UniProtKB - P35343 (CXCR2_MOUSE)
Protein
C-X-C chemokine receptor type 2
Gene
Cxcr2
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.1 Publication
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- C-C chemokine receptor activity Source: GO_Central
- chemokine binding Source: GO_Central
- chemokine receptor activity Source: MGI
- C-X-C chemokine receptor activity Source: MGI
- G protein-coupled receptor activity Source: MGI
- interleukin-8 binding Source: MGI
- interleukin-8 receptor activity Source: MGI
GO - Biological processi
- acute inflammatory response to antigenic stimulus Source: MGI
- calcium-mediated signaling Source: GO_Central
- cell chemotaxis Source: GO_Central
- cell surface receptor signaling pathway Source: MGI
- cellular defense response Source: MGI
- chemotaxis Source: MGI
- immune response Source: GO_Central
- interleukin-8-mediated signaling pathway Source: MGI
- metanephric tubule morphogenesis Source: MGI
- midbrain development Source: Ensembl
- negative regulation of apoptotic process Source: MGI
- negative regulation of neutrophil apoptotic process Source: MGI
- neutrophil activation Source: MGI
- neutrophil chemotaxis Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
- positive regulation of angiogenesis Source: MGI
- positive regulation of cardiac muscle cell apoptotic process Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of leukocyte chemotaxis Source: MGI
- positive regulation of neutrophil chemotaxis Source: MGI
- positive regulation of vascular permeability Source: MGI
- receptor internalization Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Chemotaxis |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: C-X-C chemokine receptor type 2Short name: CXC-R2 Short name: CXCR-2 Alternative name(s): GRO/MGSA receptor High affinity interleukin-8 receptor B Short name: IL-8R B CD_antigen: CD182 |
Gene namesi | Name:Cxcr2 Synonyms:Cmkar2, Gpcr16, Il8rb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:105303, Cxcr2 |
Subcellular locationi
Plasma membrane
Cytoskeleton
- microtubule cytoskeleton Source: MGI
- mitotic spindle Source: MGI
Lysosome
- mast cell granule Source: MGI
Nucleus
- nucleoplasm Source: MGI
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 47 | ExtracellularSequence analysisAdd BLAST | 47 | |
Transmembranei | 48 – 74 | Helical; Name=1Sequence analysisAdd BLAST | 27 | |
Topological domaini | 75 – 83 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 84 – 104 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 105 – 119 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 120 – 141 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 142 – 162 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 163 – 182 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 183 – 207 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 208 – 230 | Helical; Name=5Sequence analysisAdd BLAST | 23 | |
Topological domaini | 231 – 250 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 251 – 272 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 273 – 293 | ExtracellularSequence analysisAdd BLAST | 21 | |
Transmembranei | 294 – 314 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 315 – 359 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069339 | 1 – 359 | C-X-C chemokine receptor type 2Add BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 23 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 118 ↔ 195 | PROSITE-ProRule annotation |
Post-translational modificationi
Phosphorylated upon ligand binding; which is required for desensitization.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P35343 |
MaxQBi | P35343 |
PaxDbi | P35343 |
PRIDEi | P35343 |
PTM databases
GlyGeni | P35343, 1 site |
iPTMneti | P35343 |
PhosphoSitePlusi | P35343 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026180, Expressed in granulocyte and 40 other tissues |
Interactioni
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- chemokine binding Source: GO_Central
- interleukin-8 binding Source: MGI
Protein-protein interaction databases
CORUMi | P35343 |
STRINGi | 10090.ENSMUSP00000102512 |
Chemistry databases
BindingDBi | P35343 |
Miscellaneous databases
RNActi | P35343, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214381 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P35343 |
OMAi | INKHAVV |
OrthoDBi | 865441at2759 |
PhylomeDBi | P35343 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR000057, Chemokine_CXCR2 IPR000174, Chemokine_CXCR_1/2 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00427, INTRLEUKIN8R PR00573, INTRLEUKN8BR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P35343-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGEFKVDKFN IEDFFSGDLD IFNYSSGMPS ILPDAVPCHS ENLEINSYAV
60 70 80 90 100
VVIYVLVTLL SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL
110 120 130 140 150
PVWAASKVNG WTFGSTLCKI FSYVKEVTFY SSVLLLACIS MDRYLAIVHA
160 170 180 190 200
TSTLIQKRHL VKFVCIAMWL LSVILALPIL ILRNPVKVNL STLVCYEDVG
210 220 230 240 250
NNTSRLRVVL RILPQTFGFL VPLLIMLFCY GFTLRTLFKA HMGQKHRAMR
260 270 280 290 300
VIFAVVLVFL LCWLPYNLVL FTDTLMRTKL IKETCERRDD IDKALNATEI
310 320 330 340 350
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAT YGLVSKEFLA KEGRPSFVSS
SSANTSTTL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L23637 Genomic DNA Translation: AAA39305.1 L26549 Genomic DNA Translation: AAL31314.1 L13239 Genomic DNA Translation: AAA62109.1 U31207 Genomic DNA Translation: AAC52239.1 D17630 mRNA Translation: BAA04536.1 AK158234 mRNA Translation: BAE34417.1 CH466548 Genomic DNA Translation: EDL00307.1 BC051677 mRNA Translation: AAH51677.1 L20337 mRNA Translation: AAA16853.1 |
CCDSi | CCDS15040.1 |
PIRi | A48921 |
RefSeqi | NP_034039.1, NM_009909.3 XP_006495701.1, XM_006495638.3 |
Genome annotation databases
Ensembli | ENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180 ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180 |
GeneIDi | 12765 |
KEGGi | mmu:12765 |
UCSCi | uc007bll.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L23637 Genomic DNA Translation: AAA39305.1 L26549 Genomic DNA Translation: AAL31314.1 L13239 Genomic DNA Translation: AAA62109.1 U31207 Genomic DNA Translation: AAC52239.1 D17630 mRNA Translation: BAA04536.1 AK158234 mRNA Translation: BAE34417.1 CH466548 Genomic DNA Translation: EDL00307.1 BC051677 mRNA Translation: AAH51677.1 L20337 mRNA Translation: AAA16853.1 |
CCDSi | CCDS15040.1 |
PIRi | A48921 |
RefSeqi | NP_034039.1, NM_009909.3 XP_006495701.1, XM_006495638.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
CORUMi | P35343 |
STRINGi | 10090.ENSMUSP00000102512 |
Chemistry databases
BindingDBi | P35343 |
ChEMBLi | CHEMBL4105830 |
GuidetoPHARMACOLOGYi | 69 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P35343, 1 site |
iPTMneti | P35343 |
PhosphoSitePlusi | P35343 |
Proteomic databases
EPDi | P35343 |
MaxQBi | P35343 |
PaxDbi | P35343 |
PRIDEi | P35343 |
Protocols and materials databases
Antibodypediai | 4268, 979 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027372; ENSMUSP00000027372; ENSMUSG00000026180 ENSMUST00000106899; ENSMUSP00000102512; ENSMUSG00000026180 |
GeneIDi | 12765 |
KEGGi | mmu:12765 |
UCSCi | uc007bll.1, mouse |
Organism-specific databases
CTDi | 3579 |
MGIi | MGI:105303, Cxcr2 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214381 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P35343 |
OMAi | INKHAVV |
OrthoDBi | 865441at2759 |
PhylomeDBi | P35343 |
TreeFami | TF330966 |
Enzyme and pathway databases
Reactomei | R-MMU-380108, Chemokine receptors bind chemokines R-MMU-418594, G alpha (i) signalling events R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 12765, 1 hit in 17 CRISPR screens |
ChiTaRSi | Cxcr2, mouse |
PROi | PR:P35343 |
RNActi | P35343, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026180, Expressed in granulocyte and 40 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000057, Chemokine_CXCR2 IPR000174, Chemokine_CXCR_1/2 IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00427, INTRLEUKIN8R PR00573, INTRLEUKN8BR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXCR2_MOUSE | |
Accessioni | P35343Primary (citable) accession number: P35343 Secondary accession number(s): Q53X27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 170 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries