UniProtKB - P35345 (MC5R_RAT)
Protein
Melanocortin receptor 5
Gene
Mc5r
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- hormone binding Source: RGD
- melanocortin receptor activity Source: RGD
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: RGD
- regulation of metabolic process Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Melanocortin receptor 5Short name: MC5-R |
Gene namesi | Name:Mc5r |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3058, Mc5r |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 37 | ExtracellularSequence analysisAdd BLAST | 37 | |
Transmembranei | 38 – 61 | Helical; Name=1Sequence analysisAdd BLAST | 24 | |
Topological domaini | 62 – 73 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 74 – 97 | Helical; Name=2Sequence analysisAdd BLAST | 24 | |
Topological domaini | 98 – 114 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 115 – 138 | Helical; Name=3Sequence analysisAdd BLAST | 24 | |
Topological domaini | 139 – 155 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 156 – 179 | Helical; Name=4Sequence analysisAdd BLAST | 24 | |
Topological domaini | 180 – 186 | ExtracellularSequence analysis | 7 | |
Transmembranei | 187 – 211 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 212 – 239 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 240 – 265 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 266 – 273 | ExtracellularSequence analysis | 8 | |
Transmembranei | 274 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 298 – 325 | CytoplasmicSequence analysisAdd BLAST | 28 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069732 | 1 – 325 | Melanocortin receptor 5Add BLAST | 325 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 15 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 311 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 312 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, PalmitateProteomic databases
PaxDbi | P35345 |
PRIDEi | P35345 |
PTM databases
GlyGeni | P35345, 3 sites |
PhosphoSitePlusi | P35345 |
Expressioni
Tissue specificityi
Very low expression levels is detected in brain, while high levels are found in adrenals, stomach, lung and spleen.
Gene expression databases
Bgeei | ENSRNOG00000016685, Expressed in esophagus and 13 other tissues |
Genevisiblei | P35345, RN |
Interactioni
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000022364 |
Chemistry databases
BindingDBi | P35345 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00960000186617 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P35345 |
OMAi | ARTHVKR |
OrthoDBi | 877700at2759 |
PhylomeDBi | P35345 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001908, Melancort_rcpt IPR000621, Melancort_rcpt_5 IPR001671, Melcrt_ACTH_rcpt |
PANTHERi | PTHR22750:SF5, PTHR22750:SF5, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01063, MELNOCORTN5R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P35345-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSSSHLTLL DLTLNASEDN ILGQNVNNKS SACEDMGIAV EVFLTLGLVS
60 70 80 90 100
LLENILVIGA IVKNKNLHSP MYFFVGSLAV ADMLVSMSNA WETITIYLIN
110 120 130 140 150
NKHVVIADTF VRHIDNVFDS MICISVVASM CSLLAIAVDR YITIFYALRY
160 170 180 190 200
HHIMTARRSG VIIACIWTFC ISCGIVFIIY YESKYVIVCL ISMFFTMLFF
210 220 230 240 250
MVSLYIHMFL LARNHVKRIA ASPRYNSVRQ RASMKGAITL TMLLGIFIVC
260 270 280 290 300
WSPFFLHLIL MISCPQNVYC ACFMSYFNMY LILIMCNSVI DPLIYALRSQ
310 320
EMRRTFKEII CCHGFRRTCT LLGRY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L27081 mRNA Translation: AAA41577.1 |
PIRi | JC2193 |
RefSeqi | NP_037314.1, NM_013182.2 XP_017456350.1, XM_017600861.1 |
Genome annotation databases
Ensembli | ENSRNOT00000022364; ENSRNOP00000022364; ENSRNOG00000016685 |
GeneIDi | 25726 |
KEGGi | rno:25726 |
UCSCi | RGD:3058, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L27081 mRNA Translation: AAA41577.1 |
PIRi | JC2193 |
RefSeqi | NP_037314.1, NM_013182.2 XP_017456350.1, XM_017600861.1 |
3D structure databases
SMRi | P35345 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000022364 |
Chemistry databases
BindingDBi | P35345 |
ChEMBLi | CHEMBL2701 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35345, 3 sites |
PhosphoSitePlusi | P35345 |
Proteomic databases
PaxDbi | P35345 |
PRIDEi | P35345 |
Genome annotation databases
Ensembli | ENSRNOT00000022364; ENSRNOP00000022364; ENSRNOG00000016685 |
GeneIDi | 25726 |
KEGGi | rno:25726 |
UCSCi | RGD:3058, rat |
Organism-specific databases
CTDi | 4161 |
RGDi | 3058, Mc5r |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00960000186617 |
HOGENOMi | CLU_009579_13_0_1 |
InParanoidi | P35345 |
OMAi | ARTHVKR |
OrthoDBi | 877700at2759 |
PhylomeDBi | P35345 |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors |
Miscellaneous databases
PROi | PR:P35345 |
Gene expression databases
Bgeei | ENSRNOG00000016685, Expressed in esophagus and 13 other tissues |
Genevisiblei | P35345, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001908, Melancort_rcpt IPR000621, Melancort_rcpt_5 IPR001671, Melcrt_ACTH_rcpt |
PANTHERi | PTHR22750:SF5, PTHR22750:SF5, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00534, MCRFAMILY PR00535, MELNOCORTINR PR01063, MELNOCORTN5R |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MC5R_RAT | |
Accessioni | P35345Primary (citable) accession number: P35345 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries