UniProtKB - P35346 (SSR5_HUMAN)
Protein
Somatostatin receptor type 5
Gene
SSTR5
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.4 Publications
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
- somatostatin receptor activity Source: GO_Central
GO - Biological processi
- cellular response to glucocorticoid stimulus Source: GO_Central
- glucose homeostasis Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
- negative regulation of cell population proliferation Source: ProtInc
- neuropeptide signaling pathway Source: GO_Central
- positive regulation of cytokinesis Source: UniProtKB
- regulation of insulin secretion Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P35346 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P35346 |
Names & Taxonomyi
Protein namesi | Recommended name: Somatostatin receptor type 5Short name: SS-5-R Short name: SS5-R Short name: SS5R |
Gene namesi | Name:SSTR5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000162009.8 |
HGNCi | HGNC:11334, SSTR5 |
MIMi | 182455, gene |
neXtProti | NX_P35346 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: HPA
Other locations
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 38 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 39 – 66 | Helical; Name=1Sequence analysisAdd BLAST | 28 | |
Topological domaini | 67 – 76 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 77 – 101 | Helical; Name=2Sequence analysisAdd BLAST | 25 | |
Topological domaini | 102 – 113 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 114 – 135 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 136 – 157 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 158 – 178 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 179 – 197 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 198 – 222 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 223 – 247 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 248 – 273 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 274 – 283 | ExtracellularSequence analysis | 10 | |
Transmembranei | 284 – 308 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 309 – 364 | CytoplasmicSequence analysisAdd BLAST | 56 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6755 |
OpenTargetsi | ENSG00000162009 |
PharmGKBi | PA36158 |
Miscellaneous databases
Pharosi | P35346, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1792 |
DrugBanki | DB15494, Edotreotide gallium Ga-68 DB06791, Lanreotide DB13985, Lutetium Lu 177 dotatate DB06663, Pasireotide DB09099, Somatostatin DB04894, Vapreotide |
DrugCentrali | P35346 |
GuidetoPHARMACOLOGYi | 359 |
Polymorphism and mutation databases
BioMutai | SSTR5 |
DMDMi | 12644225 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070130 | 1 – 364 | Somatostatin receptor type 5Add BLAST | 364 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 13 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 112 ↔ 186 | PROSITE-ProRule annotation | ||
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 320 | S-palmitoyl cysteine; by ZDHHC5By similarity | 1 | |
Modified residuei | 325 | Phosphoserine; by PKASequence analysis | 1 |
Post-translational modificationi
Palmitoylated by ZDHHC5, but not ZDHHC3, nor ZDHHC8. Palmitoylation creates an additional intracellular loop which is thought to be important for efficient coupling to G-proteins and may target the protein to lipid rafts.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
jPOSTi | P35346 |
PaxDbi | P35346 |
PeptideAtlasi | P35346 |
PRIDEi | P35346 |
ProteomicsDBi | 55025 |
PTM databases
GlyGeni | P35346, 3 sites |
iPTMneti | P35346 |
PhosphoSitePlusi | P35346 |
Expressioni
Tissue specificityi
Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary.3 Publications
Gene expression databases
Bgeei | ENSG00000162009, Expressed in right atrium auricular region and 72 other tissues |
Genevisiblei | P35346, HS |
Organism-specific databases
HPAi | ENSG00000162009, Tissue enhanced (gallbladder, lymphoid tissue, pituitary gland) |
Interactioni
Subunit structurei
Heterodimer with SSTR2. Heterodimerization with SSTR2 increases cell growth inhibition activity of SSTR2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 112633, 10 interactors |
CORUMi | P35346 |
STRINGi | 9606.ENSP00000293897 |
Chemistry databases
BindingDBi | P35346 |
Miscellaneous databases
RNActi | P35346, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160265 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P35346 |
OMAi | AGLYFFV |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P35346 |
TreeFami | TF315737 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001184, Somatstn_rcpt_5 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00591, SOMATOSTTN5R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P35346-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPLFPASTP SWNASSPGAA SGGGDNRTLV GPAPSAGARA VLVPVLYLLV
60 70 80 90 100
CAAGLGGNTL VIYVVLRFAK MKTVTNIYIL NLAVADVLYM LGLPFLATQN
110 120 130 140 150
AASFWPFGPV LCRLVMTLDG VNQFTSVFCL TVMSVDRYLA VVHPLSSARW
160 170 180 190 200
RRPRVAKLAS AAAWVLSLCM SLPLLVFADV QEGGTCNASW PEPVGLWGAV
210 220 230 240 250
FIIYTAVLGF FAPLLVICLC YLLIVVKVRA AGVRVGCVRR RSERKVTRMV
260 270 280 290 300
LVVVLVFAGC WLPFFTVNIV NLAVALPQEP ASAGLYFFVV ILSYANSCAN
310 320 330 340 350
PVLYGFLSDN FRQSFQKVLC LRKGSGAKDA DATEPRPDRI RQQQEATPPA
360
HRAAANGLMQ TSKL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 348 – 352 | PPAHR → RPRT in AAA20828 (PubMed:7908405).Curated | 5 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029222 | 37 | G → R. Corresponds to variant dbSNP:rs4988482Ensembl. | 1 | |
Natural variantiVAR_029223 | 48 | L → M. Corresponds to variant dbSNP:rs4988483Ensembl. | 1 | |
Natural variantiVAR_029224 | 52 | A → V. Corresponds to variant dbSNP:rs4988484Ensembl. | 1 | |
Natural variantiVAR_033484 | 105 | W → R. Corresponds to variant dbSNP:rs34803074Ensembl. | 1 | |
Natural variantiVAR_029225 | 109 | P → S. Corresponds to variant dbSNP:rs4988487Ensembl. | 1 | |
Natural variantiVAR_049442 | 234 | R → C. Corresponds to variant dbSNP:rs34070276Ensembl. | 1 | |
Natural variantiVAR_033485 | 251 | L → S. Corresponds to variant dbSNP:rs34474910Ensembl. | 1 | |
Natural variantiVAR_049443 | 267 | V → I. Corresponds to variant dbSNP:rs35125411Ensembl. | 1 | |
Natural variantiVAR_029226 | 333 | T → M. Corresponds to variant dbSNP:rs12596873EnsemblClinVar. | 1 | |
Natural variantiVAR_020073 | 335 | P → L2 PublicationsCorresponds to variant dbSNP:rs169068Ensembl. | 1 | |
Natural variantiVAR_033486 | 339 | R → K. Corresponds to variant dbSNP:rs35072648Ensembl. | 1 | |
Natural variantiVAR_049444 | 357 | G → R. Corresponds to variant dbSNP:rs34947461Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14865 Genomic DNA Translation: AAA20828.1 D16827 Genomic DNA Translation: BAA04107.1 AY081193 Genomic DNA Translation: AAL88744.1 AE006466 Genomic DNA Translation: AAK61266.1 AL031713 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85687.1 |
CCDSi | CCDS10429.1 |
PIRi | I57955 JN0763 |
RefSeqi | NP_001044.1, NM_001053.3 NP_001166031.1, NM_001172560.1 |
Genome annotation databases
Ensembli | ENST00000293897; ENSP00000293897; ENSG00000162009 |
GeneIDi | 6755 |
KEGGi | hsa:6755 |
UCSCi | uc002ckq.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14865 Genomic DNA Translation: AAA20828.1 D16827 Genomic DNA Translation: BAA04107.1 AY081193 Genomic DNA Translation: AAL88744.1 AE006466 Genomic DNA Translation: AAK61266.1 AL031713 Genomic DNA No translation available. CH471112 Genomic DNA Translation: EAW85687.1 |
CCDSi | CCDS10429.1 |
PIRi | I57955 JN0763 |
RefSeqi | NP_001044.1, NM_001053.3 NP_001166031.1, NM_001172560.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112633, 10 interactors |
CORUMi | P35346 |
STRINGi | 9606.ENSP00000293897 |
Chemistry databases
BindingDBi | P35346 |
ChEMBLi | CHEMBL1792 |
DrugBanki | DB15494, Edotreotide gallium Ga-68 DB06791, Lanreotide DB13985, Lutetium Lu 177 dotatate DB06663, Pasireotide DB09099, Somatostatin DB04894, Vapreotide |
DrugCentrali | P35346 |
GuidetoPHARMACOLOGYi | 359 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35346, 3 sites |
iPTMneti | P35346 |
PhosphoSitePlusi | P35346 |
Polymorphism and mutation databases
BioMutai | SSTR5 |
DMDMi | 12644225 |
Proteomic databases
jPOSTi | P35346 |
PaxDbi | P35346 |
PeptideAtlasi | P35346 |
PRIDEi | P35346 |
ProteomicsDBi | 55025 |
Protocols and materials databases
Antibodypediai | 3358, 306 antibodies |
DNASUi | 6755 |
Genome annotation databases
Ensembli | ENST00000293897; ENSP00000293897; ENSG00000162009 |
GeneIDi | 6755 |
KEGGi | hsa:6755 |
UCSCi | uc002ckq.4, human |
Organism-specific databases
CTDi | 6755 |
DisGeNETi | 6755 |
EuPathDBi | HostDB:ENSG00000162009.8 |
GeneCardsi | SSTR5 |
HGNCi | HGNC:11334, SSTR5 |
HPAi | ENSG00000162009, Tissue enhanced (gallbladder, lymphoid tissue, pituitary gland) |
MIMi | 182455, gene |
neXtProti | NX_P35346 |
OpenTargetsi | ENSG00000162009 |
PharmGKBi | PA36158 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00940000160265 |
HOGENOMi | CLU_009579_8_1_1 |
InParanoidi | P35346 |
OMAi | AGLYFFV |
OrthoDBi | 1011272at2759 |
PhylomeDBi | P35346 |
TreeFami | TF315737 |
Enzyme and pathway databases
PathwayCommonsi | P35346 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P35346 |
Miscellaneous databases
BioGRID-ORCSi | 6755, 2 hits in 843 CRISPR screens |
ChiTaRSi | SSTR5, human |
GeneWikii | Somatostatin_receptor_5 |
GenomeRNAii | 6755 |
Pharosi | P35346, Tclin |
PROi | PR:P35346 |
RNActi | P35346, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000162009, Expressed in right atrium auricular region and 72 other tissues |
Genevisiblei | P35346, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000586, Somatstn_rcpt IPR001184, Somatstn_rcpt_5 |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00246, SOMATOSTATNR PR00591, SOMATOSTTN5R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SSR5_HUMAN | |
Accessioni | P35346Primary (citable) accession number: P35346 Secondary accession number(s): P34988, Q541E0, Q9UJI5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 185 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries