heart rate Source: RGD
• negative regulation of icosanoid secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1 and AT2 receptors."
    Abdel-Rahman E.M., Abadir P.M., Siragy H.M.
    Am J Physiol Regul Integr Comp Physiol 295:R1473-8(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of neurotrophin TRK receptor signaling pathway Source: RGD
• negative regulation of norepinephrine secretion Source: RGDInferred from direct assayⁱ
  • "Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts."
    Sasaoka T., Egi Y., Tawa M., Yamamoto A., Ohkita M., Takaoka M., Maruyama T., Akira T., Matsumura Y.
    J Cardiovasc Pharmacol 52:176-183(2008) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: RGDTraceable author statementⁱ
  • "The angiotensin type 2 receptor of angiotensin II and neuronal differentiation: from observations to mechanisms."
    Gendron L., Payet M.D., Gallo-Payet N.
    J Mol Endocrinol 31:359-372(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of blood vessel diameter Source: RGDInferred from mutant phenotypeⁱ
  • "Upregulation of AT2 receptor and iNOS impairs angiotensin II-induced contraction without endothelium influence in young normotensive diabetic rats."
    Lee J.H., Xia S., Ragolia L.
    Am J Physiol Regul Integr Comp Physiol 295:R144-54(2008) [PubMed] [Europe PMC] [Abstract]
  • "Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts."
    Souza A.P., Sobrinho D.B., Almeida J.F., Alves G.M., Macedo L.M., Porto J.E., Vencio E.F., Colugnati D.B., Santos R.A., Ferreira A.J., Mendes E.P., Castro C.H.
    Clin Sci (Lond) 125:449-459(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Effects of dexamethasone exposure on rat metanephric development: in vitro and in vivo studies."
    Singh R.R., Moritz K.M., Bertram J.F., Cullen-McEwen L.A.
    Am J Physiol Renal Physiol 293:F548-54(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "The involvement of angiotensin type 1 and type 2 receptors in estrogen-induced cell proliferation and vascular endothelial growth factor expression in the rat anterior pituitary."
    Lawnicka H., Ptasinska-Wnuk D., Mucha S., Kunert-Radek J., Pawlikowski M., Stepien H.
    ScientificWorldJournal 2012:358102-358102(2012) [PubMed] [Europe PMC] [Abstract]
• positive regulation of extrinsic apoptotic signaling pathway Source: RGD
• positive regulation of metanephric glomerulus development Source: RGD
• positive regulation of nitric-oxide synthase activity Source: RGD
• positive regulation of phosphoprotein phosphatase activity Source: RGD
• positive regulation of renal sodium excretion Source: RGDInferred from mutant phenotypeⁱ
  • "Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat."
    Padia S.H., Howell N.L., Siragy H.M., Carey R.M.
    Hypertension 47:537-544(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: RGD
• regulation of metanephros size Source: RGD
• regulation of protein import into nucleus Source: RGDInferred from direct assayⁱ
  • "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy."
    Senbonmatsu T., Saito T., Landon E.J., Watanabe O., Price E. Jr., Roberts R.L., Imboden H., Fitzgerald T.G., Gaffney F.A., Inagami T.
    EMBO J 22:6471-6482(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of systemic arterial blood pressure by circulatory renin-angiotensin Source: RGD
• renin-angiotensin regulation of aldosterone production Source: RGDInferred from mutant phenotypeⁱ
  • "Mechanism of Ang II involvement in activation of NF-kappaB through phosphorylation of p65 during aging."
    Kim J.M., Heo H.S., Ha Y.M., Ye B.H., Lee E.K., Choi Y.J., Yu B.P., Chung H.Y.
    Age (Dordr) 34:11-25(2012) [PubMed] [Europe PMC] [Abstract]
• response to organonitrogen compound Source: RGDInferred from expression patternⁱ
  • "Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression."
    Li C., Cao L., Zeng Q., Liu X., Zhang Y., Dai T., Hu D., Huang K., Wang Y., Wang X., Li D., Chen Z., Zhang J., Li Y., Sharma R.
    Cardiovasc Drugs Ther 19:105-112(2005) [PubMed] [Europe PMC] [Abstract]
• vasodilation Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• G-protein alpha-subunit binding Source: RGDTraceable author statementⁱ
  • "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy."
    Senbonmatsu T., Saito T., Landon E.J., Watanabe O., Price E. Jr., Roberts R.L., Imboden H., Fitzgerald T.G., Gaffney F.A., Inagami T.
    EMBO J 22:6471-6482(2003) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: RGDInferred from physical interactionⁱ
  • "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy."
    Senbonmatsu T., Saito T., Landon E.J., Watanabe O., Price E. Jr., Roberts R.L., Imboden H., Fitzgerald T.G., Gaffney F.A., Inagami T.
    EMBO J 22:6471-6482(2003) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKDNFSFAAT SRNITSSLPF DNLNATGTNE SAFNCSHKPA DKHLEAIPVL 
        60         70         80         90        100
YYMIFVIGFA VNIVVVSLFC CQKGPKKVSS IYIFNLAVAD LLLLATLPLW 
       110        120        130        140        150
ATYYSYRYDW LFGPVMCKVF GSFLTLNMFA SIFFITCMSV DRYQSVIYPF 
       160        170        180        190        200
LSQRRNPWQA SYVVPLVWCM ACLSSLPTFY FRDVRTIEYL GVNACIMAFP 
       210        220        230        240        250
PEKYAQWSAG IALMKNILGF IIPLIFIATC YFGIRKHLLK TNSYGKNRIT 
       260        270        280        290        300
RDQVLKMAAA VVLAFIICWL PFHVLTFLDA LTWMGIINSC EVIAVIDLAL 
       310        320        330        340        350
PFAILLGFTN SCVNPFLYCF VGNRFQQKLR SVFRVPITWL QGKRETMSCR 
       360 
KSSSLREMDT FVS                                         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families