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Protein

Somatostatin receptor type 5

Gene

SSTR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • neuropeptide binding Source: GO_Central
  • somatostatin receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Somatostatin receptor type 5
Short name:
SS-5-R
Short name:
SS5-R
Short name:
SS5R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSTR5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162009.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11334 SSTR5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
182455 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P35346

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 66Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini67 – 76CytoplasmicSequence analysis10
Transmembranei77 – 101Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini102 – 113ExtracellularSequence analysisAdd BLAST12
Transmembranei114 – 135Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini136 – 157CytoplasmicSequence analysisAdd BLAST22
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 197ExtracellularSequence analysisAdd BLAST19
Transmembranei198 – 222Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini223 – 247CytoplasmicSequence analysisAdd BLAST25
Transmembranei248 – 273Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini274 – 283ExtracellularSequence analysis10
Transmembranei284 – 308Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini309 – 364CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6755

Open Targets

More...
OpenTargetsi
ENSG00000162009

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36158

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1792

Drug and drug target database

More...
DrugBanki
DB06791 Lanreotide
DB00104 Octreotide
DB06663 Pasireotide
DB04894 Vapreotide

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
359

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SSTR5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12644225

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000701301 – 364Somatostatin receptor type 5Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi112 ↔ 186PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi320S-palmitoyl cysteine; by ZDHHC5By similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei325Phosphoserine; by PKASequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P35346

PeptideAtlas

More...
PeptideAtlasi
P35346

PRoteomics IDEntifications database

More...
PRIDEi
P35346

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55025

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P35346

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P35346

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162009 Expressed in 63 organ(s), highest expression level in right atrium auricular region

CleanEx database of gene expression profiles

More...
CleanExi
HS_SSTR5

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P35346 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA066503

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112633, 3 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P35346

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000293897

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P35346

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P35346

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P35346

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160265

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230485

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106919

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P35346

KEGG Orthology (KO)

More...
KOi
K04221

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVLCLRK

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0HEN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P35346

TreeFam database of animal gene trees

More...
TreeFami
TF315737

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000586 Somatstn_rcpt
IPR001184 Somatstn_rcpt_5

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR00246 SOMATOSTATNR
PR00591 SOMATOSTTN5R

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P35346-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV
60 70 80 90 100
CAAGLGGNTL VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN
110 120 130 140 150
AASFWPFGPV LCRLVMTLDG VNQFTSVFCL TVMSVDRYLA VVHPLSSARW
160 170 180 190 200
RRPRVAKLAS AAAWVLSLCM SLPLLVFADV QEGGTCNASW PEPVGLWGAV
210 220 230 240 250
FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR RSERKVTRMV
260 270 280 290 300
LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN
310 320 330 340 350
PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA
360
HRAAANGLMQ TSKL
Length:364
Mass (Da):39,202
Last modified:December 1, 2000 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i905744715F31121C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti348 – 352PPAHR → RPRT in AAA20828 (PubMed:7908405).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02922237G → R. Corresponds to variant dbSNP:rs4988482Ensembl.1
Natural variantiVAR_02922348L → M. Corresponds to variant dbSNP:rs4988483Ensembl.1
Natural variantiVAR_02922452A → V. Corresponds to variant dbSNP:rs4988484Ensembl.1
Natural variantiVAR_033484105W → R. Corresponds to variant dbSNP:rs34803074Ensembl.1
Natural variantiVAR_029225109P → S. Corresponds to variant dbSNP:rs4988487Ensembl.1
Natural variantiVAR_049442234R → C. Corresponds to variant dbSNP:rs34070276Ensembl.1
Natural variantiVAR_033485251L → S. Corresponds to variant dbSNP:rs34474910Ensembl.1
Natural variantiVAR_049443267V → I. Corresponds to variant dbSNP:rs35125411Ensembl.1
Natural variantiVAR_029226333T → M. Corresponds to variant dbSNP:rs12596873Ensembl.1
Natural variantiVAR_020073335P → L2 PublicationsCorresponds to variant dbSNP:rs169068Ensembl.1
Natural variantiVAR_033486339R → K. Corresponds to variant dbSNP:rs35072648Ensembl.1
Natural variantiVAR_049444357G → R. Corresponds to variant dbSNP:rs34947461Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L14865 Genomic DNA Translation: AAA20828.1
D16827 Genomic DNA Translation: BAA04107.1
AY081193 Genomic DNA Translation: AAL88744.1
AE006466 Genomic DNA Translation: AAK61266.1
AL031713 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85687.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10429.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I57955
JN0763

NCBI Reference Sequences

More...
RefSeqi
NP_001044.1, NM_001053.3
NP_001166031.1, NM_001172560.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.449840

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000293897; ENSP00000293897; ENSG00000162009

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6755

UCSC genome browser

More...
UCSCi
uc002ckq.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14865 Genomic DNA Translation: AAA20828.1
D16827 Genomic DNA Translation: BAA04107.1
AY081193 Genomic DNA Translation: AAL88744.1
AE006466 Genomic DNA Translation: AAK61266.1
AL031713 Genomic DNA No translation available.
CH471112 Genomic DNA Translation: EAW85687.1
CCDSiCCDS10429.1
PIRiI57955
JN0763
RefSeqiNP_001044.1, NM_001053.3
NP_001166031.1, NM_001172560.1
UniGeneiHs.449840

3D structure databases

ProteinModelPortaliP35346
SMRiP35346
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112633, 3 interactors
CORUMiP35346
STRINGi9606.ENSP00000293897

Chemistry databases

BindingDBiP35346
ChEMBLiCHEMBL1792
DrugBankiDB06791 Lanreotide
DB00104 Octreotide
DB06663 Pasireotide
DB04894 Vapreotide
GuidetoPHARMACOLOGYi359

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP35346
PhosphoSitePlusiP35346

Polymorphism and mutation databases

BioMutaiSSTR5
DMDMi12644225

Proteomic databases

PaxDbiP35346
PeptideAtlasiP35346
PRIDEiP35346
ProteomicsDBi55025

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6755
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293897; ENSP00000293897; ENSG00000162009
GeneIDi6755
KEGGihsa:6755
UCSCiuc002ckq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6755
DisGeNETi6755
EuPathDBiHostDB:ENSG00000162009.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SSTR5
HGNCiHGNC:11334 SSTR5
HPAiHPA066503
MIMi182455 gene
neXtProtiNX_P35346
OpenTargetsiENSG00000162009
PharmGKBiPA36158

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000160265
HOGENOMiHOG000230485
HOVERGENiHBG106919
InParanoidiP35346
KOiK04221
OMAiKVLCLRK
OrthoDBiEOG091G0HEN
PhylomeDBiP35346
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SSTR5 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Somatostatin_receptor_5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6755

Protein Ontology

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PROi
PR:P35346

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162009 Expressed in 63 organ(s), highest expression level in right atrium auricular region
CleanExiHS_SSTR5
GenevisibleiP35346 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000586 Somatstn_rcpt
IPR001184 Somatstn_rcpt_5
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00246 SOMATOSTATNR
PR00591 SOMATOSTTN5R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSR5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P35346
Secondary accession number(s): P34988, Q541E0, Q9UJI5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: December 1, 2000
Last modified: December 5, 2018
This is version 172 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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