Cxcr2

Functionⁱ

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.1 Publication

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
C-C chemokine receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine receptor activity
Source: MGI
Inferred from direct assayⁱ
- 16618742
C-X-C chemokine receptor activity Source: MGI
G protein-coupled receptor activity Source: MGI
interleukin-8 binding Source: MGI
interleukin-8 receptor activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acute inflammatory response to antigenic stimulus Source: MGI
calcium-mediated signaling
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell surface receptor signaling pathway Source: MGI
cellular defense response Source: MGI
chemotaxis Source: MGI
immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-8-mediated signaling pathway Source: MGI
metanephric tubule morphogenesis Source: MGI
midbrain development Source: Ensembl
negative regulation of apoptotic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 16618742
negative regulation of neutrophil apoptotic process Source: MGI
neutrophil activation Source: MGI
neutrophil chemotaxis Source: MGI
phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
positive regulation of angiogenesis Source: MGI
positive regulation of cardiac muscle cell apoptotic process Source: MGI
positive regulation of cell proliferation Source: MGI
positive regulation of cytosolic calcium ion concentration Source: MGI
positive regulation of leukocyte chemotaxis Source: MGI
positive regulation of neutrophil chemotaxis Source: MGI
positive regulation of vascular permeability Source: MGI
receptor internalization Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Chemotaxis

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-X-C chemokine receptor type 2 Short name: CXC-R2 Short name: CXCR-2 Alternative name(s): GRO/MGSA receptor High affinity interleukin-8 receptor B Short name: IL-8R B CD_antigen: CD182
Gene namesⁱ	Name:Cxcr2 Synonyms:Cmkar2, Gpcr16, Il8rb
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:105303 Cxcr2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 47	ExtracellularSequence analysisAdd BLAST	47
Transmembraneⁱ	48 – 74	Helical; Name=1Sequence analysisAdd BLAST	27
Topological domainⁱ	75 – 83	CytoplasmicSequence analysis	9
Transmembraneⁱ	84 – 104	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	105 – 119	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	120 – 141	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	142 – 162	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	163 – 182	Helical; Name=4Sequence analysisAdd BLAST	20
Topological domainⁱ	183 – 207	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	208 – 230	Helical; Name=5Sequence analysisAdd BLAST	23
Topological domainⁱ	231 – 250	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	251 – 272	Helical; Name=6Sequence analysisAdd BLAST	22
Topological domainⁱ	273 – 293	ExtracellularSequence analysisAdd BLAST	21
Transmembraneⁱ	294 – 314	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	315 – 359	CytoplasmicSequence analysisAdd BLAST	45

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	69

GuidetoPHARMACOLOGYⁱ

69

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069339	1 – 359	C-X-C chemokine receptor type 2Add BLAST		359

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	23	N-linked (GlcNAc...) asparagineSequence analysis		1
Disulfide bondⁱ	118 ↔ 195	PROSITE-ProRule annotation

Post-translational modificationⁱ

Phosphorylated upon ligand binding; which is required for desensitization.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P35343
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P35343
PaxDbⁱ	P35343
PRIDEⁱ	P35343

PTM databases

PhosphoSitePlusⁱ	P35343

PhosphoSitePlusⁱ

P35343

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000026180 Expressed in 16 organ(s), highest expression level in placenta
CleanExⁱ	MM_IL8RB

Interactionⁱ

GO - Molecular functionⁱ

C-C chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-8 binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	P35343
STRINGⁱ	10090.ENSMUSP00000027372

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P35343
SMRⁱ	P35343
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEHI Eukaryota ENOG410Y9Y6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154636
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	P35343
KEGG Orthology (KO) More...KOⁱ	K05050
OMAⁱ	INKHAVV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0C7W
PhylomeDBⁱ	P35343
TreeFamⁱ	TF330966

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15178 7tmA_CXCR1_2, 1 hit
InterProⁱ	View protein in InterPro IPR000057 Chemokine_CXCR2 IPR000174 Chemokine_CXCR_1/2 IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00427 INTRLEUKIN8R PR00573 INTRLEUKN8BR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P35343-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGEFKVDKFN IEDFFSGDLD IFNYSSGMPS ILPDAVPCHS ENLEINSYAV 
        60         70         80         90        100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL 
       110        120        130        140        150
PVWAASKVNG WTFGSTLCKI FSYVKEVTFY SSVLLLACIS MDRYLAIVHA 
       160        170        180        190        200
TSTLIQKRHL VKFVCIAMWL LSVILALPIL ILRNPVKVNL STLVCYEDVG 
       210        220        230        240        250
NNTSRLRVVL RILPQTFGFL VPLLIMLFCY GFTLRTLFKA HMGQKHRAMR 
       260        270        280        290        300
VIFAVVLVFL LCWLPYNLVL FTDTLMRTKL IKETCERRDD IDKALNATEI 
       310        320        330        340        350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAT YGLVSKEFLA KEGRPSFVSS 

SSANTSTTL

Length:359

Mass (Da):40,425

Last modified:June 1, 1994 - v1

Checksum:ⁱ74BD166E9B679F88

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L23637 Genomic DNA Translation: AAA39305.1 L26549 Genomic DNA Translation: AAL31314.1 L13239 Genomic DNA Translation: AAA62109.1 U31207 Genomic DNA Translation: AAC52239.1 D17630 mRNA Translation: BAA04536.1 AK158234 mRNA Translation: BAE34417.1 CH466548 Genomic DNA Translation: EDL00307.1 BC051677 mRNA Translation: AAH51677.1 L20337 mRNA Translation: AAA16853.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15040.1
PIRⁱ	A48921
NCBI Reference Sequences More...RefSeqⁱ	NP_034039.1, NM_009909.3 XP_006495701.1, XM_006495638.3
UniGeneⁱ	Mm.234466

Genome annotation databases

Ensemblⁱ	ENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180 ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180
GeneIDⁱ	12765
KEGGⁱ	mmu:12765
UCSC genome browser More...UCSCⁱ	uc007bll.1 mouse

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P35343	C-X-C chemokine receptor type 2	)	HUMAN		360	UniRef50_P25025
C-X-C chemokine receptor type 2 (Fragment)		PANTR		357
C-X-C chemokine receptor type 2 (Fragment)		GORGO		353
C-X-C chemokine receptor type 2 (Fragment)		MACMU		353
C-X-C chemokine receptor type 2		RAT		359
+387

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L23637 Genomic DNA Translation: AAA39305.1 L26549 Genomic DNA Translation: AAL31314.1 L13239 Genomic DNA Translation: AAA62109.1 U31207 Genomic DNA Translation: AAC52239.1 D17630 mRNA Translation: BAA04536.1 AK158234 mRNA Translation: BAE34417.1 CH466548 Genomic DNA Translation: EDL00307.1 BC051677 mRNA Translation: AAH51677.1 L20337 mRNA Translation: AAA16853.1
CCDSⁱ	CCDS15040.1
PIRⁱ	A48921
RefSeqⁱ	NP_034039.1, NM_009909.3 XP_006495701.1, XM_006495638.3
UniGeneⁱ	Mm.234466

3D structure databases

ProteinModelPortalⁱ	P35343
SMRⁱ	P35343
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	P35343
STRINGⁱ	10090.ENSMUSP00000027372

Chemistry databases

GuidetoPHARMACOLOGYⁱ	69

GuidetoPHARMACOLOGYⁱ

69

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	P35343

PhosphoSitePlusⁱ

P35343

Proteomic databases

EPDⁱ	P35343
MaxQBⁱ	P35343
PaxDbⁱ	P35343
PRIDEⁱ	P35343

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180 ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180
GeneIDⁱ	12765
KEGGⁱ	mmu:12765
UCSCⁱ	uc007bll.1 mouse

Organism-specific databases

CTDⁱ	3579
MGIⁱ	MGI:105303 Cxcr2

Phylogenomic databases

eggNOGⁱ	ENOG410IEHI Eukaryota ENOG410Y9Y6 LUCA
GeneTreeⁱ	ENSGT00940000154636
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	P35343
KOⁱ	K05050
OMAⁱ	INKHAVV
OrthoDBⁱ	EOG091G0C7W
PhylomeDBⁱ	P35343
TreeFamⁱ	TF330966

Enzyme and pathway databases

Reactomeⁱ	R-MMU-380108 Chemokine receptors bind chemokines R-MMU-418594 G alpha (i) signalling events R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P35343
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026180 Expressed in 16 organ(s), highest expression level in placenta
CleanExⁱ	MM_IL8RB

Family and domain databases

CDDⁱ	cd15178 7tmA_CXCR1_2, 1 hit
InterProⁱ	View protein in InterPro IPR000057 Chemokine_CXCR2 IPR000174 Chemokine_CXCR_1/2 IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00427 INTRLEUKIN8R PR00573 INTRLEUKN8BR
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXCR2_MOUSE
Accessionⁱ	P35343Primary (citable) accession number: P35343 Secondary accession number(s): Q53X27
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
	Last sequence update:	June 1, 1994
	Last modified:	December 5, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P35343 (CXCR2_MOUSE)

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C-X-C chemokine receptor type 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Lysosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ