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UniProtKB - P35349 (GRM6_RAT)
Protein
Metabotropic glutamate receptor 6
Gene
Grm6
Organism
Rattus norvegicus (Rat)
Status
Functioni
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity).
Signaling stimulates TRPM1 channel activity and Ca2+ uptake. Required for normal vision.
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 148 | GlutamateBy similarity | 1 | |
Binding sitei | 219 | GlutamateBy similarity | 1 | |
Binding sitei | 301 | GlutamateBy similarity | 1 | |
Binding sitei | 394 | GlutamateBy similarity | 1 |
GO - Molecular functioni
- adenylate cyclase inhibiting G protein-coupled glutamate receptor activity Source: RGD
- glutamate receptor activity Source: UniProtKB
- protein homodimerization activity Source: RGD
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: RGD
- chemical synaptic transmission Source: RGD
- detection of light stimulus involved in visual perception Source: UniProtKB
- G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
- locomotory behavior Source: RGD
- positive regulation of calcium ion import Source: UniProtKB
- regulation of synaptic transmission, glutamatergic Source: GO_Central
- retina development in camera-type eye Source: RGD
- sensory perception of light stimulus Source: RGD
- signal transduction Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Sensory transduction, Vision |
Enzyme and pathway databases
Reactomei | R-RNO-418594, G alpha (i) signalling events R-RNO-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Names & Taxonomyi
Protein namesi | Recommended name: Metabotropic glutamate receptor 6Short name: mGluR6 |
Gene namesi | Name:Grm6 Synonyms:Gprc1f, Mglur6 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2747, Grm6 |
Subcellular locationi
Plasma membrane
Golgi apparatus
- Golgi apparatus membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- dendrite By similarity
Note: Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane. Detected at dendritic tips of bipolar cells (By similarity).By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Other locations
- dendrite Source: UniProtKB-SubCell
- integral component of membrane Source: RGD
- new growing cell tip Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 579 | ExtracellularSequence analysisAdd BLAST | 556 | |
Transmembranei | 580 – 602 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 603 – 616 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 617 – 637 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 638 – 648 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 649 – 667 | Helical; Name=3Sequence analysisAdd BLAST | 19 | |
Topological domaini | 668 – 691 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 692 – 712 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 713 – 742 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 743 – 764 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 765 – 777 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 778 – 800 | Helical; Name=6Sequence analysisAdd BLAST | 23 | |
Topological domaini | 801 – 813 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 814 – 839 | Helical; Name=7Sequence analysisAdd BLAST | 26 | |
Topological domaini | 840 – 871 | CytoplasmicSequence analysisAdd BLAST | 32 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL3842 |
DrugCentrali | P35349 |
GuidetoPHARMACOLOGYi | 294 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000012937 | 24 – 871 | Metabotropic glutamate receptor 6Add BLAST | 848 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 51 ↔ 93 | By similarity | ||
Disulfide bondi | 238 ↔ 530 | By similarity | ||
Glycosylationi | 290 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 361 ↔ 377 | By similarity | ||
Disulfide bondi | 417 ↔ 424 | By similarity | ||
Glycosylationi | 445 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 473 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 512 ↔ 531 | By similarity | ||
Disulfide bondi | 516 ↔ 534 | By similarity | ||
Disulfide bondi | 537 ↔ 549 | By similarity | ||
Disulfide bondi | 552 ↔ 565 | By similarity | ||
Glycosylationi | 561 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P35349 |
PRIDEi | P35349 |
PTM databases
GlyGeni | P35349, 4 sites |
PhosphoSitePlusi | P35349 |
Expressioni
Tissue specificityi
Restricted expression in the inner nuclear layer of the retina.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000000233, Expressed in brain and 3 other tissues |
Genevisiblei | P35349, RN |
Interactioni
Subunit structurei
Homodimer.
By similarityGO - Molecular functioni
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
BioGRIDi | 246584, 4 interactors |
IntActi | P35349, 2 interactors |
MINTi | P35349 |
STRINGi | 10116.ENSRNOP00000000249 |
Chemistry databases
BindingDBi | P35349 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 169 – 171 | Glutamate bindingBy similarity | 3 | |
Regioni | 850 – 871 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01030000234595 |
HOGENOMi | CLU_005389_0_0_1 |
InParanoidi | P35349 |
OMAi | MFIQTAT |
OrthoDBi | 1154468at2759 |
PhylomeDBi | P35349 |
TreeFami | TF313240 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR000112, GPCR_3_mtglu_rcpt_6 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01056, MTABOTROPC6R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P35349-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRLPVLLLW LAWWLSQAGI ACGAGSVRLA GGLTLGGLFP VHARGAAGRA
60 70 80 90 100
CGALKKEQGV HRLEAMLYAL DRVNADPELL PGVRLGARLL DTCSRDTYAL
110 120 130 140 150
EQALSFVQAL IRGRGDGDEA SVRCPGGVPP LRSAPPERVV AVVGASASSV
160 170 180 190 200
SIMVANVLRL FAIPQISYAS TAPELSDSTR YDFFSRVVPP DSYQAQAMVD
210 220 230 240 250
IVRALGWNYV STLASEGNYG ESGVEAFVQI SREAGGVCIA QSIKIPREPK
260 270 280 290 300
PGEFHKVIRR LMETPNARGI IIFANEDDIR RVLEATRQAN LTGHFLWVGS
310 320 330 340 350
DSWGSKISPI LNLEEEAVGA ITILPKRASI DGFDQYFMTR SLENNRRNIW
360 370 380 390 400
FAEFWEENFN CKLTSSGGQS DDSTRKCTGE ERIGQDSAYE QEGKVQFVID
410 420 430 440 450
AVYAIAHALH SMHQALCPGH TGLCPAMEPT DGRTLLHYIR AVRFNGSAGT
460 470 480 490 500
PVMFNENGDA PGRYDIFQYQ ATNGSASSGG YQAVGQWAEA LRLDMEVLRW
510 520 530 540 550
SGDPHEVPPS QCSLPCGPGE RKKMVKGVPC CWHCEACDGY RFQVDEFTCE
560 570 580 590 600
ACPGDMRPTP NHTGCRPTPV VRLTWSSPWA ALPLLLAVLG IMATTTIMAT
610 620 630 640 650
FMRHNDTPIV RASGRELSYV LLTGIFLIYA ITFLMVAEPC AAICAARRLL
660 670 680 690 700
LGLGTTLSYS ALLTKTNRIY RIFEQGKRSV TPPPFISPTS QLVITFGLTS
710 720 730 740 750
LQVVGVIAWL GAQPPHSVID YEEQRTVDPE QARGVLKCDM SDLSLIGCLG
760 770 780 790 800
YSLLLMVTCT VYAIKARGVP ETFNEAKPIG FTMYTTCIIW LAFVPIFFGT
810 820 830 840 850
AQSAEKIYIQ TTTLTVSLSL SASVSLGMLY VPKTYVILFH PEQNVQKRKR
860 870
SLKKTSTMAA PPQNENAEDA K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13963 mRNA Translation: BAA03066.1 |
PIRi | A46742 |
RefSeqi | NP_075209.1, NM_022920.1 XP_017452483.1, XM_017596994.1 |
Genome annotation databases
Ensembli | ENSRNOT00000000249; ENSRNOP00000000249; ENSRNOG00000000233 |
GeneIDi | 24419 |
KEGGi | rno:24419 |
UCSCi | RGD:2747, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D13963 mRNA Translation: BAA03066.1 |
PIRi | A46742 |
RefSeqi | NP_075209.1, NM_022920.1 XP_017452483.1, XM_017596994.1 |
3D structure databases
SMRi | P35349 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 246584, 4 interactors |
IntActi | P35349, 2 interactors |
MINTi | P35349 |
STRINGi | 10116.ENSRNOP00000000249 |
Chemistry databases
BindingDBi | P35349 |
ChEMBLi | CHEMBL3842 |
DrugCentrali | P35349 |
GuidetoPHARMACOLOGYi | 294 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35349, 4 sites |
PhosphoSitePlusi | P35349 |
Proteomic databases
PaxDbi | P35349 |
PRIDEi | P35349 |
Genome annotation databases
Ensembli | ENSRNOT00000000249; ENSRNOP00000000249; ENSRNOG00000000233 |
GeneIDi | 24419 |
KEGGi | rno:24419 |
UCSCi | RGD:2747, rat |
Organism-specific databases
CTDi | 2916 |
RGDi | 2747, Grm6 |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT01030000234595 |
HOGENOMi | CLU_005389_0_0_1 |
InParanoidi | P35349 |
OMAi | MFIQTAT |
OrthoDBi | 1154468at2759 |
PhylomeDBi | P35349 |
TreeFami | TF313240 |
Enzyme and pathway databases
Reactomei | R-RNO-418594, G alpha (i) signalling events R-RNO-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Miscellaneous databases
PROi | PR:P35349 |
Gene expression databases
Bgeei | ENSRNOG00000000233, Expressed in brain and 3 other tissues |
Genevisiblei | P35349, RN |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR017979, GPCR_3_CS IPR000162, GPCR_3_mtglu_rcpt IPR000112, GPCR_3_mtglu_rcpt_6 IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00248, GPCRMGR PR01056, MTABOTROPC6R PR00593, MTABOTROPICR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00979, G_PROTEIN_RECEP_F3_1, 1 hit PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS00981, G_PROTEIN_RECEP_F3_3, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GRM6_RAT | |
Accessioni | P35349Primary (citable) accession number: P35349 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families