UniProtKB - P35348 (ADA1A_HUMAN)
Protein
Alpha-1A adrenergic receptor
Gene
ADRA1A
Organism
Homo sapiens (Human)
Status
Functioni
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.2 Publications
GO - Molecular functioni
- alpha1-adrenergic receptor activity Source: BHF-UCL
- G protein-coupled receptor activity Source: GO_Central
- protein heterodimerization activity Source: UniProtKB
GO - Biological processi
- activation of phospholipase C activity Source: BHF-UCL
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adult heart development Source: Ensembl
- aging Source: BHF-UCL
- apoptotic process Source: ProtInc
- calcium ion transport into cytosol Source: BHF-UCL
- cell-cell signaling Source: GO_Central
- cell growth involved in cardiac muscle cell development Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- intracellular signal transduction Source: ProtInc
- micturition Source: Ensembl
- negative regulation of autophagy Source: Ensembl
- negative regulation of cell population proliferation Source: ProtInc
- negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
- negative regulation of Rho protein signal transduction Source: BHF-UCL
- neuron-glial cell signaling Source: ARUK-UCL
- norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: Ensembl
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
- pilomotor reflex Source: Ensembl
- positive regulation of action potential Source: BHF-UCL
- positive regulation of cardiac muscle contraction Source: BHF-UCL
- positive regulation of cardiac muscle hypertrophy Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- positive regulation of heart rate by epinephrine-norepinephrine Source: GO_Central
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of non-membrane spanning protein tyrosine kinase activity Source: Ensembl
- positive regulation of protein kinase C signaling Source: BHF-UCL
- positive regulation of smooth muscle contraction Source: Ensembl
- positive regulation of synaptic transmission, GABAergic Source: BHF-UCL
- positive regulation of systemic arterial blood pressure Source: Ensembl
- positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: Ensembl
- positive regulation of vasoconstriction Source: BHF-UCL
- regulation of synaptic vesicle exocytosis Source: Ensembl
- response to drug Source: BHF-UCL
- response to hormone Source: BHF-UCL
- signal transduction Source: ProtInc
- smooth muscle contraction Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P35348 |
Reactomei | R-HSA-390696, Adrenoceptors R-HSA-416476, G alpha (q) signalling events R-HSA-416482, G alpha (12/13) signalling events |
SignaLinki | P35348 |
SIGNORi | P35348 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-1A adrenergic receptorAlternative name(s): Alpha-1A adrenoreceptor Short name: Alpha-1A adrenoceptor Alpha-1C adrenergic receptor Alpha-adrenergic receptor 1c |
Gene namesi | Name:ADRA1A Synonyms:ADRA1C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:277, ADRA1A |
MIMi | 104221, gene |
neXtProti | NX_P35348 |
VEuPathDBi | HostDB:ENSG00000120907.17 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Other locations
- caveola 1 Publication
Note: Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear membrane Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- caveola Source: UniProtKB-SubCell
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic membrane Source: Ensembl
- integral component of presynaptic membrane Source: Ensembl
- plasma membrane Source: UniProtKB
- T-tubule Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB
- dopaminergic synapse Source: Ensembl
- GABA-ergic synapse Source: Ensembl
- glutamatergic synapse Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
- Z disc Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularBy similarityAdd BLAST | 27 | |
Transmembranei | 28 – 51 | Helical; Name=1By similarityAdd BLAST | 24 | |
Topological domaini | 52 – 64 | CytoplasmicBy similarityAdd BLAST | 13 | |
Transmembranei | 65 – 88 | Helical; Name=2By similarityAdd BLAST | 24 | |
Topological domaini | 89 – 99 | ExtracellularBy similarityAdd BLAST | 11 | |
Transmembranei | 100 – 122 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 123 – 143 | CytoplasmicBy similarityAdd BLAST | 21 | |
Transmembranei | 144 – 167 | Helical; Name=4By similarityAdd BLAST | 24 | |
Topological domaini | 168 – 181 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 182 – 205 | Helical; Name=5By similarityAdd BLAST | 24 | |
Topological domaini | 206 – 273 | CytoplasmicBy similarityAdd BLAST | 68 | |
Transmembranei | 274 – 297 | Helical; Name=6By similarityAdd BLAST | 24 | |
Topological domaini | 298 – 305 | ExtracellularBy similarity | 8 | |
Transmembranei | 306 – 329 | Helical; Name=7By similarityAdd BLAST | 24 | |
Topological domaini | 330 – 466 | CytoplasmicBy similarityAdd BLAST | 137 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 334 | K → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-335; A-342; A-348 and A-349. 1 Publication | 1 | |
Mutagenesisi | 335 | K → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-334; A-342; A-348 and A-349. 1 Publication | 1 | |
Mutagenesisi | 342 | R → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-334; A-335; A-348 and A-349. 1 Publication | 1 | |
Mutagenesisi | 348 | R → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-334; A-335; A-342 and A-349. 1 Publication | 1 | |
Mutagenesisi | 349 | K → A: Abolishes targeting to the nuclear membrane of cardiac myocytes; when associated with A-334; A-335; A-342 and A-348. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 148 |
OpenTargetsi | ENSG00000120907 |
PharmGKBi | PA34 |
Miscellaneous databases
Pharosi | P35348, Tclin |
Chemistry databases
ChEMBLi | CHEMBL229 |
DrugBanki | DB01472, 4-Methoxyamphetamine DB01614, Acepromazine DB00346, Alfuzosin DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB00964, Apraclonidine DB09229, Aranidipine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB09204, Arotinolol DB06216, Asenapine DB00865, Benzphetamine DB01295, Bevantolol DB01200, Bromocriptine DB00490, Buspirone DB00248, Cabergoline DB01136, Carvedilol DB00477, Chlorpromazine DB09202, Cirazoline DB00575, Clonidine DB00363, Clozapine DB00298, Dapiprazole DB01151, Desipramine DB01576, Dextroamphetamine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00449, Dipivefrin DB11278, DL-Methylephedrine DB00841, Dobutamine DB09167, Dosulepin DB00590, Doxazosin DB01142, Doxepin DB04855, Dronedarone DB00450, Droperidol DB06262, Droxidopa DB01364, Ephedrine DB05492, Epicept NP-1 DB00751, Epinastine DB00668, Epinephrine DB01049, Ergoloid mesylate DB01253, Ergometrine DB00696, Ergotamine DB01175, Escitalopram DB09194, Etoperidone DB00800, Fenoldopam DB00875, Flupentixol DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB11577, Indigotindisulfonic acid DB08950, Indoramin DB06706, Isometheptene DB00598, Labetalol DB00555, Lamotrigine DB04948, Lofexidine DB09195, Lorpiprazole DB00408, Loxapine DB00934, Maprotiline DB01365, Mephentermine DB00610, Metaraminol DB01403, Methotrimeprazine DB00723, Methoxamine DB06148, Mianserin DB00211, Midodrine DB00370, Mirtazapine DB09205, Moxisylyte DB06711, Naphazoline DB01149, Nefazodone DB00622, Nicardipine DB00699, Nicergoline DB09239, Niguldipine DB00368, Norepinephrine DB00540, Nortriptyline DB06229, Ocaperidone DB00334, Olanzapine DB00935, Oxymetazoline DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB08922, Perospirone DB01579, Phendimetrazine DB00925, Phenoxybenzamine DB00692, Phentolamine DB00388, Phenylephrine DB09286, Pipamperone DB06153, Pizotifen DB00457, Prazosin DB00433, Prochlorperazine DB00420, Promazine DB01069, Promethazine DB00777, Propiomazine DB12278, Propiverine DB00852, Pseudoephedrine DB01224, Quetiapine DB00908, Quinidine DB05469, R450 DB11124, Racepinephrine DB00243, Ranolazine DB00734, Risperidone DB00268, Ropinirole DB06144, Sertindole DB06207, Silodosin DB09203, Synephrine DB00706, Tamsulosin DB01162, Terazosin DB06764, Tetryzoline DB01622, Thioproperazine DB00679, Thioridazine DB13025, Tiapride DB00697, Tizanidine DB00797, Tolazoline DB00656, Trazodone DB00831, Trifluoperazine DB00726, Trimipramine DB00661, Verapamil DB06694, Xylometazoline DB00246, Ziprasidone DB01624, Zuclopenthixol |
DrugCentrali | P35348 |
GuidetoPHARMACOLOGYi | 22 |
Genetic variation databases
BioMutai | ADRA1A |
DMDMi | 1168246 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069063 | 1 – 466 | Alpha-1A adrenergic receptorAdd BLAST | 466 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 22 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 176 | PROSITE-ProRule annotation | ||
Modified residuei | 215 | Phosphoserine; by PKASequence analysis | 1 | |
Lipidationi | 345 | S-palmitoyl cysteineSequence analysis | 1 |
Post-translational modificationi
C-terminal Ser or Thr residues may be phosphorylated.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P35348 |
PeptideAtlasi | P35348 |
PRIDEi | P35348 |
ProteomicsDBi | 55026 [P35348-1] 55027 [P35348-2] 55028 [P35348-3] 55029 [P35348-4] 55030 [P35348-5] 55031 [P35348-6] 55032 [P35348-7] 55033 [P35348-8] 55034 [P35348-9] |
PTM databases
GlyGeni | P35348, 3 sites |
iPTMneti | P35348 |
PhosphoSitePlusi | P35348 |
Expressioni
Tissue specificityi
Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.3 Publications
Gene expression databases
Bgeei | ENSG00000120907, Expressed in liver and 133 other tissues |
ExpressionAtlasi | P35348, baseline and differential |
Genevisiblei | P35348, HS |
Organism-specific databases
HPAi | ENSG00000120907, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Binary interactionsi
Isoform 1 [P35348-1]
With | #Exp. | IntAct |
---|---|---|
CRELD1 [Q96HD1] | 3 | EBI-21288891,EBI-713009 |
GO - Molecular functioni
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 106658, 25 interactors |
CORUMi | P35348 |
DIPi | DIP-33401N |
IntActi | P35348, 33 interactors |
MINTi | P35348 |
STRINGi | 9606.ENSP00000369960 |
Chemistry databases
BindingDBi | P35348 |
Miscellaneous databases
RNActi | P35348, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 334 – 349 | Nuclear localization signalAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000159105 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P35348 |
OMAi | HLQSVTH |
OrthoDBi | 1095345at2759 |
PhylomeDBi | P35348 |
TreeFami | TF331895 |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR001004, ADRA1A_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00557, ADRENRGCA1AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (9+)i Sequence
Sequence statusi: Complete.
This entry describes 9 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 9 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P35348-1) [UniParc]FASTAAdd to basket
Also known as: Alpha 1c-1, Alpha(1A-1)
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVFLSGNASD SSNCTQPPAP VNISKAILLG VILGGLILFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEVLG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGLMALLCV
160 170 180 190 200
WALSLVISIG PLFGWRQPAP EDETICQINE EPGYVLFSAL GSFYLPLAII
210 220 230 240 250
LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN APAGGSGMAS
260 270 280 290 300
AKTKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
310 320 330 340 350
FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLCRKQ
360 370 380 390 400
SSKHALGYTL HPPSQAVEGQ HKDMVRIPVG SRETFYRISK TDGVCEWKFF
410 420 430 440 450
SSMPRGSARI TVSKDQSSCT TARVRSKSFL QVCCCVGPST PSLDKNHQVP
460
TIKVHTISLS ENGEEV
Isoform 7 (identifier: P35348-7) [UniParc]FASTAAdd to basket
Also known as: 2b/3b
The sequence of this isoform differs from the canonical sequence as follows:
296-324: SFFPDFKPSETVFKIVFWLGYLNSCINPI → TYILKYDVLFWRKGLSVCTRLRERKEIKN
325-466: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE7EW16 | E7EW16_HUMAN | Alpha-1A adrenergic receptor | ADRA1A | 427 | Annotation score: |
Sequence cautioni
The sequence ACA05900 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 43 | G → C in AAA93114 (PubMed:8564208).Curated | 1 | ||
Sequence conflicti | 129 | S → T in AAA93114 (PubMed:8564208).Curated | 1 | ||
Sequence conflicti | 130 | Y → H in AAK77197 (Ref. 9) Curated | 1 | ||
Sequence conflicti | 185 | V → A in AAH95512 (PubMed:15489334).Curated | 1 | ||
Sequence conflicti | 338 | Q → C (PubMed:8024574).Curated | 1 | ||
Sequence conflicti | 359 | T → P in AAA93114 (PubMed:8564208).Curated | 1 | ||
Sequence conflicti | 384 | T → A in AAK77197 (Ref. 9) Curated | 1 | ||
Sequence conflicti | 387 | R → G in AAK77197 (Ref. 9) Curated | 1 | ||
Sequence conflicti | 390 | K → R in AAK77197 (Ref. 9) Curated | 1 | ||
Sequence conflicti | 431 | Q → E in BAA04960 (PubMed:8396931).Curated | 1 | ||
Sequence conflicti | 437 | G → E in AAK77197 (Ref. 9) Curated | 1 | ||
Sequence conflicti | 442 | S → C in AAA93114 (PubMed:8564208).Curated | 1 | ||
Isoform 6 (identifier: P35348-6) | |||||
Sequence conflicti | 302 | E → Q in AAR84650 (PubMed:10493934).Curated | 1 | ||
Isoform 4 (identifier: P35348-4) | |||||
Sequence conflicti | 453 | S → L in AAC06138 (PubMed:9490024).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035756 | 40 | G → W in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_049370 | 200 | I → S. Corresponds to variant dbSNP:rs2229125Ensembl. | 1 | |
Natural variantiVAR_019509 | 347 | C → R9 PublicationsCorresponds to variant dbSNP:rs1048101Ensembl. | 1 | |
Natural variantiVAR_049371 | 414 | K → R. Corresponds to variant dbSNP:rs3730247Ensembl. | 1 | |
Natural variantiVAR_049372 | 465 | E → D. Corresponds to variant dbSNP:rs2229126Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011046 | 295 – 466 | GSFFP…NGEEV → DEVSLCHQAGVQWHDLGSLQ PPPPGFKRFSCLSLPSSWDY RDVPPGRRHQAQLIFVFLVE TGFHHVGQDDLDLLTS in isoform 8. 1 PublicationAdd BLAST | 172 | |
Alternative sequenceiVSP_011053 | 295 – 342 | GSFFP…QNVLR → DEETEAQEGKNDSPSFKQPV HHAAVLGLEVMEKENLEGVS RKDTCGVW in isoform 6. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_011049 | 296 – 466 | SFFPD…NGEEV → THTHDMKPASRPRLLSLLPK EGEHETHHWSCDPLSLESTP GAQEPCLTLGFTSLSSIHLT KAQIQHVTVTDTGKTVT in isoform 9. 1 PublicationAdd BLAST | 171 | |
Alternative sequenceiVSP_011047 | 296 – 324 | SFFPD…CINPI → TYILKYDVLFWRKGLSVCTR LRERKEIKN in isoform 7. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_011051 | 296 – 297 | SF → KS in isoform 5. 1 Publication | 2 | |
Alternative sequenceiVSP_011052 | 298 – 466 | Missing in isoform 5. 1 PublicationAdd BLAST | 169 | |
Alternative sequenceiVSP_011048 | 325 – 466 | Missing in isoform 7. 1 PublicationAdd BLAST | 142 | |
Alternative sequenceiVSP_011054 | 343 – 466 | Missing in isoform 6. 1 PublicationAdd BLAST | 124 | |
Alternative sequenceiVSP_011055 | 424 – 466 | VRSKS…NGEEV → TKSRSVTRLECSGMILAHCN LRLPGSRDSPASASQAAGTT GMCHQADATRPS in isoform 2. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_011050 | 424 – 466 | VRSKS…NGEEV → RGMDCRYFTKNCREHIKHVN FMMPPWRKGSEC in isoform 4. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_011044 | 424 – 429 | VRSKSF → GHTPMT in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_011045 | 430 – 466 | Missing in isoform 3. 1 PublicationAdd BLAST | 37 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 106658, 25 interactors |
CORUMi | P35348 |
DIPi | DIP-33401N |
IntActi | P35348, 33 interactors |
MINTi | P35348 |
STRINGi | 9606.ENSP00000369960 |
Chemistry databases
BindingDBi | P35348 |
ChEMBLi | CHEMBL229 |
DrugBanki | DB01472, 4-Methoxyamphetamine DB01614, Acepromazine DB00346, Alfuzosin DB00321, Amitriptyline DB00543, Amoxapine DB00182, Amphetamine DB00964, Apraclonidine DB09229, Aranidipine DB01238, Aripiprazole DB14185, Aripiprazole lauroxil DB09204, Arotinolol DB06216, Asenapine DB00865, Benzphetamine DB01295, Bevantolol DB01200, Bromocriptine DB00490, Buspirone DB00248, Cabergoline DB01136, Carvedilol DB00477, Chlorpromazine DB09202, Cirazoline DB00575, Clonidine DB00363, Clozapine DB00298, Dapiprazole DB01151, Desipramine DB01576, Dextroamphetamine DB11273, Dihydroergocornine DB13345, Dihydroergocristine DB00449, Dipivefrin DB11278, DL-Methylephedrine DB00841, Dobutamine DB09167, Dosulepin DB00590, Doxazosin DB01142, Doxepin DB04855, Dronedarone DB00450, Droperidol DB06262, Droxidopa DB01364, Ephedrine DB05492, Epicept NP-1 DB00751, Epinastine DB00668, Epinephrine DB01049, Ergoloid mesylate DB01253, Ergometrine DB00696, Ergotamine DB01175, Escitalopram DB09194, Etoperidone DB00800, Fenoldopam DB00875, Flupentixol DB00502, Haloperidol DB04946, Iloperidone DB00458, Imipramine DB11577, Indigotindisulfonic acid DB08950, Indoramin DB06706, Isometheptene DB00598, Labetalol DB00555, Lamotrigine DB04948, Lofexidine DB09195, Lorpiprazole DB00408, Loxapine DB00934, Maprotiline DB01365, Mephentermine DB00610, Metaraminol DB01403, Methotrimeprazine DB00723, Methoxamine DB06148, Mianserin DB00211, Midodrine DB00370, Mirtazapine DB09205, Moxisylyte DB06711, Naphazoline DB01149, Nefazodone DB00622, Nicardipine DB00699, Nicergoline DB09239, Niguldipine DB00368, Norepinephrine DB00540, Nortriptyline DB06229, Ocaperidone DB00334, Olanzapine DB00935, Oxymetazoline DB01267, Paliperidone DB00715, Paroxetine DB01186, Pergolide DB08922, Perospirone DB01579, Phendimetrazine DB00925, Phenoxybenzamine DB00692, Phentolamine DB00388, Phenylephrine DB09286, Pipamperone DB06153, Pizotifen DB00457, Prazosin DB00433, Prochlorperazine DB00420, Promazine DB01069, Promethazine DB00777, Propiomazine DB12278, Propiverine DB00852, Pseudoephedrine DB01224, Quetiapine DB00908, Quinidine DB05469, R450 DB11124, Racepinephrine DB00243, Ranolazine DB00734, Risperidone DB00268, Ropinirole DB06144, Sertindole DB06207, Silodosin DB09203, Synephrine DB00706, Tamsulosin DB01162, Terazosin DB06764, Tetryzoline DB01622, Thioproperazine DB00679, Thioridazine DB13025, Tiapride DB00697, Tizanidine DB00797, Tolazoline DB00656, Trazodone DB00831, Trifluoperazine DB00726, Trimipramine DB00661, Verapamil DB06694, Xylometazoline DB00246, Ziprasidone DB01624, Zuclopenthixol |
DrugCentrali | P35348 |
GuidetoPHARMACOLOGYi | 22 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35348, 3 sites |
iPTMneti | P35348 |
PhosphoSitePlusi | P35348 |
Genetic variation databases
BioMutai | ADRA1A |
DMDMi | 1168246 |
Proteomic databases
PaxDbi | P35348 |
PeptideAtlasi | P35348 |
PRIDEi | P35348 |
ProteomicsDBi | 55026 [P35348-1] 55027 [P35348-2] 55028 [P35348-3] 55029 [P35348-4] 55030 [P35348-5] 55031 [P35348-6] 55032 [P35348-7] 55033 [P35348-8] 55034 [P35348-9] |
Protocols and materials databases
Antibodypediai | 10062, 358 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 148 |
DisGeNETi | 148 |
GeneCardsi | ADRA1A |
HGNCi | HGNC:277, ADRA1A |
HPAi | ENSG00000120907, Tissue enhanced (liver) |
MIMi | 104221, gene |
neXtProti | NX_P35348 |
OpenTargetsi | ENSG00000120907 |
PharmGKBi | PA34 |
VEuPathDBi | HostDB:ENSG00000120907.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000159105 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P35348 |
OMAi | HLQSVTH |
OrthoDBi | 1095345at2759 |
PhylomeDBi | P35348 |
TreeFami | TF331895 |
Enzyme and pathway databases
PathwayCommonsi | P35348 |
Reactomei | R-HSA-390696, Adrenoceptors R-HSA-416476, G alpha (q) signalling events R-HSA-416482, G alpha (12/13) signalling events |
SignaLinki | P35348 |
SIGNORi | P35348 |
Miscellaneous databases
BioGRID-ORCSi | 148, 2 hits in 989 CRISPR screens |
GeneWikii | Alpha-1A_adrenergic_receptor |
GenomeRNAii | 148 |
Pharosi | P35348, Tclin |
PROi | PR:P35348 |
RNActi | P35348, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120907, Expressed in liver and 133 other tissues |
ExpressionAtlasi | P35348, baseline and differential |
Genevisiblei | P35348, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002233, ADR_fam IPR001004, ADRA1A_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01103, ADRENERGICR PR00557, ADRENRGCA1AR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA1A_HUMAN | |
Accessioni | P35348Primary (citable) accession number: P35348 Secondary accession number(s): A8K0I3 Q9UD67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 206 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families